Naeem Raza¹, Muhammad Asif Habib¹, Mudassar Ahmad¹, Qaisar Abbas^2,*, Mutlaq B. Aldajani², Muhammad Ahsan Latif³

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 911-931, 2024, DOI:10.32604/cmc.2024.055049 - 15 October 2024

Abstract Vision-based vehicle detection in adverse weather conditions such as fog, haze, and mist is a challenging research area in the fields of autonomous vehicles, collision avoidance, and Internet of Things (IoT)-enabled edge/fog computing traffic surveillance and monitoring systems. Efficient and cost-effective vehicle detection at high accuracy and speed in foggy weather is essential to avoiding road traffic collisions in real-time. To evaluate vision-based vehicle detection performance in foggy weather conditions, state-of-the-art Vehicle Detection in Adverse Weather Nature (DAWN) and Foggy Driving (FD) datasets are self-annotated using the YOLO LABEL tool and customized to four vehicle… More >

Artur V. Dmitrenko^1,2,*, Vladislav M. Ovsyannikov²

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.9, pp. 1925-1939, 2024, DOI:10.32604/fdmp.2024.048389 - 23 August 2024

Abstract The differential equations of continuum mechanics are the basis of an uncountable variety of phenomena and technological processes in fluid-dynamics and related fields. These equations contain derivatives of the first order with respect to time. The derivation of the equations of continuum mechanics uses the limit transitions of the tendency of the volume increment and the time increment to zero. Derivatives are used to derive the wave equation. The differential wave equation is second order in time. Therefore, increments of volume and increments of time in continuum mechanics should be considered as small but finite More >

STEPHEN E. LANGABEER^*

Oncology Research, Vol.32, No.9, pp. 1423-1427, 2024, DOI:10.32604/or.2024.051218 - 23 August 2024

Abstract Hairy cell leukemia (HCL) is an uncommon mature B-cell malignancy characterized by a typical morphology, immunophenotype, and clinical profile. The vast majority of HCL patients harbor the canonical BRAF V600E mutation which has become a rationalized target of the subsequently deregulated RAS-RAF-MEK-MAPK signaling pathway in HCL patients who have relapsed or who are refractory to front-line therapy. However, several HCL patients with a classical phenotype display non-canonical BRAF mutations or rearrangements. These include sequence variants within alternative exons and an oncogenic fusion with the IGH gene. Care must be taken in the molecular diagnostic work-up of patients More >

SEUNG-HEE GWAK¹, JUHYUN LEE¹, EUNJI OH¹, DOHYUN LEE^1,2, WONSHIK HAN³, JONGMIN KIM^1,*, KYONG-TAI KIM^4,*

Oncology Research, Vol.32, No.2, pp. 421-432, 2024, DOI:10.32604/or.2023.031031 - 28 December 2023

Abstract Genetic information is transcribed from genomic DNA to mRNA, which is then translated into three-dimensional proteins. mRNAs can undergo various post-transcriptional modifications, including RNA editing that alters mRNA sequences, ultimately affecting protein function. In this study, RNA editing was identified at the 499th base (c.499) of human vaccinia-related kinase 2 (VRK2). This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine (with adenine base) to valine (with guanine base). Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2, which leads to an increase in tumor cell proliferation. Earlier we… More > Graphic Abstract

PRIYADHARSHINI THANJAVUR SRIRAMAMOORTHI^1,2, GAYATHRI GOPAL^1,2, SHIBI MURALIDAR^1,2, SAI RAMANAN ESWARAN^1,2, DANUSH NARAYAN PANNEERSELVAM^1,2, BHUVANESWARAN MEIYANATHAN^1,2, SRICHANDRASEKAR THUTHIKKADU INDHUPRAKASH^1,2, SENTHIL VISAGA AMBI^1,2,*

BIOCELL, Vol.47, No.11, pp. 2335-2350, 2023, DOI:10.32604/biocell.2023.029379 - 27 November 2023

Abstract The novel coronavirus pneumonia (COVID-19) is spreading worldwide and threatening people greatly. The routes by which SARS-CoV-2 causes lung injury have grown to be a major concern in the scientific community since patients with new Coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV-2) have a high likelihood of developing acute respiratory distress syndrome (ARDS) in severe cases. The mortality rate of COVID-19 has increased over the period due to rapid spread, and it becomes crucial to understand the disease epidemiology, pathogenic mechanisms, and suitable treatment strategies. ARDS is a respiratory disorder and is one of the… More > Graphic Abstract

Baran Hekimoğlu^*

Energy Engineering, Vol.120, No.7, pp. 1515-1540, 2023, DOI:10.32604/ee.2023.029024 - 04 May 2023

Abstract Two novel improved variants of reptile search algorithm (RSA), RSA with opposition-based learning (ORSA) and hybrid ORSA with pattern search (ORSAPS), are proposed to determine the proportional, integral, and derivative (PID) controller parameters of an automatic voltage regulator (AVR) system using a novel objective function with augmented flexibility. In the proposed algorithms, the opposition-based learning technique improves the global search abilities of the original RSA algorithm, while the hybridization with the pattern search (PS) algorithm improves the local search abilities. Both algorithms are compared with the original RSA algorithm and have shown to be highly… More > Graphic Abstract

Xinyi Zhang, Zimeng Yu, Pingfang Yang^*

Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1665-1679, 2023, DOI:10.32604/phyton.2023.029482 - 11 April 2023

Abstract Sacred lotus (Nelumbo nucifera) is a typical aquatic plant, belonging to basal eudicot plant, which is ideal for genome and genetic evolutionary study. Understanding lotus gene diversity is important for the study of molecular genetics and breeding. In this research, public RNA-seq data and the annotated reference genome were used to identify the genes in lotus. A total of 26,819 consensus and 1,081 novel genes were identified. Meanwhile, a comprehensive analysis of gene alternative splicing events was conducted, and a total of 19,983 “internal” alternative splicing (AS) events and 14,070 “complete” AS events were detected in… More >

Hassam Tahir¹, Muhammad Shahbaz Khan¹, Fawad Ahmed², Abdullah M. Albarrak³, Sultan Noman Qasem³, Jawad Ahmad^4,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3517-3535, 2023, DOI:10.32604/cmc.2023.035410 - 31 March 2023

Abstract The COVID-19 outbreak began in December 2019 and was declared a global health emergency by the World Health Organization. The four most dominating variants are Beta, Gamma, Delta, and Omicron. After the administration of vaccine doses, an eminent decline in new cases has been observed. The COVID-19 vaccine induces neutralizing antibodies and T-cells in our bodies. However, strong variants like Delta and Omicron tend to escape these neutralizing antibodies elicited by COVID-19 vaccination. Therefore, it is indispensable to study, analyze and most importantly, predict the response of SARS-CoV-2-derived t-cell epitopes against Covid variants in vaccinated… More >

Cherith Somerville^1,2, Kelsey Kalbfleisch^1,2, Roozbeh Manshaei^1,2, Qiliang Ding^1,2, John B.A. Okello^1,2,3, Rachel Silver⁴, David Chitayat^2,4, Varsha Thakur⁵, Olivier Villemain^5,6,7, Rebekah Jobling^1,2,8,*

Congenital Heart Disease, Vol.18, No.2, pp. 213-218, 2023, DOI:10.32604/chd.2023.023042 - 15 March 2023

Abstract We report a three-year-old male child who presented with congenital valvular defects, right ventricular malformation, and initial developmental delay. Genome sequencing showed rare deleterious biallelic missense variants in PLD1. In his parents’ second pregnancy, echocardiogram at 13 weeks gestation revealed right-sided cardiac malformations resembling the clinical presentation of the family’s first child. Targeted DNA analysis showed that the fetus carried the same biallelic PLD1 variants as their older sibling. This case helps to further delineate the clinical spectrum of PLD1-related defects and highlights the value of both genome sequencing in congenital heart disease and early fetal echocardiography More >

Ji-Yang Zuo^1,2, Huan-Xin Chen^1,2, Zhi-Gang Liu^1,2, Qin Yang^1,2, Guo-Wei He^1,2,*

Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451 - 09 January 2023

Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first… More > Graphic Abstract