Hong Pang¹, Ao Lu¹, Ming Xiong¹, Chen Chen¹, Xian Cao¹, Xiong Xu^2,3,*, Jing Wang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1063-1074, 2024, DOI:10.32604/fdmp.2023.044000

Abstract Conventional repairing methods for asphalt pavement have some inconveniences, such as insufficient strength, and are typically time-consuming. To address these issues, this study proposes a new technological method to design and prepare a high-performance assembled asphalt concrete block for fast repair of the potholes. A series of composite modified asphalt binders with 10% crumb rubber (CR) and different dosages (0%, 1%, 3%, 5%) of polyurethane (PU) are examined to determine the optimized binder. Subsequently, the corresponding asphalt mixtures are prepared for further comparison and assessment of engineering properties, such as moisture-induced damage, high-temperature deformation, and More >

Seyed Mohammad Reza Abtahi¹, Saeid Ansari Sadrabadi^2,*, Gholam Hosein Rahimi¹, Gaurav Singh², Hamid Abyar³, Daniele Amato⁴, Luigi Federico⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1783-1806, 2024, DOI:10.32604/cmes.2024.047575

Abstract Repairs of corroded high-pressure pipelines are essential for fluids transportation under high pressure. One of the methods used in their repairs is the use of layered composites. The composite used must have the necessary strength. Therefore, the experiments and analytical solutions presented in this paper are performed according to the relevant standards and codes, including ASME PCC-2, ASME B31.8S, ASME B31.4, ISO 24817 and ASME B31.G. In addition, the experimental tests are replicated numerically using the finite element method. Setting the strain gauges at different distances from the defect location, can reduce the nonlinear effects, More >

Toshi Maeda^*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945

Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

Keqiang Wang¹, Pengyang Zhao¹, Changjian Wang², Zimeng Zhang¹, Yu Zhang¹, Jia Lu¹, Zedong Yang^2,*

Energy Engineering, Vol.121, No.4, pp. 1091-1108, 2024, DOI:10.32604/ee.2023.044016

Abstract The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system (RIENGS). With the growing level of coupling between electric and natural gas systems, it is critical to enhance the load restoration capability of both systems. This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming (MISOCP) model. The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems, minimizing the total system load More >

Jae Hong Lee¹, Sungkyu Cho^2,*, Jae Gun Kwak², Hye Won Kwon², Woong-Han Kim², Mi Kyoung Song³, Sang-Yun Lee³, Gi Beom Kim³, Eun Jung Bae³

Congenital Heart Disease, Vol.19, No.1, pp. 69-83, 2024, DOI:10.32604/chd.2024.045137

Abstract Background: The optimal surgical timing and clinical outcomes of ventricular septal defect (VSD) closure in neonates remain unclear. We aimed to evaluate the clinical outcomes of VSD closure in neonates (age ≤ 30 days). Methods: We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June 2021. Indications for the procedure included congestive heart failure/failure to thrive and pulmonary hypertension. Major adverse events (MAEs) were defined as the composite of all-cause mortality, reoperation, persistent atrioventricular block, and significant (≥grade 2) valvular dysfunction. Results: The median age and body weight… More >

Jie Huang^*, Rongbin Jiang, Xiaobo Sun, Yingyong Shuai

Journal of Renewable Materials, Vol.12, No.1, pp. 187-201, 2024, DOI:10.32604/jrm.2023.044232

Abstract The reuse of waste recycled concrete from harsh environments has become a research hotspot in the field of construction. This study investigated the repair effect of carbonation treatment on second-generation recycled fine aggregate (SRFA) obtained from recycled fine aggregate concrete (RFAC) subjected to freeze-thaw (FT) cycles. Before and after carbonation, the properties of SRFA were evaluated. Carbonated second-generation recycled fine aggregate (CSRFA) at five substitution rates (0%, 25%, 50%, 75%, 100%) to replace SRFA was used to prepare carbonated second-generation recycled fine aggregate concrete (CSRFAC). The water absorption, porosity and mechanical properties of CSRFAC were More >

Ali Akbar Firoozi^1,*, Ali Asghar Firoozi²

Structural Durability & Health Monitoring, Vol.18, No.1, pp. 1-18, 2024, DOI:10.32604/sdhm.2023.044573

Abstract The discipline of damage tolerance assessment has experienced significant advancements due to the emergence of smart materials and self-repairable structures. This review offers a comprehensive look into both traditional and innovative methodologies employed in damage tolerance assessment. After a detailed exploration of damage tolerance concepts and their historical progression, the review juxtaposes the proven techniques of damage assessment with the cutting-edge innovations brought about by smart materials and self-repairable structures. The subsequent sections delve into the synergistic integration of smart materials with self-repairable structures, marking a pivotal stride in damage tolerance by establishing an autonomous More >

CHIWEN BU^1,2, LIGANG ZHAO¹, LISHAN WANG¹, ZEQIAN YU¹, JIAHUA ZHOU^1,*

Oncology Research, Vol.31, No.4, pp. 495-503, 2023, DOI:10.32604/or.2023.029309

Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. Moreover, we found that knockdown of the More > Graphic Abstract

DHANYA K. NAMBIAR¹, DEEPALI MISHRA², RANA P. SINGH^2,3,*

Oncology Research, Vol.31, No.4, pp. 405-421, 2023, DOI:10.32604/or.2023.028310

Abstract Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 (PARP-1) causing resistance to radiation therapy. Thus, PARP-1 represents an important target in multiple cancer types, including prostate cancer. PARP is a nuclear enzyme essential for single-strand DNA breaks repair. Inhibiting PARP-1 is lethal in a wide range of cancer cells that lack the homologous recombination repair (HR) pathway. This article provides a concise and simplified overview of the development of PARP inhibitors in the laboratory and their clinical More > Graphic Abstract

Andrei George Iosifescu^1,2,*, Roxana Enache^1,3, Ioana Marinică⁴, Corina Radu², Vlad Anton Iliescu^1,2

Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598

Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical More > Graphic Abstract