Miao Huang¹, Maedeh Lotfi¹, Heyang Wang⁴, Hayley Sussman⁵, Kevin Connell¹, Quang Vo¹, Malisa Sarntinoranont¹, Hitomi Yamaguchi¹, Juan Guan², Xin Tang^1,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011130

Abstract Mechanotransduction, i.e., living cells sense and transduce mechanical forces into intracellular biochemical signaling and gene expression, is ubiquitous across diverse organisms. Increasing evidence suggests that mechanotransduction significantly influences cell functions and its mis-regulation is at the heart of various pathologies. A quantitative characterization of the relationship between mechanical forces and resulted mechanotransduction is pivotal in understanding the rules of life and innovating new therapeutic strategies [1-3]. However, while such relationship on the cell surface membrane and cytoskeleton have been well studied, little is known about whether/how mechanical forces applied on the cell interior nucleus (“headquarter… More >

Shuyu Chen^1,*, Jun Zeng¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.2, pp. 1-2, 2023, DOI:10.32604/icces.2023.09672

Abstract The engineering application prospects of soft materials in key areas such as aerospace and life science have stimulated extensive research interests in the academic community. An important topic here is to predict the service and failure behavior of such materials. Although considerable progress has been made, realworld application scenarios usually involve bi-material as well as multi-material adhesion, with cohesive interface rupture as the main failure vehicle. Inconsistent asymptotic solutions in the context of large deformations pose obstacles to the establishment of a theoretical framework for the interface fracture problem in soft materials [1]. Driven by… More >

B Keerthika¹, Y P Cao², D Raabe¹

CMC-Computers, Materials & Continua, Vol.10, No.3, pp. 243-258, 2009, DOI:10.3970/cmc.2009.010.243

Abstract In this study, effects of the plastic deformation and the time-dependent deformation behavior on the fundamental relations in the Oliver & Pharr method are studied by using finite element analysis based on a viscoelastic-plastic model developed for polymers. The study eventually yields an experimental protocol and using which, the instantaneous modulus of the viscoelastic-plastic materials may be reliably determined. Experiments have been performed on four polymers to verify the conclusions from the numerical analysis. More >