CHAO LIU^*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.047044

Abstract Introduction: Osteoarthritis (OA) is still an important health problem, and understanding its pathological mechanisms is essential for its diagnosis and treatment. There is evidence that autophagy may play a role in OA progression, but the exact mechanism remains unclear. Methods: In this study, we adopted a multi-prong approach to systematically identify the key autophagy-related genes (ARGs) associated with OA. Through weighted gene co-expression network analysis, we initially identified significant gene modules associated with OA. Subsequent differential gene analysis performed on normal and OA specimens. Further analysis later using the MCC algorithm highlighted hub ARGs. These genes were then incorporated into… More >

BINGJIE WANG¹, YEWEN ZHOU^1,2,3, TONGJUAN NIU¹, MENGQING YIN¹, SHENG CUI^1,2,3,*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.044630

Abstract Introduction: The regulation of thyroid-stimulating hormone (TSH) synthesis involves neurotransmitters, with melatonin being a subject of ongoing debate. TSH transcription, synthesis, and secretion from the pituitary pars distalis (PD) is primarily regulated in a photoperiodic manner by thyrotropin-releasing hormone (TRH). In contrast, in the pituitary pars tuberalis (PT), mRNA transcription and alpha/beta chain synthesis, but not secretion, of a TSH-like product is regulated by melatonin. Conversely, non-photoperiodic melatonin might also affect the secretion of a TSH-like product from the PT. Nevertheless, the impact of exogenous melatonin on the underlying PD-TSH synthesis remains unclear. Casein kinase 1α (CK1α) plays a negative… More >

DAIXIN ZHAO¹, QINGYU WANG², JIANBO WANG^1,*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.029094

Abstract Background: Esophageal cancer (ESCA) is a common digestive tract tumor. As a result, optimization of the early diagnosis of ESCA and identifying the contributing prognostic genes is urgently required. Herein, the prognosis of mitochondrial autophagy-related genes was analyzed in different subtypes of ESCA, and prognostic models were constructed to identify the immune cell infiltration with significant differences between subtypes. Methods: The Cancer Genome Atlas database was searched to download 185 ESCA samples, covering gene expression level data and clinical follow-up data, and 179 samples from the Gene Expression Omnibus database for subsequent validation analysis. The consensus Cluster Plus analysis method… More >

Gang Niu^1,2, Zhaoyang Jin², Wei Zhang^3,*, Yiqun Huang³

Structural Durability & Health Monitoring, Vol., , DOI:10.32604/sdhm.2023.044580

Abstract Amid urbanization and the continuous expansion of transportation networks, the necessity for tunnel construction and maintenance has become paramount. Addressing this need requires the investigation of efficient, economical, and robust tunnel reinforcement techniques. This paper explores fiber reinforced polymer (FRP) and steel fiber reinforced concrete (SFRC) technologies, which have emerged as viable solutions for enhancing tunnel structures. FRP is celebrated for its lightweight and high-strength attributes, effectively augmenting load-bearing capacity and seismic resistance, while SFRC’s notable crack resistance and longevity potentially enhance the performance of tunnel segments. Nonetheless, current research predominantly focuses on experimental analysis, lacking comprehensive theoretical models. To… More >

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol., , DOI:10.32604/or.2024.046679

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results: EBV-miRNA-BART6-5p exhibits pronounced upregulation… More >

Verônica Távilla Ferreira Silva, Adriane Maria Ferreira Milagres^*

Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.045726

Abstract This study was conducted to evaluate the effectiveness of enzymes in purifying and reducing the degree of polymerization of cellulose for the production of dissolving pulp. Our goal was to determine the contributions of xylanase (X) and endoglucanase (EG) in the treatment of pulp, specifically by quantifying the formation of soluble and insoluble reducing sugars using the dinitrosalycilic acid (DNS) test. Predominantly, the release of soluble reducing sugars (RSSol) was enhanced after xylanase treatment, while endoglucanase (EG) treatment led to changes in insoluble reducing sugars (RSIns). The maximum synergism was observed for RSIns when a high ratio of endoglucanase to… More > Graphic Abstract

Ruirui Zhang¹, Xuguang Zhang², Minxin Yang³, Haoran Zhang^4,5,*

International Journal of Mental Health Promotion, Vol., , DOI:10.32604/ijmhp.2023.045819

Abstract Contingent self-esteem captures the fragile nature of self-esteem and is often regarded as suboptimal to psychological functioning. Self-compassion is another important self-related concept assumed to promote mental health and well-being. However, research on the relation of self-compassion to contingent self-esteem is lacking. Two studies were conducted to explore the role of self-compassion, either as a personal characteristic or an induced mindset, in influencing the effects of contingent self-esteem on well-being. Study 1 recruited 256 Chinese college students (30.4% male, mean age = 21.72 years) who filled out measures of contingent self-esteem, self-compassion, and well-being. The results found that self-compassion moderated… More >

Shihu Liu, Chunsheng Yang^*, Yingjie Liu

Intelligent Automation & Soft Computing, Vol., , DOI:10.32604/iasc.2023.040818

Abstract Many network presentation learning algorithms (NPLA) have originated from the process of the random walk between nodes in recent years. Despite these algorithms can obtain great embedding results, there may be also some limitations. For instance, only the structural information of nodes is considered when these kinds of algorithms are constructed. Aiming at this issue, a label and community information-based network presentation learning algorithm (LC-NPLA) is proposed in this paper. First of all, by using the community information and the label information of nodes, the first-order neighbors of nodes are reconstructed. In the next, the random walk strategy is improved… More >

Yongguo Li^1,2, Caiyin Xu^1,2,*, Can Qin^1,2, Dingjian Zheng^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.044804

Abstract The so-called ORC (Organic Rankine Cycle) heat recovery technology has attracted much attention with regard to medium and low temperature waste heat recovery. In the present study, it is applied to a Tesla turbine. At the same time, the effects of the disc speed, diameter and inter-disc gap on the internal flow field and output power of the turbine are also investigated by means of CFD (Computational Fluid Dynamics) numerical simulation, by which the pressure, velocity, and output efficiency of the internal flow field are obtained under different internal and external conditions. The highest efficiency (66.4%) is obtained for a… More >

PEI QIN^#, MIAO LIU^#, XIN WANG, JIANHUA MA^*

BIOCELL, Vol., , DOI:10.32604/biocell.2023.045640

Abstract Background: L-dopa (Levodopa) is well known for managing PD (Parkinson’s disease); however, its prolonged use caused dyskinesia (LID). Due to the varied presentation of LID, effective treatment options are scarce. Flavonoids reported their neuroprotective activity by ameliorating acetylcholinesterase, monoamine oxidase, and neuroinflammation. Kaempferol is another flavonoid bearing these potentials. Aim: To evaluate neuroprotective activity of kaempferol in dyskinetic rats. Methods: PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid (10 µL) + 6-OHDA (12 µg) in medial forebrain bundle to induce neuronal damage in substantial nigra (SNr). LID was induced by administrating combination of L-dopa (20 mg/kg)… More > Graphic Abstract