JING HUI^1,2, NANA SUN³, YONG LIU⁴, CHUNBO YU^1,2, YONG KE⁴, YONG CAO⁴, ANXIAO YU⁴, QINGHONG KONG^1,2,*, YUN LIU^1,2,4,*

BIOCELL, Vol., , DOI:10.32604/biocell.2024.047122

Abstract Background: Although it has been established that the human Solute Carrier Family 22 (SLC22) functions as a cationic transporter, influencing cellular biological metabolism by modulating the uptake of various cations, its impact on cancer prognosis remains unclear. Methods: We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas (TCGA) and other databases to assess the prognostic value and functional implications across various tumors. Silence of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lower-grade glioma (LGG) progression. Results: Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time… More >

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol., , DOI:10.32604/or.2024.051112

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype glioblastomas (n… More > Graphic Abstract

Sowon Lee¹, Boyoung Kim^1,*, Chung Kil Park^2,*

International Journal of Mental Health Promotion, Vol., , DOI:10.32604/ijmhp.2024.048803

Abstract This study explored how mental health professionals collaborate with peer supporters with mental disabilities in a community mental health institution. From January 19 to February 23, 2021, three 60 min interviews were conducted with six mental health professionals working at a Korean community center. The results were qualitatively analyzed and divided into four themes and eight categories. The four themes were the perceptions of and challenges in working with peer supporters with mental disabilities, conflict and confusion about working with peer supporters, forming partnerships with peer supporters, and policy support for peer supporters’ job security. Participants reported vague anxiety about… More >

Yi Tu^1,*, Yuan Wu², Yu Zeng³

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2024.045624

Abstract The formation of ice on the leading edge of aircraft engines is a serious issue, as it can have catastrophic consequences. The Swirl Anti-Icing (SAI) system, driven by ejection, circulates hot fluid within a 360° annular chamber to heat the engine inlet lip surface and prevent icing. This study employs a validated Computational Fluid Dynamics (CFD) approach to study the impact of key geometric parameters of this system on flow and heat transfer characteristics within the anti-icing chamber. Additionally, the entropy generation rate and exergy efficiency are analyzed to assess the energy utilization in the system. The research findings indicate… More >

J. Sheril Angel¹, A. Diana Andrushia^1,*, T. Mary Neebha¹, Oussama Accouche², Louai Saker², N. Anand³

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2024.047326

Abstract Facial emotion recognition (FER) has become a focal point of research due to its widespread applications, ranging from human-computer interaction to affective computing. While traditional FER techniques have relied on handcrafted features and classification models trained on image or video datasets, recent strides in artificial intelligence and deep learning (DL) have ushered in more sophisticated approaches. The research aims to develop a FER system using a Faster Region Convolutional Neural Network (FRCNN) and design a specialized FRCNN architecture tailored for facial emotion recognition, leveraging its ability to capture spatial hierarchies within localized regions of facial features. The proposed work enhances… More >

Yiyi Cen^1,3, Wenzheng Jia², Wen Dai^3,*, Chun Wang⁴, He Wu¹

Revue Internationale de Géomatique, Vol., , DOI:10.32604/rig.2024.050273

Abstract Color, as a significant element of village landscapes, serves various functions such as enhancing aesthetic appeal and attractiveness, conveying emotions and cultural values. To explore the three-dimensional spatial characteristics of color landscapes in beautiful villages, this study conducted a comparative experiment involving eight provinciallevel beautiful villages and eight ordinary villages in Jinzhai County. Landscape pattern indices were used to analyze the color landscape patterns on the facades of these villages, complemented by a quantitative analysis of color attributes using the Munsell color system. The results indicate that (1) Natural landscape colors in beautiful villages are primarily concentrated in the yellow-red… More >

Chengxu Qian¹, Qiangwen Chen^1,2, Leiyu Jiang¹, Xiaoyan Yang³, Shen Rao⁴, Weiwei Zhang¹, Feng Xu^1,*

Phyton-International Journal of Experimental Botany, Vol., , DOI:10.32604/phyton.2024.050893

Abstract The objective of this study was to explain the physiological mechanisms through which Na₂SeO₃ mitigates the growth and developmental inhibition of pakchoi under HgCl₂ stress. The results showed that treatment with HgCl₂ (40 mg L⁻¹ ) led to reduced biomass, dwarfing, root shortening, and root tip necrosis in pakchoi. Compared to control (CK), the activities of superoxide dismutase (SOD) and peroxidase (POD) in Hg treatment increased, and the content of malondialdehyde (MDA) also dramatically increased, which negatively impacted the growth of pakchoi. Low concentrations of Na₂SeO₃ (0.2 mg L⁻¹ ) significantly increased the content of soluble sugars compared with control,… More >

Md. Munirul Hasan¹, Md Mustafizur Rahman^2,*, Mohammad Saiful Islam³, Wong Hung Chan⁴, Yasser M. Alginahi⁵, Muhammad Nomani Kabir⁶, Suraya Abu Bakar¹, Devarajan Ramasamy²

Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2024.047428

Abstract A vehicle engine cooling system is of utmost importance to ensure that the engine operates in a safe temperature range. In most radiators that are used to cool an engine, water serves as a cooling fluid. The performance of a radiator in terms of heat transmission is significantly influenced by the incorporation of nanoparticles into the cooling water. Concentration and uniformity of nanoparticle distribution are the two major factors for the practical use of nanofluids. The shape and size of nanoparticles also have a great impact on the performance of heat transfer. Many researchers are investigating the impact of nanoparticles… More >

Penghui Liu^1,2,*, Yaning Zhang¹, Yuxing Dai², Yanzhou Sun^1,3

Energy Engineering, Vol., , DOI:10.32604/ee.2024.049318

Abstract Arc grounding faults occur frequently in the power grid with small resistance grounding neutral points. The existing arc fault identification technology only uses the fault line signal characteristics to set the identification index, which leads to detection failure when the arc zero-off characteristic is short. To solve this problem, this paper presents an arc fault identification method by utilizing integrated signal characteristics of both the fault line and sound lines. Firstly, the waveform characteristics of the fault line and sound lines under an arc grounding fault are studied. After that, the convex hull, gradient product, and correlation coefficient index are… More >

Yanqun Yu^1,*, Wenhao Xu¹, Yahui Huangfu¹, Jinhai Liu^1,2, Bensheng Wang¹, Kai Liu¹

Energy Engineering, Vol., , DOI:10.32604/ee.2024.047986

Abstract China’s unconventional gas fields have a large number of low-productivity and low-efficiency wells, many of which are located in remote and environmentally harsh mountainous areas. To address the long-term stable production of these gas wells, plunger-lift technology plays an important role. In order to fully understand and accurately grasp the drainage and gas production mechanisms of plunger-lift, a mechanical model of plunger-liquid column uplift in the plunger-lift process was established, focusing on conventional plunger-lift systems and representative wellbore configurations in the Linxing region. The operating casing pressure of the plunger-lift process and the calculation method for the maximum daily fluid… More >