Pshtiwan Shakor^1,2,*, Nadarajah Gowripalan³, Paul Rocker⁴

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 395-408, 2024, DOI:10.32604/sdhm.2024.049366

Abstract Self-compacting concrete (SCC) is the most flowable concrete type that exerts high pressure on formwork. SCC is the most commonly used concrete globally for construction applications due to its cost-effectiveness. However, to make a formwork resist the exerted lateral pressure of SCC, it is required to have a suitable design for formwork. This paper presents a novel approach on how could create and prepare the Fiber Bragg Grating (FBG) optics using as a sensor to measure lateral pressure and temperature of SCC. To ensure the FBG sensor works properly a validated methodology is conducted. In More > Graphic Abstract

De-Zhong Zhang^*, Bing-He Chen^*, Lan-Fang Zhang^†, Ming-Kun Cheng^‡, Xiang-Jie Fang^*, Xin-Jun Wu^*

Oncology Research, Vol.25, No.9, pp. 1453-1462, 2017, DOI:10.3727/096504017X14886494526344

Abstract Gastric cancer (GC) is the most common epithelial malignancy worldwide. Basic transcription factor 3 (BTF3) plays a crucial role in the regulation of various biological processes. We designed experiments to investigate the molecular mechanism underlying the role of BTF3 in GC cell proliferation and metastasis. We confirmed that BTF3 expression was decreased in GC tissues and several GC cell lines. Lentivirus-mediated downregulation of BTF3 reduced cell proliferation, induced S and G₂/M cell cycle arrest, and increased apoptosis. Knockdown of BTF3 significantly reduced the expression of Forkhead box M1 (FOXM1). Upregulation of FOXM1 significantly inhibited the decrease… More >

Huan Shen^*1, Li Liu^†1, Yongjin Yang^*, Wenxing Xun^‡, Kewen Wei^‡, Guang Zeng^‡

Oncology Research, Vol.25, No.7, pp. 1141-1152, 2017, DOI:10.3727/096504017X14841698396784

Abstract Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid. The present study was designed to explore the effects of BA on OSCC KB cell proliferation in vitro and on implanted tumor growth in vivo and to examine the possible molecular mechanisms. The results showed that BA dose-dependently inhibited KB cell proliferation and decreased implanted tumor volume. In addition, BA significantly promoted mitochondrial apoptosis, as reflected by an increase in TUNEL+ cells and the activities of caspases 3 and 9, an increase… More >

Wenzhang Zhang^*1, Xin Wu^†1, Liang Hu^*, Yuefan Ma^*, Zihan Xiu^*, Bingyu Huang^*, Yun Feng^*, Xudong Tang^*†‡

Oncology Research, Vol.25, No.5, pp. 843-852, 2017, DOI:10.3727/096504016X14813880882288

Abstract The human papillomavirus (HPV) infection may be associated with the development and progression of nonsmall cell lung cancer (NSCLC). However, the role of HPV-16 oncoproteins in the development and progression of NSCLC is not completely clear. Epithelial–mesenchymal transition (EMT), a crucial step for invasion and metastasis, plays a key role in the development and progression of NSCLC. Here we explored the effect of HPV-16 oncoproteins on EMT and the underlying mechanisms. NSCLC cell lines, A549 and NCI-H460, were transiently transfected with the EGFP-N1-HPV-16 E6 or E7 plasmid. Real-time PCR and Western blot analysis were performed… More >

Xuesong Wang^*, Yong Lin^†, Lei Peng^‡, Ruifu Sun^*, Xiaojin Gong^*, Jinlong Du^*, Xiugong Zhang^*

Oncology Research, Vol.26, No.6, pp. 933-940, 2018, DOI:10.3727/096504017X15144741233346

Abstract Osteosarcoma is one of the most aggressive malignancies with poor prognosis rates. Many studies have demonstrated that miRNAs were involved in osteosarcoma, but the role of miR-103a in osteosarcoma remains elusive. In this study, we detected the expression levels of miR-103 in osteosarcoma and non-osteosarcoma tissues and cell lines. The binding effect of miR-103 on p57 was detected by luciferase reporter assay. After altering expressions of miR-103 or p57, viability, migration, invasion, and apoptosis of MG63 cells and expressions of proteins related with the JNK/STAT and mTOR pathways were all detected. We found the higher More >

XINRU FENG¹, LI XIAO^2,*

BIOCELL, Vol.48, No.5, pp. 793-801, 2024, DOI:10.32604/biocell.2024.048395

Abstract Background: Galectin 2 (LGALS2) is a protein previously reported to serve as a mediator of disease progression in a range of cancers. The function of LGALS2 in oral squamous cell carcinoma (OSCC), however, has yet to be explored, prompting the present study to address this literature gap. Methods: Overall, 144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western immunoblotting. The LGALS2 coding sequence was introduced into the pcDNA3.0 vector, to enable the overexpression of this gene, while an LGALS2-specific shRNA and… More >

Doaa Sami Khafaga¹, Zongming Lv², Imran Khan^3,4, Shebnam M. Sefat⁵, Amel Ali Alhussan^1,*

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3723-3740, 2023, DOI:10.32604/cmc.2023.039956

Abstract With the capacities of self-learning, acquainted capacities, high-speed looking for ideal arrangements, solid nonlinear fitting, and mapping self-assertively complex nonlinear relations, neural systems have made incredible advances and accomplished broad application over the final half-century. As one of the foremost conspicuous methods for fake insights, neural systems are growing toward high computational speed and moo control utilization. Due to the inborn impediments of electronic gadgets, it may be troublesome for electronic-implemented neural systems to make the strides these two exhibitions encourage. Optical neural systems can combine optoelectronic procedures and neural organization models to provide ways… More >

XUELIAN CHEN^1,*, YUNZHENG ZHANG², JUNJIAN HE³, YIBING LI⁴

BIOCELL, Vol.47, No.10, pp. 2283-2300, 2023, DOI:10.32604/biocell.2023.030086

Abstract Background: The late detection of endometrial carcinoma (EC) at an advanced stage often results in a poor patient prognosis. It is hence important to identify reliable biomarkers to facilitate early detection of EC. Signal transducer and activator of transcription (STAT) family members play an important role in several tumors, however, their impact on EC development and progression remains unclear. Methods: Machine learning methods were used to investigate the importance of STAT5B in EC. Results: Hence, we explored the UALCAN data mining platform and found that while STAT1 and STAT2 were upregulated, STAT5A, STAT5B, and STAT6 were… More >

Dan Shan, Yumin Shang, Tongxiu Hu

Oncology Research, Vol.27, No.3, pp. 349-358, 2019, DOI:10.3727/096504018X15247361080118

Abstract Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths in women around the world. Substantial evidence has demonstrated that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Therefore, identification of miRNAs and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer. MicroRNA-411 (miR-411) has been reported to play an important role in several… More >

S. Narayan^1,*, M. U. Kaisan², Shitu Abubakar², Faisal O. Mahroogi³, Vipul Gupta⁴

Sound & Vibration, Vol.55, No.3, pp. 221-234, 2021, DOI:10.32604/sv.2021.016539

Abstract The health monitoring has been studied to ensure integrity of design of engine structure by detection, quantification, and prediction of damages. Early detection of faults may allow the downtime of maintenance to be rescheduled, thus preventing sudden shutdown of machines. In cylinder pressure developed, vibrations and noise emissions data provide a rich source of information about condition of engines. Monitoring of vibrations and noise emissions are novel non-intrusive methodologies for which positioning of various transducers are important issue. The presented work shows applicability of these diagnosis methodologies adopted in case of diesel engines. The effects More >