Low-thermal argon plasma treatment activates anti-tumor responses through diverse mechanisms, including the generation of reactive oxygen and nitrogen species (RONS),...
On the Cover This study demonstrates a cost-effective and efficient strategy for fabricating high-hardness Ge₄₅As₄₀Se₁₅ chalcogenide glass by combining ball milling...
This paper presents the development of the Broad-scope Environment for Dual-phase advanced reactor Operation simulation Kit (BEDOK), an in-house nuclear reactor...
We are pleased to announce that the Canadian Journal of Urology (CJU) has received notification from Clarivate that it will be indexed in BIOSIS Citation Index, BIOSIS Previews, and Biological...
We are pleased to announce that Revue Internationale de Géomatique (ISSN: 2116-7060) has been accepted for inclusion in Scopus, a leading abstract and citation database of peer-reviewed literature.Scopus...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
Zinc substitution in Cd1−xZnxTe (CZT) alloys emerges as a powerful strategy for engineering their structural, elastic, mechanical, acoustic and thermal...
A lightweight flow-based intrusion detection system is proposed for identifying Mirai-based distributed denial-of-service attacks in Internet of Things...
In doped two-dimensional nanomaterials, magnetism is one of the important physical properties. By introducing foreign doping atoms or molecules, the electronic...
The integration of Deep Learning, Deep Reinforcement Learning, and massive Vision-Language-Action (VLA) foundation models has catalysed a profound paradigm...
Lung cancer in individuals who have never smoked (LCINS) represents a clinically and biologically distinct subset of non–small cell lung cancer, driven...
Breast cancer (BC) management has transitioned from histological classification to molecular subtyping, yet therapeutic resistance and intratumor heterogeneity...
Despite the use of targeted and/or immune-based therapeutic approaches, mortality rates among melanoma patients are high, mainly due to drug-induced resistance...
Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
Zinc substitution in Cd1−xZnxTe (CZT) alloys emerges as a powerful strategy for engineering their structural, elastic, mechanical, acoustic and thermal...
A lightweight flow-based intrusion detection system is proposed for identifying Mirai-based distributed denial-of-service attacks in Internet of Things...
In doped two-dimensional nanomaterials, magnetism is one of the important physical properties. By introducing foreign doping atoms or molecules, the electronic...
The integration of Deep Learning, Deep Reinforcement Learning, and massive Vision-Language-Action (VLA) foundation models has catalysed a profound paradigm...
Lung cancer in individuals who have never smoked (LCINS) represents a clinically and biologically distinct subset of non–small cell lung cancer, driven...
Breast cancer (BC) management has transitioned from histological classification to molecular subtyping, yet therapeutic resistance and intratumor heterogeneity...
Despite the use of targeted and/or immune-based therapeutic approaches, mortality rates among melanoma patients are high, mainly due to drug-induced resistance...
Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Objective: Mitochondrial dysfunction and ferroptosis contribute critically to acute lung injury (ALI), yet therapies targeting this pathway remain limited. This study investigates whether Salviadione, a rare alkaloid, protects against lipopolysaccharide (LPS)-induced epithelial damage by modulating the mitochondrial ferroptosis pathway. Methods: Network pharmacology, molecular docking, and molecular dynamics simulations identified potential targets. An in vitro model of lung epithelial injury was established using BEAS-2B cells exposed to LPS. Cell viability, lactate dehydrogenase (LDH) release, lipid peroxidation, Fe2+ accumulation, glutathione…
Background: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by inflammation and fibrosis. Oridonin (Ori) exhibits anti-inflammatory and anti-fibrotic properties, but its role in NASH remains unclear. The study aimed to investigate whether Ori alleviates NASH injury by regulating pyroptosis through the nuclear factor-κB (NF-κB)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) axis. Methods: An in vitro NASH model was established in HepG2 cells using free fatty acids (FFA), and an in vivo model was induced in mice using…
Background: Opioids can modulate mitochondrial redox homeostasis and autophagy and are implicated in the regulation of key physiological and pathological processes, including aging, cellular metabolism, and tumorigenesis. The study aimed to investigate how opioid receptor agonists influence lipopolysaccharide-induced senescence in microglia. Methods: C8-B4 microglial cells were either left untreated or pretreated with different opioid agonists and subsequently exposed to lipopolysaccharide (LPS). Colorimetric assays, fluorescence microscopy, flow cytometry, and Western blotting were used to assess cellular senescence,…
Cardio-kidney-metabolic (CKM) syndrome and periodontal diseases are bi-directionally linked pathologies driven by systemic inflammation, oxidative stress, and metabolic dysregulation. Identifying pleiotropic therapeutic agents targeting this axis is a major clinical priority. This review evaluates the bio-cellular role of propolis, a natural resinous hive product, in mitigating CKM syndrome and periodontal disease. Propolis exerts robust protective effects by modulating key intracellular signaling pathways. Specifically, it upregulates nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant defenses, which…
Background: Myocardial ischemia-reperfusion (I/R) injury represents a severe pathological process in cardiovascular diseases. This study aims to elucidate the mechanism of the yeast ovarian tumor (OTU) domain-containing protein 1 (YOD1) in cardiomyocyte injury. Methods: A hypoxia/reoxygenation (H/R) model was established using human AC16 cells to simulate I/R injury in vitro. Reverse transcription quantitative PCR (RT-qPCR) and western blotting were used to detect gene and protein expression. Cellular functions were evaluated using Cell Counting Kit-8 (CCK-8), lactate dehydrogenase…
This review discusses the dual role of DNA double-strand breaks (DSBs) in the brain, where they can act as both physiological regulators of gene expression and contributors to neuronal dysfunction under pathological conditions. In post-mitotic neurons, which rely mainly on non-homologous end joining, the balance between DSB formation and repair appears to be especially important. Recent studies show that transient activity-induced DSBs, particularly at regulatory regions of immediate early genes (IEGs), support chromatin remodeling and…
Objectives: Neuroinflammation, largely mediated by microglial activation, plays a central role in the pathogenesis of neurodegenerative diseases. In this study, we aimed to evaluate olive leaf extracts (OLEs) from three Croatian cultivars (Buža, Oblica, and Leccino) in the context of lipopolysaccharide (LPS)-induced activation of BV-2 microglia. Methods: Extracts were prepared by aqueous maceration and ethanol extraction under conditions compatible with downstream cell-culture use. Total phenolic and flavonoid contents were determined for both extract types, alongside targeted…
Costunolide, a sesquiterpene lactone from Saussurea lappa Clarke, exhibits broad pharmacological properties, including anti-inflammatory and anticancer effects. This review examines its emerging potential as a host-directed antiviral compound. Costunolide modulates conserved host signaling pathways frequently exploited during viral infection, including nuclear factor-kappa B (NF-κB), the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, and mitogen-activated protein kinase (MAPK) cascades. Inhibition of NF-κB may suppress viral transcription in human immunodeficiency virus (HIV-1) infection, while NLRP3 blockade may…
Peroxiredoxin 5 (PRX5) is an atypical 2-Cys peroxiredoxin distributed across mitochondria, peroxisomes, cytosol, and nucleus. Unlike other PRX isoforms, PRX5 acts not only as a reactive oxygen species (ROS) scavenger but also as a redox-dependent regulator of oncogenic signaling. Cancer stem cells (CSCs) maintain low intracellular ROS to preserve self-renewal and drug resistance, and PRX5 has emerged as a key mediator of this redox control. This review examines the. PRX5-ROS-Signal Transducer and Activator of Transcription…
Idiopathic pulmonary fibrosis (IPF) is an age-associated, progressive fibrotic interstitial lung disease with limited disease-modifying therapies and poor long-term outcomes. Increasing evidence indicates that senescence of alveolar type II epithelial (AT2) cells is not merely a bystander phenomenon but a central driver of epithelial dysfunction, failed alveolar regeneration, and fibrotic remodeling. In this narrative review, we summarize recent mechanistic, single-cell, epigenetic, and translational studies that have reshaped the epithelial-centered model of IPF. We first outline…
Triple-negative breast cancer (TNBC) is defined by the absence of estrogen, progesterone, and human epidermal growth factor receptor 2 expression and exhibits significant molecular heterogeneity and aggressive clinical behavior. The main treatment remains traditional chemotherapy, despite the modest duration of its effects, which has intensified the search for novel, non-chemotherapeutic drugs. Over the past few years, various molecularly targeted and immune-based treatments targeting TNBC’s diverse oncogenic drivers have been uncovered. In immunotherapy, checkpoint blockade and…
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related critical illness, i.e., severe form of coronavirus disease 2019 (COVID-19), is associated with a hyperinflammatory state. In COVID-19 disease, several components of the body, including the complement system, different cells such as endothelial cells, platelets, monocytes, and neutrophils, and various pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor α, can contribute to a state of coagulopathy, and ultimately, all these factors cause extensive tissue damage. This pathological…
The development of efficient and migration-resistant plasticizers from renewable resources is an important challenge for the modern polymer industry. This work presents a thermodynamic approach for the rapid screening of novel bio-based plasticizers-esters of dicarboxylic acids. Using differential scanning calorimetry (DSC), the temperatures and enthalpies of melting and crystallization of the individual esters were determined, and the hysteresis of phase transition parameters was calculated as a predictive indicator. It is shown that bio-based butoxyethyl esters…
The search for sustainable alternatives to expanded polystyrene (EPS) has led to the development of starch-based foams reinforced with agro-industrial by-product. This study aimed to evaluate the effect of sugarcane bagasse ash (SBA) content on the physical, mechanical, and water-interaction properties of cassava starch foam trays, and to determine the maximum feasible ash content that could be incorporated. Sugarcane bagasse ash was collected from the boiler air preheater. Foam trays were prepared by thermopressing using…
Randu wood is a fast-growing wood species with a low density, ranging from 0.21 to 0.28 g/cm3. This limits the utilization of this species, particularly for structural purposes. Improving the quality and strength of wood can be done by applying a densification process. The effectiveness of this process may be improved by applying in-situ delignification using peracetic acid as a pretreatment. Therefore, this study aimed to analyze the physical (moisture content and density), dimensional stability (TR-ratios,…
The promotion of bio-carbon for developing superior electrodes has become a trending topic in realising the practical application of supercapacitor devices. This study aimed to prepare porous carbon (PC) with a taproot fiber-like nanostructure that was decorated with self-doped oxygen. The waste of red suren leaves (RSL) was further treated using a direct heating method with the catalyst effect of ZnCl2 (0.3, 0.5, and 0.7 M) in an N2/CO2 environment at 850°C, being examined. The results…
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