HYUNHO KIM¹, UIJU CHO², SOOK HEE HONG³, HYUNG SOON PARK¹, IN-HO KIM³, HO JUNG AN¹, BYOUNG YONG SHIM¹, JIN HYOUNG KANG^3,*

Oncology Research, Vol.32, No.6, pp. 1021-1030, 2024, DOI:10.32604/or.2024.048919 - 23 May 2024

Abstract Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC. Methods: Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with MIBC. The APOBEC3B expression in MIBC cell lines was assessed… More >

Abdulelah Alwabel^*

Intelligent Automation & Soft Computing, Vol.36, No.2, pp. 2217-2232, 2023, DOI:10.32604/iasc.2023.033703 - 05 January 2023

Abstract The reliability and availability of cloud systems have become major concerns of service providers, brokers, and end-users. Therefore, studying fault-tolerance mechanisms in cloud computing attracts intense attention in industry and academia. The task-scheduling mechanisms can improve the fault-tolerance level of cloud systems. A task-scheduling mechanism distributes tasks to a group of instances to be executed. Much work has been undertaken in this direction to improve the overall outcome of cloud computing, such as improving service quality and reducing power consumption. However, little work on task scheduling has studied the problem of lost tasks from the… More >

H. L. Chandrakala^1,*, R. Loganathan²

Computer Systems Science and Engineering, Vol.45, No.3, pp. 3151-3164, 2023, DOI:10.32604/csse.2022.027873 - 21 December 2022

Abstract Most social networks allow connections amongst many people based on shared interests. Social networks have to offer shared data like videos, photos with minimum latency to the group, which could be challenging as the storage cost has to be minimized and hence entire data replication is not a solution. The replication of data across a network of read-intensive can potentially lead to increased savings in cost and energy and reduce the end-user’s response time. Though simple and adaptive replication strategies exist, the solution is non-deterministic; the replicas of the data need to be optimized to… More >

M. Revathi, V. V. Ramalingam^*, B. Amutha

Computer Systems Science and Engineering, Vol.45, No.3, pp. 3023-3036, 2023, DOI:10.32604/csse.2023.033600 - 21 December 2022

Abstract The impact of a Distributed Denial of Service (DDoS) attack on Software Defined Networks (SDN) is briefly analyzed. Many approaches to detecting DDoS attacks exist, varying on the feature being considered and the method used. Still, the methods have a deficiency in the performance of detecting DDoS attacks and mitigating them. To improve the performance of SDN, an efficient Real-time Multi-Constrained Adaptive Replication and Traffic Approximation Model (RMCARTAM) is sketched in this article. The RMCARTAM considers different parameters or constraints in running different controllers responsible for handling incoming packets. The model is designed with multiple… More >

S. Lavanya^1,*, N. M. Saravanakumar²

Computer Systems Science and Engineering, Vol.45, No.3, pp. 2869-2883, 2023, DOI:10.32604/csse.2023.029040 - 21 December 2022

Abstract Many cutting-edge methods are now possible in real-time commercial settings and are growing in popularity on cloud platforms. By incorporating new, cutting-edge technologies to a larger extent without using more infrastructures, the information technology platform is anticipating a completely new level of development. The following concepts are proposed in this research paper: 1) A reliable authentication method Data replication that is optimised; graph-based data encryption and packing colouring in Redundant Array of Independent Disks (RAID) storage. At the data centre, data is encrypted using crypto keys called Key Streams. These keys are produced using the More >

M. A. Fazlina, Rohaya Latip^*, Hamidah Ibrahim, Azizol Abdullah

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 415-433, 2023, DOI:10.32604/cmc.2023.020764 - 22 September 2022

Abstract As the amount of data continues to grow rapidly, the variety of data produced by applications is becoming more affluent than ever. Cloud computing is the best technology evolving today to provide multi-services for the mass and variety of data. The cloud computing features are capable of processing, managing, and storing all sorts of data. Although data is stored in many high-end nodes, either in the same data centers or across many data centers in cloud, performance issues are still inevitable. The cloud replication strategy is one of best solutions to address risk of performance… More >

B. Prabhu Shankar^1,*, S. Chitra²

Computer Systems Science and Engineering, Vol.41, No.2, pp. 661-676, 2022, DOI:10.32604/csse.2022.019507 - 25 October 2021

Abstract Social networks (SNs) are sources with extreme number of users around the world who are all sharing data like images, audio, and video to their friends using IoT devices. This concept is the so-called Social Internet of Things (SIot). The evolving nature of edge-cloud computing has enabled storage of a large volume of data from various sources, and this task demands an efficient storage procedure. For this kind of large volume of data storage, the usage of data replication using edge with geo-distributed cloud service area is suited to fulfill the user’s expectations with low… More >

Hongde Li^*†‡, Yueshuo Li^*†‡, Jianmin Hu^*†‡, Sufang Liu^§, Xiangjian Luo^*†‡¶, Min Tang^*†‡, Ann M. Bode^#, Zigang Dong^#**, Xinqi Liu^††, Weihua Liao^‡‡, Ya Cao^{*†‡¶ §§¶¶}

Oncology Research, Vol.28, No.7-8, pp. 763-778, 2020, DOI:10.3727/096504021X16135618512563

Abstract Epstein–Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays an important oncogenic role in the viral latent infection. Recently, increasing evidence indicates that the high expression of LMP1 during EBV lytic cycle is related to the viral lytic replication. However, the mechanism by which LMP1 regulates EBV lytic replication remains unclear. (−)-Epigallocatechin-3-gallate (EGCG) prevents carcinogenesis by directly targeting numerous membrane proteins and effectively inhibits EBV lytic cascade. Here, we demonstrated that LMP1 promotes EBV lytic replication through the downstream signal molecules MAPKs, including ERKs, p38, and JNKs. LMP1 induces the phosphorylation of p53 through MAPKs… More >

Masood Niazi Torshiz^1,∗, Azadeh Salehi Esfaji^1,†, Haleh Amintoosi^2,‡

Computer Systems Science and Engineering, Vol.35, No.2, pp. 99-112, 2020, DOI:10.32604/csse.2020.35.099

Abstract With the growth of information technology and computer networks, there is a vital need for optimal design of distributed databases with the aim of performance improvement in terms of minimizing the round-trip response time and query transmission and processing costs. To address this issue, new fragmentation, data allocation, and replication techniques are required. In this paper, we propose enhanced vertical fragmentation, allocation, and replication schemes to improve the performance of distributed database systems. The proposed fragmentation scheme clusters highly-bonded attributes (i.e., normally accessed together) into a single fragment in order to minimize the query processing More >

Wei LI, Huihui GAO, Ran TAO, Lifang LIU, Shiqiang SHANG^*

BIOCELL, Vol.43, No.4, pp. 285-291, 2019, DOI:10.32604/biocell.2019.08177

Abstract As a response factor of interferon, tripartite motif (TRIM) 22 was reported to exert antiviral activity against viruses. In this study, THP-1 macrophages were infected with human cytomegalovirus (HCMV) to establish the HCMV lytic infection model. The mRNA levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and interferonbeta (IFN-β) were significantly up-regulated in THP-1 macrophages at different infection time and titers. Moreover, for the first time, upregulation of TRIM22 expression was found during HCMV infection at both mRNA and protein levels in THP-1 macrophages. Furthermore, IFN-β could induce TRIM22 expression in THP-1 macrophages or HCMV More >