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  • Open Access

    ARTICLE

    Study of Hygrothermal Behavior of Bio-Sourced Material Treated Ecologically for Improving Thermal Performance of Buildings

    Soumia Mounir1,2,*, Miloudia Slaoui2, Youssef Maaloufa1,2, Fatima Zohra El Wardi2,3, Yakubu Aminu Dodo4,5, Sara Ibn-Elhaj2, Abdelhamid Khabbazi2

    Journal of Renewable Materials, Vol.12, No.5, pp. 1007-1027, 2024, DOI:10.32604/jrm.2024.049392

    Abstract Creating sustainable cities is the only way to live in a clean environment, and this problem can be solved by using bio-sourced and recycled materials. For this purpose, the authors contribute to the valuation of sheep wool waste as an eco-friendly material to be used in insulation. The paper investigates the thermal, hygrothermal, and biological aspects of sheep wool by testing a traditional treatment. The biological method of aerobic mesophilic flora has been applied. Fluorescence X was used to determine the chemical composition of the materials used. Also, thermal characterization has been conducted. The thermal… More >

  • Open Access

    ARTICLE

    An Integrated Bipolar Picture Fuzzy Decision Driven System to Scrutinize Food Waste Treatment Technology through Assorted Factor Analysis

    Navaneethakrishnan Suganthi Keerthana Devi1, Samayan Narayanamoorthy1, Thirumalai Nallasivan Parthasarathy1, Chakkarapani Sumathi Thilagasree2, Dragan Pamucar3,4,*, Vladimir Simic5,6, Hasan Dinçer7,8, Serhat Yüksel7,8

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2665-2687, 2024, DOI:10.32604/cmes.2024.050954

    Abstract Food Waste (FW) is a pressing environmental concern that affects every country globally. About one-third of the food that is produced ends up as waste, contributing to the carbon footprint. Hence, the FW must be properly treated to reduce environmental pollution. This study evaluates a few available Food Waste Treatment (FWT) technologies, such as anaerobic digestion, composting, landfill, and incineration, which are widely used. A Bipolar Picture Fuzzy Set (BPFS) is proposed to deal with the ambiguity and uncertainty that arise when converting a real-world problem to a mathematical model. A novel Criteria Importance Through… More >

  • Open Access

    ARTICLE

    Mediating Effect of Mindfulness, Self-Esteem and Psychological Resilience in the Relation between Childhood Maltreatment and Life Satisfaction

    He Zhong1,*, Yaping Zhou2, Chenwei Liu3, Yintao Cao2

    International Journal of Mental Health Promotion, Vol.26, No.6, pp. 481-489, 2024, DOI:10.32604/ijmhp.2024.049408

    Abstract Childhood maltreatment, as a typical early adverse environment, is known to have a negative impact on one’s life satisfaction. Mindfulness, on the other hand, may serve as a protective factor. This study explored the mediating role of mindfulness and its related variables–positive thoughts, psychological resilience and self-esteem. In order to testify the mechanism, we administered Childhood Trauma Questionnaire (CTQ), Satisfaction with Life Scale (SWLS), Mindful Attention Awareness Scale (MAAS), Connor–Davidson Resilience Scale (CD-RISC) and Rosenberg Self-Esteem Scale (RSES) to a non-clinical sample of Chinese university students (N = 1021). The results indicated that positive thoughts More >

  • Open Access

    ARTICLE

    Genome-Wide Identification of Tomato (Solanum lycopersicum L.) CKX Gene Family and Expression Analysis in the Callus Tissue under Zeatin Treatment

    Zhengfeng Lai, Dongmei Lian, Shaoping Zhang, Yudong Ju, Bizhen Lin, Yunfa Yao, Songhai Wu, Jianji Hong, Zhou Li*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1143-1158, 2024, DOI:10.32604/phyton.2024.051207

    Abstract The cytokinin oxidase/dehydrogenase (CKX) enzyme is essential for controlling the fluctuating levels of endogenous cytokinin (CK) and has a significant impact on different aspects of plant growth and development. Nonetheless, there is limited knowledge about CKX genes in tomato (Solanum lycopersicum L.). Here we performed genome-wide identification and analysis of nine SlCKX family members in tomatoes using bioinformatics tools. The results revealed that nine SlCKX genes were unevenly distributed on five chromosomes (Chr.1, Chr.4, Chr.8, Chr.10, and Chr.12). The amino acid length, isoelectric points, and molecular weight of the nine SlCKX proteins ranged from 453 to 553, 5.77… More >

  • Open Access

    ARTICLE

    Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma

    LISANNE K.A. NEIJENHUIS1,2,3,#, LEUTA L. NAUMANN4,#, SONIA A.M. FERKEL1, SAMUEL J.S. RUBIN1, STEPHAN ROGALLA1,*

    Oncology Research, Vol.32, No.7, pp. 1163-1172, 2024, DOI:10.32604/or.2024.050907

    Abstract Background: Osteosarcoma is the most common malignant primary bone tumor. The prognosis for patients with disseminated disease remains very poor despite recent advancements in chemotherapy. Moreover, current treatment regimens bear a significant risk of serious side effects. Thus, there is an unmet clinical need for effective therapies with improved safety profiles. Taurolidine is an antibacterial agent that has been shown to induce cell death in different types of cancer cell lines. Methods: In this study, we examined both the antineoplastic and antiangiogenic effects of taurolidine in animal models of osteosarcoma. K7M2 murine osteosarcoma cells were… More >

  • Open Access

    REVIEW

    Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

    PAULINA CHMIEL1,2, ALEKSANDRA SłOWIKOWSKA1,2, ŁUKASZ BANASZEK1,2, ANNA SZUMERA-CIEćKIEWICZ3, BARTłOMIEJ SZOSTAKOWSKI1, MATEUSZ J. SPAłEK1,4,*, TOMASZ ŚWITAJ1, PIOTR RUTKOWSKI1, ANNA M. CZARNECKA1

    Oncology Research, Vol.32, No.7, pp. 1141-1162, 2024, DOI:10.32604/or.2024.050350

    Abstract Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic rate. Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features. However, IMT is identified by the fusion of the anaplastic lymphoma kinase (ALK) gene, which is present in approximately 70% of cases, with various fusion partners, including ran-binding protein 2 (RANBP2), which allows confirmation of the diagnosis. While surgery is the preferred approach for localized tumors, the optimal long-term treatment for advanced or metastatic disease is difficult… More >

  • Open Access

    REVIEW

    Application of Plant-Based Coagulants and Their Mechanisms in Water Treatment: A Review

    Abderrezzaq Benalia1,2,*, Kerroum Derbal2, Zahra Amrouci2,3, Ouiem Baatache2, Amel Khalfaoui4, Antonio Pizzi5,*

    Journal of Renewable Materials, Vol.12, No.4, pp. 667-698, 2024, DOI:10.32604/jrm.2024.048306

    Abstract This review describes the mechanisms of natural coagulants. It provides a good understanding of the two key processes of coagulation-flocculation: adsorption and charge neutralization, as well as adsorption and bridging. Various factors have influence the coagulation/flocculation process, including the effect of pH, coagulant dosage, coagulant type, temperature, initial turbidity, coagulation speed, flocculation speed, coagulation and flocculation time, settling time, colloidal particles, zeta potential, the effects of humic acids, and extraction density are explained. The bio-coagulants derived from plants are outlined. The impact of organic coagulants on water quality, focusing on their effects on the physicochemical… More > Graphic Abstract

    Application of Plant-Based Coagulants and Their Mechanisms in Water Treatment: A Review

  • Open Access

    ARTICLE

    OPA3 overexpression modulates lipid droplet production and sensitizes colorectal cancer cells to bevacizumab treatment

    HONGBIAO WU*, DONGFANG LIU

    BIOCELL, Vol.48, No.6, pp. 971-980, 2024, DOI:10.32604/biocell.2024.049466

    Abstract Background: Colorectal cancer (CRC) represents a substantial risk to public health. Bevacizumab, the first US FDA-approved antiangiogenic drug (AAD) for human CRC treatment, faces resistance in patients. The role of lipid metabolism, particularly through OPA3-regulated lipid droplet production, in overcoming this resistance is under investigation. Methods: The protein expression pattern of OPA3 in CRC primary/normal tissues was evaluated by bioinformatics analysis. OPA3-overexpressed SW-480 and HCT-116 cell lines were established, and bevacizumab resistance and OPA3 effects on cell malignancy were examined. OPA3 protein/mRNA expression and lipid droplet-related genes were measured with Western blot and qRT-PCR. OPA3… More > Graphic Abstract

    OPA3 overexpression modulates lipid droplet production and sensitizes colorectal cancer cells to bevacizumab treatment

  • Open Access

    REVIEW

    Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

    BINGJIE LI1,#, WENBO CAO1,2,3,#, JINJING XIAO1, YIXIAO CHEN1, QIYING WEI1, MINGJIN YUE4, SAIJUN MO1,2,3,*

    BIOCELL, Vol.48, No.6, pp. 923-934, 2024, DOI:10.32604/biocell.2024.049160

    Abstract Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond the primary tumor site, infiltrating distant regions devoid of lymphatic or vascular structures. PNI often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of cancers. Despite its clinical significance, the underlying molecular mechanisms of PNI remain elusive, complicating the development of specific and efficacious diagnostic and therapeutic strategies. In the realm of cancer research, non-coding RNAs (ncRNAs) have attracted considerable… More >

  • Open Access

    ARTICLE

    Gemcitabine Plus Vinorelbine as Second-Line Therapy in Patients With Metastatic Esophageal Cancer Previously Treated With Platinum-Based Chemotherapy

    Yue-shen Wang*1, Jing Tian†1, Yong Han, Shu-mei Han, Sheng-bin Shi

    Oncology Research, Vol.24, No.2, pp. 129-135, 2016, DOI:10.3727/096504016X14618564639213

    Abstract We evaluated the efficacy and feasibility of the combination of gemcitabine plus vinorelbine in patients with platinum-based chemotherapy-refractory esophageal cancer. We enrolled 35 patients who received gemcitabine plus vinorelbine as second-line treatment after platinum-based chemotherapy failure between May 2009 and April 2012. Dosage: gemcitabine 1,000 mg/m2 plus vinorelbine 25 mg/m2 ; all drugs were administered on days 1 and 8 of a 21-day cycle, and this was continued until failure or unacceptable toxicity. A total of 125 cycles of treatment were administered, and all patients received at least two cycles of treatment (two to five cycles;… More >

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