Denis Miroshnichenko¹, Vladimir Lebedev², Katerina Lebedeva², Аnna Cherkashina², Sergey Petrushenko^3,4,*, Olena Bogoyavlenska¹, Аnzhela Olkhovska⁵, Ihor Hrubnyk⁶, Liudmyla Maloshtan⁶, Natalja Klochko⁷

Journal of Renewable Materials, Vol.12, No.10, pp. 1691-1713, 2024, DOI:10.32604/jrm.2024.054769 - 23 October 2024

Abstract The main goal of the article is the creation and study of thermosensitive and wound-healing gelatin-alginate biopolymer hydrogels modified with humic acids. Their rheological properties, swelling and contraction behavior were experimentally investigated, elucidated using Fourier transform infrared spectroscopy and used to achieve the physiological melting point, which is necessary for successful drug delivery. It has been shown that in the gelatin-alginate-humic acid biopolymer hydrogels systems, it is possible to obtain a gel-sol transition temperature close to the physiological temperature of 37°C, which is important for drug delivery in the treatment of wounds. By changing the… More >

SOBHA KOTA^*, RATNAKUMARI ANANTHA, VAYUNANDANA RAO GOVADA, PRADEEP DUMPALA

Journal of Polymer Materials, Vol.40, No.3-4, pp. 285-303, 2023, DOI:10.32381/JPM.2023.40.3-4.10

Abstract The exoskeleton of marine shrimp contains a natural, biocompatible polymer chitin, which is dumped as a waste. The study proposes the sustainable single-pot-extraction of chitosan from the waste and its use in the fabrication of wound-dressings, and thus leverage its piezoelectric, antioxidant, hypoglycaemic and medicinal properties in wound-healing. The Fourier transform infrared spectrum revealed that marine chitosan contains functional groups with N-O, O-H, and CO stretching. Scanning electron micrographs demonstrated the spherical and mesoporous structures of the extracted chitosan. X-ray diffraction analysis showed a semi-crystalline phase of chitosan particles with a mean size of 28.9… More >

MASSIMO CONESE^1,*, AURELIO PORTINCASA²

BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448 - 22 April 2022

Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound More >

YUNLONG ZHANG^1,#, JINGWEI ZHANG^2,#, YU ZHU¹, BIN CAI^1,*

BIOCELL, Vol.46, No.5, pp. 1329-1338, 2022, DOI:10.32604/biocell.2022.015592 - 06 January 2022

Abstract Diabetic patients often exhibit delayed or incomplete progress in the healing of acute wounds, owing to poor blood perfusion. Platelet-rich plasma (PRP) has attracted much attention as a means to improve wound healing, because it contains high growth factor concentrations. However, the burst-like release of PRP growth factors results in a short half-life of these therapeutic proteins, thus greatly limiting the therapeutic effect. In this study, we prepared PRP from human umbilical cord blood and developed an in situ photocrosslinkable PRP hydrogel glue (HNPRP) by adding a photoresponsive hyaluronic acid (HA-NB) into PRP. The HNPRP hydrogel… More >

Fuat USLUSOY¹, Mustafa NAZIROĞLU^2,3,*

BIOCELL, Vol.43, No.4, pp. 271-283, 2019, DOI:10.32604/biocell.2019.08333

Abstract The wound is induced by several mechanical and metabolic factors. In the etiology of the wound recovery, excessive oxidative stress, calcium ion (Ca²⁺) influx, and apoptosis have important roles. Ca²⁺-permeable TRPM2 channel is activated by oxidative stress. Protective roles of Hypericum perforatum extract (HP) on the mechanical nerve injury-induced apoptosis and oxidative toxicity through regulation of TRPM2 in the experimental animals were recently reported. The potential protective roles in HP treatment were evaluated on the TRPM2-mediated cellular oxidative toxicity in the renal epithelium (MPK) cells. The cells were divided into three groups as control, wound, and wound… More >

Hana Chang^*, Melissa L. Knothe Tate^∗,†,‡

Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 297-318, 2011, DOI:10.3970/mcb.2011.008.297

Abstract In the preceding study (Part A), we showed that prescribed seeding conditions as well as seeding density can be used to subject multipotent stem cells (MSCs) to volume changing stresses and that changes in volume of the cell are associated with changes in shape, but not volume, of the cell nucleus. In the current study, we aim to control the mechanical milieu of live cells using these prescribed seeding conditions concomitant to delivery of shape changing stresses via fluid flow, while observing adaptation of the cytoskeleton, a major cellular transducer that modulates cell shape, stiffness… More >

F. Despa¹, M. Chioffe¹, N. Yu¹, C. Spiro², J. Hicks², R. C. Lee¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 237-238, 2006, DOI:10.32604/mcb.2006.003.237

Abstract This article has no abstract. More >

C. E. Pullar¹, R. R. Isseroff¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 233-234, 2006, DOI:10.32604/mcb.2006.003.233

Abstract This article has no abstract. More >

K. HIDALGO¹, I. G. ROJAS², A. B. PENISSI³, M. I. RUDOLPH¹

BIOCELL, Vol.29, No.3, pp. 303-311, 2005, DOI:10.32604/biocell.2005.29.303

Abstract TNFα has been associated with both, tumor survival and apoptosis. This cytokine is also involved in promoting cell migration during wound healing and tumorigenesis. SW756 is a HPV18-positive cervical carcinoma cell line, which has been used to study different mechanisms of cervical cancer progression. An in vitro assay of scratch wound healing onto monolayers of SW756 cells was used to assess the effect of TNFα on cell migration into a wound space. It was found that SW756 cells have the ability to migrate, but not proliferate in response to scratch wounding in a serum-free medium supplemented More >