Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1379-1379, 2024, DOI:10.32604/or.2024.055034

Abstract This article has no abstract. More >

WEI JIANG¹, MEI ZHOU^2,*

Oncology Research, Vol.32, No.8, pp. 1359-1368, 2024, DOI:10.32604/or.2024.043423

Abstract Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for in vitro experiments. Cell counting kit-8 (CCK-8), flow cytometry, and trans-well assays were performed for the assessment of cell viability, apoptosis, migration, and invasion, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess the mRNA expression… More > Graphic Abstract

M. Sridevi¹, B. Shankar Goud², Ali Hassan^3,4,*, D. Mahendar⁵

Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 939-953, 2024, DOI:10.32604/fhmt.2024.050929

Abstract This study intends to evaluate the influence of temperature stratification on an unsteady fluid flow past an accelerated vertical plate in the existence of viscous dissipation. It is assumed that the medium under study is a grey, non-scattered fluid that both fascinates and transmits radiation. The leading equations are discretized using the finite difference method (FDM). Using MATLAB software, the impacts of flow factors on flow fields are revealed with particular examples in graphs and a table. In this regard, FDM results show that the velocity and temperature gradients increase with an increase of Eckert More >

Weijian Song^1,, Xi Li^1,, Peng Chen^1,*, Juan Chen¹, Jianhua Ren², Yunni Xia^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3001-3016, 2024, DOI:10.32604/cmes.2024.048563

Abstract With the rapid development of Internet of Things (IoT) technology, IoT systems have been widely applied in healthcare, transportation, home, and other fields. However, with the continuous expansion of the scale and increasing complexity of IoT systems, the stability and security issues of IoT systems have become increasingly prominent. Thus, it is crucial to detect anomalies in the collected IoT time series from various sensors. Recently, deep learning models have been leveraged for IoT anomaly detection. However, owing to the challenges associated with data labeling, most IoT anomaly detection methods resort to unsupervised learning techniques.… More >

Yuanqing He^*, Xinyue Yu, Yu Xia, Yanhua Cao

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 463-474, 2024, DOI:10.32604/ijmhp.2024.051909

Abstract Background: Teacher burnout is a serious issue in the field of education, particularly in early childhood education, where teachers face high levels of work stress and emotional labor, leading to emotional exhaustion and job burnout. However, past research has not sufficiently explored the mechanisms of social skills, empathy, and mindfulness in mitigating teacher burnout. Therefore, this study aims to investigate the relationship between preschool teachers’ social skills, empathy, and mindfulness with job burnout, in order to provide theoretical basis and practical guidance for reducing teacher burnout. Methods: This research utilized a convenience sampling approach to… More >

Shengchao Zhang, Jun Yuan, Ruheng Zheng

Oncology Research, Vol.24, No.4, pp. 263-269, 2016, DOI:10.3727/096504016X14666990347392

Abstract Recently, deubiquitinating enzymes (DUBs) are emerging as new regulators in cancer progression. However, understanding of the involvement of DUBs in non-small cell lung cancer (NSCLC) is just beginning. In this study, we investigated the expression and biological function of ubiquitin-specific peptidase 17 (USP17) in NSCLC progression in vitro and in vivo. We found that the expression of USP17 was higher than in a normal control. We further efficiently depleted USP17 expression in two different NSCLC cells, A549 and H1299. The anchorage-independent growth ability of these cells, estimated by soft agar colony formation assay, was significantly More >

Hu-yin Yang, Da-zhao Fang, Lian-shu Ding, Xiao-bo Hui, Dai Liu

Oncology Research, Vol.25, No.6, pp. 923-930, 2017, DOI:10.3727/096504016X14798241682647

Abstract Protease serine 8 (PRSS8), a serine peptidase, has a widespread expression in normal epidermal cells. Recently, many researchers demonstrated downregulation of PRSS8 in cancer tissues as well as its tumor suppressor role in cancer development. However, the biological functions of PRSS8 in glioma remain unclear. In the current study, we demonstrated a decreased expression of PRSS8 in glioma tissues and cell lines. PRSS8 upregulation inhibited glioma cell proliferation, migration, and invasion. In addition, xenograft experiments showed that PRSS8 overexpression suppressed glioma cell growth in vivo. We also found that upregulated PRSS8 reduced the protein expression More >

Chaonan Ma^*1, Wei Ma^*1, Nannan Zhou^*, Na Chen^*, Li An^†, Yijie Zhang^*

Oncology Research, Vol.25, No.5, pp. 781-787, 2017, DOI:10.3727/096504016X14772417575982

Abstract Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. However, the role of PRSS8 in non-small cell lung cancer (NSCLC) pathogenesis remains unclear. The objective of this study was to investigate PRSS8 expression, biological function, and its related molecular mechanism in NSCLC. Our results showed that PRSS8 was expressed in a low amount in NSCLC cell lines. Ectopic expression of PRSS8 inhibited tumor growth in vitro and in vivo. Furthermore, ectopic expression of PRSS8 inhibited the migration and invasion of More >

Dengfeng Zhang¹, Feng Jiang¹, Xiao Wang, Guojun Li

Oncology Research, Vol.25, No.5, pp. 743-751, 2017, DOI:10.3727/096504016X14772395226335

Abstract Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigating the expression of USP22 in osteosarcoma (OS) and its association with OS progression. In this study, we explored the role of USP22 in OS. We demonstrated that USP22 was highly expressed in OS tissue and cell lines. Downregulation of USP22 inhibited OS cell proliferation, invasion, and epithelial–mesenchymal transition (EMT) in vitro. In addition, More >

Jin Zhang, Danjie Zhang, Liangzhang Sun

Oncology Research, Vol.25, No.2, pp. 249-257, 2017, DOI:10.3727/096504016X693164

Abstract Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes (DUBs), plays an essential role in the development of human carcinoma. However, to the best of our knowledge, the role of USP14 in esophageal squamous cell carcinoma (ESCC) is unknown. In the current study, we investigated the expression and role of USP14 in ESCC. Our results showed that the level of USP14 was significantly increased in ESCC tissues and cell lines. Downregulation of USP14 significantly inhibited ESCC cell proliferation and ESCC tumor growth in nude mice. Downregulation of USP14 also suppressed the migration/invasion in ESCC More >