Muhammad Waqas Ahmed¹, Nouf Abdullah Almujally², Abdulwahab Alazeb³, Asaad Algarni⁴, Jeongmin Park^5,*

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2024.046501

Abstract Advances in machine vision systems have revolutionized applications such as autonomous driving, robotic navigation, and augmented reality. Despite substantial progress, challenges persist, including dynamic backgrounds, occlusion, and limited labeled data. To address these challenges, we introduce a comprehensive methodology to enhance image classification and object detection accuracy. The proposed approach involves the integration of multiple methods in a complementary way. The process commences with the application of Gaussian filters to mitigate the impact of noise interference. These images are then processed for segmentation using Fuzzy C-Means segmentation in parallel with saliency mapping techniques to find the most prominent regions. The… More >

Hui Du, Zhiyuan Hu^*, Depeng Lu, Jingrui Liu

CMC-Computers, Materials & Continua, Vol., , DOI:10.32604/cmc.2024.046314

Abstract Traditional clustering algorithms often struggle to produce satisfactory results when dealing with datasets with uneven density. Additionally, they incur substantial computational costs when applied to high-dimensional data due to calculating similarity matrices. To alleviate these issues, we employ the KD-Tree to partition the dataset and compute the K-nearest neighbors (KNN) density for each point, thereby avoiding the computation of similarity matrices. Moreover, we apply the rules of voting elections, treating each data point as a voter and casting a vote for the point with the highest density among its KNN. By utilizing the vote counts of each point, we develop… More >

CARLOS ALBERTO-SILVA^*, BRENDA RUFINO DA SILVA

BIOCELL, Vol., , DOI:10.32604/biocell.2024.050443

Abstract Venom snake-derived peptides have multiple biochemical, pharmacological, and toxicological profiles, allowing for the discovery of new medicinal products and therapeutic applications. This review specifically examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake venom. It also includes a brief evaluation of short peptides that are being considered as potential therapeutic agents. Proline-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes, specifically Bothrops atrox, Bothrops jararaca, and Bothrops moojeni, have been shown to have pro-survival properties, the ability to reduce oxidative stress, and the ability to promote cell viability and mitochondrial… More >

JIAWEI YIN¹, YONGSHENG WANG^2,3, GUANGWEI WEI⁴, MINGXIN WEN^3,*

BIOCELL, Vol., , DOI:10.32604/biocell.2024.049349

Abstract Objectives: This study aimed to reveal the role and possible mechanism of the ubiquitin-conjugating enzyme 2T (UBE2T) in the biological activities of breast cancer stem cells (BCSCs). Methods: The specific protein and gene expression were quantified by Western blotting and quantitative real-time polymerase chain reaction, the proportion of BCSCs was examined by flow cytometry, and the self-renewal and proliferation of BCSCs were verified by serial sphere formation and soft agar. Results: Increasing expression of UBE2T was drastically found in breast cancer than that in adjacent tissues. Furthermore, UBE2T overexpression significantly increased the proportion of BCSCs in breast cancer cells and… More >

P. Pai Nityanand, B. Devaki, G. Bhat Pareekshith, V. S. Sampath Kumar^*

Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2024.050237

Abstract The study in this manuscript aims to analyse the impact of thermal radiation on the two-dimensional magnetohydrodynamic flow of upper convected Maxwell (UCM) fluid between parallel plates. The lower plate is porous and stationary, while the top plate is impermeable and moving. The equations that describe the flow are transformed into non-linear ordinary differential equations with boundary conditions by employing similarity transformations. The Homotopy Perturbation Method (HPM) is then employed to approach the obtained non-linear ordinary differential equations and get an approximate analytical solution. The analysis includes plotting the velocity profile for different Reynolds number values and temperature distribution curves… More >

WEN YANG, BIN TANG, DAN XU, WENXIU YANG^*

Oncology Research, Vol., , DOI:10.32604/or.2024.050036

Abstract Background: The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma (DLBCL) has been reported previously. However, the detailed mechanisms of CCR7 in DLBCL, particularly regarding its interaction with lenalidomide treatment, are not fully understood. Methods: Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups. Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL. Furthermore, in vitro and in vivo experiments were conducted to clarify the role of CCR7… More > Graphic Abstract

ZHIGANG XIA^1,#, MENGYAO TIAN^1,#, YUCAI CHENG¹, WENFANG YI¹, ZEFAN DU^1,2, TIANWEN LI^1,2, YUCHEN WEN¹, LINDI LI^1,2, YONG LIU^1,2,*, CHUN CHEN^1,*

Oncology Research, Vol., , DOI:10.32604/or.2024.049792

Abstract Background: Chimeric antigen receptor T (CAR-T) cell therapy has achieved marked therapeutic success in ameliorating hematological malignancies. However, there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T (CAR-T) cell therapy, as well as the optimal timing for CAR-T cell infusion post-chemotherapy. Materials and Methods: We employed cell-derived tumor xenograft (CDX) murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for CAR-T cell treatment. Furthermore, transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment regimen. Results: Our preclinical in… More >