Wadhah Mohammed M. Aqlan¹, Ghassan Ahmed Ali^2,*, Khairan Rajab², Adel Rajab², Asadullah Shaikh², Fekry Olayah², Shehab Abdulhabib Saeed Alzaeemi^3,*, Kim Gaik Tay³, Mohd Adib Omar¹, Ernest Mangantig⁴

CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 665-686, 2023, DOI:10.32604/cmc.2023.039228 - 08 June 2023

Abstract Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production, resulting in a drop in the size of red blood cells. In severe forms, it can lead to death. This genetic disorder has posed a major burden on public health wherein patients with severe thalassemia need periodic therapy of iron chelation and blood transfusion for survival. Therefore, controlling thalassemia is extremely important and is made by promoting screening to the general population, particularly among thalassemia carriers. Today Twitter is one of the most influential social media platforms for sharing opinions… More >

Xinyan Li¹, Xiaoxia Qiu¹, Huan Huang¹, Yili Zhao², Xueqin Li¹, Meng Li¹, Xiaoxian Tian¹

Congenital Heart Disease, Vol.13, No.2, pp. 282-287, 2018, DOI:10.1111/chd.12568

Abstract Objective: To evaluate the efficacy of using fetal heart size measurements derived from axial echocardiography to predict homozygous α-thalassemia-1.
Design: Prospective diagnostic study.
Setting: The carrier rate of α-thalassemia-1 (–/αα) in China’s Guangxi Zhuang Autonomous Region is approximately 15%. If both parents are carriers, the risk of homozygous a-thalassemia-1 in one pregnancy is 25%.
Patients: Singleton mid-pregnancies at risk of homozygous α-thalassemia-1 were enrolled.
Outcome Measures: Fetal heart measurements, including heart diameter (HD), heart length (HL), heart circumference (HC), and heart area (HA), were measured. The z-scores for these heart parameters were then calculated separately based on previously constructed z-score… More >