Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (21,942)
  • Open Access

    ARTICLE

    Prolonged Survival in Patients with Human Epidermal Growth Factor Receptor-2-Overexpressed Metastatic Breast Cancer after Targeted Therapy is Dominantly Contributed by Luminal-Human Epidermal Growth Factor Receptor-2 Population

    Keiichi Kontani1,*, Kana Kuraishi1, Shin-ichiro Hashimoto1, Shoko Norimura2, Nozomi Hashimoto1, Masahiro Ohtani3, Naomi Fujiwara-Honjo4, Manabu Date5, Koji Teramoto6, Hiroyasu Yokomise1

    Oncologie, Vol.23, No.2, pp. 229-239, 2021, DOI:10.32604/Oncologie.2021.016277

    Abstract The prognosis of patients with human epidermal growth factor receptor-2 (HER2)-overexpressed metastatic breast cancer (MBC) has improved drastically following the development of anti-HER2 therapies. We question what factors are involved in the improved outcome by the treatment. One hundred and two MBC patients who received chemotherapy were classified into groups according to breast cancer subtype: luminal/HER2-negative (n = 50), HER2 (n = 26), and triple-negative subtypes (n = 26). Clinicopathologic features and clinical outcomes of the groups were compared. Disease-free intervals in the triple-negative group were significantly shorter than those in the other two groups. Age, tumor grade, the number… More >

  • Open Access

    ARTICLE

    Alteration of Ornithine Metabolic Pathway in Colon Cancer and Multivariate Data Modelling for Cancer Diagnosis

    Xin Hu1,2,#, Fangyu Jing3,#, Qingjun Wang1,4, Linyang Shi1, Yunfeng Cao4,5, Zhitu Zhu1,4,*

    Oncologie, Vol.23, No.2, pp. 203-217, 2021, DOI:10.32604/Oncologie.2021.016155

    Abstract It is noteworthy that colon cancer is the fourth place in new cases and the fifth in mortalities according to global cancer statistics 2018. Tumorigenesis displays specific correlation with metabolic alterations. A variety of metabolites, including ornithine (Orn), are related to colon cancer according to sources of disease metabolic information retrieval in human metabolome database. The metabolic regulation of Orn pathway is a key link in the survival of cancer cells. In this study, the plasma Orn levels in colon cancer patients and healthy participants were measured by liquid chromatography tandem mass spectrometry, and the metabolic disturbances of Orn in… More >

  • Open Access

    ARTICLE

    Growth and Invasion of 3D Spheroid Tumor of HeLa and CasKi Cervical Cancer Cells

    Kalaivani Muniandy1, Zuhaida Asra Ahmad1,4, Sylvia Annabel Dass1, Shaharum Shamsuddin2, Nethia Mohana Kumaran3, Venugopal Balakrishnan1,*

    Oncologie, Vol.23, No.2, pp. 279-291, 2021, DOI:10.32604/Oncologie.2021.015969

    Abstract Spheroids are generally self-assembled cells with the ability to generate their extracellular matrix, including the complex cell-matrix and the cell-cell interactions that resemble the functional characteristics of the corresponding tissue in vivo. The study aimed to develop a three-dimensional (3D) spheroid system for the cervical cancer cell lines, HeLa (HPV18), CaSki (HPV16), SiHa (HPV16), C33A (non-HPV), HT3 (non-HPV) as well as to identify its biological activity in the extracellular form. For the formation of the cervical cancer spheroids, the liquid overlay approach was applied, followed by embedding to the bovine collagen I matrix. Spheroid formation using the liquid overlay approach… More >

  • Open Access

    ARTICLE

    Tolerance and Efficacy of Regorafenib according to UGT Pharmacogenetical Status in the Treatment of Metastatic Refractory Colorectal Cancer

    Pierre-Guillaume Poureau1,2,*, Estelle Dhamelincourt2, Jessica Nguyen2, Hélène Babey2, Emmanuelle Renaud2, Margaux Geier2, Michèle Boisdron-Celle3, Jean-Philippe Metges2

    Oncologie, Vol.23, No.2, pp. 195-202, 2021, DOI:10.32604/Oncologie.2021.015929

    Abstract Introduction: Regorafenib is a multi tyrosin-kinase inhibitor prescribed in metastatic refractory colorectal cancer treatment. Its toxicity is significant but inconstant. The metabolism of regorafenib includes oxydation via cytochrome P3A4, then glucuroconjugation. A pharmacogenetical approach of mutational status of Uridine-Diphospho-Glucuronosyltransfersase (UDP-glucuronosyl-transferase, UGT) could be a strategy to optimise the use of regorafenib. Patients and Method: This is a restrospective, unicentric study. All adult patients treated with regorafenib for a metastatic colorectal cancer in our center between 2013 and 2017 were analysed. UGT1A1 polypmorphism was previously researched in the laboratory after written informed consent. Results: Thirty-five patients received regorafenib during the study… More >

  • Open Access

    REVIEW

    MicroRNA in HCC: Biomarkers and Therapeutic Targets

    Zheng Wang1, Yongxia He1, Yuwei Song1, Yue Wang2, Feng Chen3,*

    Oncologie, Vol.23, No.2, pp. 177-184, 2021, DOI:10.32604/Oncologie.2021.014773

    Abstract Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. At present, diagnostic methods such as imaging observation, serum testing and tissue biopsy, as well as treatment methods such as surgical resection, radiotherapy, and chemotherapy have certain limitations in clinical interventions for HCC due to the complex pathogenesis and drug resistance of liver cancer, which seriously affect the survival and prognosis of patients. As a large-scale cytokine, microRNA (miRNA) plays an important role in regulating various life activities of cells. Extensive evidence proved that certain miRNAs are specifically expressed in the tissues and blood of HCC patients, and… More >

  • Open Access

    ARTICLE

    Optimization for Variable Height Wind Farm Layout Model

    Bin Xu1,2,3,*, Jianming Zhu1, Junzhe Wen1, Shanshan Lin1, Yunkai Zhao1, Jin Qi1,2, Yu Xue4, Sichong Qin5

    Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 525-537, 2021, DOI:10.32604/iasc.2021.018338

    Abstract The optimization of wind farm layouts is very important for the effective utilization of wind resources. A fixed wind turbine hub height in the layout of wind farms leads to a low wind energy utilization and a higher LCOE (levelized cost of electricity). WOMH (Wind Farm Layout Optimization Model Considering Multiple Hub Heights) is proposed in this paper to tackle the above problem. This model is different from the traditional fixed hub height model, as it uses a variable height wind turbine. In WOMH, the Jensen wake and Weibull distribution are used to describe the wake effect on the wind… More >

  • Open Access

    ARTICLE

    Optimal Parameter Estimation of Proton Exchange Membrane Fuel Cells

    A. M. Abdullah1, Hegazy Rezk2,3,*, A. Hadad1, Mohamed K. Hassan1,4, A. F. Mohamed1,5

    Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 619-631, 2021, DOI:10.32604/iasc.2021.018289

    Abstract The problem of parameter estimation of the proton exchange membrane fuel cell (PEMFC) model plays a significant role in the simulation and optimization of a PEMFC system. In the current research, a moth flame optimization algorithm (MFOA) is used to identify the best parameters of PEMFC. Two different PEMFCs, Nedstack PS6, 6 kW, and SR-12 PEM 500 W are used to demonstrate the accuracy of the MFOA. Throughout the optimization process, seven unidentified parameters (1, 2, 3, 4, λ, ℛ, and B) of PEMFC are appointed to be decision variables. The fitness function, which needed to be minimum, is represented… More >

  • Open Access

    ARTICLE

    Paralleling Collision Detection on Five-Axis Machining

    Cheng-Yan Siao1, Jhe-Wei Lin1, Ting-Hsuan Chien2,*, Rong-Guey Chang1

    Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 559-569, 2021, DOI:10.32604/iasc.2021.018252

    Abstract With the rapid growth of the Fourth Industrial Revolution (or Industry 4.0), five-axis machining has played an important role nowadays. Due to the expensive cost of five-axis machining, how to solve the collision detection for five-axis machining in real-time is very critical. In this paper, we present a parallel method to detect collision for five-axis machining. Moreover, we apply the bounding volume hierarchy technique with two-level bounding volume represent the surface or solid of the object to reduce triangle meshes inside each axis of the five-axis machine tool, and then matching the operating range limit of the five-axis machine tool… More >

  • Open Access

    ARTICLE

    Investigating the Role of Trust Dimension as a Mediator on CC-SaaS Adoption

    Hiba Jasim Hadi*, Mohd Adan Omar, Wan Rozaini Sheik Osman

    Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 373-386, 2021, DOI:10.32604/iasc.2021.018207

    Abstract The public sector of Iraq has been struggling from poor management of resources and numerous difficulties that affect its governmental organization’s development, such as financial issues resulting from corruption, insecurity, and the lack of IT resources and infrastructure. Thus, cloud computing Software as a Service (CC-SaaS) can be a useful solution to help governmental organizations increase their service efficiency through the adoption of low-cost technology and provision of better services. The adoption of CC-SaaS remains limited in Iraqi public organizations due to numerous challenges, including privacy and protection, legal policy, and trust. Trust was found to be an effective facilitator… More >

  • Open Access

    ARTICLE

    Attitude Towards Adopting Cloud Computing in the Saudi Banking Sector

    Mohammed Hamdi1, Fekry Olayah2, Amin A. Al-Awady3, Ahlam F. Shamsan4, Mokhtar M. Ghilan5,*

    Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 605-617, 2021, DOI:10.32604/iasc.2021.018170

    Abstract Cloud computing plays a significant role in business organisations by offering many benefits and opportunities. However, the adoption of cloud computing involves some trepidation. The adoption of cloud computing in developing countries is still in the early phase. The bank sector in Saudi Arabia aims to benefit from opportunities offered by the cloud computing technology; however, some banks continue to hesitate in the implementation of this technology. Therefore, this study aims to investigate factors that influence the attitude of the Saudi Arabian bank sector towards adopting cloud computing. A model that incorporates factors derived from the literature is developed in… More >

Displaying 11391-11400 on page 1140 of 21942. Per Page