Ruikang Ma¹, Guangfei Wei², Songzi Li², Tongle Li¹, Fugang Wei³, Yong Wang⁴, Guozhuang Zhang^2,*, Linlin Dong^1,2,*

Phyton-International Journal of Experimental Botany, DOI:10.32604/phyton.2026.075657

Abstract Keystone taxa are critical for microbial community homeostasis and ecological niche interactions. However, the functions and genomic traits of endophytic keystone fungi in plant tissues remain unclear. Via network analysis, this study identified keystone fungi Plectosphaerella (Plec) and Cladosporium (Clad) in roots/leaves of medicinal Panax plants (P. ginseng, P. quinquefolius, P. notoginseng). Both correlated strongly positively with ginsenoside Rd content in respective tissues (ρ > 0.6, p < 0.001). Co-cultivation confirmed their ability to convert ginsenoside Rb1 to Rd, linked to β-glucosidase activity. Whole-genome sequencing/assembly/evolutionary analysis of the two strains elucidated genomic features for their keystone roles and saponin biotransformation. More > Graphic Abstract

Xiao Wang^*, E Liang, Xiaohui Song, Deyan Li

Phyton-International Journal of Experimental Botany, DOI:10.32604/phyton.2026.075656

Abstract Three-year-old Panax japonicus was exposed to elevated CO₂ concentrations using open-top chambers: ambient CO₂ (aCO₂), moderately elevated (e1CO₂, 550 μmol/mol), and highly elevated (e2CO₂, 750 μmol/mol). Gas exchange parameters, photosynthetic pigments, sugar accumulation, and total saponin content were measured to assess the effects of CO₂ enrichment on photosynthesis, sugar metabolism, and saponin biosynthesis. The e1CO₂ treatment significantly increased net photosynthetic rate (by 17.22% at 36 days and 69.62% at 92 days), chlorophyll a content, and soluble sugar, sucrose, and starch accumulation. Key sugar metabolism enzymes, including sucrose phosphate synthase (SPS), also showed enhanced activity. Consequently, underground rhizome total saponins rose More >

Abdul Manan^1,2, Sidra Ilyas^2,*

Oncology Research, DOI:10.32604/or.2026.074185

Abstract Hepatocellular carcinoma (HCC) remains a significant global health challenge, with therapeutic efficacy in advanced stages often limited by underlying liver dysfunction and adaptive resistance. In this review, the evolving landscape of molecular targets and combinatorial strategies is critically examined, with a particular focus on the transition from preclinical discovery to clinical application. While traditional molecular heterogeneity is acknowledged, the aim is to elucidate how emerging computational paradigms are redefining target discovery and therapeutic stratification in HCC. The primary purpose is to evaluate the role of Artificial Intelligence (AI) and Machine Learning (ML) as integrative tools… More > Graphic Abstract

Yingzheng Tan^1,#, Jiao Xiao^2,#, Liyun Tang^3,4,#, Jian Wan^3,#, Tian Zeng³, Wenchao Zhou³, Xueru Liu³, Xun Chen^3,5,*, Yukun Li^3,*

Oncology Research, DOI:10.32604/or.2026.071536

Abstract Background: Lactate, as a critical byproduct of tumor metabolic reprogramming, plays an important role in DNA damage repair and tumor immune infiltration. This work aims to elucidate the molecular mechanisms by which lactate promotes tumor DNA damage repair (DDR) and subsequent immune evasion. Methods: Hepatocellular carcinoma (HCC), lung adenocarcinoma (LUAD), and ovarian cancer (OC) cells with cisplatin-induced DNA damage were treated with lactate at a concentration gradient, Endothelial cell-specific molecule 1 (ESM1) shRNA, ESM1 overexpression plasmid, or the Protein Kinase B (AKT) Serine/Threonine Kinase 1 (Akt1) inhibitor LY294002. Proliferation, apoptosis, and DNA damage levels were… More >

Daniel Burg¹, Aryeh Babkoff¹, Omer Or², Noam Olshinka², Jonathan Abraham Demma³, Mohamad Adila^1,3, Marc Wygoda⁴, Philip Blumenfeld⁴, Judith Diment⁵, Masha Galiner⁶, Yusef Azraq⁶, Daniela Katz^1,7, Petachia Reissman⁸, Sadie Ostrowicki⁹, Gabriella Sebbag¹⁰, Narmine Elkhateeb^1,11, Anat Hershko Moshe^1,11, Dania Jaber^1,11, Adi Hollander^1,11, Limor Rubin^1,11, Aviad Zick^1,12,*

Oncology Research, DOI:10.32604/or.2026.070233

Abstract Background: —Synovial sarcoma is a rare soft tissue sarcoma. Treatment of synovial sarcoma includes surgery, radiation, pazopanib, and chemotherapy. Targeted therapies, such as B-Raf proto-oncogene, serine/threonine kinase (BRAF) inhibitors, are emerging as a potential treatment option. We describe the sixth case of a BRAF^V600E synovial sarcoma, the first extra-thoracic case. This case is the first to show a complete pathological response to BRAF & mitogen-activated protein kinase kinase (MEK) inhibitors. Case description: —We treated a 22-year-old male with a left groin BRAF^V600E synovial sarcoma with doxorubicin, Ifosphamide & Sodium 2-Mercaptoethanesulfonate. When we identified BRAF^V600E in the tumor,… More >

Adam Khorasanchi, Merve Hasanov, Richard Wu, Hisham Alsharif, Kari Kendra, Claire Verschraegen^*

Oncology Research, DOI:10.32604/or.2026.069012

Abstract Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and typically involves the head and neck. Systemic therapy is often required for patients with advanced CSCC to achieve optimal disease control. Immune checkpoint inhibitors (ICIs) are now the standard of care for these patients, with a 50%–60% response rate and sustainable remission for at least 30% of patients. Given the activity of ICIs in advanced head and neck CSCC, ICIs are being studied in early-stage disease or neoadjuvant situations. The purpose of this review is to provide an overview of More >

Jia Wu^1,#, Wei Luo^2,#, Qianguo Xiao¹, Qinhong Xie¹, Xiaodong Li¹, Taiyong Bi^1,*, Hui Kou^1,*

Journal of Psychology in Africa, DOI:10.32604/jpa.2026.072761

Abstract This study examines the mediating role of positive psychological capital and the moderating role of ethnicity in the relationship between mindfulness and internalizing/externalizing problems among adolescents. The study sample comprized Chinese adolescents (N = 637 ethnic minority; females = 40.97%, meam age = 12.68, SD = 0.49 years; N = 636 Han; females = 49.06%, mean age = 12.71, SD = 0.47 years). The participants completed the Child and Adolescent Mindfulness Measure, the Positive Psycap Questionnaire, and the Youth Self-Report. Results from the moderated mediation analysis showed mindfulness was negatively associated with both internalizing and externalizing More >

Mahmut Selçuk^1,*, Fulden Cantaş Türkiş², Fatma Taşkın Koca³, Volkan Dizman⁴, Sevilay Yerlikaya Boz⁴

International Journal of Mental Health Promotion, DOI:10.32604/ijmhp.2026.076391

Abstract Background: Self-esteem, life satisfaction, resilience, and coping strategies are closely linked to depression; however, their interrelationships and relative contributions to depressive outcomes remain insufficiently understood. This study aimed to examine these associations in individuals with major depressive disorder (MDD) and healthy controls and to evaluate their predictive and mediating roles in depression. Methods: This analytical cross-sectional study included 311 participants (158 patients with MDD and 153 healthy controls) recruited from the Psychiatry Outpatient Clinics of Mugla Training and Research Hospital. Psychiatric diagnoses were confirmed using the Structured Clinical Interview for DSM-5 (SCID-5). Groups were balanced for… More >

Fankun Meng^1,2,3, Yuyang Liu^1,2,*, Xiaohua Liu⁴, Chenlong Duan^1,2, Yuhui Zhou^1,2,3

FDMP-Fluid Dynamics & Materials Processing, DOI:10.32604/fdmp.2026.075865

Abstract Carbonate gas reservoirs are often characterized by strong heterogeneity, complex inter-well connectivity, extensive edge or bottom water, and unbalanced production, challenges that are also common in many heterogeneous gas reservoirs with intricate storage and flow behavior. To address these issues within a unified, data-driven framework, this study develops a multi-block material balance model that accounts for inter-block flow and aquifer influx, and is applicable to a wide range of reservoir types. The model incorporates inter-well and well-group conductive connectivity together with pseudo–steady-state aquifer support. The governing equations are solved using a Newton–Raphson scheme, while particle More > Graphic Abstract

Yang Zhang¹, Xiaoping Yang¹, Yalan Zhang¹, Mingzhe Han¹, Jiayi Sun², Zhengsheng Xia^3,*

FDMP-Fluid Dynamics & Materials Processing, DOI:10.32604/fdmp.2026.075388

Abstract Self-suspended proppants, which enable clear-water fracturing, represent a promising new class of materials for reservoir stimulation. Given the economic limitations associated with their exclusive use, this study investigates proppant transport behavior in hybrid systems combining self-suspended proppants with conventional 40/70 mesh quartz sand at various mixing ratios. A dedicated experimental apparatus was developed to replicate field-relevant complex fracture networks, consisting of a main fracture and two branching fractures with different deflection angles. Using this system, sand bank formation and proppant distribution were examined for both conventional quartz sand fracturing and fracturing augmented with self-suspended proppants.… More >