XIAOJIA HUANG^1,#, CAILU SONG^2,#, JINHUI ZHANG², LEWEI ZHU^3,*, HAILIN TANG^2,*

Oncology Research, Vol.32, No.2, pp. 241-249, 2024, DOI:10.32604/or.2023.046582

Abstract Breast cancer has surpassed lung cancer to become the most common malignancy worldwide. The incidence rate and mortality rate of breast cancer continue to rise, which leads to a great burden on public health. Circular RNAs (circRNAs), a new class of noncoding RNAs (ncRNAs), have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression. In breast cancer, circRNAs have significant roles in tumorigenesis, recurrence and multidrug resistance that are mediated by various mechanisms. Therefore, circRNAs may serve as promising targets of therapeutic strategies for breast cancer management. This study reviews the most recent studies about the… More >

KEGANG JIA^1,#, YAWEI WANG^2,#, QI CAO^3,*, YOUYU WANG^1,*

Oncology Research, Vol.32, No.2, pp. 409-419, 2024, DOI:10.32604/or.2023.042863

Abstract Background: Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death worldwide. Therapeutic failure in lung cancer (LUAD) is heavily influenced by drug resistance. This challenge stems from the diverse cell populations within the tumor, each having unique genetic, epigenetic, and phenotypic profiles. Such variations lead to varied therapeutic responses, thereby contributing to tumor relapse and disease progression. Methods: The Genomics of Drug Sensitivity in Cancer (GDSC) database was used in this investigation to obtain the mRNA expression dataset, genomic mutation profile, and drug sensitivity information of NSCLS. Machine Learning (ML) methods, including Random Forest… More >

FATEMEH HEIDARI^1,2, REIHANEH SEYEDEBRAHIMI^1,2, PIAO YANG³, MOHSEN ESLAMI FARSANI^1,2, SHIMA ABABZADEH^2,4, NASER KALHOR⁵, HAMED MANOOCHEHRI⁶, MOHSEN SHEYKHHASAN^7,*, MARYAM AZIMZADEH^8,9,*

BIOCELL, Vol.47, No.12, pp. 2597-2608, 2023, DOI:10.32604/biocell.2023.043351

Abstract Exosomes are small vesicles that carry molecules from one cell to another. They have many features that make them interesting for research, such as their stability, low immunogenicity, size of the nanoscale, toxicity, and selective delivery. Exosomes can also interact with viruses in diverse ways. Emerging research highlights the significant role of exosomes in viral infections, particularly in the context of diseases like COVID-19, HIV, HBV and HCV. Understanding the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral therapies. An important aspect is gaining clarity on how exosomes influence the… More >

KUAILU LIN^1,2, QIANYU GU², XIXI LAI^2,3,*

BIOCELL, Vol.47, No.12, pp. 2681-2696, 2023, DOI:10.32604/biocell.2023.043298

Abstract Objectives: Triple-negative breast cancer (TNBC) poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior. Methods: We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA. Utilizing weighted gene coexpression network analysis, we pinpointed 34 TNBC immune genes linked to survival. The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction. We calculated chemotherapy sensitivity scores using the “pRRophetic” package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and… More >

YUN ZHANG^1,2,#, SHALING TANG^1,2,#, YUBO GAO^1,2, ZHONGTING LU^1,2, YUAN YANG^1,2, JING CHEN³, TAO LI^4,*

Oncology Research, Vol.32, No.1, pp. 61-71, 2024, DOI:10.32604/or.2023.043481

Abstract Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since… More > Graphic Abstract

QIUQIANG CHEN^1,*, XUEJUN GUO², WENXUE MA^3,*

Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383

Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More > Graphic Abstract

ABHISHEK WAHI¹, MAMTA BISHNOI², NEHA RAINA¹, MEGHNA AMRITA SINGH¹, PIYUSH VERMA¹, PIYUSH KUMAR GUPTA^3,4, GINPREET KAUR⁵, HARDEEP SINGH TULI^6,*, MADHU GUPTA^1,*

Oncology Research, Vol.32, No.1, pp. 19-47, 2024, DOI:10.32604/or.2023.042228

Abstract Cancer is a leading cause of death globally, with limited treatment options and several limitations. Chemotherapeutic agents often result in toxicity which long-term conventional treatment. Phytochemicals are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the resistance. These phytoconstituents act in several ways and deliver optimum effectiveness against cancer. Nevertheless, the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility, bioavailability, and stability. Nanotechnology presents a promising avenue for transforming current cancer treatment methods through the… More > Graphic Abstract

Suprapto Suprapto, Putri Augista Nur Azizah, Yatim Lailun Ni’mah^*

Journal of Renewable Materials, Vol.11, No.12, pp. 4007-4023, 2023, DOI:10.32604/jrm.2023.031210

Abstract This research focuses on the effective removal of methylene blue dye using silica gel synthesized from chemical glass bottle waste as an environmentally friendly and cost-effective adsorbent. The adsorption process was optimized using Box-Behnken Design (BBD) and Response Surface Methodology (RSM) to investigate the influence of pH (6; 8 and 10), contact time (15; 30 and 45 min), adsorbent mass (30; 50 and 70 mg), and initial concentration (20; 50 and 80 mg/L) of the adsorbate on the adsorption efficiency. The BBD was conducted using Google Colaboratory software, which encompassed 27 experiments with randomly assigned combinations. The silica gel synthesized… More > Graphic Abstract

XIANGYU QUAN¹, XUETING MA¹, GUODONG LI², XUEQI FU¹, JIANGTAO LI¹, LINLIN ZENG^1,*

BIOCELL, Vol.47, No.10, pp. 2163-2176, 2023, DOI:10.32604/biocell.2023.031226

Abstract Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes. In recent years, scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease (AD) across the blood-brain barrier due to their nanoscale size and low immunogenicity. A large amount of evidence shows that exosomes are rich in biomarkers, and it has been found that the changes in biomarker content in blood, cerebrospinal fluid, and urine are often associated with the onset of AD patients. In this paper, some recent advances in the use of exosomes in the treatment of AD are… More > Graphic Abstract

Yueying Liu^#, Yuqing Wang^#, Lijiao Gu^*

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2937-2946, 2023, DOI:10.32604/phyton.2023.043306

Abstract WRKY transcription factors play important roles in plant growth, development, and stress responses. Our previous research has shown that the GhWRKY91 gene can delay age-, abscisic acid (ABA)-, and drought-induced leaf senescence when overexpressed in transgenic Arabidopsis plants. To explore in more depth the biological functions of the GhWRKY91 gene, we further observed the root growth of overexpressing transgenic Arabidopsis thaliana under ABA and drought treatment. In this study, we transplanted the germinated seeds of wild-type (WT) and three transgenic lines (OE-12, OE-13 and OE-20) to 1/2 MS solid medium containing ABA and different concentrations of mannitol (simulated drought treatment)… More >