ELISA CEBRAL1,2, ISABEL CARRASCO1 , DAVID VANTMAN1, ROSITA SMITH1
BIOCELL, Vol.31, No.1, pp. 51-59, 2007, DOI:10.32604/biocell.2007.31.051
Abstract Exposure of either gametes or embryos to conditions and/or factors that generate oxidative
stress has been associated with impaired early embryogenesis. The effects of reactive oxygen species (ROS)
on mouse preimplantation development, depending of the ROS-concentration and time of exposition, were
studied. Two-cell embryos were incubated with 5, 10, 25 and 50 μM of hydrogen peroxide (H2O2) for 30 and
60 minutes of exposition and allowed to develop for 72 h to study the quality of development. The incubation
with 50 μM H2O2
for 30 or 60 minutes, strongly inhibited the 2-cell embryo development as compared… More >
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