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  • Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells
  • Abstract As one of the adjuvant treatments for cancer treatment, traditional Chinese medicine treatment has a wide range of cancer treatments, such as preventing metastasis and relapse, improving the efficacy of radiotherapy and chemotherapy, reducing the side effects of chemotherapy, improving body function, extending life and improving the life quality. Geniposide (GEN) is a bioactive substance extracted from the fruit of gardenia. In recent years, it has attracted attention due to its anti-tumor effect. In this study, we aimed to investigate whether GEN could inhibit the proliferation of human breast cancer cells (MCF-7) and promote its apoptosis. The half-inhibitory concentration (IC50)…
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  • The Effect of Continued Training with Crocin on Apoptosis Markers in Liver Tissue of High Fat Diet Induced Diabetic Rats
  • Abstract Diabetes mellitus (DM) disease can affect process of apoptosis by increasing oxidative stress, nevertheless exercise and crocin can improve apoptosis; therefore present study aimed to investigate the effect of continued training with crocin on apoptosis markers in liver tissue of diabetic rats. In this experimental study 32 diabetic rats based on fasting glucose divided into four groups of eight rats including: 1) sham, 2) training, 3) crocin, and 4) training with crocin also for investigate the effect of DM induction on apoptosis markers, eight healthy rats assigned in healthy control group. During eight weeks groups 2 and 4 ran 60…
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  • The Kinematics and Surface Electromyography Characteristics of Round Kick of Martial Arts Athletes
  • Abstract In order to improve the level of athletes, modern scientific and technological means can be used to understand the characteristics and rules of movement. This study mainly analyzed the whip leg technique of Sanda athletes. Taking ten athletes as an example, the kinematics and surface electromyography (sEMG) data of them were measured, calculated and sorted out when they were doing the action of round kick. The results showed that the movement completion time of the first-level athletes was shorter, 0.34 ± 0.33 s. In the stage of turning hip and hitting, the angle of hip joint increased significantly. In the…
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  • Application of Dual Modality Contrast Agent Combined with Multi-Scale Representation in Ultrasound-Magnetic Resonance Imaging Registration Scheme
  • Abstract To achieve the image registration/fusion and perfect the quality of the integration, with dual modality contrast agent (DMCA), a novel multi-scale representation registration method between ultrasound imaging (US) and magnetic resonance imaging (MRI) is presented in the paper, and how DMCA influence on registration accuracy is chiefly discussed. Owing to US’s intense speckle noise, it is a tremendous challenge to register US with any other modality images. How to improve the algorithms for US processing has become the bottleneck, and in the short term it is difficult to have a breakthrough. In that case, DMCA is employed in both US…
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  • Dynamic Resistance Parameters of Arm Stroke during Swimming
  • Abstract Swimming, as a sport beneficial to body and mind, also has a place in international sports. For swimmers and coaches, it is always the most important to improve the propulsion and reduce the resistance during swimming. This paper briefly introduced the resistance of human body in swimming, described the dynamic resistance of human body in arm stroke, and then introduced the principle of micro disturbance method which was used for measuring the dynamic resistance in swimming. Finally, ten swimmers from school team and ten beginners were tested for the dynamic resistance in freestyle, backstroke and breaststroke when they swam with…
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  • Hierarchical Rigid Registration of Femur Surface Model Based on Anatomical Features
  • Abstract Existing model registration of individual bones does not have a high certainly of success due to the lack of anatomic semantic. In light of the surface anatomy and functional structure of bones, we hypothesized individual femur models would be aligned through feature points both in geometrical level and in anatomic level, and proposed a hierarchical approach for the rigid registration (HRR) of point cloud models of femur with high resolution. Firstly, a coarse registration between two simplified point cloud models was implemented based on the extraction of geometric feature points (GFPs); and then, according to the anatomic feature points (AFPs)…
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  • Meta-Analysis of the Relationship between Normal Tension Glaucoma, Open-Angle Glaucoma, and Fractional Pressure Reserve
  • Abstract Aim: To investigate the relationship between glaucoma and intraocular pressure (IOP), intracranial pressure (ICP), trans-laminar cribrosa pressure difference (TLCPD), and the newly proposed fractional pressure reserve (FPR). Methods: Ten articles were analyzed by meta-analysis, and subgroup analysis of three factors was conducted. Results: The patients with normal tension glaucoma (NTG) and open-angle glaucoma (OAG) have higher TLCPD and lower ICP than healthy subjects, with obvious heterogeneity. The greater heterogeneity may arise from different ICP measurements and from different countries or regions. FPR performs better than TLCPD in some ways. Conclusion: Both FPR and TLCPD can be used as indicators of…
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  • Morphologies of Fibronectin Fibrils Formed under Shear Conditions and Their Cellular Adhesiveness Properties
  • Abstract Fibrillar fibronectin (FFN) is a biological active form of FN which form linear and branched meshwork around cells and support cellular activities. Previous studies have demonstrated that shear stress can induce cell-free FN fibrillogenesis. In this study, we further examined the effect of shear stress conditions on morphology of formed FFN and preliminarily looked for relationship between FFN’s morphology and cell adhesion. Plasma FN at 50 µg/ml was perfused through channel slides at shear rates of 500 s-1 or 4000 s-1. Our results showed that there were four FFN structures formed: (1) FN nodules, (2) fibril in different sizes (3)…
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  • Genetically Encoded FRET Biosensor Detects the Enzymatic Activity of Prostate-Specific Antigen
  • Abstract Prostate cancer is the most common cancer among men beyond 50 years old, and ranked the second in mortality. The level of Prostate-specific antigen (PSA) in serum has been a routine biomarker for clinical assessment of the cancer development, which is detected mostly by antibody-based immunoassays. The proteolytic activity of PSA also has important functions. Here a genetically encoded biosensor based on fluorescence resonance energy transfer (FRET) technology was developed to measure PSA activity. In vitro assay showed that the biosensor containing a substrate peptide ‘RLSSYYSGAG’ had 400% FRET change in response to 1 µg/ml PSA within 90 min, and…
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  • New Applications for Cryotherapy
  • Abstract Cryotherapy, or more commonly known as cold therapy, is the use of low temperatures in medical treatment. The most prominent use of cryotherapy is for cryosurgery where application of very low temperatures is used to ablate diseased tissue (e.g., most commonly in dermatology). Recent research, however, shows that low temperature may modulate collagen fibers beyond the already known effects of extreme cooling on joint pain relieve and inflammation. The goal of this brief review is to outline the known effects of extreme cooling on molecular, fiber and cell physiology and to leverage these properties in various potential medical applications. Specially,…
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  •   Views:1452       Downloads:884        Download PDF
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