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European Cytokine Network
REVIEW

Emerging viral infections: role of flavivirus NS1-mediated rewiring of PRR signaling

Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health...

European Cytokine Network
REVIEW

Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment

Cytokines, as key signaling molecules, are involved in the regulation of physiological and pathological processes such as inflammation, immunity, and...

European Cytokine Network
REVIEW

Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications

Severe immune-mediated complications following viral infections and vaccinations, including COVID-19 and anti–SARS-CoV-2 immunization, display remarkable...

Computer Modeling in Engineering & Sciences
ARTICLE

Frequency-Selective Transmission Control of Ultrasonic Guided Waves in T-Shaped Pipes Using Acoustic Metamaterials: Computer Modeling and Experimental Validation

Structural health monitoring (SHM) of ship piping systems is a core component of predictive maintenance strategies for complex marine engineering systems....

Computer Modeling in Engineering & Sciences
ARTICLE

Bearing Fault Diagnosis with Hybrid CNN-RNN: A Unified-Loop Hyperparameter Optimization Framework via Surrogate-Based Bayesian Optimization

In bearing fault diagnosis for Prognostics and Health Management (PHM), the overall performance of data-driven models is strongly influenced by the coupled...

Computer Modeling in Engineering & Sciences
ARTICLE

Enhanced-WOA Optimized FOPID Controller for Energy-Efficient Path-Tracking Robot

In industrial and service robotics, autonomous mobile robots must achieve accurate trajectory tracking while maintaining low energy consumption to avoid...

BIOCELL
ARTICLE

Organ-Specific Metabolic Adaptations to Acute Injury and Their Modulation by Fumarate

Objectives: Metabolic substrate deficiency is a key factor in many pathologies, with organ vulnerability depending on specialized metabolic profiles....

BIOCELL
REVIEW

Cellular Senescence in the Cardiovascular System: Molecular Mechanisms, Pathophysiology, and Senotherapeutic Interventions

Cellular senescence and the Senescence-Associated Secretory Phenotype (SASP) play both physiological and pathological roles in the cardiovascular system....

BIOCELL
REVIEW

Decoding Enterovirus 71: Molecular Functions of Structural and Nonstructural Proteins in Viral Replication and Host Manipulation

Enterovirus 71 (EV71), a member of the family Picornaviridae, genus Enterovirus, is an agent of hand, foot, and mouth disease (HFMD) and remains a persistent...

Energy Engineering
ARTICLE

Parametric Optimization of Battery Capacity and Electric Motor Power for Electric Vehicles under Varying Loads and Capacities

Nowadays, battery electric vehicles are increasingly used, from passenger cars to heavy-duty commercial vehicles, trains, and ships, all in an effort...

Energy Engineering
REVIEW

Next-Generation Wind Hybrid Energy Systems: Grid-Interactive, Hydrogen-Enabled, and AI-Orchestrated Pathways for Sustainable Electrification

The big challenge in developing wind energy over the past century, which has focused on environmentally friendly production methods to meet the requirements...

Energy Engineering
ARTICLE

Intelligent Operation Strategies for PVT-ASHP Heating and Hot Water Systems in Industrial Parks Based on Reinforcement Learning

In response to the high energy consumption, large load fluctuations, and insufficient adaptability associated with conventional control strategies in...

Oncology Research
REVIEW

Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies

Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with...

Oncology Research
REVIEW

Prognostic Value of Spatial and Topological Features of Tumor Microenvironment in Classic Hodgkin Lymphoma

Classic Hodgkin lymphoma (CHL) constitutes a B-cell malignant lymphoid neoplasm derived from the germinal center. Despite current treatment protocols...

Oncology Research
REVIEW

Engineering the Future of ADCs in Non-Small Cell Lung Cancer

Antibody–drug conjugates (ADCs) are a promising strategy in non-small cell lung cancer (NSCLC), but early-generation drugs were limited by suboptimal...

Oncology Research
REVIEW

Clostridiaceae in Cancer Management

Unfavorable epidemiological forecasts indicating a significant increase in cancer incidence and mortality, as well as limitations of traditional cancer...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

Energy Engineering
Special Issue

Model-based and Learning Methods for Optimization and Management of Energy Flows in Decentralized Smart Grids

The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Oncology Research
Special Issue

Targeting the Tumor Microenvironment: Emerging Insights into Cancer Progression and Therapeutics

The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...

Oncology Research
Special Issue

Tumor Biomarkers for Diagnosis, Prognosis and Targeted Therapy

Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Computer Modeling in Engineering & Sciences
Special Issue

Machine learning and Blockchain for AIoT: Robustness, Privacy, Trust and Security

Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...

European Cytokine Network
REVIEW

Emerging viral infections: role of flavivirus NS1-mediated rewiring of PRR signaling

Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health...

European Cytokine Network
REVIEW

Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment

Cytokines, as key signaling molecules, are involved in the regulation of physiological and pathological processes such as inflammation, immunity, and...

European Cytokine Network
REVIEW

Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications

Severe immune-mediated complications following viral infections and vaccinations, including COVID-19 and anti–SARS-CoV-2 immunization, display remarkable...

Computer Modeling in Engineering & Sciences
ARTICLE

Frequency-Selective Transmission Control of Ultrasonic Guided Waves in T-Shaped Pipes Using Acoustic Metamaterials: Computer Modeling and Experimental Validation

Structural health monitoring (SHM) of ship piping systems is a core component of predictive maintenance strategies for complex marine engineering systems....

Computer Modeling in Engineering & Sciences
ARTICLE

Bearing Fault Diagnosis with Hybrid CNN-RNN: A Unified-Loop Hyperparameter Optimization Framework via Surrogate-Based Bayesian Optimization

In bearing fault diagnosis for Prognostics and Health Management (PHM), the overall performance of data-driven models is strongly influenced by the coupled...

Computer Modeling in Engineering & Sciences
ARTICLE

Enhanced-WOA Optimized FOPID Controller for Energy-Efficient Path-Tracking Robot

In industrial and service robotics, autonomous mobile robots must achieve accurate trajectory tracking while maintaining low energy consumption to avoid...

BIOCELL
ARTICLE

Organ-Specific Metabolic Adaptations to Acute Injury and Their Modulation by Fumarate

Objectives: Metabolic substrate deficiency is a key factor in many pathologies, with organ vulnerability depending on specialized metabolic profiles....

BIOCELL
REVIEW

Cellular Senescence in the Cardiovascular System: Molecular Mechanisms, Pathophysiology, and Senotherapeutic Interventions

Cellular senescence and the Senescence-Associated Secretory Phenotype (SASP) play both physiological and pathological roles in the cardiovascular system....

BIOCELL
REVIEW

Decoding Enterovirus 71: Molecular Functions of Structural and Nonstructural Proteins in Viral Replication and Host Manipulation

Enterovirus 71 (EV71), a member of the family Picornaviridae, genus Enterovirus, is an agent of hand, foot, and mouth disease (HFMD) and remains a persistent...

Energy Engineering
ARTICLE

Parametric Optimization of Battery Capacity and Electric Motor Power for Electric Vehicles under Varying Loads and Capacities

Nowadays, battery electric vehicles are increasingly used, from passenger cars to heavy-duty commercial vehicles, trains, and ships, all in an effort...

Energy Engineering
REVIEW

Next-Generation Wind Hybrid Energy Systems: Grid-Interactive, Hydrogen-Enabled, and AI-Orchestrated Pathways for Sustainable Electrification

The big challenge in developing wind energy over the past century, which has focused on environmentally friendly production methods to meet the requirements...

Energy Engineering
ARTICLE

Intelligent Operation Strategies for PVT-ASHP Heating and Hot Water Systems in Industrial Parks Based on Reinforcement Learning

In response to the high energy consumption, large load fluctuations, and insufficient adaptability associated with conventional control strategies in...

Oncology Research
REVIEW

Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies

Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with...

Oncology Research
REVIEW

Prognostic Value of Spatial and Topological Features of Tumor Microenvironment in Classic Hodgkin Lymphoma

Classic Hodgkin lymphoma (CHL) constitutes a B-cell malignant lymphoid neoplasm derived from the germinal center. Despite current treatment protocols...

Oncology Research
REVIEW

Engineering the Future of ADCs in Non-Small Cell Lung Cancer

Antibody–drug conjugates (ADCs) are a promising strategy in non-small cell lung cancer (NSCLC), but early-generation drugs were limited by suboptimal...

Oncology Research
REVIEW

Clostridiaceae in Cancer Management

Unfavorable epidemiological forecasts indicating a significant increase in cancer incidence and mortality, as well as limitations of traditional cancer...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

Energy Engineering
Special Issue

Model-based and Learning Methods for Optimization and Management of Energy Flows in Decentralized Smart Grids

The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Oncology Research
Special Issue

Targeting the Tumor Microenvironment: Emerging Insights into Cancer Progression and Therapeutics

The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...

Oncology Research
Special Issue

Tumor Biomarkers for Diagnosis, Prognosis and Targeted Therapy

Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Computer Modeling in Engineering & Sciences
Special Issue

Machine learning and Blockchain for AIoT: Robustness, Privacy, Trust and Security

Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...

Unsafe Sanitation and the Global Incidence of Congenital Heart Disease: A Spatial Correlation Analysis

Background: Congenital heart disease (CHD) is the most common congenital anomaly worldwide, yet the contribution of environmental factors to its global geographic variation remains incompletely understood. We aimed to systematically identify environmental factors associated with CHD incidence using an integrated framework combining machine learning and spatial epidemiology. Methods: Country-level data were obtained from the Global Burden of Disease (GBD) 2021 study. Boruta algorithm-based feature selection and random forest SHAP value ranking were applied to identify environmental…

Structural and Congenital Heart Disease
Review

Improving Fetal Cardiovascular Care through the Fetal Cardiac Intervention Registry and the Fetal Heart Society

Improvements in fetal cardiac imaging have highlighted the need for large, multidisciplinary collaborations to further advance fetal cardiovascular care. The Fetal Cardiac Intervention Registry (IFCIR), established in 2011, aims to improve outcomes in fetuses with congenital heart disease (CHD) considered amenable to fetal cardiac intervention (FCI). The registry compiles data from multiple international centers to better define indications, selection criteria, procedural techniques, complications, and outcomes of FCI. The Fetal Heart Society (FHS), founded in 2014,…

Structural and Congenital Heart Disease
Article

Role of Imaging in Surgical Decision Making for Patients with Double Outlet Right Ventricle

Background: Double-outlet right ventricle (DORV) encompasses a spectrum of disorders characterized by both great vessels arising from the right ventricle. This study compared the diagnostic accuracy of multislice computed tomography (MSCT) and transthoracic echocardiography (TTE) in predicting the optimal surgical strategy by evaluating the concordance between preoperative imaging-based decisions and intraoperative findings. Methods: This single-center, retrospective study included 112 patients with DORV (56 MSCT + TTE and 56 TTE only) who underwent surgical correction between January…

Structural and Congenital Heart Disease
Review

The Advanced Cardiac Therapies Improving Outcomes Network (ACTION): A Multicenter Registry and Learning Health System for Pediatric and Congenital Heart Disease Associated Heart Failure

Pediatric heart failure is associated with substantial morbidity, mortality, and health care utilization across diverse diagnoses and care settings. Despite major advances in surgical and medical care, evidence-based management of heart failure in the pediatric population, especially with congenital heart disease (CHD), remains limited due to a small patient population, marked anatomic and physiologic heterogeneity, and barriers to conducting traditional randomized clinical trials. Clinical registries have provided important insights into pediatric heart failure, and the…

Structural and Congenital Heart Disease
COMMENTARY

Spirituality in Congenital Heart Disease Counseling: Toward a Practical, Evidence-Informed Framework for Family-Centered Care

The diagnosis of congenital heart disease (CHD) brings profound uncertainty and emotional distress to families, yet the spiritual dimension of this experience is often overlooked in routine counseling. Based on a narrative review of the literature and our group’s prior scoping work, this commentary proposes a practical, ethically grounded framework for integrating spiritual awareness into fetal and pediatric CHD counseling. We distinguish spirituality from related constructs, religiosity, coping, resilience, and cultural values, and discuss both…

Structural and Congenital Heart Disease
Case Report

Successful Ductus Arteriosus Stenting Using a Veno-Arterial Loop for Severe Pulmonary Hypertension in an Infant: A Case Report

Background: A reverse Potts shunt is performed as a palliative intervention for severe pulmonary hypertension (PH) to decompress the right ventricle. Several reports have described transcatheter stenting of the patent ductus arteriosus (PDA) to create an endogenous Potts shunt in infants with severe PH, typically via the femoral vein approach. Case Description: We present the case of a 7-month-old, 7.5 kg female infant diagnosed with severe PH dependent on PDA circulation, who was treated with PDA stenting

Structural and Congenital Heart Disease
Article

Association of Time Interval between Pulmonary Artery Banding and Bidirectional Cavopulmonary Shunt on Postoperative Outcomes in Univentricular Heart Defect

Background: Univentricular heart defects with unrestricted pulmonary blood flow are commonly managed using pulmonary artery banding (PAB) followed by bidirectional cavopulmonary shunt (BCPS) as part of staged palliation, but the optimal interval between these procedures remains uncertain. Methods: This retrospective cohort study evaluated the association between the PAB–BCPS interval and postoperative outcomes after BCPS in patients treated at the National Cardiovascular Center Harapan Kita, Indonesia, from January 2015 to January 2024. Patients with univentricular heart defects…

Structural and Congenital Heart Disease
Article

Integrated Proteomic and Metabolomic Profiling Reveals Impaired Mitochondrial Oxidative Phosphorylation in Hypertrophic Cardiomyopathy

Background: Hypertrophic cardiomyopathy (HCM) is increasingly recognized as a disease of impaired myocardial energetics, but integrated proteomic–metabolomic data from human myocardium are scarce. This study combined quantitative proteomics and untargeted metabolomics to obtain a systems-level view of myocardial remodeling and to identify pathways jointly dysregulated at the protein and metabolite levels. Methods: Myocardial tissue from 7 patients with HCM who underwent surgical myectomy and 5 healthy control donors at Guangdong Provincial People’s Hospital was analyzed by…

Structural and Congenital Heart Disease
Case Report

Dynamic 3D Simulation Modeling for Surgical Management of Giant Congenital Left Ventricular Diverticulum: A Case Report

Background: Congenital left ventricular diverticulum is an uncommon cardiac malformation that may present with chest pain, ventricular arrhythmia, thromboembolism, or rupture risk depending on lesion morphology and wall composition. Case description: We report an adolescent male with chest pain and frequent premature ventricular complexes who was found to have a giant apical left ventricular diverticulum with marked wall thinning and regional hypokinesia. Multimodality imaging, including transthoracic echocardiography, computed tomography, cardiac magnetic resonance, and myocardial perfusion/metabolic assessment, supported…

Structural and Congenital Heart Disease
Article

A Prediction Nomogram for Early Major Adverse Events after Cardiac Surgery in Infants with Congenital Heart Disease: A Retrospective Study

Background: Early major adverse events (MAEs) after cardiac surgery are associated with substantial postoperative morbidity and mortality in infants with congenital heart disease (CHD). Early identification of patients at increased risk may facilitate timely intervention and optimize postoperative management. This study aimed to identify perioperative predictors of early MAEs and to develop a nomogram for individualized postoperative risk assessment. Methods: This single-center retrospective study included 766 infants with CHD who underwent cardiac surgery with cardiopulmonary bypass…

Fluid Dynamics & Materials Processing
Article

Numerical Investigation of Aeroacoustic Response of an Oscillating-Wing Power Extractor

Oscillating-wing power extractors (OWPEs) are an alternative to rotary wind turbines for small- and medium-scale renewable energy applications. However, the aeroacoustic response of such systems remains largely unexplored. In this study, the power extraction performance and near-field aeroacoustic characteristics of an OWPE are numerically investigated using transient computational fluid dynamics (CFD) simulations coupled with the Ffowcs Williams–Hawkings (FW–H) acoustic model at a Reynolds number Re of 8.58 × 10⁴. Two important operating parameters, namely the pitching…

Fluid Dynamics & Materials Processing
Article

Experimental Development and Optimization of a Particle-Fiber-Powder Composite Temporary Plugging System for Diversion Fracturing

This study develops a particle-fiber-powder composite temporary plugging system and systematically investigates the dynamic plugging behavior of single-component, binary, and ternary formulations to elucidate the mechanisms governing plug formation and optimize material composition for diversion fracturing applications. Conventional temporary plugging materials often exhibit inadequate plug formation, limited pressure-bearing capacity, and poor plugging stability, compromising stimulation effectiveness in heterogeneous reservoirs. Experimental results show that neither the particle-only nor the particle-powder system can establish a stable load-bearing…

Fluid Dynamics & Materials Processing
Article

Experimental Investigation of Seepage-Induced Rheological Deformation in Mucky Soft Soil Containing Medium-Fine Sand

Seepage-induced rheological deformation represents a critical factor governing the long-term stability of coastal soft-soil excavations subjected to intense rainfall infiltration and groundwater fluctuations. This study elucidates the individual and interactive effects of seepage pressure and seepage duration on the time-dependent deformation behavior of undisturbed mucky soft soil containing medium-fine sand, collected from a deep foundation pit. A comprehensive experimental campaign based on triaxial seepage-shear rheological testing for a confining pressure of 180 kPa is presented,…

Fluid Dynamics & Materials Processing
Article

Experimental Investigation of Residual Acid Effects on Flushing Efficiency, Rheological Compatibility, and Thickening Behavior in a Novel Pre-Cementing Acidification Process

To overcome the inherent limitations of conventional post-cementing acidification, including limited acid penetration into the formation and the potential impairment of zonal isolation, a novel pre-cementing acidification approach is proposed. This method aims to remove near-wellbore formation damage before cementing operations. Its feasibility, however, critically depends on the physicochemical compatibility between residual acid and the subsequent cementing fluids, namely spacer fluids and cement slurries. In this study, a comprehensive series of laboratory experiments was conducted…

Fluid Dynamics & Materials Processing
Article

Molecular Dynamics Investigation of Pressure-Driven Water Transport in Kaolinite Nanopores

This study investigates the microscopic mechanisms governing water transport in kaolinite-rich nanoporous media, a topic of considerable importance for shale gas recovery, seepage in fine-grained soils, and the migration of contaminants in low-permeability geological formations. To this end, molecular dynamics (MD) simulations are performed on slit-shaped kaolinite nanopores with different degrees of surface wettability in order to elucidate the influence of solid-liquid interactions on the structure and dynamics of confined water. The analysis focuses on…

Fluid Dynamics & Materials Processing
Article

Optimizing Hollow Block Roof Design: A Numerical Investigation of Coupled Heat Transfer under Solar Radiation

The complex interplay of heat transfer mechanisms, namely conduction, natural convection, and radiation, within hollow block roofs exposed to solar irradiation gives rise to an inherently nonlinear thermal exchange problem. A key yet insufficiently explored question is the extent to which this nonlinearity governs the macroscopic thermal behavior of roofing systems. In this study, a computational investigation is conducted on two roof configurations incorporating five hollow block geometries representative of common construction practices in hot…