Chenchen Zhou^1,2, Shuaishuai Liang³, Bin Qi³, Chenxu Liu², Nam-Joon Cho^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.012380

Abstract Micro tools/parts are attracting increasing attention due to the miniaturization evolutionary tendency in many fields, whose functionalities are critically determined by their materials and shapes [1- 5]. Sharp-edged ceramic microparticles have great prospects to be used as micromachining tools and micro components. However, it remains a huge challenge to fabricate nontransparent ceramic sharp-edged microparticles in a high-throughput way while taking their shape complexity, precision, and strength into account [6-8]. Herein, we present an online mixing and in-situ polymerization strategy: “one-pot microfluidic fabrication” along with two novel microfluidic device fabrication methods: “groove & tongue” and sliding More >

Liang Jiang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.012946

Abstract The Materials Genome Engineering (MGE) spurs the developments and applications of methods and tools in high-throughput experiments, integrated computation materials engineering and big data. Due to the unique importance and characteristics of structural alloys, there are great needs for MGE high throughput experimental methods and tools to enable efficient establishment of the complex alloy composition-microstructures-property relationships. To explore the alloy composition-phase relationships, several high-throughput experimental concepts are discussed. The diffusion-based high-throughput experimental concepts and approaches are highlighted from generating composition spread, automating characterization, and to illustrating systematic analysis. In particular, the evolution of diffusion multiple More >

Lixia Yang^1,*, Danqi Huang¹, Zongxin Liu², Lei Zhao¹, Xuejing Shen¹, Haizhou Wang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.012690

Abstract Neutrons possess unique advantages in the study of element and component distribution, internal damage defects, crystal structure, and multi-scale stress field evolution of engineering materials due to their strong penetrating ability, sensitivity to light elements, and non-destructive properties. This study introduces the application of neutron diffraction technology for characterizing residual stress in full-size high-speed iron wheels and neutron imaging technology for three-dimensional characterization of hydrogen distribution in titanium alloys treated with hot hydrogen.
Residual stress plays a critical role in the design, manufacturing, assembly, and service life cycle of wheel structures. It is a significant factor… More >

Bo Hwan Kim^1,#, Sheikh Mansoor^2,#, Gyung Deok Han³, Ji Eun Park⁴, Wook Kim^1,*, Yong Suk Chung^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2339-2347, 2024, DOI:10.32604/phyton.2024.056439 - 30 September 2024

Abstract Recognizing the variation of genetic resources is the first step in selection. One of the most important variations in grain crops is the uniformity of seed grain weight, which can be converted into seed size. However, it has been challenging since it needs high labor costs and time to measure it on a large scale. The current study used an image analysis technique to measure the grain seed area of about 100 seeds per accession with 64 germplasm of Tartary buckwheat (Fagopyrum tataricum) to study variation among and within them. To understand the nature of variation, More >

Jinyu Chen¹, Long Shi^1,*, Qisheng Huang², Taotao Wang³, Daojing He⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1755-1773, 2024, DOI:10.32604/cmes.2023.046826 - 29 January 2024

Abstract In permissioned blockchain networks, the Proof of Authority (PoA) consensus, which uses the election of authorized nodes to validate transactions and blocks, has been widely advocated thanks to its high transaction throughput and fault tolerance. However, PoA suffers from the drawback of centralization dominated by a limited number of authorized nodes and the lack of anonymity due to the round-robin block proposal mechanism. As a result, traditional PoA is vulnerable to a single point of failure that compromises the security of the blockchain network. To address these issues, we propose a novel decentralized reputation management… More > Graphic Abstract

MESFER AL SHAHRANI, REEM GAHTANI, MOHAMMAD ABOHASSAN, MOHAMMAD ALSHAHRANI, YASSER ALRAEY, AYED DERA, MOHAMMAD RAJEH ASIRI, PRASANNA RAJAGOPALAN^*

Oncology Research, Vol.32, No.2, pp. 251-259, 2024, DOI:10.32604/or.2023.043139 - 28 December 2023

Abstract Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation, adhesion, angiogenesis, and metastasis. Conventional therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic mutations. Hence, dual inhibition strategies are recommended to increase potency and reduce cytotoxicity. In this study, we have conducted computational high-throughput screening of the ChemBridge library followed by in vitro assays and identified novel selective inhibitors that have a dual impediment of EGFR/HER2 kinase activities. Diversity-based High-throughput Virtual Screening (D-HTVS) was used to screen the whole ChemBridge small molecular… More > Graphic Abstract

ZHIWANG LI, HAN YU, YUPING LIU, WEISHENG WU, HAIJING ZENG, EN LI^*

BIOCELL, Vol.47, No.11, pp. 2409-2422, 2023, DOI:10.32604/biocell.2023.031186 - 27 November 2023

Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a high probability of becoming cancerous. Many RNAs potentially associated with FAP have not been identified. In this study, a circRNA (circular RNA) expression profile of FAP was established using a circRNA microarray, and differentially expressed circRNAs were verified by RT-qPCR. The effects of hsa_circ_0036740 on the malignant behavior of tumor cells (proliferation, apoptosis, and epithelial mesenchymal transition) and the levels of C3A complement protein expression were evaluated. Moreover, neutrophils were isolated and co-cultured with colorectal cancer cells (CRCs), followed by measurements of MPO-DNA, citrullinated… More > Graphic Abstract

ZIYU LIU^1,2, AKIKO OKANO^3,4, EMIKO SANADA^1,3,4, YUSHI FUTAMURA^3,4, TOSHIHIKO NOGAWA^3,5, KOSUKE ISHIKAWA⁶, KENTARO SEMBA^7,8, JIANG LI⁹, XIAOMENG LI¹⁰, HIROYUKI OSADA^3,4,11,*, NOBUMOTO WATANABE^1,2,4,*

Oncology Research, Vol.31, No.5, pp. 655-666, 2023, DOI:10.32604/or.2023.030248 - 21 July 2023

Abstract

Myc belongs to a family of proto-oncogenes that encode transcription factors. The overexpression of c-Myc causes many types of cancers. Recently, we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library. The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained. In this study, we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp. RK19-A0402 strongly inhibits c-Myc transcriptional activity. After purification of the hit broth, we identified compounds closely related to the aglycone

More > Graphic Abstract

XINTONG LIU^1,2,3, EMIKO SANADA^1,3,4, JIANG LI⁵, XIAOMENG LI⁶, HIROYUKI OSADA^1,4,7,*, NOBUMOTO WATANABE^1,2,3,*

Oncology Research, Vol.31, No.5, pp. 645-654, 2023, DOI:10.32604/or.2023.030240 - 21 July 2023

Abstract β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands of β-TrCP useful for the proteolysis targeting chimera (PROTAC) system using β-TrCP in the future, we developed a high-throughput screening system for small molecule β-TrCP ligands. We screened the chemical library utilizing the system and obtained several hit compounds. The effects of the hit compounds on in vitro ubiquitination activity of SCF^β-TrCP1 and on downstream signaling pathways were examined. Hit compounds NPD5943, NPL62020-01, and NPL42040-01 inhibited the… More > Graphic Abstract

Rajesh Bharati^*, Vahida Attar

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 763-775, 2023, DOI:10.32604/iasc.2023.035503 - 29 April 2023

Abstract Online Transaction Processing (OLTP) gets support from data partitioning to achieve better performance and scalability. The primary objective of database and application developers is to provide scalable and reliable database systems. This research presents a novel method for data partitioning and load balancing for scalable transactions. Data is efficiently partitioned using the hybrid graph partitioning method. Optimized load balancing (OLB) approach is applied to calculate the weight factor, average workload, and partition efficiency. The presented approach is appropriate for various online data transaction applications. The quality of the proposed approach is examined using OLTP database More >