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  • Open Access

    ARTICLE

    Characterization, In Vitro Dissolution, and Drug Release Kinetics in Hard Capsule Shells Made from Hydrolyzed κ-Carrageenan and Xanthan Gum

    Tri Susanti1,2, Syahnur Haqiqoh1, Pratiwi Pudjiastuti2,*, Siti Wafiroh2,*, Esti Hendradi3, Oktavia Eka Puspita4, Nashriq Jailani5

    Journal of Renewable Materials, Vol.13, No.9, pp. 1841-1857, 2025, DOI:10.32604/jrm.2025.02024-0084 - 22 September 2025

    Abstract This study aims to enhance the mechanical properties, disintegration, and dissolution rates of cross-linked carrageenan (CRG) capsule shells by shortening the long chains of CRG through a hydrolysis reaction with citric acid (CA). The hydrolysis of CRG was carried out using varying concentrations of CA, resulting in hydrolyzed CRG (HCRG). This was followed by cross-linking with xanthan gum (XG) and the addition of sorbitol (SOR) as a plasticizer. The results indicated that the optimal swelling capacity of HCRG-XG/SOR hard-shell capsules occurred at a CA concentration of 0.5%, achieving a maximum swelling rate of 445.39% after… More >

  • Open Access

    ARTICLE

    Study on Sustained-Release Pesticides Blended with Fosthiazate-Stearic Acid/Expanded Perlite

    Huimin Huang1, Zijun Wu2, Zhijian Zhou1, Qiulin Xu1, Jie Yan1,*, Qiaoguang Li1,*

    Journal of Renewable Materials, Vol.11, No.1, pp. 257-272, 2023, DOI:10.32604/jrm.2023.021073 - 10 August 2022

    Abstract The low utilization rate of pesticides makes the migration of pesticides in water and soil, which brings great harm to the ecosystem. The development of pesticide carriers with good drug loading capacity and release control ability is an effective method to realize effective utilization of pesticides and reduce pesticide losses. In this work, fosthiazate-stearic acid/expanded perlite sustained-release particles were successfully prepared by vacuum impregnation using expanded perlite (EP) as carrier, fosthiazate (FOS) as model pesticide and stearic acid (SA) as hydrophobic matrix. The structure and morphology of the samples were studied by BET, FT-IR, TGA,… More > Graphic Abstract

    Study on Sustained-Release Pesticides Blended with Fosthiazate-Stearic Acid/Expanded Perlite

  • Open Access

    ARTICLE

    Toll-like receptor agonists, poly(I:C) and flagellin, lead to IL-36g induction with divergent release kinetics and differentially alter autophagy in primary human keratinocytes

    Christopher J. Papayannakos1,*, Daniel Zhu1,*, Bongseok Jung2, Ali A. Rana2, James A. DeVoti2,3, Allan L. Abramson4, Vincent R. Bonagura2,3, Bettie M. Steinberg2,5

    European Cytokine Network, Vol.33, No.2, pp. 19-29, 2022, DOI:10.1684/ecn.2022.0479

    Abstract IL-36γ, a pro-inflammatory member of the IL-1 cytokine superfamily, can be induced and secreted by normal human foreskin keratinocytes (HFKs) in response to pathogenic stimuli, however, the mechanisms underlying the secretion are unknown. In this study, we demonstrate that stimulation with the TLR3 agonist, poly (I:C), led to a delayed secretion of IL-36γ compared to stimulation with the TLR5 agonist, flagellin, despite equal levels of the cytokine (p = 0.006). IL-36γ was shown to be released from HFKs in its inactive, uncleaved form, based on western blotting. Moreover, recombinant IL-36γ in its activated, cleaved form… More >

  • Open Access

    ARTICLE

    Effects of Cold Plasma on Surface, Thermal and Antimicrobial Release Properties of Chitosan Film

    S.K. Pankaj1, C. Bueno-Ferrer1, N.N. Misra1, L. O’Neill2, Paula Bourke1, P.J. Cullen3*

    Journal of Renewable Materials, Vol.5, No.1, pp. 14-20, 2017, DOI:10.7569/JRM.2016.634105

    Abstract This work aims to analyze the effects of cold atmospheric air plasma treatment of antimicrobial chitosan film with different levels of thymol. Optical characterization of the dielectric barrier discharge showed the generation of reactive nitrogen and oxygen species by the system. A significant increase (p < 0.05) in the surface roughness was observed after cold plasma treatment of the films. No significant difference (p > 0.05) was observed in the thermal profile of the plasma-treated films. A significant increase (p < 0.05) in the thymol diffusion coefficient was observed after the plasma treatment for all More >

  • Open Access

    ARTICLE

    Surface, Thermal and Antimicrobial Release Properties of Plasma-Treated Zein Films

    S.K. Pankaj1, C. Bueno-Ferrer1, N.N. Misra1, L. O’Neill2, A. Jiménez3, P. Bourke1, P.J. Cullen1,4,*

    Journal of Renewable Materials, Vol.2, No.1, pp. 77-84, 2014, DOI:10.7569/JRM.2013.634129

    Abstract The effects of dielectric barrier discharge plasma treatment on zein fi lm containing thymol as an active ingredient were evaluated. The plasma discharge was optically characterized to identify the reactive species. A signifi cant increase in the fi lm roughness (p < 0.05) was observed due to the etching effect of DBD plasma, which was correlated with the increase in the diffusion rate of thymol in the food simulant. The diffusion of thymol from the zein fi lm was measured in aqueous solution. The kinetics of thymol release followed the Fick’s law of diffusion as More >

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