Heavy metals like cadmium, lead, and mercury in soil threaten crop growth and food safety. This review explores how modern technologies—genomics, transcriptomics,...
The image illustrates an intelligent driver monitoring framework for enhancing transportation safety. The system analyzes visual cues from the driver using deep...
Within a neuronal nucleus, contrasting DNA states symbolize the dual role of double-strand breaks in the brain. Transient, regulated breaks support activity-dependent...
Tech Science Press (TSP) is pleased to announce that five of its journals have been included in China’s 2025 list of the world’s leading science and technology journals. The five TSP journals...
The Canadian Journal of Urology (CJU) officially became a DOAJ (Directory of Open Access Journals)-indexed journal on 03 September 2026, marking another important milestone in the journal’s...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Background: Volatile anesthetics such as sevoflurane are ubiquitous in perioperative care, yet their unintended consequences on pulmonary microvascular integrity and the upstream intracellular signaling pathways remain incompletely defined. This study elucidates the precise transcriptional mechanisms linking sevoflurane exposure to pulmonary endothelial hyperpermeability. Methods: Transendothelial electrical resistance (TEER) and macromolecular permeability were dynamically quantified in human pulmonary microvascular endothelial cell (HPMEC) monolayers following sevoflurane exposure. Global transcriptomic profiling (RNA-seq) was employed to identify core regulatory nodes, which…
Oxidative stress results from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms and contributes to cellular damage and the pathogenesis of various diseases. This review summarizes recent advances in the molecular and biochemical mechanisms associated with oxidative stress in ocular diseases, including dry eye disease, diabetic retinopathy, age-related macular degeneration (AMD), glaucoma, and cataract. A literature search was conducted using PubMed and Google Scholar databases to identify relevant studies published up
Background: Macrophage-derived eicosanoids are involved in airway inflammation associated with asthma, but the mechanisms regulating their production remain incompletely understood. The study aimed to evaluate the effects of isorhynchophylline (IRN) on eicosanoid production and inflammatory activation in LPS/IFN-γ-stimulated THP-1-derived macrophages and to further investigate whether these effects are mediated through the miR-200a/FOXC1/NF-κB axis. Methods: THP-1 cells were differentiated into M0 (PMA) and polarized into M1 (LPS+IFN-γ) phenotypes. IRN (5–20 μM) was applied. Eicosanoids (PGE2, LTB4) were measured…
Neutrophil extracellular traps (NETs) are increasingly recognized as significant contributors to neurovascular damage following ischemic brain injuries. This review examines how NETs link intravascular thrombosis to downstream neuroinflammation via a pathway-centric framework. We synthesize recent preclinical and clinical evidence showing that NET-derived histones, extracellular DNA, and granular enzymes activate convergent inflammatory pathways, including the high mobility group box 1–Toll-like receptor 4 axis, nuclear factor kappa B, Janus kinase 2/signal transducer and transcription activator 3, NOD-like
Oral squamous cell carcinoma (OSCC) is an aggressive malignancy often diagnosed at advanced stages and associated with poor prognosis. This review aims to summarize the role of Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling in OSCC progression, with particular emphasis on its involvement in the regulation of autophagy, apoptosis, and oxidative stress. KRAS contributes to tumor progression despite the low frequency of activating mutations, primarily through increased KRAS expression associated with activation of downstream
Objective: Periodontal diseases can cause pro-inflammatory cytokine overproduction, particularly tumor necrosis factor-alpha (TNF-α), and this inflammatory microenvironment is a critical driver of oral cancer progression. MicroRNA-146a-5p is a key regulator of inflammation, linked to both periodontal disease and carcinogenesis. The objective of this study was to illustrate the regulatory function of miR-146a-5p in gingival squamous cell carcinoma OECM-1 cells under conditions that mimic those of periodontal disease. Methods: OECM-1 cells were stimulated with 25 ng/mL TNF-α…
Objectives: Middle ear cholesteatoma (MEC) is a destructive and locally invasive disease that leads to erosion of bone structure and serious complications. This study aimed to investigate the role of GDF11 in promoting the differentiation of macrophages into osteoclasts in vitro and elucidate the bone erosion mechanism in MEC. Methods: The MEC dataset GSE116142 was subjected to bioinformatics analysis. The Growth Differentiation Factor 11 (GDF11) and Transforming Growth Factor Beta Receptor 1 (TGFBR1) expression levels in MEC…
Metabolically–dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a systemic disorder at the intersection of metabolic dysregulation, inflammation, and carcinogenesis. Progression from simple steatosis to metabolic dysfunction–associated steatohepatitis (MASH), fibrosis, and hepatocellular carcinoma (HCC) reflects the interplay between metabolic overload, oxidative stress, immune activation, and gut microbiota dysbiosis. In this review, we propose the Redox–Microbiota–Inflammatory Axis as an integrative framework linking metabolic stress to fibrogenesis
Objectives: Tumor-associated macrophages (TAMs) within the hypoxic tumor microenvironment critically drive colorectal cancer (CRC) progression, yet their specific regulatory mechanisms on endoplasmic reticulum (ER) homeostasis via microRNAs remain understood. This study aims to assess the impact of hypoxia-induced TAMs on CRC cells through the microRNA-320 (miR-320)/SRY-box transcription factor 4 (SOX4) axis, focusing on ER homeostasis and malignant behaviors. Methods: Human CRC cell lines HCT116 and SW480 were co-cultured with hypoxia-induced macrophages. Cells were treated with miR-320…
Telomere homeostasis is intrinsically integrated into the cellular metabolic network through a complex mito-nuclear communication system. Telomeric chromatin acts as a sensitive sensor of mitochondrial flux, where the stability of telomeres depends on mitochondrial-derived metabolites essential for epigenetic remodeling. Three primary axes govern this control: (1) Acetyl-CoA-mediated histone acetylation necessary for human Telomerase Reverse Transcriptase (hTERT) expression; (2) the competitive balance between α-ketoglutarate/succinate, modulating Jumonji-C (JmjC)-demethylases and Ten-eleven translocation (TET) enzymes; (3) the mitochondrial NAD+/NADH ratio,…
Aging and brain injury remodel the central nervous system (CNS) physical microenvironment, yet the contribution of these mechanical changes to neurodegenerative disease remains underappreciated. While traditional models emphasize biochemical mechanisms, emerging evidence indicates that altered tissue stiffness, extracellular matrix composition, and interstitial fluid dynamics actively reprogram intracellular signaling via dysregulated mechanotransduction. This review describes key physical cues shaping the brain microenvironment, including substrate rigidity and fluid flow within the cerebrospinal fluid (CSF) and glymphatic system.…
Type 1 diabetes (T1D) is traditionally described as a T cell–mediated autoimmune disease, yet accumulating longitudinal evidence indicates that metabolic and environmental perturbations—including depletion of short-chain fatty acid (SCFA)–producing gut microbiota—precede seroconversion and overt autoimmunity. We propose that SCFA loss represents an upstream trigger of endocannabinoid system (ECS) imbalance in T1D. Integrating evidence from microbiome, lipid signaling, mitochondrial biology, and immunometabolic research, we construct a mechanistic model in which reduced SCFA availability impairs lipid homeostasis…
Arachidonic acid (AA) and its mediators, including prostaglandins (PGs) and lipoxygenase (LOX) products, have different and sometimes opposing effects on neuronal survival and inflammatory signaling. Evidence indicates a functional and dynamic interaction between AA-derived lipid mediators and the nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and cytoprotective responses. Certain AA metabolites, such as the cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and LOX-derived products including 5-oxo-eicosatetraenoic acid (5-oxo-ETE), have been shown to activate Nrf2…
Background: Kindergarten teachers are particularly vulnerable to burnout because their work involves substantial emotional and caregiving demands, which may be associated with teaching quality and children’s development. Using a sample of kindergarten teachers in China, this study tested a moderated mediation model to examine how workplace friendship, job satisfaction, and relative deprivation were associated with kindergarten teachers’ burnout. Methods: Using a cross-sectional self-report design, 344 kindergarten teachers from Jiangsu Province, mainland China, completed measures of workplace…
Background: Excessive pressure from parents to achieve academically has been acknowledged as a substantial risk factor associated with adolescents’ psychological adjustment. However, the mechanisms through which parental achievement pressure contributes to adolescents’ emotional and behavioral problems remain insufficiently understood. This study examined the relationship between parental achievement pressure and emotional and behavioral problems in adolescents, with parent–adolescent conflict and adolescent distress as sequential mediators. Methods: A total of 676 adolescents aged 12–15 years from the Batman…
Background: Young and middle-aged adults are susceptible to depression, which may impose health and economic burdens on both individuals and society. eHealth literacy is the ability for individuals to obtain health information through digital channels, which may be beneficial to their mental health. This study aims to investigate the association between eHealth literacy and depression, as well as the mediating roles of lifestyle behaviors. Methods: The study adopted a cross-sectional survey to collect data from 1280…
Guest Editors: Van-Tu Nguyen; Ould el Moctar; Anh Dinh Le; Hemant J. Sagar Deadline: 30 September 2027
Guest Editors: Jin-Gyun Kim; Hee-Sun Choi; Seongji Han Deadline: 30 September 2027
Guest Editors: Hung-Yu Lin; Hsing-Ju Wu Deadline: 31 May 2027
Guest Editors: Carlos Vargas-Salgado; Dácil Diaz-Bello Deadline: 30 April 2027
Guest Editors: Leonardo Di G. Sigalotti; Carlos A. Vargas; Carlos E. Alvarado-Rodríguez Deadline: 30 April 2027
Guest Editors: Sabrina Tosi; Annabelle Lewis Deadline: 30 April 2027
Guest Editors: Wenlong Sun; Mengyao Li Deadline: 31 March 2027
Guest Editors: Wenbing Zhao; Pan Wang Deadline: 31 March 2027
Guest Editors: Wenfeng Zheng; Choon Kit Chan; Kyungtae Kang; Chao Liu Deadline: 31 March 2027
Guest Editors: Joanna Zawitkowska; Małgorzata Mitura-Lesiuk; Maciej Dubaj Deadline: 28 February 2027
Guest Editors: Wenfeng Zheng; Lirong Yin; Shan Liu Deadline: 15 February 2027
Guest Editors: Wei-Chiang Hong; Yi Liang; Ming-Wei Li; Zhong-Yi Yang Deadline: 15 February 2027
Guest Editors: Jungpil Shin; Yong Seok Hwang Deadline: 31 January 2027
Guest Editors: Denise Mafra; Jessyca Sousa de Brito Deadline: 31 January 2027
Guest Editors: Qi Chen; Yunhui Tang Deadline: 31 December 2026
Guest Editors: Hung-Yu Lin Deadline: 31 December 2026






