Haowen Liang¹, Jiaming Bai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012563

Abstract Defects are pivotal in influencing the mechanical performance of the hydroxyapatite (HAp) porous structure. In vat photopolymerization (VP) fabrication, directly peeling HAp/polymer green structure from the platform is an efficient approach but often introduces defects, compromising the mechanical performance of sintered HAp scaffolds. The peeling process is a physical phenomenon where the photocured HAp/polymer green structure exhibits resistance against applied peeling forces, which is influenced by its modulus and toughness. In this study, the peeling behavior of cubic-pore HAp (CP-HAp) green structures with varying levels of modulus and toughness was investigated in detail. The characterization… More >

Dmitry Bratsun^*, Natalia Elenskaya, Ramil Siraev, Mikhail Tashkinov

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1463-1479, 2024, DOI:10.32604/fdmp.2024.047928 - 23 July 2024

Abstract In this work, we numerically study the hydrodynamic permeability of new-generation artificial porous materials used as scaffolds for cell growth in a perfusion bioreactor. We consider two popular solid matrix designs based on triply periodic minimal surfaces, the Schwarz P (primitive) and D (diamond) surfaces, which enable the creation of materials with controlled porosity gradients. The latter property is crucial for regulating the shear stress field in the pores of the scaffold, which makes it possible to control the intensity of cell growth. The permeability of functionally graded materials is studied within the framework of… More > Graphic Abstract

ZEHRA GÜL MORÇIMEN¹, ŞEYMA TAŞDEMIR², AYLIN ŞENDEMIR^3,4,*

BIOCELL, Vol.48, No.1, pp. 79-96, 2024, DOI:10.32604/biocell.2023.045361 - 30 January 2024

Abstract Neurodegeneration is a catastrophic process that develops progressive damage leading to functional and structural loss of the cells of the nervous system and is among the biggest unavoidable problems of our age. Animal models do not reflect the pathophysiology observed in humans due to distinct differences between the neural pathways, gene expression patterns, neuronal plasticity, and other disease-related mechanisms in animals and humans. Classical in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting the complex pathophysiology of neurodegenerative diseases. Today, modern, engineered techniques are applied to develop multicellular, intricate in vitro More >

Soliman Abdalla^1,2,*, Shiref Kandil²

Journal of Renewable Materials, Vol.10, No.11, pp. 2699-2716, 2022, DOI:10.32604/jrm.2022.022334 - 29 June 2022

Abstract In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get More >

FABIANO BINI^1,*, ANDRADA PICA¹, ANDREA MARINOZZI², FRANCO MARINOZZI¹

BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150 - 13 June 2022

Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization More >

MASSIMO CONESE^1,*, AURELIO PORTINCASA²

BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448 - 22 April 2022

Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound More >

GIORDANO WOSGRAU CALLONI^1,*, MARCO AUGUSTO STIMAMIGLIO^2,*

BIOCELL, Vol.46, No.6, pp. 1375-1381, 2022, DOI:10.32604/biocell.2022.019681 - 07 February 2022

Abstract Mesenchymal stem cells (MSCs) and their byproducts have been widely validated as potential therapeutic products for regenerative medicine. The therapeutic effects result mainly from the paracrine activity of MSCs, which consists of the secretion of bioactive molecules, whether dispersed in medium conditioned by cell culture or encapsulated in extracellular vesicles. The composition of the MSC secretome, which represents the set of these secreted cellular products, is crucial for the performance of the desired therapeutic functions. Different cell culture strategies have been employed to adjust the secretome composition of MSCs to obtain the best therapeutic responses More >

OK-HYEON KIM^1,2,#, EUN RAN KIM^3,#, JUN HYUNG PARK², HYUN JUNG LEE^1,2,*

BIOCELL, Vol.46, No.6, pp. 1439-1443, 2022, DOI:10.32604/biocell.2022.018921 - 07 February 2022

Abstract Exogenously delivered mesenchymal stromal cells (MSCs) are therapeutically beneficial owing to their paracrine effect; they secrete various cytokines, nucleic acids, and proteins. Multiple bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions (both structurally and functionally). Various scaffolds mimic the natural extracellular matrix (ECM) using both natural and synthetic polymers, providing favorable environments for MSC proliferation and differentiation. Depending on material properties, either topographically or elastically structured scaffolds can be fabricated. Three-dimensional scaffolds have tunable substrate rigidities and structures, aiding MSC cultivation. Decellularized ECM-derived hydrogels are similar to the More >

Qingxi Hu^1,2,3, Yiming Wang¹, Dongchao Yang⁴, Haiguang Zhang^1,2,3,*, Zhicheng Song⁴, Yan Gu^4,*

Journal of Renewable Materials, Vol.9, No.1, pp. 1-16, 2021, DOI:10.32604/jrm.2021.013319 - 30 November 2020

Abstract Acellular dermal matrix (ADM) as a biomaterial is currently believed to be promising tissue repair improvement. With the development of tissue engineering, ADM is increasingly used as biological scaffolds. We explored the feasibility and performance of ADM biological scaffolds that fabricated by 3D printing. This paper presented our study on the printability of 3D printed ADM scaffolds, with a focus on identifying the influence of printing parameters/conditions on printability. To characterize the printability, we examined the fiber morphology, pore size, strand diameter, and mechanical property of the printed scaffolds. Our results revealed that the printability… More >

Xiaodong Wang^1,2, Meng Su², Chuntai Liu², Changyu Shen², Xianhu Liu^2,*

Journal of Renewable Materials, Vol.8, No.1, pp. 89-99, 2020, DOI:10.32604/jrm.2020.08493 - 01 January 2020

Abstract Poly (vinyl alcohol) (PVA)/reduced graphene oxide (rGO) nanocomposites is prepared by the immersion of PVA/graphene oxide (GO) nanocomposites in the reducing agent aqueous solution. The PVA/graphene nanocomposites can be used as scaffold after treatment by chemical crosslinking agents. The surface hydrophilicity of the nanocomposite scaffolds decreased with the addition of GO or rGO by measuring the contact angles of scaffolds. The electrical conductivity of PVA/rGO nanocomposite scaffold increased with rGO content increased. The highest conductivity of PVA/rGO nanocomposite scaffolds with 10 wt% rGO could reach to 12.16 × 10⁻³ S/m. The NIH-3T3 fibroblasts attach and grow More >