S. Sivakumar^1,*, L. Jayakumar²

Sound & Vibration, Vol.53, No.6, pp. 277-296, 2019, DOI:10.32604/sv.2019.08099

Abstract This paper elaborates a nonlinear fluidic low frequency vibration isolator designed with the characteristics of quasi-zero stiffness (QZS). The existing model of QZS vibration isolator enhances amplitude of vibration and attenuating vibration frequencies. This concern with displacement plays a vital role in the performance and instability of oblique spring setup reduces the isolator performance in horizontal non-nominal loads, in this accordance; this paper associates double acting hydraulic cylinder (fluidic actuators in short) in oblique and helical coil spring. An approximate expression of unique analytical relationship between the stiffness of vertical spring and bulk modulus of the fluid is derived for… More >

Zhiqiang Huang^{1, 2}, Yufeng Nie^{1, *}, Yiqiang Li¹

CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 245-265, 2020, DOI:10.32604/cmc.2020.06284

Abstract This paper is devoted to the microstructure geometric modeling and mechanical properties computation of cancellous bone. The microstructure of the cancellous bone determines its mechanical properties and a precise geometric modeling of this structure is important to predict the material properties. Based on the microscopic observation, a new microstructural unit cell model is established by introducing the Schwarz surface in this paper. And this model is very close to the real microstructure and satisfies the main biological characteristics of cancellous bone. By using the unit cell model, the multiscale analysis method is newly applied to predict the mechanical properties of… More >

Long Yu¹, Kesong Xu¹, Jun Wan², Haiyan Lu^3,*, Shengzhang Wang^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 835-844, 2019, DOI:10.32604/cmes.2019.07428

Abstract Fractional flow reserve (FFR) computed from computed tomography angiography (CTA), i.e., FFR_CT has been used in the clinic as a noninvasive parameter for functional assessment of coronary artery stenosis. It has also been suggested to be used in the assessment of carotid artery stenosis. The wall thickness of the vessel is an important parameter when establishing a fluid-structure coupling model of carotid stenosis. This work studies the effect of the vessel wall thickness on hemodynamic parameters such as FFR_CT in carotid stenosis. Models of carotid stenosis are established based on CTA image data using computer-aided design software. It is assumed… More >

Cheng Hu^*

Sound & Vibration, Vol.53, No.5, pp. 199-206, 2019, DOI:10.32604/sv.2019.07712

Abstract Taking the complex mechanical systems as the research project, a theoretical multi-degree-of-freedom (MDOF) model was established. Based on the vibration characteristics analysis of this system, a novel method of vibration mitigation was proposed, which can be applied to most of the complex mechanical systems. Through this method, limited grounding stiffness was made use of and added to certain degree of freedom (DOF) discretely. Thus, the root-meansquare (RMS) of the systems amplitude can be reduced to ideal level. The MATLAB code based on this method was attached, which was tested on the theoretical model. Consider that complex mechanical systems are nonlinear… More >

Fan Feng¹, Tingting Xia¹, Runze Zhao¹, Mengyue Wang¹, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 131-131, 2019, DOI:10.32604/mcb.2019.07211

Abstract Objective: To study the effects of different substrate stiffness on human hepatocytes using RNA sequencing (RNA-Seq) technology. The stiffness was corresponding to physiology and pathology stiffness of liver tissues.
Results: With the aid of RNA-Seq technology, our study characterizes the transcriptome of hepatocytes cultured on soft, moderate, stiff and plastic substrates. Compared to soft substrate, our RNA-Seq results revealed 1131 genes that were up-regulated and 2534 that were down-regulated on moderate substrate, 1370 genes that were up-regulated and 2677 down-regulated genes on stiff substrate. Functional enrichment analysis indicated that differentially expressed genes were associated with the regulation of actin… More >

Mengyue Wang¹, Runze Zhao¹, Fan Feng¹, Tingting Xia^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 130-130, 2019, DOI:10.32604/mcb.2019.07154

Abstract Hepatocellular carcinoma (HCC) is the third most common cancer in the world. Previous studies have shown that hard matrix promotes the proliferation of liver tumor cells. However, the role of matrix stiffness on hepatic cancer stem cells (HCSCs) is still unclear. Three-dimensional hydrogels with different stiffness were used to mimic the normal liver tissue (4kPa) and cancerous liver tissue (26kPa) stiffness. The proliferation, stemness and invasion properties of HCSCs under 3D different stiffness were detected. METHOD: HSCSs were screened and cultured by enrichment method, and the effect of matrix stiffness on HCSCs was studied by three-dimensional culture of HCSCs in… More >

Qiuping Liu¹, Guanbin Song^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 127-127, 2019, DOI:10.32604/mcb.2019.07105

Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Increased matrix stiffness of extracellular matrix (ECM) is commonly associated with HCC. During tumour formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumour cells. Yet, the correlation between matrix stiffness and glucose metabolism in the development of HCC remains unknown. In this study, we aim to investigate the effect of matrix stiffness on glucose metabolism and migration of MHCC97L and HepG2 hepatoma cells, and explore the mechanotransduction involved in this process. Polyacrylamide hydrogels with stiffness gradients of 6, 25, 54 kPa were produced… More >

Shaoxiong Yang¹, Xiaobo Gong^1,*, Yingxin Qi², Zonglai Jiang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 9-10, 2019, DOI:10.32604/mcb.2019.05701

Abstract Blood vessels interact with their mechanical environments in a comprehensive way. Local mechanical stimuli outside the biological range play important roles in various human cardiovascular diseases. Although many mechanobiological studies of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in vitro have been reported in mimicking cellular dysfunctions, their quantitative correlations to the in vivo vascular conditions remain unclear. In order to interpret the stress-modulated dysfunctions of vascular cells and explore the key mechanical factors in vascular diseases, it is important to investigate the mechanical environments of vessel walls in vivo under various physiological conditions. Based on nonlinear continuum… More >

Chengquan Wang¹, Yonggang Shen^2,*, Yun Zou¹, Tianqi Li¹, Xiaoping Feng¹

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.1, pp. 75-93, 2018, DOI:10.3970/cmes.2018.114.075

Abstract The failure behavior of the precast prestressed concrete T girder was investigated by destructive test and finite-element analysis, and the mid-span deflection, girder stiffness and the variation of the cross section strain in the loading process were obtained, and the mechanical properties, mechanical behavior, elastic and plastic behavior and ultimate bearing capacity of T girder with large span were revealed. Furthermore, the relationship between the beam stiffness degradation, the neutral axis in cross-section, steel yielding and concrete cracking are investigated and analyzed. A method was proposed to predict the residual bearing capacity of a bridge based on the variation of… More >

D. Shaw, W.L. Su

The International Conference on Computational & Experimental Engineering and Sciences, Vol.18, No.3, pp. 81-82, 2011, DOI:10.3970/icces.2011.018.081

Abstract Linear rolling ball guideway is a key component of many machines. However, due to the point contact between the ball and the groove, stiffness of linear guideway is the major factor which affects the rigidity and precision of machines. Preload in the guideway can increase the stiffness of linear guideway and thus reduces the position deviation under an external load. The purpose of this study is to develop FEA and compare the results with experimental results to prove the correctness of the FEA model. This model can be used to predict the stiffness of linear guideway with 4 rows of… More >