Charis Tan^1,2 , Diana Zannino³, Carley Clendenning³, Sophie Offen⁴, Thomas L. Gentles⁵, Julian Ayer⁶, David Tanous⁷, Vishva Wijesekera⁸, Leeanne Grigg⁹, David Celermajer^2,4,10, Mark McGuire^2,4 , Yves d’Udekem^3,11,12, Rachael Cordina^2,4,10,*

Congenital Heart Disease, Vol., , DOI:10.32604/chd.2023.028829

Abstract Objective: Sudden cardiac death (SCD) and malignant ventricular arrhythmia (VA) are increasingly recognized as important issues for people living with a Fontan circulation, but data are lacking. We sought to characterize the cohort who had sudden cardiac death, most likely related to VA and/or documented VA in the Australia and New Zealand Fontan Registry including risk factors and clinical outcomes. Methods: A retrospective cohort study was performed. Inclusion criteria were documented non-sustained ventricular tachycardia, sustained ventricular tachycardia, ventricular fibrillation, resuscitated cardiac arrest or SCD > 30 days post-Fontan completion. Results: Of 1611 patients, 20 (1.2%) had VA; 14 (1.0%) had… More >

JIJIE XIAO¹, HONG XIAO², YUJUN CAI³, JIANWEI LIAO¹, JUE LIU¹, LIN YAO¹, SHAOLIN LI^1,*

Oncology Research, Vol., , DOI:10.32604/or.2023.030767

Abstract Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the photosensitizer Chlorin e6 (Ce6) and CD47 monoclonal antibodies (aCD47), to deliver synergistic photodynamic and immunotherapy of osteosarcoma. On laser irradiation, Ce6 can generate reactive oxygen species (ROS) to… More > Graphic Abstract

A. C. Filankembo Kava^*, B. C. Ndjengue Bengono, P. L. Nzamba Bissielou, C. Nziengui Tirogo, A. Kabena, T. Mpami, E. Belembaogo

Psycho-Oncologie, Vol., , DOI:10.32604/po.2023.044512

Abstract Aim: Oncologists are particularly prone to developing burnout syndrome due to the demanding task of caring for cancer patients. Undiagnosed and incorrectly managed, burnout can have a negative impact on professional performance. The objective of the study is to measure the frequency of burnout among nursing staff at the Institut de Cancérologie d’Akanda (ICA) and to assess the main risk factors. Procedure: We conducted a cross-sectional study at the ICA during the month of January 2022. Burnout was assessed using the Maslach Burnout Inventory (MBI). Results: Between the 42 participants, there was a female predominance (57.1%) with a male to… More >

Meng Jia, Mingjun Pang^*

Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2023.044286

Abstract The interphase mass, heat transfer efficiency, and flow resistance are strongly dependent on bubble size in gasliquid two-phase systems, so it is very important for engineering applications to effectively control bubble size. In this paper, the formation, growth, and detachment of single bubbles in Newtonian liquids based on capillary needles were studied in detail using a volume of fluid method. The authors investigated the effects of gas injection velocity, gravitational level, surface tension coefficient, needle radius, and liquid−phase properties (liquid viscosity and density) on the process of bubble generation, and the effects of the above factors on bubble shape, detachment… More >

Yongwei Duan, Zhaopeng Zhu, Hui He^*, Gaoliang Xuan, Xuemeng Yu

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.042659

Abstract The gas-water two-phase flow occurring as a result of fracturing fluid flowback phenomena is known to impact significantly the productivity of shale gas well. In this work, this two-phase flow has been simulated in the framework of a hybrid approach partially relying on the embedded discrete fracture model (EDFM). This model assumes the region outside the stimulated reservoir volume (SRV) as a single-medium while the SRV region itself is described using a double-medium strategy which can account for the fluid exchange between the matrix and the micro-fractures. The shale gas adsorption, desorption, diffusion, gas slippage effect, fracture stress sensitivity, and… More >

Ahmed Abdu¹, Zhengjun Zhai^1,2, Hakim A. Abdo³, Redhwan Algabri^4,*, Sungon Lee^5,*

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2023.043680

Abstract Cross-project software defect prediction (CPDP) aims to enhance defect prediction in target projects with limited or no historical data by leveraging information from related source projects. The existing CPDP approaches rely on static metrics or dynamic syntactic features, which have shown limited effectiveness in CPDP due to their inability to capture higher-level system properties, such as complex design patterns, relationships between multiple functions, and dependencies in different software projects, that are important for CPDP. This paper introduces a novel approach, a graph-based feature learning model for CPDP (GB-CPDP), that utilizes NetworkX to extract features and learn representations of program entities… More >

JUAN SHEN^1,#, WEIYU ZHANG^2,3,#, QINQIN JIN^2,3,#, FUYU GONG^4,#, HEPING ZHANG⁵, HONGLIANG XU⁵, JIEJIE LI^2,3, HUI YAO^2,3, XIYA JIANG^2,3, YINTING YANG^2,3, LIN HONG^2,3, JIE MEI^2,3, YANG SONG^6,*, SHUGUANG ZHOU^2,3,7,*

Oncology Research, Vol., , DOI:10.32604/or.2023.030887

Abstract Background: Invasive breast carcinoma (BRCA) is associated with poor prognosis and high risk of mortality. Therefore, it is critical to identify novel biomarkers for the prognostic assessment of BRCA. Methods: The expression data of polo-like kinase 1 (PLK1) in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases. PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Single sample gene set enrichment analysis (ssGSEA) was performed to evaluate immune infiltration in the BRCA microenvironment, and the random forest (RF) and support vector machine (SVM) algorithms… More >

Jingjing Gao, Xingkai Zhang^*

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.030106

Abstract A new approach and a new related distribution system are proposed to address the issue of uneven steam injection caused by the different suction capacities of the used wells during the application of steam “stimulation” methods for enhanced oil recovery. The new distribution system consists of a swirler, spiral dividing baffles, and critical flow nozzles. Numerical simulations are used to analyze the flow-field and degree of steam homogeneity obtained with such an approach. The results indicate that a higher inlet pressure leads to better results. Additionally, the internal flow field becomes more stable, and the deviation from an even distribution… More >

Dali Geagea^*

Psycho-Oncologie, Vol., , DOI:10.32604/po.2023.043338

Abstract Hypnosis, one of the earliest mind-body treatments, has been the subject of renewed interest in the last decade with research indicating its effectiveness for varied physiological and psychological ailments including pain, distress, and psychosomatic disorders. However, the adoption and acceptance of hypnosis are still hindered by myths and misconceptions that prevail among the general public and clinicians. Considering their significant role in promoting the successful delivery and acceptance of interventions, informing clinicians about hypnosis is crucial to promote balanced views, and thereby the adoption of this intervention when warranted. This narrative review traces the historical roots of myths surrounding hypnosis,… More >

Zongjun Yin^*, Rong Su, Hui Xu

FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.042631

Abstract In this study, numerical simulations of the pinching-off phenomena displayed by the dispersed phase in a continuous phase have been conducted using COMSOL Multiphysics (level-set method). Four flow patterns, namely “drop flow”, “jet flow”, “squeeze flow”, and “co-flow”, have been obtained for different flow velocity ratios, channel diameter ratios, density ratios, viscosity ratios, and surface tension. The flow pattern map of two-phase flow in coaxial microchannels has been obtained accordingly, and the associated droplet generation process has been critically discussed considering the related frequency, diameter, and pinch-off length. In particular, it is shown that the larger the flow velocity ratio,… More >