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  • Open Access

    ARTICLE

    Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

    Wenjie Dong1,2,#, Zhibin Hong1,#, Aqian Wang2, Kaiyu Jiang2, Hai Zhu2, Fu zhang2, Zhaoxia Guo2, Hongling Su2,*, Yunshan Cao3,*

    Congenital Heart Disease, Vol.19, No.3, pp. 325-339, 2024, DOI:10.32604/chd.2024.052267 - 26 July 2024

    Abstract Background: Current guidelines for managing pulmonary arterial hypertension (PAH) recommend a risk stratification approach. However, the applicability and accuracy of these strategies for PAH associated with congenital heart disease (PAH-CHD) require further validation. This study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year follow-up. Additionally, new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD patients. Methods: This retrospective study included 126 PAH-CHD patients. Clinical and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s… More > Graphic Abstract

    Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

  • Open Access

    ARTICLE

    Convection and Stratification of Temperature and Concentration

    Alexey Fedyushkin*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1351-1364, 2024, DOI:10.32604/fdmp.2024.050267 - 27 June 2024

    Abstract This study is devoted to an analysis of natural convection and the emergence of delamination in an incompressible fluid encapsulated in a closed region heated from the side. Weak, medium and intensive modes of stationary laminar thermal and thermo-concentration convection are considered. It is shown that nonlinear flow features can radically change the flow structure and characteristics of heat and mass transfer. Moreover, the temperature and concentration segregation in the center of the square region display a non-monotonic dependence on the Grashof number (flow intensity). The formation of a nonstationary periodic structure of thermal convection More >

  • Open Access

    ARTICLE

    On the Features of Thermal Convection in a Compressible Gas

    Igor B. Palymskiy1,2,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 957-974, 2024, DOI:10.32604/fdmp.2024.048829 - 07 June 2024

    Abstract The fully nonlinear equations of gas dynamics are solved in the framework of a numerical approach in order to study the stability of the steady mode of Rayleigh-Bénard convection in compressible, viscous and heat-conducting gases encapsulated in containers with no-slip boundaries and isothermal top and bottom walls. An initial linear temperature profile is assumed. A map of the possible convective modes is presented assuming the height of the region and the value of the temperature gradient as influential parameters. For a relatively small height, isobaric convection is found to take place, which is taken over… More >

  • Open Access

    ARTICLE

    Investigation the Influence of Phase Change Material Amount on a Hot-Water Stratification in Charging Mode

    Abeer H. Falih*, Basim Freegah, Adnan A. Abdulrasool

    Frontiers in Heat and Mass Transfer, Vol.21, pp. 141-160, 2023, DOI:10.32604/fhmt.2023.01525 - 30 November 2023

    Abstract Among the various techniques for enhancing the storage and consumption of energy in a thermal energy storage system, the establishment of thermal stratification in a hot-water container is an effective technology. The current study aims to assess the performance of the thermal stratification for hot-water containers using (ANSYS Fluent) R.1.0, 2022, through the study of the impact of different numbers of paraffin-filled containers, namely 3, 5, and 7, that are equivalent to 5, 7, and 9 kg of paraffin, respectively. To validate the present numerical model, a comparison between the current study results and the… More > Graphic Abstract

    Investigation the Influence of Phase Change Material Amount on a Hot-Water Stratification in Charging Mode

  • Open Access

    ARTICLE

    Substrate, Hormone, Winnowing, and Stratification Influence the Seed Germination of Ilex asprella (Hook. et Arn.) Champ. ex Benth

    Yuquan Huang1,2, Fan Wei1, Qing Ma2, Yang Lin1, Jinpeng Huang2, Yanxia Zhu1,*, Danfeng Tang1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2105-2116, 2023, DOI:10.32604/phyton.2023.029205 - 29 May 2023

    Abstract Ilex asprella (Hook. et Arn.) Champ. ex Benth is one of the most important traditional Chinese medicines in southern China. The seeds of Ilex asprella usually have extremely low germination due to their dormancy characteristics, which severely impacts the efficiency of seedling raising and increases labor costs. In this study, to improve the seed germination of I. asprella, the effects of germination substrate, hormone, winnowing, and stratification treatments on the seed germination of I. asprella were investigated. The results of the germination matrix showed that the highest germination percentage of 45.2% was achieved under the 20°C/10°C day/night temperature and… More >

  • Open Access

    ARTICLE

    Analysis of the personalized treatment and the relevant prognostic factors in children with medulloblastoma

    LIHUA CHEN1,2,#, HONGTIAN ZHANG1,2,#, YONG XIA1,2, KAI SUN1, WENJIN CHEN1, RUXIANG XU1,2,*

    BIOCELL, Vol.47, No.5, pp. 1065-1073, 2023, DOI:10.32604/biocell.2023.025924 - 10 April 2023

    Abstract Purpose: The present study summarized cases of children (n = 32) with medulloblastoma (MB) who were treated using stratified therapy based on risk grading and also discussed the factors affecting prognosis. Methods: According to the risk stratification criteria, the cases were divided into the following four risk groups: low, standard, high, and very high. The 5-year overall survival (OS) and progression-free survival (PFS) rates were summarized. Further, the effects on the prognosis of tumor size, tumor stage, degree of resection, treatment mode, metastatic recurrence, molecular typing, and risk stratification were analyzed. Results: In the present study, following… More >

  • Open Access

    REVIEW

    Numerical Analysis of the Mixed Flow of a Non-Newtonian Fluid over a Stretching Sheet with Thermal Radiation

    Nourhan I. Ghoneim1,*, Ahmed M. Megahed2

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.2, pp. 407-419, 2023, DOI:10.32604/fdmp.2022.020508 - 29 August 2022

    Abstract A mathematical model is elaborated for the laminar flow of an Eyring-Powell fluid over a stretching sheet. The considered non-Newtonian fluid has Prandtl number larger than one. The effects of variable fluid properties and heat generation/absorption are also discussed. The balance equations for fluid flow are reduced to a set of ordinary differential equations through a similarity transformation and solved numerically using a Chebyshev spectral scheme. The effect of various parameters on the rate of heat transfer in the thermal boundary regime is investigated, i.e., thermal conductivity, the heat generation/absorption ratio and the mixed convection More >

  • Open Access

    VIEWPOINT

    A need for stratification of metastasis samples according to secondary site in gene expression studies

    IVANA SAMARŽIJA1,2,*

    BIOCELL, Vol.46, No.7, pp. 1747-1750, 2022, DOI:10.32604/biocell.2022.018784 - 17 March 2022

    Abstract Comparisons of gene expression profiles between primary tumors and metastasis have revealed genes that are implicated in metastasis formation. However, gene expression studies conducted on metastasis samples from the same primary site usually do not discriminate between different secondary sites. Although the change in the expression of number of genes is expected to be common to metastasis from the same primary but different secondary sites, herein the data that point to substantial differences are presented. Furthermore, the reciprocal communication between metastatic and host cells that is influencing these differences is outlined to emphasize the need More >

  • Open Access

    ARTICLE

    Assessment of Reversibility in Pulmonary Hypertension Related to Congenital Heart Disease by Using Biomarkers and Clinical Features

    Liping Wang, Mingjie Zhang, Xi Chen, Yachang Pang, Jiaqi Liu, Zhuoming Xu*

    Congenital Heart Disease, Vol.17, No.1, pp. 87-97, 2022, DOI:10.32604/CHD.2022.018452 - 26 October 2021

    Abstract Background: Reversibility of pulmonary hypertension (PH) is closely related to the treatment options for and prognosis of children with congenital heart disease. Objective: We combined patient-specific clinical features including diagnosis, age and echocardiographic results, and biomarkers of pulmonary vascular dysfunction to explore the noninvasive methods that can be used to accurately evaluate the reversibility of pulmonary hypertension in congenital heart disease (PH-CHD). Methods: Based on the preoperative systolic pulmonary arterial pressure (sPAP), 70 CHD patients were divided into normal, PH-CHD suspected, and confirmed groups. Additionally, biomarkers of circulating endothelial cells (CECs), endothelin-1 (ET-1), and endothelial nitric oxide… More >

  • Open Access

    ARTICLE

    Computational Fluid Dynamics Simulation of Indoor Air Quality and Thermal Stratification of an Underfloor Air Distribution System (UFAD) with Various Vent Layouts

    Neil Stephen Lopez1,*, Selena Kay Galeos1, Brian Raphael Calderon1, David Roy Dominguez1, Bryan Joseph Uy1, Rupesh Iyengar2

    FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.2, pp. 333-347, 2021, DOI:10.32604/fdmp.2021.011213 - 02 April 2021

    Abstract The underfloor air distribution (UFAD) system has not been able to penetrate the residential and commercial air conditioning industry significantly until now. To date, the most notable applications are found in datacenters because of their more demanding thermal stratification and cooling requirements. In addition to highlighting the advantages of the UFAD system over the traditional overhead (OH) system, this study compares various ventilation layouts for a UFAD system. Four different UFAD ventilation layouts are compared and one OH layout. The results show that using multiple swirl-type diffusers creates a more uniform floor-to-knee temperature and less More >

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