HUI ZHOU^#, ZHENGYU YU^#, JING XU, ZHONGWANG WANG, YALI TAO, JINJIN WANG, PEIPEI YANG, JINRONG YANG^*, TING NIU^*

Oncology Research, Vol.32, No.12, pp. 1903-1919, 2024, DOI:10.32604/or.2024.048138 - 13 November 2024

Abstract Background: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid cycle (TCA). However, the pathogenesis is not fully understood. We aimed to perform a more systematic and comprehensive analysis of DLAT in the occurrence and progression of tumors, and to investigate its function in patients’ prognosis and immunotherapy. Methods: The differential expression, diagnosis, prognosis, genetic and epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell analysis, and drug response across cancers were conducted based on multiple computational… More > Graphic Abstract

ZHENHUA LI¹, HUILAI LV¹, FAN ZHANG¹, ZIMING ZHU², QIANG GUO³, MINGBO WANG¹, CHAO HUANG¹, LIJUAN CHEN⁴, WENPAN ZHANG⁴, YUN LI^5,*, ZIQIANG TIAN^1,*

BIOCELL, Vol.48, No.1, pp. 123-138, 2024, DOI:10.32604/biocell.2023.031568 - 30 January 2024

Abstract Introduction: DNA polymerases are crucial for maintaining genome stability and influencing tumorigenesis. However, the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well understood. Methods: We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases (POLYs) and their clinical correlations. We also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time (OS) using Kaplan-Meier survival curves. Additionally, we investigated the correlations between POLY expression… More >

Adil Hussain Seh¹, Jehad F. Al-Amri², Ahmad F. Subahi³, Alka Agrawal¹, Nitish Pathak⁴, Rajeev Kumar^5,6,*, Raees Ahmad Khan¹

CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1387-1422, 2022, DOI:10.32604/cmes.2022.018163 - 30 December 2021

Abstract The adoption of sustainable electronic healthcare infrastructure has revolutionized healthcare services and ensured that E-health technology caters efficiently and promptly to the needs of the stakeholders associated with healthcare. Despite the phenomenal advancement in the present healthcare services, the major obstacle that mars the success of E-health is the issue of ensuring the confidentiality and privacy of the patients’ data. A thorough scan of several research studies reveals that healthcare data continues to be the most sought after entity by cyber invaders. Various approaches and methods have been practiced by researchers to secure healthcare digital… More >

Habib Ullah Khan^1,*, Mohammad Kamel Alomari¹, Sulaiman Khan², Shah Nazir², Asif Qumer Gill³, Alanoud Ali Al-Maadid⁴, Zaki Khalid Abu-Shawish¹, Mostafa Kamal Hassan¹

CMC-Computers, Materials & Continua, Vol.68, No.1, pp. 1409-1428, 2021, DOI:10.32604/cmc.2021.016058 - 22 March 2021

Abstract The revolution in Internet of Things (IoT)-based devices and applications has provided smart applications for humans. These applications range from healthcare to traffic-flow management, to communication devices, to smart security devices, and many others. In particular, government and private organizations are showing significant interest in IoT-enabled applications for smart homes. Despite the perceived benefits and interest, human safety is also a key concern. This research is aimed at systematically analyzing the available literature on smart homes and identifying areas of concern or risk with a view to supporting the design of safe and secure smart More >