NILAM BHUSARE, MAUSHMI KUMAR^*

Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

ZONGQIAN WANG, HAIWEI YANG, JIAN XING, ZHI LIU^*

Journal of Polymer Materials, Vol.36, No.2, pp. 149-159, 2019, DOI:10.32381/JPM.2019.36.02.4

Abstract Colored silk fibroin (SF) film can change the proportion of transmitted light composition and therefore shows potential application in optoelectronics area. However, few methods are reported for the preparation of colored SF film with good color fastness. Herein, colored SF film was prepared by coupling modification dyeing (CM-dyeing) of SF tyrosine residues in solution. SF film shows excellent color fastness due to the formation of the azo covalent bond formed by electrophilic substitution reaction between SF tyrosine residues and aniline diazonium salt. Furthermore, compared with the undyed film, the dyed SF film is effectively preserved its mechanical property by the… More >

WEIXUE WANG^#, TONGTONG WANG^#, YAN ZHANG, TING DENG, HAIYANG ZHANG^*, YI BA^*

Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

Zhengqing Ding, Quan Yang, Xinyan Yan, Feng Gu, Xujuan Huang^*, Zhaosheng Cai^*

Journal of Renewable Materials, Vol.12, No.1, pp. 103-117, 2024, DOI:10.32604/jrm.2023.029424

Abstract Dehydroabietyl polyethylene glycol glycidyl ether-grafted hydroxyethyl cellulose (HEC) polymer surfactant (DA(EO)₅GE-g-HEC) was prepared using ring-opening polymerization with biobased rosin and hydroxyethyl cellulose as feedstocks. Dehydroabietyl polyethylene glycol glycidyl ether (DA(EO)₅GE) was formed by condensation of dehydroabietyl alcohol polyoxyethylene ether (Rosin derivative: DA(EO)₅H) and epichlorohydrin. The grafting degree of DA(EO)₅GE-g-HEC was manipulated by adjusting the mass ratio of HEC and DA(EO)₅GE and confirmed by EA. According to the formula, when m_(HEC)/m_(DA(EO)2GE) was 1:1~1:5, the grafting rate of DA(EO)₅GE in DA(EO)₅GE-g-HEC varied from 34.43% to 38.33%. The surface activity and foam properties of DA(EO)₅GE-g-HEC aqueous solution were studied. The results showed that… More > Graphic Abstract

Yanli Liu^1,2, Fengzhen Han², Jian Zhuang⁴, Yanqiu Ou⁴, Yanji Qu⁵, Yanyan Lin², Weina Zhang², Haiping Wang^3,*, Liping Huang^1,*

Congenital Heart Disease, Vol.18, No.5, pp. 561-570, 2023, DOI:10.32604/chd.2023.030511

Abstract Background: Research on fetal congenital heart defect (CHD) mostly focuses on etiology and mechanisms. However, studies on maternal complications or pathophysiology are limited. Our objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart defects. Methods: We conducted a case-control study. 27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were selected. Every case was matched with about 2 pregnant complication-free controls without fetal abnormalities. The proangiogenic and anti-angiogenic factors and pregnancy outcomes were compared. Results: The proangiogenic factors… More > Graphic Abstract

CHANGMEI LONG, TINGTING YANG, YUJIE HAN, LIZHEN HAN^*

BIOCELL, Vol.47, No.6, pp. 1417-1430, 2023, DOI:10.32604/biocell.2023.027485

Abstract Background: The plant-growth-promoting rhizobacterium Tsukamurella tyrosinosolvens is a rare strain of actinomycete, in order to recognize and expand the ecological functions of rare actinomycetes. Methods: In this experiment, we studied the effect of Tsukamurella tyrosinosolvens P9 on the drought resistance of peanut by inoculating peanut seedlings in pots and measuring the growth and physiological indicators of peanut under drought stress and re-watering conditions. Results: The results showed that during drought stress, the relative water content of the soil and leaves, chlorophyll content, and stomatal length, width, and aperture were significantly decreased while the levels of malondialdehyde (MDA), H₂O₂ and stomatal… More >

SHU ZHAO^1,*, SHIXIN YE²

BIOCELL, Vol.47, No.6, pp. 1377-1388, 2023, DOI:10.32604/biocell.2023.023874

Abstract Background: This paper aims to establish a light-controlled phosphorylation detection method at the Y785 site of tropomyosin receptor kinase A (TrkA) receptor in mammalian cells by using genetic code expansion technology and detecting the effects of optical activation of this site on the downstream MAPK/ERK pathway. The study is based on the current situation that the regulatory mechanism of TrkA phosphorylation has not been fully elucidated. Methods: Two photosensitive unnatural amino acids, p-azido-L-phenylalanine (AzF) and photo-caged tyrosine (ONB) were introduced into the TrkA-Y785 site by genetic code expansion technology and site-directed mutagenesis. Western blotting and laser confocal imaging were conducted… More >

Shuangsheng Zhang, Bin Sun, Siyu Li, Xiangyu Lin, Muhua Chen^*, Xu Xu^*

Journal of Renewable Materials, Vol.11, No.2, pp. 853-865, 2023, DOI:10.32604/jrm.2022.022901

Abstract Hydrogels have been widely applied in agricultural drought-resistance, pollution regulation, drug delivery and so on. Acrylamide (AM) is usually used as raw material to synthesize acrylamide hydrogels. However, inherently low mechanical strength greatly limits their applications in some special areas. Therefore, it is necessary to choose suitable functional monomers to optimize acrylamide hydrogels and improve their mechanical performances. In this paper, a novel acrylamide monomer modified by rosin was synthesized, and then polyacrylamide/rosin-based acrylamide (RAM) composite hydrogels were prepared via free radical polymerization using potassium persulfate as initiator, N, N′-methylene-bisacrylamide (MBA) as a crosslinker. The influence of RAM monomer was… More > Graphic Abstract

Weishan Tang, Xin Feng, Caiyun Lin, Xiaoping Rao^*

Journal of Renewable Materials, Vol.11, No.2, pp. 523-538, 2023, DOI:10.32604/jrm.2022.022809

Abstract Environment friendly and intelligent surfactants have attracted great attention in recent years. A bio-based CO₂ responsive surfactant rosin acid dimaleimide choline (R-BMI-C) with an extremely rigid skeleton was prepared using rosin and choline as raw materials by Diels-Alder addition reaction and acid-base neutralization reactions. Its structure was confirmed by IR and ¹H NMR spectra. The foams’ properties of R-BMI-C could be adjusted by bubbling CO₂/N₂ to change the structure of the surfactant. At pH 10.4, R-BMI-C forms an unstable foam with a half-life of 1.5 h. When the pH was reduced to 7.4 by bubbling CO₂, R-BMI-C forms an extremely… More > Graphic Abstract

Thi Thanh Hien Nguyen^1,*, Nho Quyet Tran², Thi Minh Nguyet Nguyen¹, Hien Mai Trinh¹, Xuan Phuong Le¹, Trong Kien Nguyen¹

Journal of Renewable Materials, Vol.10, No.11, pp. 2765-2780, 2022, DOI:10.32604/jrm.2022.019634

Abstract This study aimed to evaluate the effect of natural weathering on some surface characteristics and mechanical properties of Styrax wood treated with mixtures of 1.0%, 2.0%, or 4.0% rosin sizing agent and 3% copper sulfate. Wood samples after treatment were exposed to outdoor conditions for one year and changes in color, glossiness, weight loss, compression strength parallel to grain (CSPG), modulus of rupture (MOR), and modulus of elasticity (MOE) were investigated after 6 and 12-month of natural weathering. The results showed that rosin-copper treatment could improve color stability and gloss of samples after weathering. Mass losses of all rosin-copper treated… More > Graphic Abstract