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  • Open Access

    ARTICLE

    Oncosexology in côte d’Ivoire: Attitudes and Practices of Physicians Involved in the Management of Breast and Prostate Cancer

    Kouamé Konan Yvon Kouassi1,*, Bitti Adde Odo1, Yenahaban Lazare Toure1, Ouowene Prisca Marina Sougue2, Petiori Gningayou Laurence épouse Kamara Touré1, N’Guessan Manlan Prosper Mebiala1, Fleur Audrey Sessegnon1, Marie Sandrine Koffi1, Akissi Marie Barbara Yvonne Nogbou1, Sherif Traore1, Asmaho Akissi Danielle Andree Traore-Kouassi1, Moctar Toure1

    Psycho-Oncologie, Vol.18, No.4, pp. 359-365, 2024, DOI:10.32604/po.2024.049816 - 04 December 2024

    Abstract Objective: To evaluate the attitudes and practices of oncosexology in the management of breast and prostate cancer in Côte d’Ivoire. Methods: A cross-sectional, multicenter, descriptive and analytical survey carried out over 02 months from 1 November to 31 December 2022, among doctors involved in the management of breast and prostate cancer in Côte d’Ivoire. Results: 78 physicians on 114 participated in the study, with a participation rate of 79.5%. Only one doctor discussed the sexual risks associated with cancer with all his patients and 7.7% of doctors said they never broached questions of sexuality with their… More >

  • Open Access

    ARTICLE

    Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer

    YUAN YIN1, ZHENGYIN WANG1, YUJIE HU1, JIA WANG1, YI WANG2,*, QUN LU1,*

    Oncology Research, Vol.32, No.12, pp. 1881-1890, 2024, DOI:10.32604/or.2024.048007 - 13 November 2024

    Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >

  • Open Access

    ARTICLE

    Prostate cancer temporal and regional trends in Brazil

    MEHRSA JALALIZADEH1,#, HEVELINE RAYANE MOURA ROESCH1,#, FERNANDO KORKES2, QUOC DIEN-TRINH3, LEONARDO OLIVEIRA REIS1,4,*

    Oncology Research, Vol.32, No.10, pp. 1565-1573, 2024, DOI:10.32604/or.2024.052179 - 18 September 2024

    Abstract Objectives: The Brazilian Unified Health System (Sistema Único de Saúde−SUS) is the universal public healthcare system of Brazil that maintains a nationwide database of its patients. Our primary objective was to analyze regional and temporal trends, while our secondary goal was to establish correlations between states’ health economy status and their prostate cancer (PCa) epidemiology. Methods: We analyzed Brazil’s nationwide data on prostate cancer (PCa) incidence, mortality, and care gathered between 2013 and 2021 by the Information Technology Department of SUS (DATA-SUS), updated monthly using the International Classification of Diseases (ICD-10) code. Results: In the period,… More >

  • Open Access

    ARTICLE

    MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression

    CHENG-GONG LUO1,2,#, JIAO ZHANG1,#, YUN-ZHAO AN1, XUAN LIU1, SHUAI-JIE LI1, WEI ZHANG1, KAI LI1, XU ZHAO1, DONG-BO YUAN1, LING-YUE AN1, WEI CHEN2, YE TIAN1,*, BIN XU1,*

    BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878 - 06 May 2024

    Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >

  • Open Access

    ARTICLE

    Attention Guided Multi Scale Feature Fusion Network for Automatic Prostate Segmentation

    Yuchun Li1,4, Mengxing Huang1,*, Yu Zhang2, Zhiming Bai3

    CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 1649-1668, 2024, DOI:10.32604/cmc.2023.046883 - 27 February 2024

    Abstract The precise and automatic segmentation of prostate magnetic resonance imaging (MRI) images is vital for assisting doctors in diagnosing prostate diseases. In recent years, many advanced methods have been applied to prostate segmentation, but due to the variability caused by prostate diseases, automatic segmentation of the prostate presents significant challenges. In this paper, we propose an attention-guided multi-scale feature fusion network (AGMSF-Net) to segment prostate MRI images. We propose an attention mechanism for extracting multi-scale features, and introduce a 3D transformer module to enhance global feature representation by adding it during the transition phase from More >

  • Open Access

    ARTICLE

    CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis

    JIANYUN XIE1,*, LINJIE LU1, JIALI ZHANG1, QIRUI LI2, WEIDONG CHEN1,*

    Oncology Research, Vol.32, No.3, pp. 529-544, 2024, DOI:10.32604/or.2023.031511 - 06 February 2024

    Abstract Objective: Circular ribose nucleic acids (circRNAs) are implicated in tumor progression and drug resistance of prostate cancer (PCa). The current work explored the function of circ_0005203 (circTHSD4) in the malignancy and docetaxel (DTX) resistance of PCa. Methods: circTHSD4 expression within PCa as well as matched non-carcinoma samples was measured through real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a subcellular fraction assay was conducted to determine circTHSD4 subcellular localization within PCa cells. In addition, we performed a Western blot (WB) assay to detect high-mobility-group A2 protein (HMGA2) levels. Besides, functional associations of two molecules… More >

  • Open Access

    ARTICLE

    Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

    ROGHAYEH GHORBANI1, MAHMOUD GHARBAVI2, ALI SHARAFI3,4, ELHAM RISMANI5, HAMED REZAEEJAM6, YOUSEF MORTAZAVI1,*, BEHROOZ JOHARI3,*

    Oncology Research, Vol.32, No.1, pp. 101-125, 2024, DOI:10.32604/or.2023.044741 - 15 November 2023

    Abstract In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics assays. ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure. The physicochemical characteristics of nanostructures were determined by FTIR, DLS, UV-vis, TEM, EDX, in vitro release, and hemolysis tests. Subsequently, the cytotoxicity properties of them with and without X-irradiation were investigated by uptake, MTT, cell cycle, apoptosis, and… More > Graphic Abstract

    Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

  • Open Access

    COMMENTARY

    Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons

    QIUQIANG CHEN1,*, XIAOLEI ZHAO2, WENXUE MA3,*

    Oncology Research, Vol.32, No.1, pp. 95-98, 2024, DOI:10.32604/or.2023.046174 - 15 November 2023

    Abstract Greenblatt and his team have unveiled vertebral skeletal stem cells (vSSCs) as a critical player in the landscape of bone metastasis. This commentary delves into the transformative discoveries surrounding vSSCs, emphasizing their distinct role in bone metastasis compared to other stem cell lineages. We illuminate the unique properties and functions of vSSCs, which may account for the elevated susceptibility of vertebral bones to metastatic invasion. Furthermore, we explore the exciting therapeutic horizons opened by this newfound understanding. These include potential interventions targeting vSSCs, modulation of associated signaling pathways, and broader implications for the treatment and More > Graphic Abstract

    Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons

  • Open Access

    ARTICLE

    Deoxynortryptoquivaline: A unique antiprostate cancer agent

    YOHKO YAMAZAKI1,*, MANABU KAWADA2, ISAO MOMOSE1

    Oncology Research, Vol.31, No.6, pp. 845-853, 2023, DOI:10.32604/or.2023.030266 - 15 September 2023

    Abstract The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new AR inhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as a screening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that the fermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cells without cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline (DNT) being identified as a novel inhibitor of AR function. More > Graphic Abstract

    Deoxynortryptoquivaline: A unique antiprostate cancer agent

  • Open Access

    ARTICLE

    Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients

    SHA ZHU#, NANWEI XU#, JIAYU LIANG, FENGNIAN ZHAO, ZILIN WANG, YUCHAO NI, JINDONG DAI, JINGE ZHAO, XINGMING ZHANG, JUNRU CHEN, GUANGXI SUN, PENGFEI SHEN*, HAO ZENG*

    Oncology Research, Vol.31, No.4, pp. 605-614, 2023, DOI:10.32604/or.2023.028321 - 25 June 2023

    Abstract Background: KMT2 (lysine methyltransferase) family enzymes are epigenetic regulators that activate gene transcription. KMT2C is mainly involved in enhancer-associated H3K4me1, and is also one of the top mutated genes in cancer (6.6% in pan-cancer). Currently, the clinical significance of KMT2C mutations in prostate cancer is understudied. Methods: We included 221 prostate cancer patients diagnosed between 2014 and 2021 in West China Hospital of Sichuan University with cell-free DNA-based liquid biopsy test results in this study. We investigated the association between KMT2C mutations, other mutations, and pathways. Furthermore, we evaluated the prognostic value of KMT2C mutations, measured by… More >

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