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  • Open Access

    ABSTRACT

    An Analytical Investigation of in Vivo Mechanical References for Mechanobiological Experiments of Vascular Cells

    Shaoxiong Yang1, Xiaobo Gong1,*, Yingxin Qi2, Zonglai Jiang2

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 9-10, 2019, DOI:10.32604/mcb.2019.05701

    Abstract Blood vessels interact with their mechanical environments in a comprehensive way. Local mechanical stimuli outside the biological range play important roles in various human cardiovascular diseases. Although many mechanobiological studies of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in vitro have been reported in mimicking cellular dysfunctions, their quantitative correlations to the in vivo vascular conditions remain unclear. In order to interpret the stress-modulated dysfunctions of vascular cells and explore the key mechanical factors in vascular diseases, it is important to investigate the mechanical environments of vessel walls in vivo under various physiological conditions. Based on nonlinear continuum… More >

  • Open Access

    ABSTRACT

    The Role of Shear Stress in Atherosclerotic Plaque Progression, Destabilization and Rupture

    J. J. Wentzel1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 7-8, 2019, DOI:10.32604/mcb.2019.05696

    Abstract The pathophysiology of atherosclerosis is complex and multifactorial, involving systemic risk factors and biomechanical stimuli. Atherosclerotic plaques predominantly form in regions that are exposed to low shear stress of the blood at the vessel wall, whereas regions of moderate and high shear stress are generally protected. For more than 20 years, my research group performs studies to investigate the role of shear stress in atherosclerotic plaque formation and rupture in coronary and carotid arteries of patients and laboratory animals. For that reason, new technology was developed to 3D reconstruct arteries based on fusion of multiple invasive and non-invasive imaging modalities.… More >

  • Open Access

    ABSTRACT

    Some Aspects in Mechano-Biology of Platelet and Leukocyte in Blood Flows

    Ying Fang1, Jianhua Wu1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 5-6, 2019, DOI:10.32604/mcb.2019.05695

    Abstract For hemostasis and thrombosis, some proteins, such as Von Willebrand Factor (VWF, a multimeric plasma glycoprotein synthesized in endothelial cells and megakaryocytes and secreted to circulation or attached to endothelial cells), the metalloprotease ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13), P-selectin (one of three selectin family members with a N-terminal C-type lectin domain, an epidermal growth factor (EGF)-like module, a series of consensus repeat (CR) units, a transmembrane segment and a short cyto-plasmic domain) and β2 integrin. In adhesion and aggregation of circulating platelets towards to the sites of vascular injury, VWF on vascular… More >

  • Open Access

    ABSTRACT

    Systems Modeling of Cardiomyocyte Mechanobiology

    Philip M. Tan1, Kyle S. Buchholz2, Shulin Cao2, Yasser Aboelkassem2, Jeffrey H. Omens2, Andrew D. McCulloch2,*, Jeffrey J. Saucerman1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 1-3, 2019, DOI:10.32604/mcb.2019.05693

    Abstract In this article, we summarize our systems model of cardiomyocyte mechano-signaling published in PLoS Computational Biology and discuss new approaches to extending these models to predict cardiac myocyte gene expression in response to stretch. More >

  • Open Access

    ABSTRACT

    Preface: The First International Symposium on Biomechanics and Mechanobiology in Cardiovascular System

    Zhiyong Li1,2,*, Dalin Tang1,3

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 1-7, 2019, DOI:10.32604/mcb.2019.05830

    Abstract Cardiovascular disease remains as the leading cause of death worldwide, and the technologies developed by different groups need to be communicated and shared with all related research communities for a boarder implementation. Challenges in imaging technology, mathematical modelling, material description, mechanical representation, disease progression, prediction methods, and final transition to clinical applications are calling for collaborative effort of the entire research community to act together and bring research effort closer to actual clinical applications. Researchers from different disciplines need to reach out to share their expertise, as well as to listen to other people to understand the big picture, understand… More >

  • Open Access

    ARTICLE

    Post-treatment with plant extracts used in Brazilian folk medicine caused a partial reversal of the antiproliferative effect of glyphosate in the Allium cepa test

    VIVIANE DAL-SOUTO FRESCURA1, ANDRIELLE WOUTERS KUHN1, HAYWOOD DAIL LAUGHINGHOUSE IV2, JUÇARA TEREZINHA PARANHOS1, SOLANGE BOSIO TEDESCO1

    BIOCELL, Vol.37, No.2, pp. 23-28, 2013, DOI:10.32604/biocell.2013.37.023

    Abstract Species of the genus Psychotria are used for multiple purposes in Brazilian folk medicine, either as water infusions, baths or poultices. This study was aimed to evaluate the genotoxic and antiproliferative effects of infusions of Psychotria brachypoda and P. birotula on the Allium cepa test. Exposure to distilled water was used as a negative control, while exposure to glyphosate was used as a positive control. The interaction of extracts (as a post-treatment) with the effects of glyphosate was also studied. Results showed that glyphosate and the extracts of both P. brachypoda and P. birotula reduced the mitotic index as compared… More >

  • Open Access

    ARTICLE

    Age related interaction of dopamine and serotonin synthesis in striatal synaptosomes

    MANOOCHEHR MESSRIPOUR1, AZADEH MESRIPOUR2

    BIOCELL, Vol.37, No.2, pp. 17-21, 2013, DOI:10.32604/biocell.2013.37.017

    Abstract Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosynthesis of dopamine and serotonin, respectively. Since both enzymes are active in striatum, and affected by age, this study was undertaken to investigate interaction between dopamine and serotonin synthesis in brain striatal synaptosomes of aging rat. Male Wistar rats (3 and 30 month old) were killed by decapitation and brain striatal synaptosomes were prepared by discontinuous Ficoll/sucrose gradient technique. Synaptosomes were incubated in the presence of added pargiline (monoamineoxidase inhibitor), dopamine or serotonin synthesized during 25 min was measured by HPLC, employing electrochemical detection. Dopamine synthesis in synaptosomes… More >

  • Open Access

    ARTICLE

    Meta-analysis of the cell cycle related C12orf48

    LOKMAN VARISLI

    BIOCELL, Vol.37, No.1, pp. 11-16, 2013, DOI:10.32604/biocell.2013.37.011

    Abstract The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms that regulate the timing and frequency of DNA replication and cell division. The temporal and spatial expression of the genes is tightly regulated to ensure accurate replication and transmission of DNA to daughter cells during the cycle. Although the genes involved in interphase are well studied, most of the genes which are involved in mitotic events still remain unidentified. Since, the discovery of mitosis related genes is still incomplete, we performed a co-expression and gene ontology analysis for revealing novel mitosis regulated genes. In this… More >

  • Open Access

    ARTICLE

    High passage numbers induce resistance to apoptosis in C2C12 muscle cells

    LUCIA PRONSATO, ANABELA LA COLLA, ANA CAROLINA RONDA, LORENA MILANESI, RICARDO BOLAND, ANDREA VASCONSUELO*

    BIOCELL, Vol.37, No.1, pp. 1-9, 2013, DOI:10.32604/biocell.2013.37.001

    Abstract Cell lines with high passage numbers exhibit alterations in cell morphology and functions. In the present work, C2C12 skeletal muscle cells with either low (<20) or high (>60) passage numbers (identified as lC2C12 or h-C2C12, respectively) were used to investigate the apoptotic response to H2 O2 as a function of culture age h-C2C12. We found that older cultures (h-C2C12 group) were depleted of mitochondrial DNA (mtDNA). When we analyzed the behavior of Bad, Bax, caspase-3 and mitochondrial transmembrane potential, we observed that cells in the h-C2C12 group were resistant to H2 O2 induction of apoptosis. We propose serially cultured C2C12… More >

  • Open Access

    ARTICLE

    Vibration Based Fault Diagnosis of a Hydraulic Brake System using Variational Mode Decomposition (VMD)

    R. Jegadeeshwaran1, V. Sugumaran2, K.P. Soman3

    Structural Durability & Health Monitoring, Vol.10, No.1, pp. 81-97, 2014, DOI:10.3970/sdhm.2014.010.081

    Abstract In automobile, brake system is an essential part responsible for control of the vehicle. Vibration signals of a rotating machine contain the dynamic information about its health condition. Many research papers have reported the suitability of vibration signals for fault diagnosis applications. Many of them are based on (Fast Fourier Transform) FFT, which have their own drawback with nonstationary signals. Hence, there is a need for development of new methodologies to infer diagnostic information from such non stationary signals. This paper uses vibration signals acquired from a hydraulic brake system under good and simulated faulty conditions for the purpose of… More >

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