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European Cytokine Network
REVIEW

Emerging viral infections: role of flavivirus NS1-mediated rewiring of PRR signaling

Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health...

European Cytokine Network
REVIEW

Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment

Cytokines, as key signaling molecules, are involved in the regulation of physiological and pathological processes such as inflammation, immunity, and...

European Cytokine Network
REVIEW

Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications

Severe immune-mediated complications following viral infections and vaccinations, including COVID-19 and anti–SARS-CoV-2 immunization, display remarkable...

BIOCELL
ARTICLE

Organ-Specific Metabolic Adaptations to Acute Injury and Their Modulation by Fumarate

Objectives: Metabolic substrate deficiency is a key factor in many pathologies, with organ vulnerability depending on specialized metabolic profiles....

BIOCELL
REVIEW

Cellular Senescence in the Cardiovascular System: Molecular Mechanisms, Pathophysiology, and Senotherapeutic Interventions

Cellular senescence and the Senescence-Associated Secretory Phenotype (SASP) play both physiological and pathological roles in the cardiovascular system....

BIOCELL
REVIEW

Decoding Enterovirus 71: Molecular Functions of Structural and Nonstructural Proteins in Viral Replication and Host Manipulation

Enterovirus 71 (EV71), a member of the family Picornaviridae, genus Enterovirus, is an agent of hand, foot, and mouth disease (HFMD) and remains a persistent...

Energy Engineering
ARTICLE

Parametric Optimization of Battery Capacity and Electric Motor Power for Electric Vehicles under Varying Loads and Capacities

Nowadays, battery electric vehicles are increasingly used, from passenger cars to heavy-duty commercial vehicles, trains, and ships, all in an effort...

Energy Engineering
REVIEW

Next-Generation Wind Hybrid Energy Systems: Grid-Interactive, Hydrogen-Enabled, and AI-Orchestrated Pathways for Sustainable Electrification

The big challenge in developing wind energy over the past century, which has focused on environmentally friendly production methods to meet the requirements...

Energy Engineering
ARTICLE

Intelligent Operation Strategies for PVT-ASHP Heating and Hot Water Systems in Industrial Parks Based on Reinforcement Learning

In response to the high energy consumption, large load fluctuations, and insufficient adaptability associated with conventional control strategies in...

Oncology Research
REVIEW

Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies

Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with...

Oncology Research
REVIEW

Prognostic Value of Spatial and Topological Features of Tumor Microenvironment in Classic Hodgkin Lymphoma

Classic Hodgkin lymphoma (CHL) constitutes a B-cell malignant lymphoid neoplasm derived from the germinal center. Despite current treatment protocols...

Oncology Research
REVIEW

Engineering the Future of ADCs in Non-Small Cell Lung Cancer

Antibody–drug conjugates (ADCs) are a promising strategy in non-small cell lung cancer (NSCLC), but early-generation drugs were limited by suboptimal...

Oncology Research
REVIEW

Clostridiaceae in Cancer Management

Unfavorable epidemiological forecasts indicating a significant increase in cancer incidence and mortality, as well as limitations of traditional cancer...

Computers, Materials & Continua
REVIEW

A Review of the Application of Machine Learning in Additive Manufacturing

Additive manufacturing (AM) has emerged as a transformative technology in modern manufacturing, offering unprecedented capabilities for producing complex...

Computers, Materials & Continua
REVIEW

Emergence of Agentic AI: A Review on Evolution, Background, Working Principles, Applications, Adoption Factors, and Future Research Directions

Agentic AI is gaining new insights and advancements in the field of Artificial Intelligence, fostering significant potential to enable rapid transformation...

Computers, Materials & Continua
REVIEW

Data-Driven Materials Science Using Machine Learning and Computational Modeling

This review emphasizes the growing role of artificial intelligence (AI) in transforming the materials discovery process into a data-driven and autonomous...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

Energy Engineering
Special Issue

Model-based and Learning Methods for Optimization and Management of Energy Flows in Decentralized Smart Grids

The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Oncology Research
Special Issue

Targeting the Tumor Microenvironment: Emerging Insights into Cancer Progression and Therapeutics

The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...

Oncology Research
Special Issue

Tumor Biomarkers for Diagnosis, Prognosis and Targeted Therapy

Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Computer Modeling in Engineering & Sciences
Special Issue

Machine learning and Blockchain for AIoT: Robustness, Privacy, Trust and Security

Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...

European Cytokine Network
REVIEW

Emerging viral infections: role of flavivirus NS1-mediated rewiring of PRR signaling

Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health...

European Cytokine Network
REVIEW

Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment

Cytokines, as key signaling molecules, are involved in the regulation of physiological and pathological processes such as inflammation, immunity, and...

European Cytokine Network
REVIEW

Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications

Severe immune-mediated complications following viral infections and vaccinations, including COVID-19 and anti–SARS-CoV-2 immunization, display remarkable...

BIOCELL
ARTICLE

Organ-Specific Metabolic Adaptations to Acute Injury and Their Modulation by Fumarate

Objectives: Metabolic substrate deficiency is a key factor in many pathologies, with organ vulnerability depending on specialized metabolic profiles....

BIOCELL
REVIEW

Cellular Senescence in the Cardiovascular System: Molecular Mechanisms, Pathophysiology, and Senotherapeutic Interventions

Cellular senescence and the Senescence-Associated Secretory Phenotype (SASP) play both physiological and pathological roles in the cardiovascular system....

BIOCELL
REVIEW

Decoding Enterovirus 71: Molecular Functions of Structural and Nonstructural Proteins in Viral Replication and Host Manipulation

Enterovirus 71 (EV71), a member of the family Picornaviridae, genus Enterovirus, is an agent of hand, foot, and mouth disease (HFMD) and remains a persistent...

Energy Engineering
ARTICLE

Parametric Optimization of Battery Capacity and Electric Motor Power for Electric Vehicles under Varying Loads and Capacities

Nowadays, battery electric vehicles are increasingly used, from passenger cars to heavy-duty commercial vehicles, trains, and ships, all in an effort...

Energy Engineering
REVIEW

Next-Generation Wind Hybrid Energy Systems: Grid-Interactive, Hydrogen-Enabled, and AI-Orchestrated Pathways for Sustainable Electrification

The big challenge in developing wind energy over the past century, which has focused on environmentally friendly production methods to meet the requirements...

Energy Engineering
ARTICLE

Intelligent Operation Strategies for PVT-ASHP Heating and Hot Water Systems in Industrial Parks Based on Reinforcement Learning

In response to the high energy consumption, large load fluctuations, and insufficient adaptability associated with conventional control strategies in...

Oncology Research
REVIEW

Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies

Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with...

Oncology Research
REVIEW

Prognostic Value of Spatial and Topological Features of Tumor Microenvironment in Classic Hodgkin Lymphoma

Classic Hodgkin lymphoma (CHL) constitutes a B-cell malignant lymphoid neoplasm derived from the germinal center. Despite current treatment protocols...

Oncology Research
REVIEW

Engineering the Future of ADCs in Non-Small Cell Lung Cancer

Antibody–drug conjugates (ADCs) are a promising strategy in non-small cell lung cancer (NSCLC), but early-generation drugs were limited by suboptimal...

Oncology Research
REVIEW

Clostridiaceae in Cancer Management

Unfavorable epidemiological forecasts indicating a significant increase in cancer incidence and mortality, as well as limitations of traditional cancer...

Computers, Materials & Continua
REVIEW

A Review of the Application of Machine Learning in Additive Manufacturing

Additive manufacturing (AM) has emerged as a transformative technology in modern manufacturing, offering unprecedented capabilities for producing complex...

Computers, Materials & Continua
REVIEW

Emergence of Agentic AI: A Review on Evolution, Background, Working Principles, Applications, Adoption Factors, and Future Research Directions

Agentic AI is gaining new insights and advancements in the field of Artificial Intelligence, fostering significant potential to enable rapid transformation...

Computers, Materials & Continua
REVIEW

Data-Driven Materials Science Using Machine Learning and Computational Modeling

This review emphasizes the growing role of artificial intelligence (AI) in transforming the materials discovery process into a data-driven and autonomous...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

Energy Engineering
Special Issue

Model-based and Learning Methods for Optimization and Management of Energy Flows in Decentralized Smart Grids

The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Oncology Research
Special Issue

Targeting the Tumor Microenvironment: Emerging Insights into Cancer Progression and Therapeutics

The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...

Oncology Research
Special Issue

Tumor Biomarkers for Diagnosis, Prognosis and Targeted Therapy

Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Computer Modeling in Engineering & Sciences
Special Issue

Machine learning and Blockchain for AIoT: Robustness, Privacy, Trust and Security

Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...

Research Advances in Drug Resistance Mechanisms to Anti-HER2 Therapy in HER2-Positive Breast Cancer

HER2-positive breast cancer accounts for 15–20% of all breast cancer cases. Although the development of monoclonal antibodies (e.g., trastuzumab, pertuzumab), tyrosine kinase inhibitors (e.g., lapatinib, pyrotinib), and antibody-drug conjugates (e.g., T-DM1, trastuzumab deruxtecan) has greatly improved patient prognosis, primary or acquired resistance to anti-HER2 therapy remains a major clinical challenge, leading to treatment failure and disease progression. Recent research has elucidated diverse resistance mechanisms, including HER2 signaling pathway aberrations (such as receptor mutations, alternative splicing,…

Oncology Research
Article

GPX4 Defines an Immune-Cold Phenotype and Poor Prognosis in Resected Lung Adenocarcinoma

Objectives: Ferroptosis resistance may contribute to tumor progression and immune escape. This study evaluated the prognostic and immunological significance of glutathione peroxidase 4 (GPX4), a core ferroptosis-suppressive enzyme, in surgically resected lung adenocarcinoma. Methods: We retrospectively analyzed 104 patients with primary lung adenocarcinoma who underwent curative resection. GPX4 protein expression was assessed by immunohistochemistry (IHC) using the histological score (H-score), and patients were classified as GPX4-low (n = 54) or GPX4-high (n = 50). Intratumoral immune…

Oncology Research
Article

Breast Cancer Cell-Derived Exosomal miR-92b-3p Promotes Tumor Angiogenesis and Metastasis by Suppressing PTEN in Vascular Endothelial Cells

Background: Tumor-driven vascular remodeling is crucial for breast cancer metastasis; yet, the role of tumor-derived exosomal miRNAs in this process remains underexplored. This study aimed to investigate the clinical relevance and the underlying mechanism of breast cancer-derived exosomal miR-92b-3p in endothelial reprogramming. Methods: miR-92b-3p expression was evaluated in the TCGA cohort and clinical patient samples. The effects of exosomal miR-92b-3p from breast cancer cells on recipient human microvascular endothelial cells (HMVECs) were assessed using in vitro angiogenesis,…

Oncology Research
Case Report

Excellent Survival Outcome in a Patient Receiving NALIRIFOX for Metastatic Pancreatic Adenocarcinoma: A Case Report

Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is frequently diagnosed at an advanced stage and remains associated with poor survival outcomes. Durable responses to systemic therapy in metastatic disease are uncommon. We report a case of metastatic PDAC with prolonged survival and sustained response following first-line treatment with NALIRIFOX. This report describes a patient with metastatic PDAC who achieved prolonged disease control and sustained response following first-line treatment with NALIRIFOX. Case Presentation: A 64-year-old…

Oncology Research
Article

UCP2 Identifies Immunosuppressive Tumor-Associated Macrophages and Is Associated with Predicted Immunotherapy Resistance in Glioma

Objectives: Uncoupling protein 2 (UCP2) has been extensively studied as a metabolic regulator in glioma; however, its relationship with the tumour immune microenvironment and the cellular source of its expression within the glioma tumour microenvironment (TME) remains poorly understood. This study aimed to characterise UCP2 expression at single-cell resolution and evaluate its immunological significance in glioma. Methods: This study employed an integrative multi-omics approach incorporating bulk transcriptomics, scRNA-seq (GSE70630, GSE84465, and GSE89567; n = 13,216…

Oncology Research
Review

Amino Acid Metabolic Enzymes in Gastric Cancer: Roles and Mechanisms in Tumorigenesis and Progression

Gastric cancer (GC) is one of the malignant tumors with high incidence and mortality worldwide. It has concealed early symptoms, poor prognosis for advanced patients, and limited efficacy of conventional treatments. Metabolic reprogramming is a core hallmark of cancer, among which amino acid metabolic reprogramming plays a critical regulatory role in the initiation and progression of GC. By linking intracellular energy supply, biosynthetic demands, and tumor microenvironment remodeling, it participates in immune escape, redox homeostasis…

Oncology Research
Review

Dual Regulatory Functions and Therapeutic Potential of CD48 in Tumor Immunity

Cluster of differentiation 48 (CD48) is a glycosylphosphatidylinositol-anchored member of the signaling lymphocyte activation molecule (SLAM) family that is predominantly expressed on hematopoietic cells and regulates immune-cell communication through 2B4 (CD244) and CD2. This narrative review critically summarizes the context-dependent role of CD48 in tumor immunity, with emphasis on the distinction between activating trans-interactions and potentially inhibitory cis-interactions. Evidence from hematologic malignancies and selected solid tumors indicates that CD48 may support antitumor immunity by facilitating…

Oncology Research
Article

miR-320d Is Associated with Reduced Nasopharyngeal Carcinoma Progression, Potentially through the NF-κB/IL-8 Axis-Mediated Inhibition of Neutrophil Extracellular Trap Formation

Objectives: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck malignancy in which post-treatment recurrence and distant metastasis remain major contributors to poor clinical outcomes. Although microRNAs are important post-transcriptional regulators of tumor progression, the role of miR-320d in NPC remains incompletely understood. This study evaluated the biological role of miR-320d and explored whether it is involved in regulating neutrophil extracellular trap (NET) formation through the nuclear factor kappa-B (NF-κB)/interleukin-8 (IL-8) signaling axis. Methods: miR-320d was…

Oncology Research
Article

Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation

Backgrounds: Cyclin-dependent kinase 7 (CDK7) plays key roles in transcription and cell cycle regulation, and its inhibition has been proposed as a potential therapeutic strategy for hepatocellular carcinoma (HCC). The primary research objective of this study is to identify and validate CDK7-associated prognostic genes in HCC using bioinformatics approaches, construct a reliable prognostic risk model, and explore the functional role of CDK7 in HCC progression through in vitro and in vivo experiments, with a specific focus on its…

Oncology Research
Article

Targeting Aurora A Kinase Enhance the CDK4/6 Inhibitor Sensitivity in HR+/HER2- Breast Cancer

Objectives: Despite the success of CDK4/6 inhibitors (CDK4/6i) in treating HR+/HER2- breast cancer (BC), some patients experience treatment failure due to CDK4/6i resistance. This study aimed to investigate whether targeting Aurora A kinase enhances CDK4/6 inhibitor sensitivity. Methods: An Abemaciclib-resistant cell line (MCF7AR) was developed by treating MCF7 cells with gradually increasing concentrations of Abemaciclib. We evaluated the relative protein levels of p-RB, p-Aurora A, Aurora A, and USP22 in cell cultures, animal tissues, and…

Oncology Research
Article

Isoliquiritigenin Suppresses Oral Squamous Cell Carcinoma Progression by Targeting FABP5-Mediated Lipid Metabolism: Association with the circPOLB/miR-548ae-3p/C-MYC Axis

Objectives: Oral squamous cell carcinoma (OSCC) is a common and deadly cancer affecting the oral cavity. This study aims to explore the regulatory role and molecular mechanism of miR-548ae-3p in OSCC proliferation, invasion, and lipid metabolism, as well as the therapeutic potential of isoliquiritigenin (ISL) targeting OSCC lipid metabolism. Methods: Expression levels of miR-548ae-3p were measured in OSCC cell lines and normal oral keratinocytes using real-time quantitative polymerase chain reaction. Functional assays, such as cell counting…

Oncology Research
Case Report

Stable Disease Achieved with Sequential Immunochemotherapy and Anti-Angiogenic TKI in Recurrent Metastatic Hidradenocarcinoma: A Case Report and Literature Review

Background: Hidradenocarcinoma is a rare and highly aggressive malignancy with limited therapeutic options. This report describes the clinical course and treatment response of a patient with recurrent metastatic hidradenocarcinoma treated with sequential immunochemotherapy combined with anti-angiogenic therapy, with the aim of providing further insight into potential treatment strategies for this rare malignancy. Case Description: A 60-year-old male initially presented in 2020 with scrotal erythema and was diagnosed with hidradenocarcinoma after surgery. Despite surgical treatment, he developed recurrent…

Oncology Research
Article

The Construction and Preclinical Evaluation of Antitumor Activity of a Novel MIgG-OXA ADC in Lung Adenocarcinoma

Background: The melanoma-associated antigen-A1 (MAGE-A1) demonstrates tumor-restricted expression patterns in diverse malignancies, positioning it as an attractive therapeutic target. This investigation aimed to engineer and validate a novel antibody-drug conjugate with oxaliplatin targeting MAGE-Al (MIg-OXA), a novel antibody-drug conjugate targeting MAGE-A1, while assessing its therapeutic potential against MAGE-A1-expressing lung adenocarcinoma through both cellular and animal models. Methods: We generated a MAGE-A1-specific immunoglobulin G (IgG) antibody (MIgG) and subsequently conjugated it with oxaliplatin (OXA) to produce MIgG-OXA.…

Oncology Research
Review

Cancer Drug Development in Never-Smoker Lung Cancer: Targeted and Immune-Based Therapeutic Strategies

Lung cancer in individuals who have never smoked (LCINS) represents a clinically and biologically distinct subset of non–small cell lung cancer, driven predominantly by oncogenic alterations rather than tobacco-related mutagenesis. This review aims to summarize current and emerging targeted and immune-based therapeutic strategies in LCINS individuals. These patients present a molecular profile that differs substantially from tobacco-associated disease and has direct consequences for treatment selection. Evidence published over the past five years has clarified how…

Oncology Research
Review

Targeting PCNA in Cancer: A Paradigm Shift from Static Inhibition to Dynamic Network Modulation

Proliferating Cell Nuclear Antigen (PCNA) is a core protein in DNA replication and repair. Its functional dysregulation drives tumorigenesis and therapeutic resistance, making it a critical anticancer target. However, the fundamental conflict between PCNA’s indispensable “guardian” function in normal cells and its hijacked “accomplice” role in cancer cells constitutes the central challenge for targeted intervention: how to eradicate tumors while avoiding severe toxicity to normal tissues. This review aims to systematically review the latest advances…

Oncology Research
Case Report

Cardiac Metastasis from Poorly Differentiated Thyroid Carcinoma: A Rare Case Report and Review of the Literature

Background: Poorly differentiated thyroid carcinoma (PDTC) is a rare, aggressive malignancy. Cardiac metastasis from PDTC is exceedingly uncommon. We report early cardiac metastasis occurring shortly after radical thyroidectomy to highlight atypical distant spread and management challenges. Case Description: A 62-year-old woman presented four months after thyroidectomy with progressive exertional dyspnoea, fatigue, productive cough, facial oedema, lip cyanosis, and dizziness. Postoperative pathology showed poorly differentiated thyroid carcinoma of the right lobe and isthmus (pT2N1bM0) with capsular and recurrent…