Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Zhongrui Jing¹, Hongzhang Yang^1,*, Jiangpu Guo²

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-25, 2026, DOI:10.32604/cmc.2025.067759 - 09 December 2025

Abstract Hard disk drives (HDDs) serve as the primary storage devices in modern data centers. Once a failure occurs, it often leads to severe data loss, significantly degrading the reliability of storage systems. Numerous studies have proposed machine learning-based HDD failure prediction models. However, the Self-Monitoring, Analysis, and Reporting Technology (SMART) attributes differ across HDD manufacturers. We define hard drives of the same brand and model as homogeneous HDD groups, and those from different brands or models as heterogeneous HDD groups. In practical engineering scenarios, a data center is often composed of a heterogeneous population of… More >

Jinyou Qiu^1,2, Jiale Liu^1,2, Yubing Li^1,2,*, Shaogeng Zhong³, Guilong Dai^1,2, Wenhua Liu⁴

Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 2025-2049, 2025, DOI:10.32604/fhmt.2025.072260 - 31 December 2025

Abstract The growing demand for energy-saving and renewable heating solutions has made photovoltaic/thermal (PV/T) heat pump systems a promising technology. However, their thermal and electrical performance, as well as the overall utilization of solar energy, strongly depend on capacity configuration and operating parameters. To address this issue, this study proposes a PV/T heat pump system featuring a novel rhombic flow channel structure that functions as the collector-evaporator. An experimental test bench was established to evaluate system performance, and a one-dimensional numerical model was developed to investigate the effects of environmental and operating parameters. The simulation results… More > Graphic Abstract

Mujahid Islam¹, Fateh Ali^1,*, Xinlong Feng^1,*, M. Zahid², Sana Naz Maqbool¹

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3511-3561, 2025, DOI:10.32604/cmes.2025.073678 - 23 December 2025

Abstract Roll coating is a vital industrial process used in printing, packaging, and polymer film production, where maintaining a uniform coating is critical for product quality and efficiency. This work models non-isothermal Carreau fluid flow between a rotating roll and a stationary wall under fixed boundary constraints to evaluate how non-Newtonian and thermal effects influence coating performance. The governing equations are transformed into non-dimensional form and simplified using lubrication approximation theory. Approximate analytical solutions are obtained via the perturbation technique, while numerical results are computed using both the finite difference method and the BVP-Midrich technique. Furthermore, More >

Sh. B. Utamuradova^a, F. A. Giyasova^b, M. S. Paizullakhanov^c, S. Yu. Gerasimenko^d, M. A. Yuldoshev^e,g,*, S. R. Boydedayev^g, M. R. Bekchanova^h

Chalcogenide Letters, Vol.22, No.8, pp. 753-764, 2025, DOI:10.15251/CL.2025.228.753

Abstract Based on the experimental data, the results of the study of photoelectric and gain characteristics of modified multi-barrier photodiode Au-nCdS-nSi-pCdTe-Au structures are presented, which are obtained by the method of vacuum evaporation in a quasi-closed volume by sputtering cadmium sulfide and cadmium telluride layers on a silicon substrate with a specific resistance of 607.47 Ohm⋅cm. It is shown that the structures in the passing direction of the current at low illumination levels operate as injection photodiodes, and also the optical spectral range (0.3÷0.95 μm) covers from the nSi-pCdTe-Au side and (1.0÷1.4 μm) from the Au-nCdS-nSi More >

Rym Akrout¹, Ludovic Leloup², Khouloud Ayed¹, Fabrice Parat², Sami Zekri^3,4, Wassim Y. Almawi¹, Rahma Boughriba¹, Hanen Attia¹, Olfa Masmoudi-Kouki⁴, Hervé Kovacic^2,*, Asma Gati^1,*

Oncology Research, Vol.33, No.12, pp. 3887-3906, 2025, DOI:10.32604/or.2025.070729 - 27 November 2025

Abstract Objectives: Cisplatin (CDDP) therapy for glioblastoma (GBM) is linked with several limitations, which include poor penetration of the blood-brain barrier (BBB), systemic toxicity, and the development of drug resistance mechanisms implicating oxidative stress dysregulation and compromised apoptotic pathways. This study evaluates C-Phycocyanin (C-PC) as a potential adjuvant to enhance CDDP efficacy by modulating redox balance and apoptosis. Methods: GBM cells (U87 and U87-EGFRvIII) were treated with CDDP, C-PC, or their combination. Cell viability was assessed by MTT assay; apoptosis was evaluated by DAPI staining and Western blot analysis of cleaved Caspase-3 and poly (ADP-ribose) polymerase… More > Graphic Abstract

Hongrong Wang^1,2, Xinjian Li^3,4, Xingjing She¹, Wenjian Ma^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2039-2055, 2025, DOI:10.32604/cmes.2025.072572 - 26 November 2025

Abstract In modern complex systems, real-time regression prediction plays a vital role in performance evaluation and risk warning. Nevertheless, existing methods still face challenges in maintaining stability and predictive accuracy under complex conditions. To address these limitations, this study proposes an online prediction approach that integrates event tracking sensitivity analysis with machine learning. Specifically, a real-time event tracking sensitivity analysis method is employed to capture and quantify the impact of key events on system outputs. On this basis, a mutual-information–based self-extraction mechanism is introduced to construct prior weights, which are then incorporated into a LightGBM prediction More >

Mutamba Ropafadzo Peace¹, Thobeka Madide^1,2, Ntethelelo Sibiya^1,*

BIOCELL, Vol.49, No.11, pp. 2069-2091, 2025, DOI:10.32604/biocell.2025.068017 - 24 November 2025

Abstract The pathogenesis of insulin resistance is influenced by environmental factors, genetic predispositions, and several medications. Various drugs used to manage multiple ailments have been shown to induce insulin resistance, which could lead to Type II Diabetes mellitus (T2DM). Central to drug-induced insulin resistance is mitochondrial dysfunction. Amongst disturbed pathways in drug-induced mitochondrial toxicity is mitophagy, a process that removes dysfunctional mitochondria through the lysosomal pathways to maintain mitochondrial quality. A balance must always be maintained between mitochondrial dynamics and mitophagy, as any alterations may contribute to the pathogenesis of metabolic diseases such as diabetes mellitus.… More >

Hakgweon Lee¹, Youngho Kim^2,*

International Journal of Mental Health Promotion, Vol.27, No.9, pp. 1411-1421, 2025, DOI:10.32604/ijmhp.2025.069543 - 30 September 2025

Abstract Background: It has been broadly witnessed that a large number of adolescents are suffering emotional and mental health problems after COVID-19, and such adverse experiences in early life often extend into adulthood, resulting in serious long-term implications. However, it is accepted that the literature examining the relationship between mental health problems in adolescents and their underlying psychological factors is limited. The purposes of the current study were to identify mental health problems of Korean adolescents and to investigate the possible influence of self-esteem, self-efficacy, and health locus of control on mental health problems. Methods: A… More >

Azhar Iqbal Kashif Butt^1,*, Tariq Ismaeel^2,*, Sara Khan², Muhammad Imran³, Waheed Ahmad², Ismail Abdulrashid⁴, Muhammad Sajid Riaz⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3463-3492, 2025, DOI:10.32604/cmes.2025.069277 - 30 September 2025

Abstract Malaria is a significant global health challenge. This devastating disease continues to affect millions, especially in tropical regions. It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes. This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria, incorporating both human and mosquito populations. We aim to identify the key factors driving the endemic spread of malaria, determine feasible solutions, and provide insights that lead to the development of effective prevention and management strategies. We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and… More >