This study demonstrates the valorization of sugarcane bagasse ash as a bio-based filler in cassava starch foam trays produced via thermopressing. Bagasse ash significantly...
This study provides a large-scale evaluation of surgical outcomes for urinary stone disease across different age groups, focusing on patients undergoing ureteroscopy...
This cover story illustrates a hybrid quantum-kernel and quantum-inspired machine learning framework for the early warning of Telephony Denial of Service (TDoS)...
The Canadian Journal of Urology (CJU) officially became a DOAJ (Directory of Open Access Journals)-indexed journal on 03 September 2026, marking another important milestone in the journal’s...
The Canadian Journal of Urology proudly congratulates its Editor-in-Chief, Leonard G. Gomella, MD, on receiving the 2026 Lifetime Achievement Award from the American Urological Association (AUA)....
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...
Programmed cell death regulates the tumor immune microenvironment. A comprehensive synthesis of how multiple programmed cell death pathways collectively orchestrate the remodeling of the urological immune landscape is currently lacking. This review summarizes and discusses how diverse programmed cell death modes, including ferroptosis, pyroptosis, autophagy, PANoptosis, necroptosis and cuproptosis, regulate immune evasion or activation in a context-dependent manner. Current preclinical evidence suggests that necroptosis, pyroptosis, and cuproptosis may enhance anti-tumor immunity by facilitating the release…
Gastric cancer (GC) remains a leading cause of global cancer mortality, with progression and therapy resistance heavily influenced by the dynamic tumor microenvironment (TME). Despite advances in surgical techniques, chemotherapy, targeted therapy, and immunotherapy, overall survival for advanced disease remains poor, underscoring the need for a deeper understanding of resistance mechanisms. A hallmark of the TME is metabolic reprogramming, which sustains tumor growth and actively shapes an immunosuppressive landscape. This review aims to detail the…
Objective: Liposomal doxorubicin (L-DOX) may alter macrophage-mediated immune regulation in triple-negative breast cancer (TNBC), but its role in programmed death-ligand 1 (PD-L1)-associated immune escape remains unclear. This study aimed to determine whether L-DOX induces a macrophage-centered PD-L1 response and affects the efficacy of PD-L1 blockade in TNBC. Methods: Public bulk and single-cell transcriptomic datasets, bone marrow-derived macrophage models, CD8+ T-cell co-culture assays, promoter-binding analyses, and syngeneic EO771 and 4T1 TNBC mouse models were used to examine PD-L1…
Bladder cancer (BC) is a prevalent malignancy characterized by a high recurrence rate and the necessity for long-term surveillance demands, creating a need for accurate yet practical tools for early detection and monitoring. While current standards including cystoscopy, urinary cytology, and imaging remain indispensable, their clinical utility is constrained by invasiveness, suboptimal sensitivity for selected lesions or low-grade lesions, inter-observer variability, and cumulative costs. Currently, biomarker research has expanded from single protein assays to multi-analyte…
Objectives: Combretastatin A-4 (CA-4) is a microtubule-disrupting agent with established anti-tumor properties. This study aimed to evaluate the effects of CA-4 on key metastatic traits of cancer cells, including migration, clonogenic potential, cytoskeletal protein expression, and microtentacle (McTN) formation, using multiple cancer cell models, including the colon patient-derived circulating tumor cell line CTC-MCC-41. Methods: H1299 (non-small cell lung cancer), MDA-MB-231 (triple-negative breast cancer), HT-29 (colorectal cancer), and CTC-MCC-41 (derived from the blood of a colon cancer…
Breast cancer (BC) continues to be a major cause of cancer-related mortality among women, and early diagnosis remains critical for improving survival outcomes. Conventional tissue biopsy and imaging techniques are constrained by invasiveness and limited sensitivity in early-stage disease, whereas routine serum tumor markers lack sufficient specificity for reliable early detection. Circular RNAs (circRNAs) have increasingly been recognized as promising non-invasive biomarkers, owing to their remarkable stability and detectability in plasma. Here, we summarize the…
Background: Exosomes mediate intercellular communication within the tumor microenvironment. However, their role in modulating mast cell activity in gastric cancer (GC) remains unclear. This study aimed to elucidate whether GC-derived exosomes activate mast cells via the SCF/c-KIT pathway to promote angiogenesis and metastasis, and to assess the therapeutic potential of targeting this axis. Methods: Exosomes were isolated from GC cell lines (AGS, MKN1), a normal gastric epithelial cell line (GES-1), and mouse gastric tumor tissues, followed…
Background: Fascin actin-bundling protein 1 (FSCN1) modulates the expression of key lipogenic enzymes fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD1) in colorectal cancer (CRC), but the underlying mechanisms remain elusive. Methods: Bioinformatics analyses were performed to evaluate FSCN1 expression and its prognostic value in CRC. Intracellular lipid levels following FSCN1 knockdown were assessed by Nile Red/DAPI co-staining and triglyceride quantification, and further validated by Oil Red O staining of xenograft tumors. Expression levels of key metabolic enzymes…
Objectives: YTH N6-Methyladenosine RNA Binding Protein F2 (YTHDF2) had been implicated in nasopharyngeal carcinoma (NPC) progression. Increasing evidence indicated that numerous circular RNAs (circRNAs) were involved in regulating tumor progression. However, how the regulation of circRNAs by YTHDF2 contributes to NPC progression remains to be uncovered. In this study, we aimed to elucidate the role and mechanism of YTHDF2-mediated circRNA regulation in NPC migration and invasion. Methods: YTHDF2 expression in NPC was assessed using GEO datasets…
Objectives: As an aggressive subtype of breast cancer, triple-negative breast cancer (TNBC) is constrained by the limited availability of effective treatments and the absence of well-validated therapeutic targets. This study aimed to explore whether honokiol, a potent YAP/TAZ inhibitor, suppresses stem cell–like properties and enhances chemotherapeutic efficacy in TNBC by blocking YAP/TAZ–TEAD transcriptional complex. Methods: Through both in vitro and in vivo models of TNBC, the current study examined how honokiol influences cell proliferation, cancer stem cell (CSC)…
Objectives: MET inhibitors have demonstrated clinical efficacy in several MET-driven malignancies; however, their therapeutic potential in pancreatic cancer remains insufficiently characterized. This study aimed to evaluate the antitumor activity of the selective MET inhibitor savolitinib in MET-high pancreatic cancer and to investigate the role of autophagy in the cellular response to MET inhibition. Methods: MET-high pancreatic cancer cell lines (AsPC-1 and BxPC-3) were treated with savolitinib. Cell viability, apoptosis, transcriptomic profiling, and signaling pathway analyses were…
Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide. Accurate early detection, timely diagnostic stratification, and robust prognostic risk assessment are essential for optimizing clinical outcomes and improving survival duration. However, conventional serological biomarkers demonstrate limited diagnostic performance owing to suboptimal sensitivity and specificity, while standard chemotherapy and targeted therapies provide only modest survival benefits in GC. Marked inter- and intratumoral heterogeneity further characterizes GC as a biologically complex and treatment-resistant malignancy. To…
Background: While radical cystectomy is standard for muscle-invasive bladder cancer (MIBC), micrometastasis-related recurrence is common. Cisplatin-based neoadjuvant therapy (NAT) confers modest benefits, while immune checkpoint inhibitors (ICIs) provide new efficacy-enhancing strategies. This study aims to compare the efficacy and safety of ICIs with chemotherapy (NAC-ICI), neoadjuvant chemotherapy (NAC), and no neoadjuvant therapy (NNAT). It also explores potential biomarkers predictive of NAT response and evaluates the real-world efficacy of NAC-IC. Method: This single-center retrospective analysis included 80…
Objectives: There is debate over the effect of sevoflurane (SEV) on different cancers. This study aims to explore SEV’s role in colon cancer (CC) progression. Methods: The CC cell lines were treated with SEV at concentrations of 1.7%, 3.4%, and 5.1%. Cell proliferation, apoptosis, migration, and invasion were assessed using Cell Counting Kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU) incorporation, colony formation assay, flow cytometry, Western blot, scratch assay, and Transwell assay. A xenograft tumor model was established to…
Triple negative breast cancer (TNBC) is defined by the absence of oestrogen receptor, progesterone receptor, and HER2 expression, and carries a disproportionate burden of breast cancer-related mortality due to its aggressive biology and historically limited therapeutic options. The treatment landscape of metastatic TNBC has undergone a fundamental transformation over the past decade, driven by immune checkpoint inhibitors, antibody-drug conjugates (ADCs), and the identification of actionable genomic alterations. This review provides a comprehensive, clinically oriented appraisal
Objectives: Sorting nexin 9 (SNX9) participates in endocytic trafficking and has been connected to several malignancies, but its involvement in breast cancer (BC) remains incompletely resolved. This work was designed to examine whether SNX9 supports BC progression and investigate signaling and cytoskeletal processes associated with its activity. Methods: The clinical relevance of SNX9 was assessed using bioinformatics analysis of publicly available cancer databases. Lentiviral vectors were used to establish BC cell models with stable SNX9 overexpression…
Guest Editors: Van-Tu Nguyen; Ould el Moctar; Anh Dinh Le; Hemant J. Sagar Deadline: 30 September 2027
Guest Editors: Jin-Gyun Kim; Hee-Sun Choi; Seongji Han Deadline: 30 September 2027
Guest Editors: Hung-Yu Lin; Hsing-Ju Wu Deadline: 31 May 2027
Guest Editors: Carlos Vargas-Salgado; Dácil Diaz-Bello Deadline: 30 April 2027
Guest Editors: Leonardo Di G. Sigalotti; Carlos A. Vargas; Carlos E. Alvarado-Rodríguez Deadline: 30 April 2027
Guest Editors: Sabrina Tosi; Annabelle Lewis Deadline: 30 April 2027
Guest Editors: Wenlong Sun; Mengyao Li Deadline: 31 March 2027
Guest Editors: Wenbing Zhao; Pan Wang Deadline: 31 March 2027
Guest Editors: Wenfeng Zheng; Choon Kit Chan; Kyungtae Kang; Chao Liu Deadline: 31 March 2027
Guest Editors: Joanna Zawitkowska; Małgorzata Mitura-Lesiuk; Maciej Dubaj Deadline: 28 February 2027
Guest Editors: Wenfeng Zheng; Lirong Yin; Shan Liu Deadline: 15 February 2027
Guest Editors: Wei-Chiang Hong; Yi Liang; Ming-Wei Li; Zhong-Yi Yang Deadline: 15 February 2027
Guest Editors: Jungpil Shin; Yong Seok Hwang Deadline: 31 January 2027
Guest Editors: Denise Mafra; Jessyca Sousa de Brito Deadline: 31 January 2027
Guest Editors: Qi Chen; Yunhui Tang Deadline: 31 December 2026
Guest Editors: Hung-Yu Lin Deadline: 31 December 2026






