Francisco Raúl Borzone^1,2,*, María Belén Giorello¹, Agustina Freire³, Leandro Marcelo Martinez⁴, Leonardo Feldman⁵, Federico Dimase⁶, Pablo Evelson³, Irene Larripa⁷, Emilio Batagelj⁸, Marcela Beatriz González Cid⁹, Norma Alejandra Chasseing^1,*

Oncology Research, DOI:10.32604/or.2026.074321

Abstract Backgrounds: Breast cancer metastasis remains the leading cause of mortality and frequently targets the bone. Breast cancer cells release soluble factors and extracellular vesicles that disrupt bone marrow (BM)/bone homeostasis, promoting osteoclastogenesis and the accumulation of senescent cells. In line with updated cancer hallmarks, senescent mesenchymal stem/ stromal cells (MSCs), osteoblasts, and osteocytes contribute to remodeling of the BM microenvironment, thereby favoring pre-metastatic niche (PMN) formation and subsequent bone metastasis. We previously demonstrated that untreated stage III-B breast cancer patients (BCPs) exhibit increased oxidative stress and elevated reactive oxygen species (ROS) levels, accompanied by senescent… More > Graphic Abstract

Awatif Rashed Z. Almotairy^1,2, Eman Fayad³, Fatimah Hadadi⁴, Ahmad F. Alhomodi⁵, Dalal Nasser Binjawhar⁶, Hanadi A. Katouah⁷, Bassma H. Elwakil^8,*, Keshav Raj Paudel^9,10,*, Mostafa El-Khatib¹¹

Oncology Research, DOI:10.32604/or.2025.070645

Abstract Objectives: Prostate cancer cells often develop mechanisms to evade conventional therapies. Nanomedicine offers the potential for targeted drug delivery, improved tumor accumulation, and reduced systemic toxicity. This study biosynthesizes silver nanoparticles (NPP/AgONPs) functionalized with propolis, evaluates their antibacterial efficacy against uropathogenic strains of Escherichia coli (E. coli), and assesses their cytotoxic effect on cancer cell proliferation using the PC-3, human prostate epithelial cell line. Methods: The synthesized NPP/AgONPs physiochemical parameters were characterized, followed by in vitro assays to evaluate their antibacterial activity against multiple uropathogenic E. coli strains; determining the cytotoxicity against HPrEC and PC-3 cells by measuring cytotoxicity (CC₅₀)… More >

Wanqing Lin^1,2,*, Mohd Azrin Mohd Nasir¹, Suzila Binti Ismail¹

Journal of Psychology in Africa, DOI:10.32604/jpa.2026.073231

Abstract This systematic review synthesizes empirical research on external risk factors for adolescent smartphone addiction. Scopus and Web of Science were searched for English peer-reviewed empirical articles from 2008 onward; 28 met inclusion criteria (excluding non-adolescents, generic internet addiction, non-empirical work, or non-English). Thematic synthesis organized findings into three external risk domains—family, school, and peers—considering cultural/contextual mechanisms. Family dynamics (parental phubbing, harsh parenting, dysfunction), school stressors, and adverse peer relationships were identified as accumulating, direct and indirect contributors to smartphone addiction. These operate within a techno-ecological framework, where digital technologies amplify vulnerabilities and create new pathways More >

Ying Zhu^1,2, Minghui Hu³, Shengxu Wang^1,2, Xiaoliang Dong^3,*, Xuewen Xiao^1,2, Richeng Liu³, Meng Wang^1,2, Zheng Yuan³

CMES-Computer Modeling in Engineering & Sciences, DOI:10.32604/cmes.2026.076381

Abstract In-situ enlargement of super-large-span tunnels can intensify excavation-induced unloading in the surrounding rock, increasing deformation demand and failure risk during construction. This study combines laboratory model tests with FLAC3D simulations to evaluate the stabilizing role of prestressed anchor cables and to establish an energy-balance framework for support optimization. Comparative model tests of existing and enlarged tunnel sections, with and without anchors, show that reinforcement increases load-carrying capacity, reduces displacement, and confines damage to more localized zones. The numerical simulations reproduce displacement fields, shear-strain localization, and plastic-zone evolution with good agreement against the experimental observations. The energy More >

Hitesh Mohapatra^*

CMC-Computers, Materials & Continua, DOI:10.32604/cmc.2026.076726

Abstract This review examines current approaches to real-time decision-making and task optimization in Internet of Things systems through the application of machine learning models deployed at the network edge. Existing literature shows that edge-based distributed intelligence reduces cloud dependency. It addresses transmission latency, device energy use, and bandwidth limits. Recent optimization strategies employ dynamic task offloading mechanisms to determine optimal workload placement across local devices and edge servers without centralized coordination. Empirical findings from the literature indicate performance improvements with latency reductions of approximately 32.8% and energy efficiency gains of 27.4% compared to conventional cloud-centric models.… More >

Ying Yao¹, Le Tian^1,2,3, Yuxiang Hu^1,2,3,*, Pengshuai Cui^1,2,3

CMC-Computers, Materials & Continua, DOI:10.32604/cmc.2026.075747

Abstract In the process of programmable networks simplifying network management and increasing network flexibility through custom packet behavior, security incidents caused by human logic errors are seriously threatening their safe operation, robust verification methods are required to ensure their correctness. As one of the formal methods, symbolic execution offers a viable approach for verifying programmable networks by systematically exploring all possible paths within a program. However, its application in this field encounters scalability issues due to path explosion and complex constraint-solving. Therefore, in this paper, we propose NetVerifier, a scalable verification system for programmable networks. To… More >

Wenchao Shi¹, Tao Wei², Chuan Yang³, Qichao Fan³, Hongxi Liu⁴, Bin Shao^5,*, Peng Jing^4,*

CMC-Computers, Materials & Continua, DOI:10.32604/cmc.2026.075293

Abstract Enhancing the strength of nanotwinned aluminum (Al) is essential for the development of next-generation high-end chip technology. To better understand the detwinning behavior of nanotwinned Al under conditions with no resolved shear stress acting on the twin boundaries, we conducted molecular dynamics simulations of uniaxial tensile deformation in nanotwinned single-crystal Al at room temperature. Detwinning is observed only when the twin boundary spacing is 7.01 Å. At larger spacings, twin boundaries remain parallel to the loading direction, with no rotation or bending, indicating negligible migration. Detwinning is triggered by localized stress from dislocation interactions, with More >

Qi Wang, Kelvin Amos Nicodemas^*

CMC-Computers, Materials & Continua, DOI:10.32604/cmc.2026.074305

Abstract Multivariate time series forecasting plays a crucial role in decision-making for systems like energy grids and transportation networks, where temporal patterns emerge across diverse scales from short-term fluctuations to long-term trends. However, existing Transformer-based methods often process data at a single resolution or handle multiple scales independently, overlooking critical cross-scale interactions that influence prediction accuracy. To address this gap, we introduce the Hierarchical Attention Transformer (HAT), which enables direct information exchange between temporal hierarchies through a novel cross-scale attention mechanism. HAT extracts multi-scale features using hierarchical convolutional-recurrent blocks, fuses them via temperature-controlled mechanisms, and optimizes More >

Guancan Liang^#, Jian Pan^#, Ruixiang Dai, Ziyi Lin, Xunbao Wang, Teng Hou, Zhicheng Luo, Xiaoming Wang^*

Canadian Journal of Urology, DOI:10.32604/cju.2026.074252

Abstract Background: The causal link between mental illness and prostatitis remains inconclusive, largely due to heterogeneity and potential confounders. This study explored the causal link between mental illness and prostatitis in men using Mendelian randomization (MR), and offered recommendations for enhancing future research. Methods: Publicly accessible genome-wide association study (GWAS) data were accessed via the IEU OpenGWAS platform and FinnGen database for this research. The inverse variance weighted (IVW) approach served as the primary Mendelian randomization analysis, while MR-Egger, weighted median, weighted mode, and simple mode methods were additionally applied to evaluate potential relationships between prostatitis… More >

Dalin Wang¹, Mingcai Zhang¹, Richard Hastings², Patrick George¹, Ryan Ranzau¹, Jinxi Wang^1,3,*

BIOCELL, DOI:10.32604/biocell.2026.074572

Abstract Objective: Although endplate (EP) injury may cause intervertebral disc (IVD) degeneration and Modic changes (MCs) in the vertebral bone marrow (VBM), EP injury-induced synchronous cellular reactions and their crosstalk in the IVD and VBM remain unclear. This protocol-based study aimed to streamline and optimize the methods of tissue harvest and cell preparation for flow cytometry (FCM) analysis of T-cell and macrophage subpopulations in both VBM and IVD adjacent to the surgically induced EP microfracture in mice. Methods: EP injury or sham procedure was performed at the spinal levels L4-5 and L5-6 in male mice. Step-by-step… More >