Ismail Bozkurt^1,*, Baris Yasar¹, Mehmet Baran Uslu², Nazan Bozdogan³

Oncologie, Vol., , DOI:10.32604/oncologie.2022.019263

Abstract Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4–5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain spinal stability). Pathology revealed malignant… More >

Jean-Claude Ferrandez^1,*, Pierre-Henri Ganchou², Serge Theys³, Maria Torres-Lacomba⁴, Daniel Serin¹

Oncologie, Vol., , DOI:10.32604/oncologie.2022.018110

Abstract Upper limb lympedema is a frequent consequence of breast cancer treatment. The International Society of Lymphology recommends physical therapy for lymphedema management. This treatment includes a combination of manual lymphatic drainage and high-compression bandaging. Actually, the effectiveness of manual lymphatic drainage remains an area of controversy, especially because of the many different techniques called “manual lymphatic drainage” since 1930. The purpose of this review was to emphasise the efficacy of these different techniques according to physiological data and evidence-based practice. To improve the manual lymphatic drainage efficiency, the pressure, sometimes important, should be tailored to each edema and the techniques… More >

Mengdan Ma^1,2, Yuchen Liu^1,*, Weiren Huang^1,*

Oncologie, Vol., , pp. 1-30, DOI:10.32604/oncologie.2022.019415

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such as base editing, transcription regulation,… More >

Xubin Yin¹, Bing Yang², Ming Su², Shaoshan Sun¹, Hao Wang^1,*

Oncologie, Vol., , pp. 1-14, DOI:10.32604/oncologie.2021.018705

Abstract Background: Tumor recurrence is one of the major problems that affect the postoperative efficacy of oral squamous cell carcinoma (OSCC) treatment. Autophagy is known to have a dual-sided effect on tumors. However, studies on autophagy and prognosis are limited. The purpose of this study is to analyze the relationship between autophagy and OSCC recurrence. Materials and methods: 72 patients with OSCC were followed for 5 years after curative surgery. Tissue specimens from each patient were divided into tumor, normal, and marginal groups. Autophagy protein expression was assessed by western blotting and immunofluorescence. Statistical significance was evaluated using the chi-square test.… More >

Dang Quang Hung^1,#, Nguyen-Thi Nhan¹, Trinh-Thi Phuong Nga¹, Nguyen Thanh Hai¹, Nguyen Quang Duc¹, Nguyen Viet Thu¹, Nguyen Truong Duc¹, Dinh-Van Thuyet¹, Nguyen Minh Duc^2,#,*,ORCID

Oncologie, Vol., , pp. 1-6, DOI: 10.32604/oncologie.2021.019519

Abstract Metastatic spread of hepatocellular carcinoma (HCC) to the spleen is uncommon, only occurring in approximately 1% of cases. Atraumatic splenic rupture due to HCC metastasis is extremely rare and affects patient prognosis, clinical management, and mortality. We report a case of a 65-year-old man with a history of chronic hepatitis B infection who presented with left-sided abdominal pain and fatigue. Clinical examination showed acute anemia with elevated levels of serum alpha-fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA-II). On ultrasound and computed tomography imaging, hemoperitoneum caused by a ruptured splenic tumor was revealed. In addition to multiple hepatic… More >

Xingyu Zhu^1,2,#, Yongjun Wang^3,#, Shuang Chang^4,#, Yue Su², Cuixia He¹, Shuang Hu⁵, Minhui Zhu¹, Yuzhou Ding², Nuannuan Ren², Qizhi Wang², Jing Xie^1,*, Huan Zhou^1,2,*

Oncologie, Vol., , pp. 1-20, DOI:10.32604/oncologie.2021.018869

Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function… More >

Ping Zhao^1,#, Yao Xu^1,#, Anqi Wu², Yuhao Hu², Aiting Cai², Xinyue Wang³, Feng Wang^2,*, Xiang Chen^1,*

Oncologie, Vol., , pp. 1-13, DOI:10.32604/oncologie.2021.018713

Abstract Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in HCC. Cell experiments… More >

Raghav Mishra^1,2,*, Nitin Kumar³, Neetu Sachan²

Oncologie, Vol., , pp. 1-22, DOI:10.32604/oncologie.2021.018532

Abstract The relevance of Retinoic acid receptor-related orphan receptors in cancer progression has sparked interest in developing multifunctional therapeutics. In the search for potentially active novel compounds with anticancer characteristics, the Gewald reaction was employed to develop different thiophene derivatives (8a–8i). Physicochemical and spectroanalytical investigations verified the molecular structures of the synthesized derivatives. Using an in vitro primary anticancer assay, NCI chose all of the synthesized molecules as prototypes and assessed their anticancer efficacy against a panel of various cancer cell lines representing nine distinct neoplasms. The compounds were found to have a wide range of anticancer activity. Following significant anticancer… More >

Çağrı Öner^1,* and Ertuğrul Çolak²

Oncologie, Vol., , pp. 1-15, DOI:10.32604/Oncologie.2021.016958

Abstract piRNAs are novel members of small non-coding RNAs and have an impact on genetic and epigenetic mechanisms of cells. It was aimed to investigate the role of piR-651 on MCF-7 benign breast cancer cells by focusing on molecular characteristics. Anti-piR-651 was transfected and effects of piR-651 on proliferation, adhesion, and motility of MCF-7 cells were detected after the 24th, 48th, and 72nd hour. Gene expressions of piR-651, Ki-67, MMP-2, ERα, HIF-1α, and hTERT were determined by using RT-PCR. piR-651 inhibition caused the decrease of proliferation, adhesion (p < 0.001), and motility of MCF-7 cells. The efficiency of anti-piR-651 transfection supported… More >

Madhumitha Kedhari Sundaram¹, Abdulmajeed G. Almutary², Shafiul Haque³, Faheem SM¹, Arif Hussain^1,*

Oncologie, Vol., , DOI:10.32604/Oncologie.2021.016002

Abstract Cervical cancer is the neoplasm of the uterine cervix in women, which is highly preventable. With the advent of vaccination against HPV infection, a gradual decline in the incidence of cervical cancer cases has been observed in developing countries. The developing nations bear the brunt of cervical cancer incidence due to low acceptance of vaccination. This survey-based study was designed to assess the awareness and opinions of female university students regarding human papilloma virus, vaccination and cervical cancer. A survey questionnaire was distributed among female expatriate students (18 to 26 years of age) of a private university. The survey sought… More >