JI SHI^1,2, YE ZHANG², YI CHEN², TANGJUN GUO^3,*, HAOZHE PIAO^2,*

BIOCELL, Vol.48, No.8, pp. 1241-1263, 2024, DOI:10.32604/biocell.2024.051049

Abstract Background: Glioblastoma multiforme (GBM) is the most general malignancy of the primary central nervous system that is characterized by high aggressiveness and lethality. Transmembrane protein 159 (TMEM159) is an endoplasmic reticulum protein that can form oligomers with seipin. The TMEM159-seipin complex decides the site of lipid droplet (LD) formation, and the formation of LDs is a marker of GBM. However, the role of TMEM159 in the progression of GBM has not been investigated to date. Methods: In this study, we examined the genes that may be associated with patient prognosis in GBM by bioinformatics analyses,… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1371-1371, 2024, DOI:10.32604/or.2024.055030

Abstract This article has no abstract. More >

MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN^*

Oncology Research, Vol.32, No.8, pp. 1347-1357, 2024, DOI:10.32604/or.2024.046170

Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >

Refah Alotaibi¹, Hoda Rezk², Ahmed Elshahhat^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3073-3103, 2024, DOI:10.32604/cmes.2024.050606

Abstract A new one-parameter Chris-Jerry distribution, created by mixing exponential and gamma distributions, is discussed in this article in the presence of incomplete lifetime data. We examine a novel generalized progressively hybrid censoring technique that ensures the experiment ends at a predefined period when the model of the test participants has a Chris-Jerry (CJ) distribution. When the indicated censored data is present, Bayes and likelihood estimations are used to explore the CJ parameter and reliability indices, including the hazard rate and reliability functions. We acquire the estimated asymptotic and credible confidence intervals of each unknown quantity. More >

Naif Alotaibi¹, A. S. Al-Moisheer², Ibrahim Elbatal¹, Mohammed Elgarhy^3,4, Ehab M. Almetwally^1,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2795-2823, 2024, DOI:10.32604/cmes.2024.049188

Abstract This article introduces a novel variant of the generalized linear exponential (GLE) distribution, known as the sine generalized linear exponential (SGLE) distribution. The SGLE distribution utilizes the sine transformation to enhance its capabilities. The updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability issues. The suggested model incorporates a hazard rate function (HRF) that may display a rising, J-shaped, or bathtub form, depending on its unique characteristics. This model includes many well-known lifespan distributions as separate sub-models. The suggested model is accompanied with a range of More >

LAN ZHOU^1,#, QI ZHANG^2,#, BO TIAN^1,*, FENG YANG^1,*

BIOCELL, Vol.48, No.7, pp. 1081-1093, 2024, DOI:10.32604/biocell.2024.049878

Abstract Background: Glioblastoma, a notably malignant tumor within the central nervous system, is distinguished by its aggressive behavior. Silvestrol, a robust inhibitor of the RNA helicase eukaryotic initiation factor 4A (eIF4A), has shown significant potential as an anticancer compound. Yet, the impact of silvestrol on glioblastoma, especially its molecular mechanisms, has not been fully elucidated. Methods: This investigation employed a variety of in vitro assays, such as cell counting kit-8 (CCK-8), clonogenic, 5-ethynyl-2′-deoxyuridine (EDU), wound healing, and flow cytometry, to evaluate cell cycle progression, apoptosis, cell viability, and migration. Western blot analysis was also performed to study… More >

Zhengyang Zhang^#, Weixue Liu^#, Yinran Huang^*, Ping Li^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1263-1274, 2024, DOI:10.32604/phyton.2024.050755

Abstract Plant antifreeze proteins (AFPs) are special proteins that can protect plant cells from ice crystal damage in low-temperature environments, and they play a crucial role in the process of plants adapting to cold environments. Proteins with these characteristics have been found in fish living in cold regions, as well as many plants and insects. Although research on plant AFPs started relatively late, their application prospects are broad, leading to the attention of many researchers to the isolation, cloning, and genetic improvement of plant AFP genes. Studies have found that the distribution of AFPs in different species… More >

YUANLIN LIU^1,3,#, YAN LIU^2,#, YAN WANG², QIANG WANG², YAN YAN¹, DANDAN ZHANG^2,*, HUIQIN LIU^2,*

Oncology Research, Vol.32, No.7, pp. 1221-1229, 2024, DOI:10.32604/or.2024.047454

Abstract At present, the role of many long non-coding RNAs (lncRNAs) as tumor suppressors in the formation and development of cervical cancer (CC) has been studied. However, lncRNA prostate cancer gene expression marker 1 (PCGEM1), whose high expression not only aggravates ovarian cancer but also can induce tumorigenesis and endometrial cancer progression, has not been studied in CC. The objective of this study was to investigate the expression and the underlying role of PCGEM1 in CC. The relative expression of PCGEM1 in CC cells was detected by real-time PCR. After the suppression of PCGEM1 expression by… More > Graphic Abstract

XIAOBI HUANG^1,#, CHUNYUAN CHEN², YONGYANG CHEN^1,#, HONGLIAN ZHOU¹, YONGHUA CHEN¹, ZHONG HUANG¹, YULIU XIE¹, BAIYANG LIU¹, YUDONG GUO¹, ZHIXIONG YANG¹, GUANGHUA CHEN^3,*, WENMEI SU^1,4,*

Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771

Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >

Yang Xiong^1,2, Jianxin Liu^1,2,*, Xianhao Yi², Bangyan Xiao², Dan Wu², Biao Wu², Chunyu Gao²

Energy Engineering, Vol.121, No.7, pp. 1759-1780, 2024, DOI:10.32604/ee.2024.048536

Abstract In the heterogeneous reservoirs, CO₂ flooding easily leads to CO₂ gas channeling, which can seriously affect sweeping efficiency and reduce oil recovery. After thoroughly investigating the advantages and shortcomings of various CO₂ plugging technologies, this paper focuses on the feasibility of improving conventional water-alternating gas (WAG) through CO₂-responsive gel materials. Based on the different chemical reaction mechanisms between the unique chemical structure and CO₂, changes in the material’s physical and chemical properties can respond to CO₂. The feasibility of utilizing these property changes for CO₂-responsive plugging is explored. Various CO₂-responsive gels and gel nanoparticles have been extensively researched in More >