Muhammad Abdullah Khan¹, Muhammad Usman², Yuhong Zhao^1,3,4,*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 1905-1952, 2024, DOI:10.32604/cmc.2024.054691 - 18 November 2024

Abstract This comprehensive review examines the structural, mechanical, electronic, and thermodynamic properties of Mg-Li-Al alloys, focusing on their corrosion resistance and mechanical performance enhancement. Utilizing first-principles calculations based on Density Functional Theory (DFT) and the quasi-harmonic approximation (QHA), the combined properties of the Mg-Li-Al phase are explored, revealing superior incompressibility, shear resistance, and stiffness compared to individual elements. The review highlights the brittleness of the alloy, supported by B/G ratios, Cauchy pressures, and Poisson’s ratios. Electronic structure analysis shows metallic behavior with varied covalent bonding characteristics, while Mulliken population analysis emphasizes significant electron transfer within the… More >

CHUAN JIANG^1,2, CHUNLEI LIU^1,3, XI YAO^1,3, JINGYA SU^1,2, WEI LU^1,3, ZHENGBO WEI^3,*, YING XIE^1,2,*

Oncology Research, Vol.32, No.12, pp. 1935-1948, 2024, DOI:10.32604/or.2024.052244 - 13 November 2024

Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer globally, with chemoresistance posing a major challenge in treatment outcomes. The efficacy of the commonly used chemotherapeutic agent, cisplatin, is diminished in patients with poor prognoses. Methods: Various bioinformatics databases were utilized to examine Carboxylesterase 1 (CES1) gene expression, clinicopathologic features, patient survival analysis, and gene function. An organoid model of HNSCC was established, along with the induction of drug-resistant HNSCC in the organoid model. CES1 expression was assessed using qRT-PCR and Western Blot, and differential markers were identified through transcriptome… More >

YUQIN YIN^1,2,#, YU WU^1,#, HONGLIANG HUANG^1,2, YINGYING DUAN^1,2, ZHONGWEN YUAN^1,2, LIHUI CAO^1,2, JINJIN YING^1,2, YONGHENG ZHOU^3,*, SENLING FENG^1,2,*

Oncology Research, Vol.32, No.12, pp. 1891-1902, 2024, DOI:10.32604/or.2024.048778 - 13 November 2024

Abstract Background: Polymethoxylated flavones (PMFs) are compounds present in citrus peels and other Rutaceae plants, which exhibit diverse biological activities, including robust antitumor and antioxidant effects. However, the mechanism of PMFs in reversing drug resistance to colon cancer remains unknown. In the present study, we aimed to investigate the potential connection between the aerobic glycolysis-ROS-autophagy signaling axis and the reversal of PTX resistance in colon cancer by PMFs. Methods: MTT Cell viability assay and colony formation assay were used to investigate the effect of PMFs combined with PTX in reversing HCT8/T cell resistance ex vivo; the mRNA… More > Graphic Abstract

CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

Yongbing Li^1,*, Yunwu Ma¹, Yujun Xia¹, Ming Lou¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012602

Abstract The implementation of lightweight materials and structures in automotive body manufacturing is a strategic approach to improve fuel efficiency of energy-efficient vehicles and driving range of new energy vehicles. However, high specific strength low-ductility light metals (like 7xxx aluminum, magnesium and cast aluminum), ultra-high strength steels, high-stiffness profile structures and their mixed use poses a big challenge to existing commercial spot joining processes, such as resistance spot welding and self-piercing riveting. In this talk, the challenges which new lightweight materials and structures pose to spot joining process will be presented, the bottleneck of the existing More >

Yeye Liu¹, Leilei Zhang^1,*, Ruonan Zhang¹, Siqi Shao¹, Lina Sun¹, Xinyi Wan¹, Tiantian Wang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012576

Abstract Superior thermal insulating and fire-retardant ceramic membranes are urgently demanded in the aerospace, construction and chemical engineering industries. However, the generic characteristics of ceramic membranes, such as brittleness, structural collapse and crystallization-induced pulverization behavior, present a great plague to their practical applications. Herein, we report a highly flexible, mechanically stable, fire retardant and high-temperature-resistant ceramic membrane based on the interlocked Si₃N₄ nanowires formed by the precursor pyrolysis method. The Si₃N₄ nanowires membrane (SNM) has excellent high temperature resistance under alcohol lamp and butane spray lance. The thermal insulation with a thermal conductivity as low as 0.056… More >

Yijun Gao^1,2, Yong Wang^1,*, Qing Na¹, Jiawei Zhang¹, Aixiang Wu¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2443-2458, 2024, DOI:10.32604/fdmp.2024.051385 - 28 October 2024

Abstract Filling methods in the mining industry can maximize the recovery of mineral resources and protect the underground and surface environments. In recent years, such methods have been widely used in metal mines where pipeline transportation typically plays a decisive role in the safety and stability of the entire filling system. Because the filling slurry contains a large percentage of solid coarse particles, the involved pipeline is typically eroded and often damaged during such a process. A possible solution is the so-called nesting repair technology. In the present study, nesting a 127 mm outer diameter pipeline… More >

SHAIL RAKESH MODI, TERRICK ANDEY^*

Oncology Research, Vol.32, No.11, pp. 1709-1721, 2024, DOI:10.32604/or.2024.053972 - 16 October 2024

Abstract Objectives: EGFR tyrosine kinase inhibitor (EGFR-TKI) therapies such as erlotinib and gefitinib are approved for the treatment of non-small cell lung cancer (NSCLC). However, the high incidence of acquired resistance to these EGFR-TKIs may preclude their effectiveness. Piperlongumine (PPL), an extract from the long pepper fruit (Piper longum), has been shown to possess anticancer properties. The purpose of the study was to investigate piperlongumine as an anticancer agent and to study a combination treatment approach with EGFR-TKIs against lung cancer cells. Methods: Anticancer efficacy of PPL, erlotinib (ERL), gefitinib (GEF), and cisplatin (CIS) were investigated in… More >

Mingzhi Chen¹, Zhandong Wang², Guifang Sun^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012203

Abstract Marine environments pose severe corrosion challenges to underwater equipment, thereby leading to significant risks and demanding immediate in-situ restoration. Here we developed an underwater laser directed energy deposition (UDMD) technique to repair the E690 steel and enhance its corrosion resistance. Systematic investigations about the underwater pressure (P) and 316L stainless steel (SS316L) coatings on the microstructure, mechanical properties, and corrosion resistance of the repaired E690 steel were conducted. Results show that water cooling can refine grain, promote the formation of lath martensite, and increase dislocation density. No obvious relationship between the pressure and microstructure evolution… More >

Fatima-Ezzahra Soussani^1,2,3, Youssef Ait Rahou^1,2,4, Chayma Ikan^1,2, Allal Douira³, Rachid Benkirane³, Essaid Ait Barka⁵, Rachid Lahlali^6,*, Abdelilah Meddich^1,2,7,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2415-2438, 2024, DOI:10.32604/phyton.2024.055050 - 30 September 2024

Abstract This study assesses the effectiveness of using arbuscular mycorrhizal fungi (M) and compost applied alone or in combination (vs. conventional chemical fertilizer application (NPK)) on tomato resistance to vascular wilt caused by Verticillium dahliae. In this study, ten treatments were applied: (1) Control (2) M: Rhizophagus irregularis (3) C: Compost (4) MC: The combination of M and compost (5) NPK: conventional chemical fertilizer (6) V: plants infected with V. dahliae (7) MV: plants infected with a conidial suspension of V. dahliae and M, (8) CV: The combination of compost and V. dahliae, (9) MCV: The combination of M, compost and V. dahliae,… More >