Weiming Huang^1,2, Baisong Liu^1,*, Zhaoliang Wang¹

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4449-4469, 2024, DOI:10.32604/cmc.2024.050389

Abstract In the tag recommendation task on academic platforms, existing methods disregard users’ customized preferences in favor of extracting tags based just on the content of the articles. Besides, it uses co-occurrence techniques and tries to combine nodes’ textual content for modelling. They still do not, however, directly simulate many interactions in network learning. In order to address these issues, we present a novel system that more thoroughly integrates user preferences and citation networks into article labelling recommendations. Specifically, we first employ path similarity to quantify the degree of similarity between user labelling preferences and articles… More >

MOHD ATHAR^1,*, ANU MANHAS², NISARG RANA², AHMAD IRFAN³

BIOCELL, Vol.48, No.6, pp. 935-944, 2024, DOI:10.32604/biocell.2024.049891

Abstract Computational methods have significantly transformed biomedical research, offering a comprehensive exploration of disease mechanisms and molecular protein functions. This article reviews a spectrum of computational tools and network analysis databases that play a crucial role in identifying potential interactions and signaling networks contributing to the onset of disease states. The utilization of protein/gene interaction and genetic variation databases, coupled with pathway analysis can facilitate the identification of potential drug targets. By bridging the gap between molecular-level information and disease understanding, this review contributes insights into the impactful utilization of computational methods, paving the way for More >

Valentina K. Todorova^*, Issam Makhoul^†, Ishwori Dhakal^‡, Jeanne Wei^§, Annjanette Stone^¶, Weleetka Carter^¶, Aaron Owen^*, V. Suzanne Klimberg^*

Oncology Research, Vol.25, No.8, pp. 1223-1229, 2017, DOI:10.3727/096504017X14876245096439

Abstract Doxorubicin (DOX) is a commonly used antineoplastic agent for the treatment of various malignancies, and its use is associated with unpredictable cardiotoxicity. Susceptibility to DOX cardiotoxicity is largely patient dependent, suggesting genetic predisposition. We have previously found that individual sensitivity to DOX cardiotoxicity was associated with differential expression of genes implicated in inflammatory response and immune trafficking, which was consistent with the increasing number of reports highlighting the important role of human leukocyte antigen (HLA) complex polymorphism in hypersensitivity to drug toxicity. This pilot study aimed to investigate DNA from patients treated with DOX-based chemotherapy… More >

Jing Wang^1,#, Wenqing Xiao^1,#, Qingnan Wang¹, Xu Wang¹, Bin Jiang¹, Yangchun Han², Yang Sun^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 859-873, 2024, DOI:10.32604/phyton.2024.048151

Abstract The basic leucine zipper (bZIP) is an important class of transcription factors in plants, playing a critical role in plant growth and development and responses to biotic and abiotic stress. Due to gene presence/absence variations, it is limited to identify bZIP genes based on the reference genome. Therefore, we performed the bZIP gene family analysis in the rice pan-genome. By employing a rice pan-genome, ninety-four OsbZIPs (72 core genes and 22 variable genes) were identified and divided into 11 groups in a phylogenetic tree. Based upon Ka/Ks values in 33 accessions, OsbZIPs were subjected to different selection… More >

Shuliang Xia^1,2,3,#, Huikang Tao^2,#, Shixin Su⁴, Xinxin Chen², Li Ma², Jianru Li⁵, Bei Gao⁶, Xumei Liu⁵, Lei Pi⁷, Jinqing Feng⁴, Fengxiang Li², Jia Li^4,*, Zhiwei Zhang^1,3,*

Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583

Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More > Graphic Abstract

Ghazi A. Alshumrani^*

Congenital Heart Disease, Vol.19, No.2, pp. 197-206, 2024, DOI:10.32604/chd.2024.049401

Abstract Objective: Coronary artery anatomical variations and anomalies are an important topic due to their potential clinical manifestations. This study aims to investigate the prevalence of coronary artery anatomical variations and anomalies in symptomatic patients with coronary computed tomography angiography (CCTA). Methods: This is a retrospective study that included all symptomatic patients who had CCTA in a tertiary care hospital in Saudi Arabia during a period of seven years. Results: The total number of included patients was 507 (60% males) with a mean age of 57.4 years. Approximately 41% had luminal stenoses, averaging 49.7%. The total number… More >

Bin Chen¹, Ziyang Li¹, Shipeng Li¹, Qingzhou Zhao¹, Xingdou Liu^2,*

Energy Engineering, Vol.121, No.5, pp. 1291-1307, 2024, DOI:10.32604/ee.2024.046374

Abstract To reduce carbon emissions, clean energy is being integrated into the power system. Wind power is connected to the grid in a distributed form, but its high variability poses a challenge to grid stability. This article combines wind turbine monitoring data with numerical weather prediction (NWP) data to create a suitable wind power prediction framework for distributed grids. First, high-precision NWP of the turbine range is achieved using weather research and forecasting models (WRF), and Kriging interpolation locates predicted meteorological data at the turbine site. Then, a preliminary predicted power series is obtained based on More >

Haoxue Wu^#, Xiaohan Zhang^§,#, Xiaoyu Chen, Kang Li, Aixia Xu, Zhen Huang, Jungang Dong, Chengyu Yu^*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 627-640, 2024, DOI:10.32604/phyton.2024.050321

Abstract Genetic manipulation (either restraint or enhancement) of the biosynthesis pathway of α-linolenic acid (ALA) in seed oil is an important goal in Brassica napus breeding. B. napus is a tetraploid plant whose genome often harbors four and six homologous copies, respectively, of the two fatty acid desaturases FAD2 and FAD3, which control the last two steps of ALA biosynthesis during seed oil accumulation. In this study, we compared their promoters, coding sequences, and expression levels in three high-ALA inbred lines 2006L, R8Q10, and YH25005, a low-ALA line A28, a low-ALA/high-oleic-acid accession SW, and the wildtype ZS11. The expression… More >

Fenglan Zhao¹, Jizhi Jin¹, Meng Yang¹, Franklin Eduardo Melo Santiago², Jianping Xue¹, Li Xu^3,*, Yongbo Duan^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 611-625, 2024, DOI:10.32604/phyton.2024.048295

Abstract

Seed germination with selenium (Se) is promising for producing Se-biofortified foods. Mungbean (Vigna radiata (L.) Wilczek) sprout is freshly eaten as a salad dressed with sauce, making it superior for Se biofortification. Since the Se safety range for the human body is extremely narrow, it is imperative to evaluate the genotypic responses of mungbean sprouts to Se. This study evaluated the Se enrichment capacity and interaction with flavonoids and antioxidant systems in sprouts of 20 mungbean germplasms. Selenium treatment was done by immersing mungbean seeds in 20 μM sodium selenite solution for 8 h. Afterward, the

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F. Sharifi^a , H. Ghaedamini^b,*, M.R. Salimpour^a

Frontiers in Heat and Mass Transfer, Vol.3, No.4, pp. 1-10, 2012, DOI:10.5098/hmt.v3.4.3005

Abstract In the present study, conductive cooling of a disc is done by means of incomplete constant and variable cross-section highly conductive inserts embedded in radial and tributary configurations. Variational calculus is invoked to determine the optimum shape of the cross-sections of the inserts. Firstly, it is tried to derive an equation for thermal resistance of the disc for radial configuration of inserts based on the procedure used in constructal studies. This is done by implementing the optimized thermal resistances of elemental sectors. Then, the computed elemental sectors are put together so that they make branching More >