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  • Open Access

    REVIEW

    Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development

    VAN THI TUONG NGUYEN1,2, KHUONG DUY PHAM1,2,3, HUONG THI QUE CAO1,2, PHUC VAN PHAM1,2,*

    BIOCELL, Vol., , DOI:10.32604/biocell.2023.043664

    Abstract Mesenchymal stem cells (MSCs) have been proposed in regenerative medicine, especially for angiogenic purposes, due to their potential to self-renew, differentiate, and regulate the microenvironment. Peripheral vascular diseases, which are associated with reduced blood supply, have been treated but not cured. An effective therapy is to recover blood supply via vessel regeneration in the affected area, and MSCs appear to be promising for such conditions. Several studies aimed to explore the role of MSCs in performing angiogenesis and have revealed numerous potential methods to enhance MSC capacity in vessel formation. Efforts have been made to modify standard MSCs to optimize… More > Graphic Abstract

    Mesenchymal stem cells and the angiogenic regulatory network with potential incorporation and modification for therapeutic development

  • Open Access

    ARTICLE

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

    QIOU GU1, CHUILIN LAI1, XIAO GUAN1, JING ZHU2, TIAN ZHAN1, JIANPING ZHANG1,*

    BIOCELL, Vol., , DOI:10.32604/biocell.2023.028336

    Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Cox regression and Least Absolute… More > Graphic Abstract

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

  • Open Access

    REVIEW

    Hydrodynamic Cavitation Enhanced SR-Aops Degradation of Organic Pollutants in Water: A Review

    Xiufeng Zhu1,2, Jingying Wang1,*

    FDMP-Fluid Dynamics & Materials Processing, Vol., , DOI:10.32604/fdmp.2023.045260

    Abstract

    SR-AOP (sulfate radical advanced oxidation process) is a novel water treatment method able to eliminate refractory organic pollutants. Hydrodynamic cavitation (HC) is a novel green technology, that can effectively produce strong oxidizing sulfate radicals. This paper presents a comprehensive review of the research advancements in these fields and a critical discussion of the principal factors influencing HC-enhanced SR-AOP and the mechanisms of synergistic degradation. Furthermore, some insights into the industrial application of HC/PS are also provided. Current research shows that this technology is feasible at the laboratory stage, but its application on larger scales requires further understanding and exploration. In… More > Graphic Abstract

    Hydrodynamic Cavitation Enhanced SR-Aops Degradation of Organic Pollutants in Water: A Review

  • Open Access

    ARTICLE

    The Impact of Social Support on the Mental Health of Cancer Patients: Evidence from China

    Wanxiu Zhu*

    Psycho-Oncologie, Vol., , DOI:10.32604/po.2023.046593

    Abstract Exploring the relationship between social support and the mental health of cancer patients is a vital endeavor for enhancing mental well-being. The objective of this study was to explore the relationship between social support and psychological well-being in cancer patients and to provide new empirical evidence for psychological improvement in cancer patients. This research holds significant practical implications for optimizing China’s public health system and strengthening the development of a healthy China. Using data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) database, we empirically examined the influence of social support on the mental health of cancer patients.… More >

  • Open Access

    ARTICLE

    CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

    JUNZHE YI1,#, BINBIN LI2,#, XIAOMIN YIN3, LINGRUI LIU1, CAILU SONG1, YING ZHAO4, MANBO CAI3, HAILIN TANG1, DONG CHEN4,*, NING LYU1,*

    Oncology Research, Vol., , DOI:10.32604/or.2024.047524

    Abstract Circular RNAs (circRNAs) have been recognized as pivotal regulators in tumorigenesis, yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma (HCC) remain elusive. We sought to unveil the expression profile and biological role of circMYBL2 in HCC. Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells, and qRT‒PCR analysis was then performed in HCC cell lines and tissues, revealing significant upregulation of circMYBL2. Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression. Furthermore, bioinformatics analysis, qRT‒PCR analysis, luciferase reporter assays, and… More >

  • Open Access

    ARTICLE

    Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

    JIANBO ZHOU1,2,3, FENG WAN2,4, BIN XIAO5, XIN LI1, CHENG PENG2,*, FU PENG1,3,*

    Oncology Research, Vol., , DOI:10.32604/or.2023.044775

    Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro, and reduced tumor growth in vivo. Moreover, transcriptomic analysis revealed that TEC modulated the activity… More > Graphic Abstract

    Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

  • Open Access

    RETRACTION

    Retraction: Psychological Support for Public-Funded Normal Students Engaged in Teaching Profession

    Shize Zhi1,2,*

    International Journal of Mental Health Promotion, Vol., , DOI:10.32604/ijmhp.2024.049077

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF)-Mass Spectrometry and 13C-NMR-Identified New Compounds in Paraberlinia bifoliolata (Ekop-Beli) Bark Tannins

    Liliane Nga1, Benoit Ndiwe1,2, Achille Bernard Biwolé1, Antonio Pizzi3,*, Jean Jalin Eyinga Biwole1, Joseph Zobo Mfomo1

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.046568

    Abstract Extracts of plant origin, particularly tannins, are attracting growing interest for the sustainable development of materials in the industrial sector. The discovery of new tannins is therefore necessary. The aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance (13C NMR). The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined, as was the mechanical strength of the resin hardened with Acacia nilotica extracts. Yield by successive water extraction was 35%. MALDI-TOF/MS analysis… More >

  • Open Access

    ARTICLE

    Enhancing the Decomposition of Paper Cups Using Galleria Mellonella and Eisenia Fetida

    Shadi Moqbel1,*, Habib Al-Ghoul2, Abd Al-Majeed Al-Ghzawi3, Rami Mukbel4

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.046369

    Abstract The composition of paper cups creates a challenge for the recycling industry, as the paperboard–plastic film composite is hard to separate. Therefore, paper cups are sent to landfills or waste incinerators. This study explores the combined use of red worms (Eisenia fetida) and Greater wax moth (Galleria mellonella) in the biodegradation of paper cups. The study investigates the conditions and combinations that promote using Eisenia fetida and Galleria mellonella for degrading paper cups. The study considered the influence of environmental temperature, the presence of food waste, varying the number of Eisenia fetida worms, and the presence of a Galleria mellonella… More > Graphic Abstract

    Enhancing the Decomposition of Paper Cups Using Galleria Mellonella and Eisenia Fetida

  • Open Access

    ARTICLE

    The Influence of Tartaric Acid in the Silver Nanoparticle Synthesis Using Response Surface Methodology

    Yatim Lailun Ni’mah1, Afaf Baktir2, Dewi Santosaningsih3, Suprapto Suprapto1,*

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.045514

    Abstract Silver nanoparticles (AgNPs) synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs. The protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity problems. These attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery applications. The aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration, sonication time and temperature on the formation of silver nanoparticles. Using Response Surface… More > Graphic Abstract

    The Influence of Tartaric Acid in the Silver Nanoparticle Synthesis Using Response Surface Methodology

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