A. NOEL GRAVINA^1,2, NOELIA D´ELÍA^1,2, LUCIANO A. BENEDINI^2,3,*, PAULA MESSINA^1,2

BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

XUELING HE, LINLU JIN, YIXUE QIN, JIAN ZHONG, ZHI OUYANG, YE ZENG^*

BIOCELL, Vol.48, No.11, pp. 1521-1529, 2024, DOI:10.32604/biocell.2024.055410 - 07 November 2024

Abstract Cellular biomechanical features contributed to the occurrence and development of various physiological and pathological phenomena. Micropillar arrays have emerged as an important tool for both the assessment and manipulation of cellular biomechanical characteristics. This comprehensive review provides an in-depth understanding of the fabrication methodologies of micropillar arrays and their applications in deciphering and fine-tuning cellular biomechanical properties and the innovative experimental platforms including organ-on-a-chip and organoids-on-a-chip. This review provides novel insights into the potential of micropillar technology, poised to update the landscape of stem cell research and tissue engineering. More >

YUN WANG¹, XIAOJIANG LI², DALONG LIU², ZHIFENG WANG³, JICHEN XIA⁴, LIJUN WANG⁵, XUDONG ZHANG^6,*

Oncology Research, Vol.32, No.10, pp. 1649-1660, 2024, DOI:10.32604/or.2024.043482 - 18 September 2024

Abstract Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging… More > Graphic Abstract

Zhengfeng Lai, Dongmei Lian, Shaoping Zhang, Yudong Ju, Bizhen Lin, Yunfa Yao, Songhai Wu, Jianji Hong, Zhou Li^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1143-1158, 2024, DOI:10.32604/phyton.2024.051207 - 27 June 2024

Abstract The cytokinin oxidase/dehydrogenase (CKX) enzyme is essential for controlling the fluctuating levels of endogenous cytokinin (CK) and has a significant impact on different aspects of plant growth and development. Nonetheless, there is limited knowledge about CKX genes in tomato (Solanum lycopersicum L.). Here we performed genome-wide identification and analysis of nine SlCKX family members in tomatoes using bioinformatics tools. The results revealed that nine SlCKX genes were unevenly distributed on five chromosomes (Chr.1, Chr.4, Chr.8, Chr.10, and Chr.12). The amino acid length, isoelectric points, and molecular weight of the nine SlCKX proteins ranged from 453 to 553, 5.77… More >

Yaming Kang^1,*, Peishun Ye¹, Yuxiu Bai¹, Shi Qiu²

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2151-2168, 2024, DOI:10.32604/cmc.2024.049360 - 15 May 2024

Abstract Hyperspectral imagery encompasses spectral and spatial dimensions, reflecting the material properties of objects. Its application proves crucial in search and rescue, concealed target identification, and crop growth analysis. Clustering is an important method of hyperspectral analysis. The vast data volume of hyperspectral imagery, coupled with redundant information, poses significant challenges in swiftly and accurately extracting features for subsequent analysis. The current hyperspectral feature clustering methods, which are mostly studied from space or spectrum, do not have strong interpretability, resulting in poor comprehensibility of the algorithm. So, this research introduces a feature clustering algorithm for hyperspectral… More >

YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056 - 09 April 2024

Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

HAO LV¹, BO ZHU^1,2, DEGAO CHEN^1,2,*

BIOCELL, Vol.48, No.3, pp. 363-378, 2024, DOI:10.32604/biocell.2023.046367 - 15 March 2024

Abstract Tumor-associated macrophages (TAMs) are emerging as targets for tumor therapy because of their primary role in promoting tumor progression. Several studies have been conducted to target TAMs by reducing their infiltration, depleting their numbers, and reversing their phenotypes to suppress tumor progression, leading to the development of drugs in preclinical and clinical trials. However, the heterogeneous characteristics of TAMs, including their ontogenetic and functional heterogeneity, limit their targeting. Therefore, in-depth exploration of the heterogeneity of TAMs, combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment. This review focuses More >

Yue Mei^1,*, Stéphane Avril²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09064

Abstract Characterizing nonhomogeneous variation in material properties of soft tissues has wide application in biomedical engineering and clinical medicine, including but not limited to cancerous disease detection and patient-specific surgical planning of cardiovascular diseases. With the advancement of imaging techniques, we are capable of acquiring not only the geometry of soft tissues in vivo, but also the associated deformation in the physiological state. With the obtained displacement data, the nonhomogeneous material property distribution of soft tissues can be determined by solving inverse problem in elasticity. In this presentation, we will present our recent work on identification More >

Taotao Yuan¹, Haitian Yang¹, Yiqian He^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09275

Abstract Computational modeling can provide insight into understanding the damage mechanisms of soft biological tissues, and identification of constitutive parameters is key issues in the computational modeling. On the other hand, although it is thought that computational model should be non-local for soft tissues based on the existence of intrinsic length scales, there is very few work for the identification of the parameters of nonlocal damage models of soft tissues. Firstly, we use the gradient-enhanced damage model presented in our previous publication showing advantages in considering the internal length scales and in satisfying mesh independence for More >

Jingyu Wang^1,#, Yongrou Zhang^4,#, Zuyue Lei¹, Junqi Wang¹, Yangming Zhao¹, Taolin Sun^3,*, Zhenyu Jiang¹, Licheng Zhou¹, Zejia Liu¹, Yiping Liu¹, Bao Yang¹, Liqun Tang^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2022.08829

Abstract In surgical training applications and experimental research, brain tissues immersed in cerebrospinal fluid often involve very complex deformation and strain rate effects, which affects their reliability and stability. Thus, it is indispensable to develop a high-fidelity human brain tissue simulant material as a physical surrogate model to understand their mechanical behavior, such as traumatic brain injury (TBI). However, the reported simulant materials have not yet been able to compare and satisfy the above two mechanical properties. Here, we developed a novel composite hydrogel with brain tissue-like mechanical properties and investigated their mechanical behavior in a… More >