This cover illustrates the transformation of bio-derived tannin from quebracho wood into porous carbon cryogels for sustainable supercapacitors. Freeze-drying preserves...
A one-year longitudinal study of 285 Chinese mother-adolescent dyads reveals that different dimensions of overparenting have distinct effects on adolescent internalizing...
This study applies the three-dimensional Ripley’s L function to quantitatively assess solid-liquid mixing homogeneity in a stirred tank. The figure presents the...
June 2026 — Tech Science Press (TSP) is pleased to announce that 17 TSP journals have received updated 2025 Scopus CiteScore and SNIP metrics.The latest results reflect the growing visibility...
Washington, DC, USA, 18 May 2026 — Canadian Journal of Urology (CJU) Managing Editor Dany Xiang attended the 2026 Annual Meeting of the American Urological Association (AUA), one of the...
Cerebral palsy is a prevalent neurodevelopmental syndrome that disrupts motor development in children, making early detection vital for effective intervention....
Current automated lesion segmentation methods have limited success, particularly for segmenting small, irregular, or heterogeneous lesions. Moreover,...
This paper presents a dynamic energy management strategy for a community-scale campus hybrid microgrid integrating photovoltaic (PV) generation, aggregated...
This study investigates the problem of prioritizing rooftop renewable energy (RE) system configurations for a multi-family residential building in Mediterranean...
This paper addresses the challenge of efficiently calculating dynamic carbon emission factors (CEFs) in large-scale power systems. Traditional methods...
Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation,...
Checkpoint kinase 1 (CHK1), a key regulator of cell cycle checkpoints, plays a central role in the DNA damage response network, serving as a critical...
Glioblastoma (GB) is the most common primary malignant brain tumor of adulthood, and despite optimal safe resection and chemoradiation, it is still lethal....
Objectives: Circulating tumor cells (CTCs) drive metastasis and exhibit resistance to conventional therapies, making them crucial therapeutic targets....
Molecular glue degraders (MGDs) are an emerging class of small molecules that promote selective protein degradation by inducing neomorphic interactions...
Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver...
Unmanned Aerial Vehicle (UAV) target tracking is one of the key technologies in aerial intelligent perception systems, playing a vital role in applications...
With the rapid development of artificial intelligence and data-driven modeling, deep learning has become an effective tool for analyzing scientific discovery...
Structural optimization is a fundamental step in density functional theory (DFT) calculations, typically driven by the Broyden–Fletcher–Goldfarb–Shanno...
Reliable vehicle detection in urban traffic environments remains challenging, particularly for fixed-view CCTV systems deployed in Southeast Asian cities,...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...
In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...
Cerebral palsy is a prevalent neurodevelopmental syndrome that disrupts motor development in children, making early detection vital for effective intervention....
Current automated lesion segmentation methods have limited success, particularly for segmenting small, irregular, or heterogeneous lesions. Moreover,...
This paper presents a dynamic energy management strategy for a community-scale campus hybrid microgrid integrating photovoltaic (PV) generation, aggregated...
This study investigates the problem of prioritizing rooftop renewable energy (RE) system configurations for a multi-family residential building in Mediterranean...
This paper addresses the challenge of efficiently calculating dynamic carbon emission factors (CEFs) in large-scale power systems. Traditional methods...
Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation,...
Checkpoint kinase 1 (CHK1), a key regulator of cell cycle checkpoints, plays a central role in the DNA damage response network, serving as a critical...
Glioblastoma (GB) is the most common primary malignant brain tumor of adulthood, and despite optimal safe resection and chemoradiation, it is still lethal....
Objectives: Circulating tumor cells (CTCs) drive metastasis and exhibit resistance to conventional therapies, making them crucial therapeutic targets....
Molecular glue degraders (MGDs) are an emerging class of small molecules that promote selective protein degradation by inducing neomorphic interactions...
Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver...
Unmanned Aerial Vehicle (UAV) target tracking is one of the key technologies in aerial intelligent perception systems, playing a vital role in applications...
With the rapid development of artificial intelligence and data-driven modeling, deep learning has become an effective tool for analyzing scientific discovery...
Structural optimization is a fundamental step in density functional theory (DFT) calculations, typically driven by the Broyden–Fletcher–Goldfarb–Shanno...
Reliable vehicle detection in urban traffic environments remains challenging, particularly for fixed-view CCTV systems deployed in Southeast Asian cities,...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...
In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...
Objective: To develop the Chinese expert consensus on the prevention and management of central venous catheter (CVC)-related thrombosis in children with congenital heart disease (CHD) (hereafter referred to as the Consensus), with the aim of standardizing and improving preventive and therapeutic strategies for CVC-related thrombosis in pediatric patients with CHD. Methods: The consensus was formulated in strict accordance with the principles of evidence-based medicine by a multidisciplinary panel of experts. Evidence was appraised and synthesized using…
Background: Adults with congenital heart disease (ACHD) experience lifelong medical and psychosocial challenges, yet research in this population is limited by incomplete longitudinal data and insufficient incorporation of patient perspectives. Although patient engagement is increasingly recognized as important, structured and sustainable engagement models in ACHD research remain limited. Objectives: The paper aims to describe the development and operational structure of the Congenital Heart Initiative (CHI) Engagement Network and to report outcomes from two annual patient-powered research…
Background: Congenital Heart Disease (CHD) is an abnormality of the heart arising before birth. CHD diagnosis poses a critical challenge, particularly in resource-constrained settings where access to doctors and skilled radiologists is limited. The maternal risk factors contributing to CHD include modifiable and non-modifiable causes. Very few studies mention about these maternal risk factors for the Indian population to build predictive machine learning models for disease forecasting. The aim is to explore the feasibility of predicting…
Background Double outlet right ventricle (DORV) is a complex congenital heart disease with significant anatomical variations. Patients with atrioventricular discordance have traditionally been managed with univentricular palliation strategies. However, advances in surgical concepts and techniques have enabled biventricular or one-and-a-half ventricle repair in selected patients, even after prior palliation. Case presentation We report a case of a 32-year-old woman with DORV and atrioventricular discordance who successfully underwent conversion to a one-and-a-half ventricle circulation using a
Objective: Cone reconstruction (CR) is the preferred surgical treatment for Ebstein’s anomaly (EA). However, the molecular mechanisms underlying postoperative cardiac repair remain unclear. This study investigated the dynamic changes of plasma exosomal microRNAs (miRNAs) in EA patients before and after CR, exploring their association with postoperative cardiac function recovery and potential molecular mechanisms. Methods: Plasma samples were collected from 10 EA patients undergoing CR preoperatively, 1 day postoperatively, and 7 days postoperatively, along with samples from…
Background: Children with congenital heart disease (CHD) complicated by severe infection often present with immature immune function and poor prognosis. Evidence supporting the use of glucocorticoids in this population, particularly with dynamic immune monitoring, remains limited. Methods: A retrospective analysis was conducted on 183 CHD children with severe infections admitted to the Pediatric Intensive Care Unit (PICU) from 2019 to 2023. Patients were divided into two groups: the glucocorticoid intervention group (n = 92, methylprednisolone + standard…
Background: Systemic right ventricular morphology is associated with poor Fontan outcomes, but its independent effect remains uncertain due to confounding by atrioventricular valve regurgitation (AVVR). The prognostic role of two adequately sized ventricles is also unclear. This study aimed to evaluate the independent impact of ventricular morphology on long-term Fontan outcomes after adjustment for AVVR, using a large national registry. Methods: A total of 1631 Fontan survivors were analyzed. Death or heart transplantation and Fontan…
Background: Many anesthetics suppress atrioventricular conduction and may exacerbate atrioventricular block (AVB), which has led to the establishment of pediatric perioperative guidelines. However, the perioperative management of patients with a history of AVB who have recovered to an apparent sinus rhythm remains unclear. Case presentation: We report the case of a 13-year-old girl who developed complete AVB following surgery for congenital heart disease in infancy and subsequently recovered sinus rhythm. She experienced a recurrence of…
Background: Congenital heart disease (CHD) refers to malformations of the heart or great vessels that occur during the intrauterine period. Critical CHD refers to heart conditions that require medical intervention or surgical procedures in the early stages of life. Methods: In this retrospective cohort study, newborns aged 0 to 28 days who were admitted to the Neonatal Intensive Care Unit and the Pediatric Cardiovascular Surgery Clinic of our hospital with a diagnosis of critical CHD between…
Objectives: Sciatic nerve injury (SNI) impairs quality of life, and Lycium barbarum polysaccharides (LBP) may exert therapeutic effects via regulating Schwann cell (SC) mitochondrial stability, though the mechanism remains unclear. The study aimed to elucidate the therapeutic mechanisms of LBP in mitigating sciatic nerve injury by protecting Schwann cells via the estrogen receptor 1 (ESR1)/thioredoxin 2 (Trx2) pathway. Methods: An in vitro SNI model was established by inducing RSC96 cells with H2O2. Cell counting kit-8 (CCK8) assay, enzyme-linked immunosorbent…
Astrocytes contribute to central nervous system (CNS) homeostasis by taking up and releasing various transmitters, ions, water, and energy molecules, thereby modulating neuronal function and maintaining the blood-brain barrier. The dynamic delivery, retrieval, and recycling of transporters, channels, receptors, and vesicular cargo at the astrocyte plasma membrane are regulated by the cytoskeleton networks composed of microtubules, actin filaments, and intermediate filaments. Increasing evidence indicates that changes in vesicle trafficking disrupt astrocyte–neuron communication and contribute to
Background: Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients. However, the mechanism by which glutamate ionotropic receptor NMDA type subunit 2B (GluN2B) contributes to POCD development remains incompletely understood. This study aimed to investigate the effects of GluN2B overexpression on POCD improvement and elucidate its underlying molecular mechanisms. Methods: In vitro, lipopolysaccharide (LPS) was used to induce inflammation in mouse primary microglia, and a microglia-HT22 neuron co-culture system was established to simulate the…
Mitochondrial dysfunction is a central hallmark of metabolic, hepatic, cardiovascular, and neurodegenerative diseases. Dietary polyphenols modulate mitochondrial pathways, but their integrated effects remain poorly appreciated. This narrative review synthesizes preclinical and clinical evidence on four polyphenols (resveratrol, epigallocatechin-3-gallate, quercetin, and oleuropein) and examines their mechanisms in mitochondrial biogenesis, mtDNA protection, and mitophagy. Experimental studies indicate that these compounds activate conserved adaptive pathways, including sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α),…
Background: Although transforming growth factor-β (TGF-β) drives hepatic stellate cell activation and fibrogenesis, the mechanisms by which 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates these processes in TGF-β1-activated hepatic stellate cells remain to be determined. Therefore, we investigated whether TPA alleviates fibrosis in TGF-β1-treated hepatic stellate cells and regulates both canonical and non-canonical pathways. Further, we assessed whether inhibitors of these pathways similarly affect proliferation and fibrosis in LX-2 cells. Methods: LX-2 hepatic stellate cells were used as the experimental…
Background: Dysfunction of decidual macrophages (dMφ) mediated by high mobility group box 1 (HMGB1) is related to unexplained recurrent spontaneous abortion (URSA), but its upstream regulatory mechanism remains unclear. The research explores whether miR-216a-5p regulates the toll-like receptor 4/nuclear factor-κB/nucleotide-binding oligomerization domain-like receptor protein 3 (TLR4/NF-κB/NLRP3) signaling axis by targeting HMGB1, thereby affecting the M1 polarization and pyroptosis of dMφ in URSA. Methods: The URSA mouse model was established, and primary dMφ was isolated and cultured.…
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed, but their long-term use frequently results in gastric mucosal injury. Emerging evidence indicates that, beyond cyclooxygenase inhibition, mitochondrial dysfunction represents a central mechanism driving NSAID-induced gastric epithelial damage. This review aims to critically synthesize current evidence on mitochondria-centered pathways involved in NSAID-induced gastric ulceration and to evaluate the therapeutic relevance of melatonin in this context. We highlight how NSAIDs impair mitochondrial bioenergetics, promote excessive reactive oxygen species generation,
Guest Editors: Carlos Vargas-Salgado; Dácil Diaz-Bello Deadline: 30 April 2027
Guest Editors: Leonardo Di G. Sigalotti; Carlos A. Vargas; Carlos E. Alvarado-Rodríguez Deadline: 30 April 2027
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Guest Editors: Wenlong Sun; Mengyao Li Deadline: 31 March 2027
Guest Editors: Wenbing Zhao; Pan Wang Deadline: 31 March 2027
Guest Editors: Joanna Zawitkowska; Małgorzata Mitura-Lesiuk; Maciej Dubaj Deadline: 28 February 2027
Guest Editors: Jungpil Shin; Yong Seok Hwang Deadline: 31 January 2027
Guest Editors: Denise Mafra; Jessyca Sousa de Brito Deadline: 31 January 2027
Guest Editors: Qi Chen; Yunhui Tang Deadline: 31 December 2026
Guest Editors: Hung-Yu Lin Deadline: 31 December 2026
Guest Editors: Víctor García Deadline: 31 December 2026
Guest Editors: Dawei Jiang; Miaojun Xu; Bo Jiang; Zijian Wu Deadline: 31 December 2026
Guest Editors: Jian-Hong Ye; Weiguaju Nong Deadline: 31 December 2026
Guest Editors: Changhong LINGHU; Hoon Eui Jeong; Ying Jiang; Jiangtao Su; Yangchengyi... Deadline: 30 December 2026
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