XIANGCAI YANG^1,2,*, YA XU³, SHUTING MEI¹, JIEJING LI^3,*

BIOCELL, Vol.46, No.2, pp. 463-470, 2022, DOI:10.32604/biocell.2021.014834

Abstract Cell migration is a finely tuned biological process that often involves epithelial-mesenchymal transition (EMT). EMT is typically characterized by the upregulation of mesenchymal markers such as Snail1. This process has been shown to be of critical importance to normal developmental processes, including neural crest migration and invasion. Interestingly, similar mechanisms are utilized in disease processes, such as tumor metastasis and migration. Notably, EMT and EMT-like processes confer tumor cells with the ability to migrate, invade, and adopt stem cell-like properties that largely account for immunosuppression and tumor recurrence. Therefore, identifying sensitive EMT markers may contribute to cancer prognosis and diagnosis… More >

XIAOXU LI, YUN WANG, JUAN FANG, ZHI WANG, XIAOAN TAO, JUAN XIA, BIN CHENG^*

BIOCELL, Vol.46, No.2, pp. 441-451, 2022, DOI: 10.32604/biocell.2021.014844

Abstract Head and neck squamous cell carcinoma is the sixth most common tumor worldwide, and half of head and neck squamous cell carcinoma patients are with oral squamous cell carcinoma (OSCC). 300,000 new cases of OSCC were reported annually. Even with multi-modality treatment, the prognosis of OSCC remains unsatisfactory. Thus, it is urgent to discover novel therapeutic targets for OSCC. Some microarray studies have revealed that Keratin 4 (KRT4) is downregulated in OSCC, whereas its role in OSCC development remains unknown. The present study revealed that KRT4 suppressed OSCC progression by inducing cell apoptosis and inhibiting cell invasion. In addition, KRT4… More >

LI PAN¹, WENTING YI², DONGMIN LIANG¹, YULONG ZHAO¹, RANRAN WANG¹, PINGYU WANG¹, YOUJIE LI¹, JIAXUAN XIN¹, YUNFEI YAN^1,*,#, SHUYANG XIE^1,*,#

BIOCELL, Vol.46, No.2, pp. 417-431, 2022, DOI:10.32604/biocell.2022.015522

Abstract Tumor progression is usually characterized by proliferation, migration, and angiogenesis, which is essential for supplying both nutrients and oxygen to the tumor cells. Therefore, targeting angiogenesis has been considered a promising therapeutic strategy for cancer prevention and treatment. In the present study, we demonstrated that in addition to suppressing lung cancer cell proliferation and migration in vitro, 10-hydroxycamptothecin (10-HCPT) is also capable of inhibiting angiogenesis in vivo with a miR-181a-dependent manner. Mechanistically, by upregulating miR-181a, which in turn downregulating FOXP1, 10-HCPT can inhibit the PI3K/Akt/ERK signaling pathwaymediated angiogenesis. Furthermore, reduced levels of miR-181a have been found in both lung cancer… More >

FUJI YANG¹, YAN HUANG¹, YOUWEN TAN^2,*, YONGMIN YAN^1,*

BIOCELL, Vol.46, No.2, pp. 389-400, 2022, DOI:10.32604/biocell.2021.015899

Abstract Nonalcoholic fatty liver disease (NAFLD) is a long-lasting condition that affects the liver, destroying its function. Liver injury can cause steatosis and inflammation, and further activation of hepatic stellate cells (HSCs) often leads to the development of nonalcoholic liver fibrosis. The patient with NAFLD is at risk of developing advanced liver disease and complications, such as liver failure, hepatocellular carcinoma (HCC), and portal hypertension. Although our understanding of the cellular and molecular mechanisms of NAFLD has greatly improved in recent years, treatment remains limited. Analysis and characterization of protein posttranslational modifications (PTMs) could improve our understanding of NAFLD pathology and… More >

XIAO HUANG^1,2,3,#,*, ZHIHAI YU^4,#, LIJUAN NING⁵, YU LEI⁵, XUEFEI ZHANG⁵, ZHUYING WANG^2,*

BIOCELL, Vol.46, No.2, pp. 383-388, 2022, DOI:10.32604/biocell.2021.015651

Abstract Myocytes power the movement of all organs in the body. Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases. Apigenin, a kind of flavone, is being used to treat many disorders. It exerts a host of different pharmacological activities, such as anti-inflammatory, anti-mutagenic, cardioprotective, and antioxidant effects. Accordingly, apigenin is considered a promising candidate for myocyte protection. In this review, we introduced the characteristics of apigenin. The means of apigenin protection of myocytes as well as the mechanism were summarized and discussed. The protective effects can be classified into proliferation-promoting, anti-inflammatory, atrophy-preventing, metabolism-increasing, and antioxidative effects. Additionally,… More >

ZHIMEI TANG, QIANG ZHANG^*

BIOCELL, Vol.46, No.2, pp. 357-366, 2022, DOI:10.32604/biocell.2022.015958

Abstract Flavonoids are a class of phytochemical molecules abundant in many plants, fruits, vegetables, and leaves. Flavonoids possess a series of significant biological activities, including anticancer, antioxidant, antiviral, and antiinflammatory properties. They become an important source of dietary supplements and natural health products. Though many studies confirmed the safety of flavonoids, the potential toxicity of flavonoids is still a remarkable field of research to be explored. The enthusiasm for flavonoids expressed by the public has sometimes overlooked their toxicity and also consumed the flavonoids exceeding the body requirements. The current review focused on the potential toxicity of flavonoids to make the… More >

Ravindra Birajdar^1,*, Appasaheb Keste², Shravan Gawande²

Sound & Vibration, Vol.55, No.4, pp. 305-327, 2021, DOI:10.32604/sv.2021.017000

Abstract The objective of the study is to find the tolerance on vane pitch dimensions of a Vertical Turbine (VT) pump impeller. For this purpose, the study is divided into two parts viz. to find the critical hydraulic eccentricity of a VT pump impeller by way of numerical simulations and design of experiments to find the vane pitch tolerance using critical hydraulic eccentricity. The effect of impeller vane pitch deviations on hydraulic unbalance is examined for a vertical turbine pump using Design of Experiments (DOE). A suitable orthogonal matrix has been selected with vane pitch at different axial locations of an… More >

Ali Askari¹, Ali Salehi Sahl Abadi^2,*, Alimardan Alinia³, Milad Pourjaafar⁴, Aref Honairi Haghighi⁵, Elham Akhlaghi Pirposhteh⁶

Sound & Vibration, Vol.55, No.4, pp. 329-341, 2021, DOI:10.32604/sv.2021.016662

Abstract Among the harmful occupational factors, noise is the most common exposure in the oil industrial workplaces. The present study aimed to prioritize sound pollution areas in central processing facilities (CPF) of an oil field in order to provide corrective action in the studied industry and similar industries. After reviewing the issued permit to work, job description and noise dosimetry test, the evaluated areas were selected then sound pressure levels in the referenced areas investigated according to ISO 9612–2009 (E) next the noise map prepared for all selected areas. For identifying the prioritized areas to implement the control measures NCPI was… More >

Olkan Çuvalcı¹, Faruk Ünker^2,*, Turgut Batuhan Baturalp³, Utku Gülbulak³, Atila Ertaş³

Sound & Vibration, Vol.55, No.4, pp. 281-294, 2021, DOI:10.32604/sv.2021.015705

Abstract In this paper, an experimental model of a horizontal cantilever beam with a rotating/oscillating attached to the shaker for harmonic excitation at the one end and a gyrostabilizer at the other end is built to verify the equations of the Lagrangian model. The primary focus of the study was to investigate the parameters of excitation amplitude, natural frequency, rotating mass (disk mass), and disk speed of gyro that would minimize the amplitude of the beam to identify these effects. Numerical and experimental results indicate that the angular momentum of the gyrostabilizer is the most effective parameter in the reduction of… More >

A. A. Soliman¹, K. R. Raslan², A. M. Abdallah^3,*

Sound & Vibration, Vol.55, No.4, pp. 263-279, 2021, DOI:10.32604/sv.2021.015014

Abstract The fundamental objective of this work is to construct a comparative study of some modified methods with Sumudu transform on fractional delay integro-differential equation. The existed solution of the equation is very accurately computed. The aforesaid methods are presented with an illustrative example. More >