Hui Yao¹, Liqun Wang³, Jia Guo¹, Weimin Liu⁴, Jingjing Li¹, Yingxiao Wang², Linhong Deng^1,*, Mingxing Ouyang^1,2,3,*

Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 101-111, 2020, DOI:10.32604/mcb.2020.09595 - 01 July 2020

Abstract Prostate cancer is the most common cancer among men beyond 50 years old, and ranked the second in mortality. The level of Prostate-specific antigen (PSA) in serum has been a routine biomarker for clinical assessment of the cancer development, which is detected mostly by antibody-based immunoassays. The proteolytic activity of PSA also has important functions. Here a genetically encoded biosensor based on fluorescence resonance energy transfer (FRET) technology was developed to measure PSA activity. In vitro assay showed that the biosensor containing a substrate peptide ‘RLSSYYSGAG’ had 400% FRET change in response to 1 µg/ml… More >

Jun-Ying Wang^*, Xin Jin^*, Xiao-Feng Li^†

Oncology Research, Vol.26, No.1, pp. 95-101, 2018, DOI:10.3727/096504017X14920318811695

Abstract TMPRSS3 belongs to the large type II transmembrane serine protease (TTSP) family, which plays an important role in the development and progression of tumors. However, the function of TMPRSS3 in nasopharyngeal carcinoma (NPC) remains unclear. The present study aimed to examine the impact of TMPRSS3 on the proliferation, migration, and invasion of NPC cells and their potential mechanisms. Our results demonstrated that the expression of TMPRSS3 was obviously upregulated in human NPC tissues and cell lines. Knockdown of TMPRSS3 expression significantly suppressed the proliferation and tumorigenicity of NPC cells in vitro and in vivo. Furthermore, More >

Emma Lefrançais^1,2, Corinne Cayrol^1,2

European Cytokine Network, Vol.23, No.4, pp. 120-127, 2012, DOI:10.1684/ecn.2012.0320

Abstract Interleukin-33 (IL-33) is the latest member of the IL-1 family that has become very attractive since the discovery of its major target cells, the innate lymphoid cells type 2 (ILC2), involved in the initiation of the type 2 immune response (secretion of IL-5 and IL-13) during parasitic infection and allergic diseases such as asthma. IL-33 is a chromatin-associated protein as it possesses in its N-terminus, a chromatin-binding domain, and is constitutively expressed in the nuclei of endothelial cells and in epithelial cells of tissues exposed to the environment. It is however, essential for IL-33 to… More >

Atefeh Golpaie^1,2, Narges Tajik^1,2, Farzad Masoudkabir³, Zohreh Karbaschian¹, Mohammad Talebpour^2,4, Mostafa Hoseini⁵, Mohammad Javad Hosseinzadeh-Attar^1,2

European Cytokine Network, Vol.22, No.4, pp. 181-186, 2011, DOI:10.1684/ecn.2011.0295

Abstract Background. The aims of this study were to evaluate the short-term effects of laparoscopic restrictive bariatric surgery (LRBS) on plasma levels of vaspin and the potential associations of changes in vaspin levels with changes in anthropometric indices, insulin-resistance and dietary intake. Methods. Thirty, severely obese subjects (21 female; mean age, 32.5 years) with a mean body mass index (BMI) of 44.1 ± 4.9 kg/m² underwent LRBS. Measurements of anthropometric indices, dietary intakes, physical activity and plasma vaspin concentrations were performed prior to, and six weeks after LRBS. Insulin-sensitivity was estimated using the homeostasis model assessment of… More >