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  • Open Access


    Computational docking and in vitro analysis identifies novel arylidene analogue FPMXY-14 against renal cancer cells by attenuating Akt


    Oncology Research, Vol.29, No.3, pp. 217-227, 2021, DOI:10.32604/or.2022.03570

    Abstract Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims to screen FPMXY- 14 (novel arylidene analogue) for Akt inhibition by computational and in vitro methods. FPMXY-14 was subjected to proton NMR analysis and Mass spectrum analysis. Vero, HEK-293, Caki-1, and A498 cell lines were used. Akt enzyme inhibition was studied with the fluorescent-based kit assay. Modeller 9.19, Schrodinger 2018-1, LigPrep module, and Glide docking were used in computational analysis. The nuclear status was assessed by PI/Hoechst- 333258 staining, cell cycle, and apoptosis assays were performed using flow cytometry. Scratch wound and migrations assays were performed.… More >

  • Open Access


    Kidney Tumor Segmentation Using Two-Stage Bottleneck Block Architecture

    Fuat Turk1,*, Murat Luy2, Necaattin Barışçı3, Fikret Yalçınkaya4

    Intelligent Automation & Soft Computing, Vol.33, No.1, pp. 349-363, 2022, DOI:10.32604/iasc.2022.023710

    Abstract Cases of kidney cancer have shown a rapid increase in recent years. Advanced technology has allowed bettering the existing treatment methods. Research on the subject is still continuing. Medical segmentation is also of increasing importance. In particular, deep learning-based studies are of great importance for accurate segmentation. Tumor detection is a relatively difficult procedure for soft tissue organs such as kidneys and the prostate. Kidney tumors, specifically, are a type of cancer with a higher incidence in older people. As age progresses, the importance of having diagnostic tests increases. In some cases, patients with kidney tumors may not show any… More >

  • Open Access


    Group Decision-Making Model of Renal Cancer Surgery Options Using Entropy Fuzzy Element Aczel-Alsina Weighted Aggregation Operators under the Environment of Fuzzy Multi-Sets

    Jing Fu1,2, Jun Ye3, Liping Xie1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1751-1769, 2022, DOI:10.32604/cmes.2022.018739

    Abstract Since existing selection methods of surgical treatment schemes of renal cancer patients mainly depend on physicians’ clinical experience and judgments, the surgical treatment options of renal cancer patients lack their scientifical and reasonable information expression and group decision-making model for renal cancer patients. Fuzzy multi-sets (FMSs) have a number of properties, which make them suitable for expressing the uncertain information of medical diagnoses and treatments in group decision-making (GDM) problems. To choose the most appropriate surgical treatment scheme for a patient with localized renal cell carcinoma (RCC) (T1 stage kidney tumor), this article needs to develop an effective GDM model… More >

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