Catalina Vargas-Acevedo¹, Gareth J. Morgan¹, Rhynn Soderstrom², Richard Ing³, Nicholas Houska³, Jenny E. Zablah^1,*

Congenital Heart Disease, Vol.19, No.4, pp. 389-397, 2024, DOI:10.32604/chd.2024.055121 - 31 October 2024

Abstract Introduction: Pulmonary hemorrhage (PHm) is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis (PVS). Inhaled racemic epinephrine (iRE) and tranexamic acid (iTXA) have been used in other conditions, but a standardized approach in PVS has not been described. We aimed to describe the current management of PHm after PVS catheter-based interventions. Methods: We present a retrospective review of episodes of PHm from July 2022 to February 2024. PHm was defined as frank blood suctioned from the endotracheal tube including blood-tinged secretions and >3% decrease in saturations and/or ventilatory… More >

Toshi Maeda^*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945 - 16 May 2024

Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

Salah Alzghoul^1,*, Othman Smadi¹, Ali Al Bataineh², Mamon Hatmal³, Ahmad Alamm⁴

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 455-470, 2023, DOI:10.32604/iasc.2023.038338 - 29 April 2023

Abstract Currently, the decision of aortic valve replacement surgery time for asymptomatic patients with moderate-to-severe aortic stenosis (AS) is made by healthcare professionals based on the patient’s clinical biometric records. A delay in surgical aortic valve replacement (SAVR) can potentially affect patients’ quality of life. By using ML algorithms, this study aims to predict the optimal SAVR timing and determine the enhancement in moderate-to-severe AS patient survival following surgery. This study represents a novel approach that has the potential to improve decision-making and, ultimately, improve patient outcomes. We analyze data from 176 patients with moderate-to-severe aortic… More >

Vitaliy Suvorov^*, Vladimir Zaitsev, Nikolay Pilyugov, Olga Tereshenko, Michail Komissarov

Congenital Heart Disease, Vol.18, No.1, pp. 57-65, 2023, DOI:10.32604/chd.2023.025522 - 09 January 2023

Abstract Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with the onset of symptoms during first hours after birth. We present a clinical case of a successful surgical correction of a critical aortic stenosis using a hybrid method applied in a newborn during the first day of life. The infant was diagnosed with a hypoplastic left heart complex with an intact atrial septum (aortic and mitral valves stenosis variant), that led to the cardiogenic shock and acute pulmonary edema. The procedure included bilateral banding of the pulmonary artery branches and More > Graphic Abstract

PANKE CHEN^*, SHUAI MA

BIOCELL, Vol.46, No.8, pp. 1903-1909, 2022, DOI:10.32604/biocell.2022.018651 - 22 April 2022

Abstract This work aimed to investigate the effects of calcitonin gene-related peptide (CGRP)-modified mesenchymal stem cells (MSCs) on vascular stenosis in carotid balloon-injured rats. The CGRP gene labeled with EGFP was transfected into bone marrow MSCs, and CGRP protein expression in MSCs was confirmed by immunofluorescence assays. A rat carotid balloon injury model was established using a surgical method. CGRP-modified MSCs were orthotopically transplanted into the injured area of the rats. At 28 days after cell transplantation, EGFP and CD31 expression was detected by immunofluorescence staining. Hematoxylin-eosin (H&E) staining was used to detect the intima/media area… More >

Olivia Lenoir^1,2, Daniel Quandt^1,2, Oliver Kretschmar^1,2, Walter Knirsch^1,2,*

Congenital Heart Disease, Vol.17, No.2, pp. 161-172, 2022, DOI:10.32604/chd.2022.016598 - 26 January 2022

Abstract Objectives: Factors influencing results of balloon valvuloplasty (BVP) of pulmonary valve stenosis (PS) in children are investigated. Background: BVP has become the standard of care for PS, medium-term results are not uniform and depend on various preconditions. Methods: We analysed the medium-term results of BVP of PS in children in an observational, single centre study. Need for additional procedure was defined as outcome after initial BVP. Results: We included 143 children (83 female) at a median (IQR) age of 2.6 (0.26–9.24) months and body weight of 5 (3.4–8) kg at BVP with a follow–up of 5.04 (1.6–10.2)… More >

Din Prathumwan¹, Inthira Chaiya², Kamonchat Trachoo^2,*

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3645-3657, 2021, DOI:10.32604/cmc.2021.018241 - 24 August 2021

Abstract Lumbar spine stenosis (LSS) is a narrowing of the spinal canal that results in pressure on the spinal nerves. This orthopedic disorder can cause severe pain and dysfunction. LSS is a common disabling problem amongst elderly people. In this paper, we developed a finite element model (FEM) to study the forces and the von Mises stress acting on the spine when people bend down. An artificial lumbar spine (L3) was generated from CT data by using the FEM, which is a powerful tool to study biomechanics. The proposed model is able to predict the effect… More >

Milica Karadzic Kocica¹, Hristina Ugrinovic¹, Dejan Lazovic², Nemanja Karamarkovic², Milos Grujic², Borivoje Lukic³, Oliver Radmili³, Vladimir Cvetic³, Mladen Kocica^2,*

Congenital Heart Disease, Vol.16, No.6, pp. 647-653, 2021, DOI:10.32604/CHD.2021.016923 - 08 July 2021

Abstract A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches. By presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery, we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare More >

Haoyu Wan, Heng Zhang, Zhizhu He^*

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.3, pp. 639-651, 2021, DOI:10.32604/fdmp.2021.012106 - 29 April 2021

Abstract Treating coronary bifurcation stenosis is still a challenging task. Existing procedures still display a relatively small rate of success. This paper aims to investigate numerically the effect of bifurcation lesions with different structures on the dynamics of blood flow and related temperature. The problem geometry is parametrically varied by changing the bifurcation angle and radius. A finite volume method is used to simulate the three-dimensional flow. The effects induced by the structure of the stenosis, the artery bifurcation angle and radius, and the inlet velocity of blood are discussed in terms of flow pattern, pressure More >

Adi Azriff Basri^1,6,*, Mohammad Zuber², Ernnie Illyani Basri¹, Muhammad Shukri Zakaria⁵, Ahmad Fazli Abd Aziz³, Masaaki Tamagawa⁴, Kamarul Arifin Ahmad^1,6

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.3, pp. 531-553, 2021, DOI:10.32604/fdmp.2021.010925 - 29 April 2021

Abstract Paravalvular Leakage (PVL) has been recognized as one of the most dangerous complications in relation to Transcathether Aortic Valve Implantation (TAVI) activities. However, data available in the literature about Fluid Structure Interaction (FSI) for this specific problem are relatively limited. In the present study, the fluid and structure responses of the hemodynamics along the patient aorta model and the aortic wall deformation are studied with the aid of numerical simulation taking into account PVL and 100% TAVI valve opening. In particular, the aorta without valve (AWoV) is assumed as the normal condition, whereas an aorta… More >