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  • Open Access

    ARTICLE

    Meiotic nuclear divisions 1 suppresses the proliferation and invasion of pancreatic cancer cells via regulating H2A.X variant histone

    DONGQIN WANG1,4, YAN SHI1, ZHIQIANG WANG4, JING ZHANG2, LUYAO WANG2, HONGYU MA3, SHUHUA SHI2, XIAOFU LIAN2, HUA HUANG4, XIAOJING WANG1,*, CHAOQUN LIAN4,*

    BIOCELL, Vol., , DOI:10.32604/biocell.2023.046903

    Abstract Introduction: Among all malignant tumors of the digestive system, pancreatic carcinoma exhibits the highest mortality rate. Currently, prevention and effective treatment are urgent issues that need to be addressed. Methods: The study focused on meiotic nuclear divisions 1 (MND1), integrating data from the Gene Expression Profiling Interactive Analysis (GEPIA) database with prognostic survival analysis. Simultaneously, experiments at cellular level were employed to demonstrate the effect of MND1 on the proliferation and migration of PC. The small-molecule inhibitor of MND1 was used to suppress the migration of PC cells by knocking down MND1 using small interfering RNA (siRNA) in Patu-8988 and… More >

  • Open Access

    REVIEW

    Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

    YANG LI1,2, JIAN LIU1,3,*, YUEDI HU1,2, CHENGZHI CONG1,2, YIMING CHEN1,2, QIAO ZHOU1,2

    BIOCELL, Vol., , DOI:10.32604/biocell.2023.045862

    Abstract Rheumatoid arthritis (RA) is a prevalent autoimmune disease whose main features include chronic synovial inflammation, bone destruction, and joint degeneration. Neutrophils are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of RA. Neutrophil extracellular traps (NETs), a meshwork of DNA-histone complexes and proteins released by activated neutrophils, are widely involved in the pathophysiology of autoimmune diseases, especially RA, in addition to playing a key role in the neutrophil innate immune response. NETs have been found to be an important source of citrullinated autoantigen antibodies and inflammatory factor release, which can… More > Graphic Abstract

    Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

  • Open Access

    ARTICLE

    Deep Autoencoder-Based Hybrid Network for Building Energy Consumption Forecasting

    Noman Khan1,2, Samee Ullah Khan1,2, Sung Wook Baik1,2,*

    Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.039407

    Abstract Energy management systems for residential and commercial buildings must use an appropriate and efficient model to predict energy consumption accurately. To deal with the challenges in power management, the short-term Power Consumption (PC) prediction for household appliances plays a vital role in improving domestic and commercial energy efficiency. Big data applications and analytics have shown that data-driven load forecasting approaches can forecast PC in commercial and residential sectors and recognize patterns of electric usage in complex conditions. However, traditional Machine Learning (ML) algorithms and their features engineering procedure emphasize the practice of inefficient and ineffective techniques resulting in poor generalization.… More >

  • Open Access

    ARTICLE

    Intrusion Detection and Prevention Model for Blockchain Based IoMT Applications

    Jameel Almalki*

    Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.038085

    Abstract The recent global pandemic has resulted in growth in the medical and healthcare sectors. Applications used in these domains have become more advanced and digitally integrated. Sensor-based Internet of Things (IoT) devices are increasing in healthcare and medical units. The emerging trend with the use of IoT devices in medical healthcare is termed as Internet of Medical Things (IoMT). The instruments used in these healthcare units comprise various sensors that can record patient body observations. These recorded observations are streamed across Internetbased channels to be stored and analyzed in centralized servers. Patient diagnostics are performed based on the information retrieved… More >

  • Open Access

    ARTICLE

    Deep Learning Based Vehicle Detection and Counting System for Intelligent Transportation

    A. Vikram1, J. Akshya2, Sultan Ahmad3,4, L. Jerlin Rubini5, Seifedine Kadry6,7,8, Jungeun Kim9,*

    Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.037928

    Abstract Traffic monitoring through remote sensing images (RSI) is considered an important research area in Intelligent Transportation Systems (ITSs). Vehicle counting systems must be simple enough to be implemented in realtime. With the fast expansion of road traffic, real-time vehicle counting becomes essential in constructing ITS. Compared with conventional technologies, the remote sensing-related technique for vehicle counting exhibits greater significance and considerable advantages in its flexibility, low cost, and high efficiency. But several techniques need help in balancing complexity and accuracy technique. Therefore, this article presents a deep learning-based vehicle detection and counting system for ITS (DLVDCS-ITS) in remote sensing images.… More >

  • Open Access

    ARTICLE

    Computational Linguistics Based Arabic Poem Classification and Dictarization Model

    Manar Ahmed Hamza1,*, Hala J. Alshahrani2, Najm Alotaibi3, Mohamed K. Nour4, Mahmoud Othman5, Gouse Pasha Mohammed1, Mohammed Rizwanullah1, Mohamed I. Eldesouki6

    Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.034520

    Abstract Computational linguistics is the scientific and engineering discipline related to comprehending written and spoken language from a computational perspective and building artefacts that effectively process and produce language, either in bulk or in a dialogue setting. This paper develops a Chaotic Bird Swarm Optimization with deep ensemble learning based Arabic poem classification and dictarization (CBSOEDL-APCD) technique. The presented CBSOEDL-APCD technique involves the classification and dictarization of Arabic text into Arabic poetries and prose. Primarily, the CBSOEDL-APCD technique carries out data pre-processing to convert it into a useful format. Besides, the ensemble deep learning (EDL) model comprising deep belief network (DBN),… More >

  • Open Access

    ARTICLE

    Steady Natural Convection from a Vertical Hot Plate with Variable Radiation

    Dewi Puspitasari1, Diah Kusuma Pratiwi1, Pramadhony Amran2, Kaprawi Sahim1,*

    Frontiers in Heat and Mass Transfer, Vol., , DOI:10.32604/fhmt.2023.041882

    Abstract The natural convection from a vertical hot plate with radiation and constant flux is studied numerically to know the velocity and temperature distribution characteristics over a vertical hot plate. The governing equations of the natural convection in two-dimension are solved with the implicit finite difference method, whereas the discretized equations are solved with the iterative relaxation method. The results show that the velocity and the temperature increase along the vertical wall. The influence of the radiation parameter in the boundary layer is significant in increasing the velocity and temperature profiles. The velocity profiles increase with the increase of the radiation… More >

  • Open Access

    ARTICLE

    Ellagic Acid Enhances Antioxidant System Activity and Maintains the Quality of Strawberry Fruit during Storage

    Jian Chen1, Jing Zhang2, Gang Pan3, Dandan Huang1,*, Shuhua Zhu1

    Phyton-International Journal of Experimental Botany, Vol., , DOI:10.32604/phyton.2023.045621

    Abstract Ellagic acid (EA) is a natural antioxidant, widely present in a lot of forms’ soft fruits, nuts, and other plant tissues, and helpful for promoting human health; however, its protective effect on postharvest fruit and improving the quality index of postharvest fruit have rarely been studied. In this experiment, the strawberries were soaked in 0, 100, 200, 300, 400, and 500 mg L−1 EA, respectively, and the influential EA on fruit quality and the antioxidant system of strawberries were studied. Compared with the control, EA treatment can reduce the browning degree and rotting rate of strawberry fruit during storage and… More >

  • Open Access

    ARTICLE

    Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

    M. F. Elkady1,2,*, E. M. El-Sayed2, Mahmoud Samy3, Omneya A. Koriem1, H. Shokry Hassan4,5

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.046585

    Abstract In this study, green zinc oxide (ZnO)/polypyrrole (Ppy)/cellulose acetate (CA) film has been synthesized via solvent casting. This film was used as supporting material for glucose oxidase (GOx) to sensitize a glucose biosensor. ZnO nanoparticles have been prepared via the green route using olive leaves extract as a reductant. ZnO/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole (Py) monomer using ferric chloride (FeCl3) as an oxidizing agent. The produced materials and the composite films were characterized using X-ray diffraction analysis (XRD), scanning electron microscope (SEM), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA). Glucose… More > Graphic Abstract

    Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

  • Open Access

    ARTICLE

    Moderating Effect of Perceived Threat of Breast Cancer on Relation between Knowledge and Breast Self Examination

    Effet modérateur de la perception de menace du cancer du sein sur la relation entre les connaissances et l’autopalpation

    Carolle Annie Njopvoui*, Armel Valdin Teague Tsopgny, Henri Rodrigue Njengoue Ngamaleu

    Psycho-Oncologie, Vol., , DOI:10.32604/po.2023.047499

    Abstract Estimated at more than 2.2 million cases worldwide, most breast cancer cases and deaths from breast cancer occur in low and middle-income countries. In Cameroon, many studies have underlined the effect of knowledge of breast cancer on screening measures such as self-examination and, to a lesser extent, the perception of the threat of this disease. This research aims to assess according to the Health Belief Model (HBM), the moderating effect of perceived threat of breast cancer on the relation between knowledge and breast self-examination. A questionnaire survey was conducted among 517 Cameroonian women to assess their general knowledge about breast… More >

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