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  • Open Access

    ARTICLE

    Uncoupling tumor necrosis factor-α and interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

    RAGHDA A. SOLIMAN1, RANA A. YOUNESS1,2,*, TAMER M. MANIE3, EMAD KHALLAF4, MOHAMED EL-SHAZLY1, MONA ABDELMOHSEN5, HEBA HANDOUSSA1, MOHAMED Z. GAD6,*

    BIOCELL, Vol.46, No.3, pp. 769-783, 2022, DOI:10.32604/biocell.2022.016636

    Abstract Triple Negative Breast Cancer (TNBC) immunotherapy has recently shown promising approach. However, some TNBC patients presented with resistance. One of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment (TME) such as Tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10). Fine regulation of these cytokines’ levels via non-coding RNAs (ncRNAs) might alleviate the immune quiescent nature of TME at TNBC tumors. However, the extrapolation of ncRNAs as therapeutic tools is highly challenging. Therefore, disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective targets is an applicable translational… More >

  • Open Access

    ARTICLE

    Calcium supplementation in colorectal cancer prevention: A systematic meta-analysis of adverse events

    XUE MEI LUO1, SHAHANAVAJ KHAN2,3,4,*, ABDUL MALIK2, FAHAD M. ALDAKHEEL5, ANIS AHMAD CHAUDHARY6, SHOUKI BAZARBASHI7, FATEMEH TABATABAIE8

    BIOCELL, Vol.46, No.3, pp. 759-767, 2022, DOI:10.32604/biocell.2022.016586

    Abstract Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer, most of the associated adverse effects are not systematically analyzed. The aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic meta-analysis. We searched Medline, PubMed Central, EMBASE (Excerpta Medica database), Scopus, Cochrane Central Register of Controlled Trials, and Web of Science published in English from database inception up to 31 July 2019. In the current systematic meta-analysis, we included human studies (including cohort studies, clinical trials, case-control studies) on supplementation of… More >

  • Open Access

    ARTICLE

    KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway

    SHUTING GU1,2,#, JINGYI QIN3,#, SAINAN GAO1, ZHEN WANG1,4, QI MENG1,4, YAN LI1,4, BING LU5, SONGLIN ZHOU1,2,*, YUNZHAO XU1,6,*

    BIOCELL, Vol.46, No.3, pp. 689-697, 2022, DOI:10.32604/biocell.2022.016225

    Abstract Recently, abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer (EOC). However, the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be enlightened. In our study, we performed to elucidate the effects of KIAA1199 on the advanced biological behavior of EOC cells through activation of the IL-6/STAT3 pathway. Confirmed by immunohistochemistry, KIAA1199 was highly expressed in ovarian borderline and malignant epithelial tumors. A retrospective analysis found that EOC patients with low expression of KIAA1199 had a significantly higher 5-year survival rate than those with high expression. Mechanistically, IL-6 was used to stimulate EOC cells, and the expression of… More >

  • Open Access

    ARTICLE

    Knockdown of lncRNA XIST prevents the epithelial-mesenchymal transition of TGF-β2-induced human lens epithelial cells via miR-124/Slug axis

    XUE JIANG1,2, HONG ZHANG1,2,*

    BIOCELL, Vol.46, No.3, pp. 785-794, 2022, DOI:10.32604/biocell.2022.016167

    Abstract Posterior capsular opacification (PCO) is linked to the pathological process of lens epithelial cells, which includes proliferation, migration, and epithelial-mesenchymal transition (EMT). Our goal was to investigate whether long noncoding RNA (lncRNA) XIST contributes to EMT via targeting miR-124/Slug axis in TGF-β2-induced SRA01/04 cells. EMT was induced by stimulating SRA01/04 cells with 10 ng/mL TGF-β2 for 24 h, and PCO microenvironment was simulated. The expressions levels of lncRNA XIST, miR-124, and Slug were measured by real-time polymerase chain reaction (RT-PCR) and western blot. The role and mechanism of lncRNA XIST in promoting EMT of TGF-β2-treated SRA01/04 cells were investigated by… More >

  • Open Access

    ARTICLE

    Anti-lipid droplets accumulation effect of Annona montana (mountain soursop) leaves extract on differentiation of preadipocytes

    IVY LEUNG1, MARIA-LUISA VEISAGA2, MARGARITA ESPINAL1, WEI ZHANG1, ROBERT BARNUM1, MANUEL ALEJANDRO BARBIERI1,2,3,4,*

    BIOCELL, Vol.46, No.3, pp. 567-578, 2022, DOI:10.32604/biocell.2022.014009

    Abstract The Annona genus is a member of Annonaceae, one of the largest families of plants across tropical and sub-tropical regions. This family has been used in several ethnomedicinal practices to treat a multitude of human diseases. However, the molecular mechanism underlying its effect on the lipid droplet formation and on the expression of adipogenic markers of this plant remain to be investigated. In this study, we examined whether the extracts from the aerial part of Annona montana affect in vitro differentiation of preadipocytes. For our investigations, both mouse embryo fibroblast 3T3-L1 and normal human primary subcutaneous preadipocytes were incubated with… More >

  • Open Access

    ARTICLE

    Analysis and Design of University Teaching Equipment Management Information System

    Yu Xue1,2,*, Xiang Jiao1, Chishe Wang2 , Huanlun Chen1,4, Moayad Aloqaily3

    Journal of Cyber Security, Vol.3, No.3, pp. 177-185, 2021, DOI:10.32604/jcs.2021.016657

    Abstract Teaching equipment management is an important factor for colleges and universities to improve their teaching level, and its management level directly affects the service life and efficiency of teaching equipment. But in recent years, our university recruitment of students scale is increasing year by year, the size of the corresponding teaching equipment is also growing, therefore to develop a teaching equipment management information system is necessary, not only can help universities to effective use of the existing teaching resources, also can update scrap equipment, related equipment maintenance, and build a good learning environment to students and to the improvement of… More >

  • Open Access

    ARTICLE

    Enterprise Cyberspace Threat Landscape: An Analysis

    Emmanuel U. Opara1,*, Oredola A. Soluade2

    Journal of Cyber Security, Vol.3, No.3, pp. 167-176, 2021, DOI:10.32604/jcs.2021.019158

    Abstract The ecosystem security platform described in this research is already impacting the threat spectrum in quantifiable ways. The global network has undergone a dramatic transformation over the course of 2020, with an unprecedented destabilization of events. Security breaches of all kinds are growing in complexity, sophistication, and impact. The bad actors are bypassing predictable security devices at will by breaching network systems at an escalating rate. This study will analyze these developments by creating awareness among security practitioners so they can be prepared to defend their enterprise systems. More >

  • Open Access

    ARTICLE

    Securing Fog Computing For E-Learning System Using Integration of Two Encryption Algorithms

    Hind A. Alshambri1,* Fawaz Alassery2

    Journal of Cyber Security, Vol.3, No.3, pp. 149-166, 2021, DOI:10.32604/jcs.2021.022112

    Abstract Currently, the majority of institutions have made use of information technologies to improve and develop their diverse educational methods to attract more learners. Through information technologies, e-learning and learning-on-the go have been adopted by the institutions to provide affordability and flexibility of educational services. Most of the educational institutes are offering online teaching classes using the technologies like cloud computing, networking, etc. Educational institutes have developed their e-learning platforms for the online learning process, through this way they have paved the way for distance learning. But e-learning platform has to face a lot of security challenges in terms of cyberattacks… More >

  • Open Access

    ARTICLE

    Awareness about the Online Security Threat and Ways to Secure the Youths

    Yeshi Nidup*

    Journal of Cyber Security, Vol.3, No.3, pp. 133-148, 2021, DOI:10.32604/jcs.2021.024136

    Abstract This study aimed to find out the awareness about the online security threat and understanding of the preventive measuresto secure the youthsfrom online risks. For this, a quantitative method was applied and the survey questionnaire was instituted to collect the data randomly from the youths studying in class eleven and higher. A total of 264 youths, 147 female and 117 male responded to the survey questionnaire. The data was organized and analyzed using Excel data analysis tool package, interpreted and represented in the form of graphs with some explanations. The awareness about the online security threat was found to be… More >

  • Open Access

    ARTICLE

    Design and Implementation of Enterprise Recruitment Mini Program

    Yu Xue1,2,*, Nan Wei1 , Junyang Han1,4, Chishe Wang2, Moayad Aloqaily3

    Journal of Cyber Security, Vol.3, No.3, pp. 125-132, 2021, DOI:10.32604/jcs.2021.016647

    Abstract Since the 21st century, the Internet has been updated and developed at an alarming speed. At the same time, WeChat applets are constantly improving and introducing new functions. Develop an enterprise recruitment system based on WeChat applets for the majority of job seekers and recruiter users, provide job seekers with easy-to-reach employment opportunities, and provide a convenient and clear screening environment for job seekers. The front-end part of the applet is developed using WeChat developer tools, and the back-end system is developed using MyEclipse. Use Spring Boot + Spring MVC framework, implemented in Java language. Data is managed using MySql… More >

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