Open Access

ARTICLE

Intravascular Ultrasound (IVUS)-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment

Mingchao Cai¹, Chun Yang², Mehmet H. Kural¹, Richard Bach³, David Muccigrosso⁴, Deshan Yang⁵, Jie Zheng⁴, Kristen L. Billia¹, Dalin Tang^1,6

1 Worcester Polytechnic Institute, Worcester, MA 01609
2 School of Mathematical Sciences, Beijing Normal University, Key Laboratory of Mathematics and Complex Systems, Ministry of Education, Beijing, 100875, China
3 Cardiovascular Division, Washington University School of Medicine, Saint Louis, MO 63110, USA
4 Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110 USA
5 Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63110, USA
6 Corresponding author, dtang@wpi.edu

Structural Longevity 2011, 6(2), 39-46. https://doi.org/10.3970/sl.2011.006.039

Abstract

Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better risk assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. We propose a procedure where intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling are combined together to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions.

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Keywords

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