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  • Open Access

    ARTICLE

    Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

    Bo Xia*, Lei Wang, Li Feng*, Baofang Tian*, Yuanjie Tan, Baoyin Du*

    Oncology Research, Vol.27, No.1, pp. 89-98, 2019, DOI:10.3727/096504018X15199511344806

    Abstract Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. This study aimed to explore the effects of long noncoding RNA CAT104 and microRNA-381 (miR-381) on osteosarcoma cell proliferation, migration, invasion, and apoptosis, as well as the underlying potential mechanism. We found that CAT104 was highly expressed in osteosarcoma MG63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration, and invasion, but promoted cell apoptosis. CAT104 regulated the expression of miR-381, and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc finger E-box-binding homeobox 1 (ZEB1) was a direct target gene of… More >

  • Open Access

    ARTICLE

    MicroRNA-377 Targets Zinc Finger E-box-Binding Homeobox 2 to Inhibit Cell Proliferation and Invasion of Cervical Cancer

    Cong Ye*, Yubo Hu, Junrong Wang*

    Oncology Research, Vol.27, No.2, pp. 183-192, 2019, DOI:10.3727/096504018X15201124340860

    Abstract A large number of microRNAs (miRNAs) are aberrantly expressed in cervical cancer and play crucial roles in the onset and progression of cervical cancer by acting as either an oncogene or a tumor suppressor. Therefore, investigation of the expression, biological roles, and underlying mechanisms of miRNAs in cervical cancer might provide valuable therapeutic targets in the treatment for patients with this disease. In this study, miRNA- 377 (miR-377) was downregulated in cervical cancer tissues and cell lines. Decreased miR-377 expression was strongly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and distant metastasis in… More >

  • Open Access

    ARTICLE

    Response of MaHMA2 gene expression and stress tolerance to zinc stress in mulberry (Morus alba L.)

    LEI WANG1,#, QIUXIA DU1,#, YISU SHI1,#, MICHAEL ACKAH1, PENG GUO1, DANYAN ZHENG1, MENGMENG WU1, XIN JIN1, PEILAN LI3, QIAONAN ZHANG1, RUIXUE LI4, ZHI YIN3, MENGDI ZHAO2,*, WEIGUO ZHAO1,*

    BIOCELL, Vol.46, No.10, pp. 2327-2342, 2022, DOI:10.32604/biocell.2022.021542

    Abstract HMA2 (heavy metal ATPase 2) plays a crucial role in extracellular and intracellular Zn2+ transport across biomembranes, maintaining ion homeostasis, and playing an important role in the normal physiological metabolism, growth, and development of plants. In our study, a novel HMA2 gene, named MaHMA2, was isolated and cloned from white mulberry (Morus alba L.). The gene sequence obtained was 1,342 bp long, with an open reading frame of 1,194 bp, encoding a protein of 397 amino acids, with a predicted molecular mass of 42.852 kD and an isoelectric point of 7.53. This protein belonged to the PIB-type ATPase transport protein… More >

  • Open Access

    ARTICLE

    Energy and Life Cycle Assessment of Zinc/Water Nanofluid Based Photovoltaic Thermal System

    Junaid Khan, Rashid Ali, Muzammil Zubair, Syed Mohd Yahya*

    Energy Engineering, Vol.119, No.2, pp. 827-846, 2022, DOI:10.32604/ee.2022.016344

    Abstract Cooling the PV surface in a Photovoltaic Thermal system is a pivotal operational aspect to be taken into account to achieve optimized values of performance parameters in a Photovoltaic Thermal System. The experimental design used in this study facilitates the flow of varying concentrations of Zn-water nanofluid in serpentine copper tubing installed at the rear of the PV panel thereby preventing the PV surface temperature from increasing beyond the threshold value at which a decrease in electrical efficiency starts to occur. This fusion of solar thermal with PV devices leads to better electrical and thermal efficiency values resulting in decreased… More >

  • Open Access

    ARTICLE

    Upregulation of Zip14 correlates with induction of endoplasmic reticulum stress (ERS) in hypertrophied hearts of Dahl salt-sensitive rats

    JINYONG HUANG1, TIANMING TENG1, BO BIAN1, YUCHEN XUE1, LONGFEI HUANG1, ZHELONG XU2, QING YANG1,*, YUEMIN SUN1,*

    BIOCELL, Vol.46, No.3, pp. 667-675, 2022, DOI:10.32604/biocell.2021.015917

    Abstract Zinc is a trace element involved in maintaining cellular structure and function. Although zinc is associated with left ventricular hypertrophy (LVH), there have been few reports on this association. This study aimed to evaluate the correlation between Zip14 and expression of endoplasmic reticulum stress (ERS) associated molecules in hypertrophied hearts of rats. Dahl salt-sensitive rats were fed a high salt diet to establish a left ventricular hypertrophy (LVH) rat model. RT-PCR was used to determine Zip14, activating transcription factor (ATF4), ATF6, x-box-binding protein 1 (xBP1), C/EBP homologous protein (CHOP), immunoglobulin-binding protein (BiP) mRNA expression. Western blotting was used to evaluate… More >

  • Open Access

    ARTICLE

    Ameliorative effects of melatonin and zinc oxide nanoparticles treatment against adverse effects of busulfan induced infertility in male albino mice

    AMOURA M. ABOU-EL-NAGA1, SHAKER A. MOUSA2, FAYEZ ALTHOBAITI3, EMAN FAYAD3,*, ENGY S. FAHIM1

    BIOCELL, Vol.46, No.2, pp. 535-545, 2022, DOI:10.32604/biocell.2022.017739

    Abstract Testicular damage is one of the most hazardous effects as it’s associated with azoospermia. Busulfan (Bu) is a highly toxic chemotherapeutic drug that affects testis. Thirty male Swiss albino mice divided into six groups of 5 animals each. Control (oral 0.9% saline daily for 75 days); Mel (20 mg/kg/day orally for 30 days); ZnO NPs (5 mg/kg/day i.p. for 30 days); BU (single i.p. injection of 40 mg/kg and then left for 45 days); BU + Mel (single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day Mel for 30 days); BU + ZnO NPs… More >

  • Open Access

    ARTICLE

    Phenotype, Physiology, and Gene Expression of Barley Seedlings in Response to Nano Zinc Oxide Stress

    Mengyuan Dong#, Rong Sun#, Qianhui Yang, Lantian Zhang, Yangying Yong, Yunxia Fang, Xian Zhang, Xiaoqin Zhang*, Dawei Xue*

    Phyton-International Journal of Experimental Botany, Vol.90, No.6, pp. 1589-1598, 2021, DOI:10.32604/phyton.2021.017465

    Abstract In recent years, zinc oxide nanoparticles (ZnO NPs) have been widely used as zinc fertilizers and pesticides. The use of ZnO NPs in this way can provide benefits to humans, but also has potential risks. ZnO NPs inevitably enter the environment during their production and use, which affects the ecological environment and crop growth. In order to investigate the phenotype, physiology, and gene expression of barley (Hordeum vulgare L.) seedlings under ZnO NPs stress, the barely cultivars ZJU3 (P21), Golden Promise (GP) and L23 were chosen for study. Different ZnO NPs concentrations were applied to compare the physiological and biochemical… More >

  • Open Access

    ARTICLE

    Integrated Fertilization Regimes Boost Heavy Metals Accumulation and Biomass of Sedum alfredii Hance

    Kangning Zhou1, Yingying Zhang1, Jiasen Wu1, Chunying Dou1,2, Zihao Ye1, Zhengqian Ye1,3,*, Weijun Fu1,3,*

    Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1217-1232, 2021, DOI:10.32604/phyton.2021.014951

    Abstract

    The hyperaccumulator Sedum alfredii Hance (S. alfredii) may be employed for zinc (Zn) and cadmium (Cd)-polluted soil remediation. However, the low phytoremediation efficiency, related to the low biomass production, limits its use with that purpose. In this experiment, nitrogen (N), phosphorus (P), and potassium (K) fertilizers, and organic manure were applied to investigate the phytoremediation ability of S. alfredii. Hydroponic and pot experiments were conducted using Zn-Cd polluted soil. The hydroponic experiment indicated that appropriate fertilizer application could increase (p < 0.05) the amount of accumulated Zn and Cd in S. alfredii. When N supply ranged from 0.5 to 2.5… More >

  • Open Access

    ARTICLE

    Zinc oxide nanoparticles and epibrassinolide enhanced growth of tomato via modulating antioxidant activity and photosynthetic performance

    MOHAMMAD FAIZAN1, AHMAD FARAZ2, SHAMSUL HAYAT3, JAVAID A. BHAT4,*, FANGYUAN YU1,*

    BIOCELL, Vol.45, No.4, pp. 1081-1093, 2021, DOI:10.32604/biocell.2021.015363

    Abstract Nanotechnology has greatly expanded the applications of nanoparticles (NPs) domain in the scientific field. In this context, the zinc oxide nanoparticles (ZnO-NPs) and 24-epibrassinolide (EBL) has been revealed to positively regulate plant metabolism and growth. In the present study, we investigated the role of ZnO-NPs and EBL in the regulation of plant growth, photosynthetic efficiency, enzymes activities and fruit yield in tomato. Foliar treatment of ZnO-NPs at three levels (10, 50 or 100 ppm) and EBL (10−8 M) were applied separately or in combination to the foliage of plant at 35–39 days after sowing (DAS); and the control plants were… More >

  • Open Access

    ARTICLE

    Genome-wide Analysis of a Plant AT-rich Sequence and Zinc-binding Protein (PLATZ) in Triticum Aestivum

    Xiaohang He1, Minjie Liu2, Zhengwu Fang1, Dongfang Ma1,2,3,*, Yilin Zhou1,3,*, Junliang Yin1

    Phyton-International Journal of Experimental Botany, Vol.90, No.3, pp. 971-986, 2021, DOI:10.32604/phyton.2021.012726

    Abstract Plant AT-rich sequence and zinc-binding protein (PLATZ) is a plant transcription factor that has been studied in corn. PLATZ can non-specifically bind to sequences rich in A/T bases to induce transcriptional repression. It is involved in the regulation of dehydration tolerance in seeds. In this study, we performed bioinformatics analysis to identify and characterize wheat PLATZ(TaPLATZ)genes. We identified 49 wheat PLATZ genes by searching the wheat genome by using known PLATZ gene sequences from rice, Arabidopsis, and maize. Phylogenetic analysis on PLATZ gene sequences from different species was performed. We found that PLATZs could be divided into three groups. The… More >

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