Xinyang Liu^*1, Zhichao Wang^†1, Guoliang Zhang^‡1, Qikun Zhu^‡, Hui Zeng^‡, Tao Wang^‡, Feng Gao^‡, Zhan Qi^‡, Jinwen Zhang^§, Rui Wang^‡

Oncology Research, Vol.25, No.4, pp. 485-493, 2017, DOI:10.3727/096504016X14749340314441

Abstract Esophageal cancer is one of the most common types of cancer, and it has a poor prognosis. The molecular mechanisms of esophageal cancer progression remain largely unknown. In this study, we aimed to investigate the clinical significance and biological function of tumor necrosis factor receptor-associated factor 6 (TRAF6) in esophageal cancer. Expression of TRAF6 in esophageal cancer was examined, and its correlation with clinicopathological factors and patient prognosis was analyzed. A series of functional and mechanism assays were performed to further investigate the function and underlying mechanisms in esophageal cancer. Expression of TRAF6 was highly… More >

CHENG-GONG LUO^1,2,#, JIAO ZHANG^1,#, YUN-ZHAO AN¹, XUAN LIU¹, SHUAI-JIE LI¹, WEI ZHANG¹, KAI LI¹, XU ZHAO¹, DONG-BO YUAN¹, LING-YUE AN¹, WEI CHEN², YE TIAN^1,*, BIN XU^1,*

BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878

Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >

Jingshan Huang, Bin Yao^*, Qixin Lan, Zhirong Pan

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 525-550, 2024, DOI:10.32604/cmes.2023.029675

Abstract Friction and wear phenomenon is a complex nonlinear system, and it is also a significant problem in the process of metal cutting. In order to systematically analyze the friction and wear process of tool material-workpiece material friction pair in the cutting process of high hardness alloy steel under different lubrication conditions, the chaotic characteristics of friction process between high hardness alloy steel and cemented carbide under the lubrication C60 nano-particles fluid are studied based on the chaos theory. Firstly, the friction and wear experiments of the friction pair between high hardness alloy steel and cemented… More >

Yi Wu, Yujiao Wang, Weimin He^*

Oncologie, Vol.24, No.4, pp. 927-935, 2022, DOI:10.32604/oncologie.2022.026720

Abstract Synovial sarcoma (SS) is typically an aggressive malignant soft tissue tumor that mostly affects adolescents and young adults. It is extremely rare in orbit and carries a high risk of recurrence and metastasis, posing a challenge to ophthalmologists in diagnosing and managing. We present two primary orbital synovial sarcoma cases with unilateral exophthalmos and limited motility. Both male patients underwent reoperation in our hospital since tumor recurrence; the pathologic diagnoses were biphasic type and occult type, respectively. Both cases were positive for EMA and CK, and SOX-9 and INI-1 were newly discovered immune markers. Fluorescence in More >

Yao Wu^1,2,#, Bin Qu^1,#, Haoming Shen¹, Hongyu Deng¹, Faqin Tang^1,*

Oncologie, Vol.24, No.3, pp. 499-512, 2022, DOI:10.32604/oncologie.2022.024951

Abstract Background: Tumor-specific growth factor (TSGF) is associated with invasion and metastasis of various malignancies and adverse clinical outcomes. TSGF is also highly expressed in cervical cancer (CC), but its clinical value is unclear. Materials and Methods: Serum samples from malignancies, including CC, non-Hodgkin’s lymphoma (NHL), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC), lung cancer (LCA), ovarian cancer (OC), breast cancer (BC), gastric carcinoma (GC), and pancreatic cancer (PC) were collected, and TSGF was detected using a chemiluminescence assay. The patients with CC were followed-up over five years, and their clinicopathological parameters were analyzed. Meanwhile, the pre- and post-treatment… More >

Xujie Zhou^1,2,3,#, Yuting Sang^1,3,#, Jiajian Chen^1,3, Miao Mo^3,4, Jianjing Hou^1,3, Benlong Yang^1,3,*, Jiong Wu^1,2,3,*

Oncologie, Vol.24, No.3, pp. 451-469, 2022, DOI:10.32604/oncologie.2022.025226

Abstract Background: To compare the time-varying recurrence patterns of different molecular subtypes of breast cancer in the contemporary era with those in the past era. Patients and Methods: This retrospective study included 14627 consecutive invasive breast cancer patients who underwent surgery from 2008 to 2016 at Fudan University Shanghai Cancer Center. We defined the period from 2013 to 2016 as the contemporary era and that from 2008 to 2012 as the past era. Five subtypes were defined according to the immunohistochemistry results. Emphasis was made on the changing patterns of recurrence for patients with different molecular subtypes changed… More >

Lan Wu¹, Xue-Yan Chen¹, Muhammet Cihat Dağli², Feng Qi^3,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.1, pp. 295-305, 2022, DOI:10.32604/cmes.2022.018778

Abstract In the paper, with the help of the Faá di Bruno formula and an identity of the Bell polynomials of the second kind, the authors define degenerate λ-array type polynomials, establish two explicit formulas, and present several recurrence relations of degenerate λ-array type polynomials and numbers. More >

Xubin Yin¹, Bing Yang², Ming Su², Shaoshan Sun¹, Hao Wang^1,*

Oncologie, Vol.23, No.4, pp. 533-546, 2021, DOI:10.32604/oncologie.2021.018705

Abstract Background: Tumor recurrence is one of the major problems that affect the postoperative efficacy of oral squamous cell carcinoma (OSCC) treatment. Autophagy is known to have a dual-sided effect on tumors. However, studies on autophagy and prognosis are limited. The purpose of this study is to analyze the relationship between autophagy and OSCC recurrence. Materials and methods: 72 patients with OSCC were followed for 5 years after curative surgery. Tissue specimens from each patient were divided into tumor, normal, and marginal groups. Autophagy protein expression was assessed by western blotting and immunofluorescence. Statistical significance was evaluated using… More >

Faten A. Momen khan¹, Saman Hanif Shahbaz², Muhammad Qaiser Shahbaz^2,*

Computer Systems Science and Engineering, Vol.41, No.1, pp. 197-208, 2022, DOI:10.32604/csse.2022.020448

Abstract Moments of generalized order statistics appear in several areas of science and engineering. These moments are useful in studying properties of the random variables which are arranged in increasing order of importance, for example, time to failure of a computer system. The computation of these moments is sometimes very tedious and hence some algorithms are required. One algorithm is to use a recursive method of computation of these moments and is very useful as it provides the basis to compute higher moments of generalized order statistics from the corresponding lower-order moments. Generalized order statistics provides… More >

F. Guillemin, F. Marchal, M. Geffroy

Oncologie, Vol.21, No.1, pp. 22-28, 2019, DOI:10.3166/onco-2019-0028

Abstract Purpose: Assessment of a second surgical conservative treatment (T) [N = 41] compared to total mastectomy (M) [N = 93] for ipsilateral breast tumor recurrence after initial breast conserving surgery in a retrospective study of 134 patients. Results: Five years global survival was 82.5% in each group. No statistical difference for the specific survival and survival without metastasis. The 5 years local control was 92.9% in group M and 66.2% in group T (RR = 4.48). Lymphovascular invasion (LVI), multifocal tumors, and clinical symptoms of the recurrence are pejorative factors for survival. Over the 134 patients, 25… More >