LUCIANA MAZZEI^1,2, MARÍA BELÉN RUIZ-ROSO³, NATALIA DE LAS HERAS³, SANDRA BALLESTEROS³, CAROLINA TORRESPALAZZOLO⁴, LEÓN FERDER⁵, ALEJANDRA BEATRIZ CAMARGO⁴, WALTER MANUCHA^1,2,*

BIOCELL, Vol.44, No.4, pp. 671-681, 2020, DOI:10.32604/biocell.2020.014175

Abstract The ancestral cultures have described many therapeutic properties of garlic; therefore, it is of central interest to elucidate the molecular basis explaining this millenary empirical knowledge. Indeed, it has been demonstrated a neuroprotective effect of allicin–a phytochemical present in garlic- linked to oxidative-inflammatory modulation. Allicin improved neuronal injury by heat shock protein 70 (Hsp70) and inducible nitric oxide synthase (iNOS) regulation. Also, allicin exerts renal protection involving a possible angiotensin type 1 receptor (AT1) interaction. In connection, AT1 overexpression has been recognized as a central deleterious factor in many brain diseases. However, there are no studies that evaluate AT1-Hsp70-iNOS interaction… More >

WEI LIU^1,#, ZI WANG^1,2,#, JING LENG¹, HENG WEI¹, SHEN REN^1,2, XIAOJIE GONG³, CHEN CHEN⁴, YINGPING WANG^1,2, RUI ZHANG^1,2,*, WEI LI^1,2,*

BIOCELL, Vol.44, No.4, pp. 655-669, 2020, DOI:10.32604/biocell.2020.013202

Abstract Heat stress (HS) reaction can lead to serious physiological dysfunction associated with cardiovascular and various organ diseases. Ginsenoside Rg3 (G-Rg3) is a representative component of ginseng rare saponin and can protect against multiple organs, also used as functional food to adjust the balance of the human body, but the therapeutic effect and molecular mechanism of G-Rg3 on male diseases under HS are underexplored. The aim of the present study, G-Rg3 was prepared through the efficient conversion of ginsenoside Rd and investigate the contribution of G-Rg3 to testicular injury induced exposure to HS. All mice were divided into four groups as… More >

LIHUA CAO¹, MINGSAN MIAO^1,*, YAN ZHENG², HUIYAUN HUANG², RUI ZHANG², DANDAN LIU²

BIOCELL, Vol.44, No.4, pp. 649-653, 2020, DOI:10.32604/biocell.2020.05093

Abstract To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model. The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains. And then, high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals. The symptom, tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed. High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom (P < 0.01), increased negative rate of strain culture (P < 0.01), and improved pathological changes of tinea corporis (P <… More >

FANGHAO SUN¹, WENCHAO ZHAO¹, LIANSHENG ZHANG², HONGGUI MA¹, JIAN ZHOU¹, YOUGAN CHEN¹, JIANQUAN HOU^1,*

BIOCELL, Vol.44, No.4, pp. 639-647, 2020, DOI:10.32604/biocell.2020.013053

Abstract Recent studies suggested that LIM and SH3 protein 1 (LASP-1) is a promising therapeutic target for renal cell cancer (RCC). This study aimed to explore the role of LASP-1 in RCC. For this purpose, LASP-1 expression in RCC tissues was analyzed by immunohistochemistry and Western blot analysis. Cell proliferation, migration, invasion, and gene expression were detected by CCK-8 assay, Transwell assay, and Western blot analysis. The results showed that LASP-1 was highly expressed in RCC, and its expression level,t was positively correlated with lymph node metastasis and tumor, nodes, and metastases (TNM) stage. The knockdown of LASP-1 expression significantly inhibited… More >

ZIMING WEI^1,2, YARONG WANG³, MINGYUAN DU^1,4, MINJIE LI², HONG HE^1,4,*

BIOCELL, Vol.44, No.4, pp. 631-638, 2020, DOI:10.32604/biocell.2020.010596

Abstract Periodontitis, as a chronic inflammatory disease, remains unsolved, and the pathogenesis of this disease has not been fully elucidated. In this study, the effect of miR-4262 was investigated in tumor necrosis factor-α (TNF-α) induced human periodontal stem cells (hPDLSCs) for the first time. The gene expression involved in this study was determined using polymerase chain reaction (PCR), the expressions of relevant proteins were determined by western blot analysis, and the levels of IL-1β, IL-6, and MCP-1 were estimated by enzyme-linked immunosorbent assay (ELISA) assay. The luciferase reporter assay was performed for verification of the target gene, alkaline phosphatase (ALP) activity… More >

JIYU WANG^#, HUIPING WANG^#, YING PAN, QIANSHAN TAO, ZHIMIN ZHAI^*

BIOCELL, Vol.44, No.4, pp. 607-611, 2020, DOI:10.32604/biocell.2020.010947

Abstract Myelodysplastic syndromes (MDS) are highly heterogeneous myeloid neoplasms, and a large number of patients are difficult to diagnose and classify by blood and bone marrow examination. As a surface marker of granulocyte, studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients. However, whether it can be used for differential diagnosis of MDS and other hematological diseases remains inconclusive. To explore the value of CD10 for differential diagnosis of MDS, 60 newly diagnosed MDS, 20 aplastic anemia (AA) patients, and 35 iron-deficient anemia (IDA) patients were selected for this study. Bone marrow (BM)… More >

XIANLIANG HOU^1,2,3,#, DONGE TANG^1,#, FENGPING ZHENG^1,#, MINGLIN OU³, YONG XU¹, HUIXUAN XU¹, XIAOPING HONG⁴, XINZHOU ZHANG¹, WEIER DAI⁵, DONGZHOU LIU^4,*, YONG DAI^1,*

BIOCELL, Vol.44, No.4, pp. 559-582, 2020, DOI:10.32604/biocell.2020.011022

Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abnormal cellular and humoral immune responses and excessive autoantibody production. The precise pathologic mechanism of SLE remains elusive. The advent of single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the molecular differences of cell populations at the single-cell level. We used scRNA-seq to profile the transcriptomes of peripheral blood mononuclear cells from an SLE patient compared with a healthy control (HC). A total of 16,021 cells were analyzed and partitioned into 12 distinct clusters. The marker genes of each cluster and the four major immune cell types (B cells,… More >

LINNA TAN^1,2, YUYONG TAN^1,2, DELIANG LIU^1,2,*

BIOCELL, Vol.44, No.4, pp. 535-543, 2020, DOI:10.32604/biocell.2020.09171

Abstract ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which, through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the regulation of endoplasmic reticulum (ER)–Golgi trafficking… More >

G. Indira Kishore¹, M. Premkumar^1,*, Ramesh Kumar Tripathi², Chandra Sekhar Nalamati²

Energy Engineering, Vol.118, No.2, pp. 199-209, 2021, DOI:10.32604/EE.2021.014079

Abstract Renewable energy with sources such as photovoltaic (PV) or fuel cells can be utilized for the generation of electrical power. But these sources generate fewer voltage values and therefore require high gain converters to match with DC bus voltage in microgrids. These high gain converters can be implemented with switched capacitors to meet the required DC bus voltage. Switched capacitors operate in a series and parallel combination during switching operation and produce high static gain, limits reverse voltage that appears across the components. A novel converter is proposed that satisfies all the features such as high voltage gain, only one… More >

Bilin Xu, Mei Han^*

Energy Engineering, Vol.118, No.2, pp. 323-339, 2021, DOI:10.32604/EE.2021.013384

Abstract Based on the theory of ecological organization, this paper analyzes the operation mechanism of chemical industry park (CIP) ecosystem by means of dynamic simulation. The research shows that the CIP ecosystem is a complex ecological system whose operation mechanism includes two levels, namely individual enterprises and ecosystem. At the level of individual enterprise, there are competition, symbiosis, invasion and other interactions between enterprises in the CIP ecosystem. Through the pre-determined judgment of the competition effect coefficient and the symbiosis effect coefficient, we calculate how the enterprises influence each other, and then generate their respective operation paths, and finally realize the… More >