YUAN YIN¹, ZHENGYIN WANG¹, YUJIE HU¹, JIA WANG¹, YI WANG^2,*, QUN LU^1,*

Oncology Research, Vol.32, No.12, pp. 1881-1890, 2024, DOI:10.32604/or.2024.048007 - 13 November 2024

Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >

Pshtiwan Shakor^1,2,*, Nadarajah Gowripalan³, Paul Rocker⁴

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 395-408, 2024, DOI:10.32604/sdhm.2024.049366 - 05 June 2024

Abstract Self-compacting concrete (SCC) is the most flowable concrete type that exerts high pressure on formwork. SCC is the most commonly used concrete globally for construction applications due to its cost-effectiveness. However, to make a formwork resist the exerted lateral pressure of SCC, it is required to have a suitable design for formwork. This paper presents a novel approach on how could create and prepare the Fiber Bragg Grating (FBG) optics using as a sensor to measure lateral pressure and temperature of SCC. To ensure the FBG sensor works properly a validated methodology is conducted. In More > Graphic Abstract

XINRU FENG¹, LI XIAO^2,*

BIOCELL, Vol.48, No.5, pp. 793-801, 2024, DOI:10.32604/biocell.2024.048395 - 06 May 2024

Abstract Background: Galectin 2 (LGALS2) is a protein previously reported to serve as a mediator of disease progression in a range of cancers. The function of LGALS2 in oral squamous cell carcinoma (OSCC), however, has yet to be explored, prompting the present study to address this literature gap. Methods: Overall, 144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western immunoblotting. The LGALS2 coding sequence was introduced into the pcDNA3.0 vector, to enable the overexpression of this gene, while an LGALS2-specific shRNA and… More >

Doaa Sami Khafaga¹, Zongming Lv², Imran Khan^3,4, Shebnam M. Sefat⁵, Amel Ali Alhussan^1,*

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3723-3740, 2023, DOI:10.32604/cmc.2023.039956 - 26 December 2023

Abstract With the capacities of self-learning, acquainted capacities, high-speed looking for ideal arrangements, solid nonlinear fitting, and mapping self-assertively complex nonlinear relations, neural systems have made incredible advances and accomplished broad application over the final half-century. As one of the foremost conspicuous methods for fake insights, neural systems are growing toward high computational speed and moo control utilization. Due to the inborn impediments of electronic gadgets, it may be troublesome for electronic-implemented neural systems to make the strides these two exhibitions encourage. Optical neural systems can combine optoelectronic procedures and neural organization models to provide ways… More >

XUELIAN CHEN^1,*, YUNZHENG ZHANG², JUNJIAN HE³, YIBING LI⁴

BIOCELL, Vol.47, No.10, pp. 2283-2300, 2023, DOI:10.32604/biocell.2023.030086 - 08 November 2023

Abstract Background: The late detection of endometrial carcinoma (EC) at an advanced stage often results in a poor patient prognosis. It is hence important to identify reliable biomarkers to facilitate early detection of EC. Signal transducer and activator of transcription (STAT) family members play an important role in several tumors, however, their impact on EC development and progression remains unclear. Methods: Machine learning methods were used to investigate the importance of STAT5B in EC. Results: Hence, we explored the UALCAN data mining platform and found that while STAT1 and STAT2 were upregulated, STAT5A, STAT5B, and STAT6 were… More >

S. Narayan^1,*, M. U. Kaisan², Shitu Abubakar², Faisal O. Mahroogi³, Vipul Gupta⁴

Sound & Vibration, Vol.55, No.3, pp. 221-234, 2021, DOI:10.32604/sv.2021.016539 - 15 July 2021

Abstract The health monitoring has been studied to ensure integrity of design of engine structure by detection, quantification, and prediction of damages. Early detection of faults may allow the downtime of maintenance to be rescheduled, thus preventing sudden shutdown of machines. In cylinder pressure developed, vibrations and noise emissions data provide a rich source of information about condition of engines. Monitoring of vibrations and noise emissions are novel non-intrusive methodologies for which positioning of various transducers are important issue. The presented work shows applicability of these diagnosis methodologies adopted in case of diesel engines. The effects More >

Dan Shan, Yumin Shang, Tongxiu Hu

Oncology Research, Vol.27, No.3, pp. 349-358, 2019, DOI:10.3727/096504018X15247361080118

Abstract Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths in women around the world. Substantial evidence has demonstrated that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Therefore, identification of miRNAs and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer. MicroRNA-411 (miR-411) has been reported to play an important role in several… More >

Fecir Duran¹, Mustafa Teke²

Intelligent Automation & Soft Computing, Vol.25, No.3, pp. 441-449, 2019, DOI:10.31209/2018.11006161

Abstract Ultrasonic cleaners are devices that perform ultrasonic cleaning by using ultrasonic converters. Ultrasonic cleaners have been employed to clean dirty and rusty materials such as optic, jewelers, automotive and dental prosthesis sectors. Due to non-identified correctly cleaning time, cavitation erosion has been occurred at some materials, which desire for cleaning. In this study, an intelligent cleaning device that runs autonomously identified cleaning time, saves energy, and makes the cleaning process safely has been designed and implemented. An ultrasonic cleaning time has been adjusted automatically by monitoring of turbidity and conductivity values of liquid that is More >

Lili Dong¹, Yang Song^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 78-78, 2019, DOI:10.32604/mcb.2019.07130

Abstract It has been widely recognized that stem cells possess the potential of osteogenic differentiation, which greatly contribute to bone repair. Recently, accumulating evidences have indicated that mechanical cues are required for bone repair ^[1,2]. However, how local and recruited stem cells in the bone architecture receive the mechanical signals is poorly understood ^[3,4]. The purpose of this study is to demonstrate that macrophages potentially transduce the mechanical signals for stem cell osteogenic lineage. This demonstration has been carried out through a co-culture system to investigate the effect of macrophages which subjected to cyclic stretch on the… More >

Jianing Zhang^1,2, Ziying Yu¹, Hengxu Yang^1,2, Ming Wu¹, Jun Yang^1,2,*

Sound & Vibration, Vol.53, No.2, pp. 2-15, 2019, DOI:10.32604/sv.2019.03783

Abstract Ultrasound can be used as a carrier to realize wireless communication to and from a metal-enclosed space, which has the characteristics such as immunity to the electromagnetic shielding effect and non-destructive penetration of metal obstacles. This paper firstly reviews the previous studies in the field of ultrasonic wireless communication through metal barriers, and summarizes their achievements and the existing problems. Secondly, an overview of the research methods involved in studying the characteristic of acoustic-electric channel is presented, and the principles are introduced for the actual measurement method, equivalent circuit method, ABCD parameter method, finite element More >