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  • Open Access

    ARTICLE

    Identification of PtGai (a DELLA protein) in trifoliate orange and expression patterns in response to drought stress

    XIAOFEN CHENG1, ABEER HASHEM2,3, ELSAYED FATHI ABD_ALLAH4, QIANGSHENG WU1,5,*, KAMIL KUČA5,*

    BIOCELL, Vol.45, No.6, pp. 1687-1694, 2021, DOI:10.32604/biocell.2021.017581

    Abstract Gibberellins (GAs) are an important hormone in regulating plant growth and development, and DELLA protein is an essential negative regulator of GA signal transduction. The aim of the study was to clone a GA-inhibiting protein DELLA from trifoliate orange (Poncirus trifoliata L. Raf.) and to analyze the bioinformations and expression patterns of the protein gene in tissues and in response to drought stress. A DELLA protein was isolated from trifoliate orange and named as PtGai (Genebank number: MZ170959). The PtGai protein had 1731 bp open reading frames, along with 576 amino acid codes, and also grouped with sweet orange (XM_006430552.4).… More >

  • Open Access

    VIEWPOINT

    Proteogenomics for pediatric brain cancer

    MARGARET SIMONIAN*

    BIOCELL, Vol.45, No.6, pp. 1459-1463, 2021, DOI:10.32604/biocell.2021.017369

    Abstract Pediatric central nervous system tumors are the most common tumors in children, it constitute 15%–20% of all malignancies in children and are the leading cause of cancer related deaths in children. Proteogenomics is an emerging field of biological research that utilizes a combination of proteomics, genomics, and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic purposes. Integrative proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis. More >

  • Open Access

    ARTICLE

    A novel nine gene signature integrates stemness characteristics associated with prognosis in hepatocellular carcinoma

    XINGHONG YAO1,2,#, CHENGQUAN LU3,#, JUNYI SHEN1, WENLI JIANG1, YAN QIU1, YE ZENG1,*, LIANG LI1,*

    BIOCELL, Vol.45, No.6, pp. 1425-1448, 2021, DOI:10.32604/biocell.2021.017289

    Abstract Cancer stem cells (CSCs) are heterogeneous with self-renewal and differentiation ability. The mRNA expression-based stemness index (mRNAsi) described the similarity between tumor cells and CSCs, which is positively associated with the poor prognosis of cancer patients. However, the key prognostic genes related to mRNAsi in hepatocellular carcinoma (HCC) remains unclear. A 9-gene signature related to mRNAsi and HCC prognosis including PSMG3, SNRPD1, DTYMK, PIGU, NME1, TXNL4A, IPO4, PES1, and REXO4 was obtained. High expression of this signature indicates poor prognosis of HCC. PIGU was an independent prognostic factor of HCC, which was significantly associated with progression of HCC. Among them,… More >

  • Open Access

    ARTICLE

    Repurposing of FDA-Approved drugs to predict new inhibitors against key regulatory genes in Mycobacterium tuberculosis

    XINJUN YANG1, AFTAB ALAM2, NAIYAR IQBAL3, KHALID RAZA4,*

    BIOCELL, Vol.45, No.6, pp. 1569-1583, 2021, DOI:10.32604/biocell.2021.017019

    Abstract

    Tuberculosis (TB) disease has become one of the major public health concerns globally, especially in developing countries. Numerous research studies have already been carried out for TB, but we are still struggling for a complete and quick cure for it. The progress of Mycobacterium tuberculosis (MTB) strains resistant to existing drugs makes its cure and control very complicated. Therefore, it is the need of the hour to search for newer and effective drugs that can inhibit an increasing number of putative drug targets. We applied the drug repurposing concept to identify promising FDA-approved drugs against five key-regulatory genes (FurB, IdeR,… More >

  • Open Access

    ARTICLE

    Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer

    RUONAN GU1,2, WENJING GUO2, WENYANG WANG1, GUIHUAN LI1, XIAOJU LAI1, ZHIBIN HUANG1, WANLU ZHAO1, ZHICONG WU1, HUA CHEN1, WENYANG LUO1, FANGYIN ZENG3,*, FAN DENG1,*

    BIOCELL, Vol.45, No.6, pp. 1585-1599, 2021, DOI:10.32604/biocell.2021.017016

    Abstract Propofol, a common intravenous anesthetic used in clinical, has been shown to regulate cells proliferation, inflammation, angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer. However, the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown. The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer (CRC). Scratches assay, Transwell assay were used to detect colon cells migration and invasion. Real-time Quantitative Polymerase Chain Reaction (RT-qPCR), Western blotting were utilized to detect the expression of related molecules.… More >

  • Open Access

    ARTICLE

    Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’ tissues

    SHADY G. EL-SAWAH1,*, FAYEZ ALTHOBAITI2, ADIL ALDHAHRANI3, EMAN FAYAD2, MARWA A. ABDEL-DAYEM4, REHAB M. AMEN5, EL SHAIMAA SHABANA6, EHAB I. EL-HALLOUS7, HANAN M. RASHWAN1

    BIOCELL, Vol.45, No.6, pp. 1561-1568, 2021, DOI:10.32604/biocell.2021.016869

    Abstract Diabetes mellitus (DM) could negatively affect patients’ health via inducing a lot of serious functional hazards in many tissues’ cells at molecular levels. Recently, many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including diabetes. Therefore, the current study was designed to investigate the antioxidant potentiality of two MSCs types in alleviating tissues’ oxidative stress dramatic elevation resulting as a consequence of Type 1 DM induction. In our 4 weeks study, animals were divided into four groups: control group, STZ-diabetic group (D), D+AD-MSCs group and D+BM-MSCs group. Data reported that diabetic… More >

  • Open Access

    ARTICLE

    Immune prognostic implications of PSMD14 and its associated genes signatures in hepatocellular carcinoma

    CHUAN TIAN1, MUBALAKE ABUDOUREYIMU1, XINRONG LIN1, HAO ZHOU2, XIAOYUAN CHU1, RUI WANG1,*

    BIOCELL, Vol.45, No.6, pp. 1527-1541, 2021, DOI:10.32604/biocell.2021.016203

    Abstract PSMD14 played a vital role in initiation and progression of hepatocellular carcinoma (HCC). However, PSMD14 and its-related genes for the immune prognostic implications of HCC patients have rarely been analyzed. Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database-Liver Hepatocellular Carcinoma (LIHC). Additionally, we used multi-dimensional bioinformatics analysis to construct and validate a PSMD14-based immune prognostic signature (including RBM45, PSMD1, OLA1, CCT6A, LCAT and IVD) for HCC prognosis prediction. Patients in the high-risk group shown significantly poorer survival than patients in the low-risk group. Calibration curves confirmed… More >

  • Open Access

    ARTICLE

    Doubled haploid production in advanced back cross generations and molecular cytogenetic characterization of rye chromatin in triticale × wheat derived doubled haploid lines

    MUNIYANDI SAMUEL JEBERSON1,*, HARINDER KUMAR CHAUDHARY2, RAKESH KUMAR CHAHOTA3, SHABIR HUSSAIN WANI4,*

    BIOCELL, Vol.45, No.6, pp. 1651-1659, 2021, DOI:10.32604/biocell.2021.015735

    Abstract The rye genome has shown potential for improvement of bread wheat, where wheat-rye substitutions and translocations have been and are frequently used in resistance breeding. Crosses belongs to different generations viz., BC1F1, BC1F2, BC1F3, BC1F4 and BC2F3 of triticale × wheat derived were used for different haploid induction parameters using Gogon grass (Imperata cylindrica) as a pollen source. The percentage of pseudo seed formation ranged from 34.55% for BC1F2 to 63.77 for BC1F1 crosses, the haploid embryo formation ranges from 9.43% for BC1F1 to 30.2% for BC1F2, the haploid plant generation ranges from 19.36% for BC1F2 to 63.25% for BC1F1.… More >

  • Open Access

    ARTICLE

    Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential

    MAJA MILOSEVIC1,2, MILOS LAZAREVIC1,2, BOSKO TOLJIC1, MILAN PETROVIC2, MIROSLAV VUKADINOVIC2, ZORAN JEZDIC2, BOBAN ANICIC2, DRAGO JELOVAC2, SVETLANA JOVANOVIC3, JELENA MILASIN1,*

    BIOCELL, Vol.45, No.6, pp. 1543-1550, 2021, DOI:10.32604/biocell.2021.015060

    Abstract Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC). Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies. However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP, Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2) markers. BCC CSCs… More >

  • Open Access

    ARTICLE

    Application of ferrous sulfate alleviates negative impact of cadmium in rice (Oryza sativa L.)

    JAVARIA AFZAL1,2,#, XIUKANG WANG3,*, MUHAMMAD HAMZAH SALEEM4,#, XUECHENG SUN1, SHAHID HUSSAIN5, IMRAN KHAN6, MUHAMMAD SHOAIB RANA1, SHAKEEL AHMED7, SAMRAH AFZAL AWAN6, SAJID FIAZ8, OMAR AZIZ9, KASHIF ALI KUBAR10, SHAFAQAT ALI11,12, CHENGXIAO HU1,*

    BIOCELL, Vol.45, No.6, pp. 1631-1649, 2021, DOI:10.32604/biocell.2021.014934

    Abstract Soil contamination with toxic heavy metals [such as cadmium (Cd)] is becoming a serious global problem due to rapid development of social economy. Iron (Fe), being an important element, has been found effective in enhancing plant tolerance against biotic and abiotic stresses. The present study investigated the extent to which different levels of Ferrous sulphate (FeSO4) modulated the Cd tolerance of rice (Oryza sativa L.), when maintained in artificially Cd spiked regimes. A pot experiment was conducted under controlled conditions for 146 days, by using natural soil, mixed with different levels of CdCl2 [0 (no Cd), 0.5 and 1 mg/kg]… More >

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