Hyung Seok Kim^1,#, Ju A Son^2,#, Minji Kang^3,4,#, Soon Sun Kim³, Geum Ok Baek³, Moon Gyeong Yoon³, Se Ha Jang^3,4, Dokyung Jung⁵, Ji Eun Han³, Jae Youn Cheong^3,*, Jung Woo Eun^3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070392 - 19 January 2026

Abstract Objectives: Early detection of hepatocellular carcinoma (HCC) is a significant challenge due to the limited sensitivity of alpha-fetoprotein (AFP). This study aimed to assess serum-derived extracellular vesicle-encapsulated GULP PTB domain-containing engulfment adaptor 1 (EV-GULP1) as a novel, noninvasive biomarker for HCC detection and prognosis, leveraging the potential of tumor-specific molecules carried by small extracellular vesicles (EVs). Methods: The study utilized both internal and external cohorts of HCC patients and controls. Small EVs were isolated from serum samples, then characterized and validated to confirm their identity. The expression levels of EV-GULP1 were quantified using quantitative reverse transcription… More >

Karim Dorgham¹, Omaira Da Mata Jardin¹, Clara Mellot^1,2, Suzanne Mouries-Martin^1,2, Maude Calixte^1,2, Ngoc Khanh Nguyen¹, Raphael Lhote², Julien Haroche^1,2, Fleur Cohen-Aubart^1,2, Micheline Pha², Miguel Hié², Matthias Papo², François Chasset^1,2,3, Pascale Ghillani-Dalbin⁴, Hans Yssel¹, Zahir Amoura^1,2, Guy Gorochov^1,4, Alexis Mathian^1,2

European Cytokine Network, Vol.36, No.2, pp. 15-23, 2025, DOI:10.1684/ecn.2025.0502 - 27 January 2026

Abstract Background: Type I interferons, which play an important role in the pathogenesis of various autoimmune diseases such as systemic lupus erythematosus (SLE), are expressed at very low levels under physiological conditions. In this study, we focused on IFN-beta (IFN-β) for its potential use as a biomarker of SLE activity and compared three different technologies for its quantification in the serum of healthy donors and patients with SLE. Methods: A total of 93 serum samples from healthy donors and 463 serum samples from lupus patients were tested using either ELISA, digital ELISA based on Single Molecule Array… More >

Abdulbari Bener^1,2,*, Ünsal Veli Üstündağ³, Emir Barışık⁴, Cem Cahit Barışık⁵

Canadian Journal of Urology, Vol.32, No.5, pp. 401-409, 2025, DOI:10.32604/cju.2025.067184 - 30 October 2025

Abstract Objectives: The evidence remains insufficient and controversial for evaluating modifiable parameters—such as vitamin D, calcium, ferritin, and uric acid—as preclinical biomarkers to contribute to the prevention and early diagnosis of prostate cancer, a disease with a prevalence of up to 10%–20% in men over 50 and strongly associated with environmental factors including diet (high in fat and red meat), obesity, physical inactivity, and carcinogen exposure. This study aims to investigate the potential biomarker role of vitamin D, calcium, ferritin, and uric acids in reducing the risk of prostate cancer (PCa). Methods: The case-control design was… More >

Eleni Kokkotou^*, Andriani Charpidou, Nikolaos Syrigos

Oncology Research, Vol.33, No.10, pp. 2657-2672, 2025, DOI:10.32604/or.2025.066228 - 26 September 2025

Abstract Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) serve an essential role in tumor angiogenesis and have emerged as potential therapeutic targets in lung cancer. This review explores the significance of serum VEGF levels as a predictive biomarker in non-small cell lung cancer (NSCLC). The VEGF family, consisting of VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor (PlGF), engages with specific receptors, including tyrosine kinase receptors (VEGFR-1, VEGFR-2, and VEGFR-3) and neuropilin receptors (NRP-1 and NRP-2), to promote angiogenesis and lymphangiogenesis. VEGF-A, the primary component of the VEGF family, binds to VEGFR-2 to stimulate… More >

Almagul Kurmanova^1,2, Gulfairuz Urazbayeva³, Laura Kayupova², Damilya Salimbaeva², Nurzhamal Dzhardemalieva⁴

European Cytokine Network, Vol.35, No.2, pp. 21-27, 2024, DOI:10.1684/ecn.2024.0497

Abstract The aim of the present study was to evaluate the diagnostic significance of the dynamics of cytokines and growth factors during pregnancy with and without preeclampsia. The study included 168 pregnant women at risk of hypertensive disorders. The levels of biomarkers of all pregnant women were studied at 12-16 weeks, 28-30 weeks and 36-38 weeks. These included cytokines (tumour necrosis factor-α, interferon-γ, interleukin-4) and growth factors (placental growth factor, vascular endothelial growth factor). All pregnant women were divided into two groups: 124 patients with preeclampsia and 44 without preeclampsia (control group). In patients with preeclampsia,… More >

YAN ZHANG, HEYANG ZHANG, JING WANG, XIN WEI, YI QU, FENG XU, LIJUN ZHANG^*

Oncology Research, Vol.32, No.5, pp. 955-963, 2024, DOI:10.32604/or.2023.043922 - 23 April 2024

Abstract Background: Bortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN. Methods: A next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR (RT-qPCR). Serum homocysteine (Hcy) levels were detected in 40 samples… More > Graphic Abstract

Mohammad Reza Haghshenas¹, Zahra Shiravani², Mohammad Samare-Najaf³, Soolmaz Khansalar¹, Seyed Ali Razavinasab⁴, Abbas Ghaderi¹, Navid Jamali⁵

European Cytokine Network, Vol.34, No.4, pp. 63-69, 2023, DOI:10.1684/ ecn.2023.0491

Abstract Background: Endometrial cancer (EC) is recognized as the second most common type of cancer among women. Interleukin-37 (IL-37) is a recently discovered member of the IL-1 cytokine family characterized by its anti-inflammatory properties, which are believed to have both anti-tumour and tumorigenic effects. However, the precise role of IL-37 in the development of EC remains largely unknown. Objective: In the current study, we aimed to explore genotype and allele frequencies of the IL-37 gene (rs4241122) and measure IL-37 protein levels in patients with EC, with a view to determining the clinical significance in these patients. Methods: A… More >

S. E. Burruel-Ibarra¹, R. A. Esquer-Osuna², R. G. Valdez-Melchor², D. A. Cuevas-Acuña², L. QuihuiCota³, J. Juárez⁴, J. C. Campos-García², E. Valbuena-Gregorio², M. A. López-Mata^2,*

Journal of Renewable Materials, Vol.11, No.6, pp. 2647-2663, 2023, DOI:10.32604/jrm.2023.027372 - 27 April 2023

Abstract This study aimed to characterize the physical-chemical and biological properties of pectin (PC)/chia seed mucilage (CM) membranes. PC/CM [100/0 (control), 80/20%, 60/40%, and 40/60% w/w] membranes were prepared using the casting method. The membranes (PC/CM) were thin, yellow, lightly opaque (≈10%) and capable of blocking light UVB (between 66 at 52%). SEM analysis showed the presence of aggregates in the shape of a sphere (≈13 µm) and ovoid (≈25 µm). The proportion of 80/20 showed an increase in tensile strength (29%) and elastic modulus (19%) when compared to the control. FTIR analysis exhibited intermolecular interactions More > Graphic Abstract

Yao Wu^1,2,#, Bin Qu^1,#, Haoming Shen¹, Hongyu Deng¹, Faqin Tang^1,*

Oncologie, Vol.24, No.3, pp. 499-512, 2022, DOI:10.32604/oncologie.2022.024951 - 19 September 2022

Abstract Background: Tumor-specific growth factor (TSGF) is associated with invasion and metastasis of various malignancies and adverse clinical outcomes. TSGF is also highly expressed in cervical cancer (CC), but its clinical value is unclear. Materials and Methods: Serum samples from malignancies, including CC, non-Hodgkin’s lymphoma (NHL), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC), lung cancer (LCA), ovarian cancer (OC), breast cancer (BC), gastric carcinoma (GC), and pancreatic cancer (PC) were collected, and TSGF was detected using a chemiluminescence assay. The patients with CC were followed-up over five years, and their clinicopathological parameters were analyzed. Meanwhile, the pre- and post-treatment… More >

Xinyue Wang^1,#, Jing Xu^1,#, Qihong Gu¹, Dingxuan Tang¹, Huoyan Ji², Shaoqing Ju², Feng Wang^2,*, Lin Chen³, Ruoyu Yuan^2,*

Oncologie, Vol.24, No.3, pp. 513-526, 2022, DOI:10.32604/oncologie.2022.024373 - 19 September 2022

Abstract Background: MicroRNAs (miRNAs) have been identified as promising novel biomarkers for cancer diagnosis and prognosis, especially for hepatocellular carcinoma (HCC). Nowadays, the expression level of miR-21 in serum samples is a diagnostic indicator for HCC diagnosis. Thus, the quantitative determination of miRNA concentration is of significance in clinical practice. It is particularly important to establish an analytical detection method for miR-21 in patient serum. Methods: The signal readout for miR-21 was based on the mass response of a reporter peptide using an isotope dilution mass spectrometry (MS) method in this work. To be more specific, miR-21… More >