Zia Ur Rahman¹, Nigar Ali^1,2, Dragan Pamucar³, Imtiaz Ahmad^1,2, Haci Mehmet Baskonus^2,*, Naseer Ul Haq¹, Zeeshan Ali⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.070268 - 29 January 2026

Abstract Hepatitis B Virus (HBV) infection and heavy alcohol consumption are the two primary pathogenic causes of liver cirrhosis. In this paper, we proposed a deterministic mathematical model and a logistic equation to investigate the dynamics of liver cirrhosis progression as well as to explain the implications of variations in alcohol consumption on chronic hepatitis B patients, respectively. The intricate interactions between liver cirrhosis, recovery, and treatment dynamics are captured by the model. This study aims to show that alcohol consumption by Hepatitis B-infected individuals accelerates liver cirrhosis progression while treatment of acutely infected individuals reduces… More >

Xinyang Li^1,2,3,#, Luyuan Ma^1,2,3,#, Chuan Shen^1,2,3, Ruolan Gu^1,2,3, Shilong Dong^1,2,3, Mingjie Liu^1,2,3, Ying Xiao^1,2,3, Wenpeng Liu^1,2,3, Yuexia Liu^1,2,3, Caiyan Zhao^1,2,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073179 - 19 January 2026

Abstract Background: Hepatocellular carcinoma (HCC) is an aggressive and lethal malignancy. Metabolic reprogramming dynamically remodels the tumor microenvironment (TME) and drives HCC progression. This study investigated the mechanism through which metabolic reprogramming remodels the TME in HCC. Methods: HCC patient transcriptome data were subjected to bioinformatics analysis to identify differentially expressed genes and immune infiltration status. Immunohistochemical analysis was performed to determine the correlation between succinate dehydrogenase complex subunit A (SDHA) expression and M2 macrophage infiltration. SDHA-knockdown or SDHA-overexpressing HCC cells were used for in vitro experiments, including co-culturing, flow cytometry, and enzyme-linked immunosorbent assay. Western blotting… More >

Jiayu Zou^1,2,3, Yajie Lu³, Jiaqi Li³, Zhaokai Zhou^4,5, Fu Peng³, Pu Qiu^2,*, Hailin Tang⁶, Cheng Peng^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071940 - 19 January 2026

Abstract Lung cancer is the most common but fatal malignant tumor worldwide. Patients with lung cancer experienced a relatively low 5-year overall survival rate, and issues such as metastasis and drug resistance remain prominent challenges in its clinical management. Neddylation, a novel type of post-translational modification, was overactivated in lung cancer and was closely associated with its occurrence, development, metastasis, and drug resistance. This review systematically summarizes the biological process of neddylation and deeply explores the latest research progress on how neddylation affects lung cancer cell proliferation, metastasis, and drug resistance mechanisms, with a focus on More >

Ping Wang^1,2,#, Yan-Han Chen^1,2,#, Ze-Tao Zhan^1,2, Jun-Xiang Zeng^1,2, Yu Chen^3,4, Yuan Lin^1,2, Tao Chen^1,5,*, Wei-Jie Zhou^1,2,5,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071902 - 19 January 2026

Abstract Background: Thimerosal is a mercury-containing preservative widely used in vaccines. This study aimed to investigate its potential antitumor effects and mechanisms in solid malignancies, particularly colorectal cancer (CRC) and melanoma. Methods: A combination of in vitro and in vivo approaches was employed. Cell proliferation, apoptosis, migration, and invasion were assessed using Cell Counting Kit-8 (CCK-8), colony formation, ATP viability, Western blotting, flow cytometry, wound-healing and Transwell assays. Subcutaneous, lung metastases, and Azoxymethane/Dextran Sulfate Sodium Salt (AOM/DSS)-induced colitis-associated CRC models were established to examine antitumor efficacy and safety. The functional role of mercury ions was validated using structural… More >

Wang Zhang^1,#, Haozhuo Cao^2,#, Qiangqiang Yao^1,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072948 - 12 January 2026

Abstract Recent advances in deep learning have significantly improved image deblurring; however, existing approaches still suffer from limited global context modeling, inadequate detail restoration, and poor texture or edge perception, especially under complex dynamic blur. To address these challenges, we propose the Multi-Resolution Fusion Network (MRFNet), a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion. The network employs a three-stage design: (1) TransformerBlocks capture long-range dependencies and reconstruct coarse global structures; (2) Nonlinear Activation Free Blocks (NAFBlocks) enhance local detail representation and mid-level feature fusion; and (3) an optimized residual subnetwork… More >

Wendong Jia^#, Ting Zhang^#, Ziying Zhang, Lingzhi Wu, Xihao Fu, Zhenxin Wang^*, Ni Yin^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068651 - 30 December 2025

Abstract Objectives: Chromobox 4 (CBX4), a polycomb protein family member linked to tumor pathogenesis via dysregulation, has an incompletely defined role in gastric cancer (GC). The study aimed to investigate the role and mechanism of CBX4 in GC progression and evaluate its potential as a therapeutic target. Methods: CBX4 expression was assessed in GC tissues vs. adjacent non-cancerous tissues and in GC cell lines vs. normal gastric mucosal epithelial cells. Clinicopathological correlations were analyzed. Functional impacts of CBX4 were determined using knockdown and overexpression models in vitro (cell proliferation, migration, invasion) and in vivo (xenograft tumorigenesis in nude… More >

Xiaopan Zou^1,2, Meiyang Sun³, Xin Jiang¹, Jingze Yu², Xiaomeng Li^4,*, Bingyu Nie^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.066662 - 30 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. Methods: The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated. In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors. The regulatory relationship between ZMIZ2 and MCM3 was also explored. Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3… More >

Dayong Huang^1,2,*, Wenjun Wang^1,2, Xiaofu Tang^1,2, Pengfei Zhu³, Xianqiong Zhao^3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.34, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012063

Abstract Accurate prediction for the tensile properties (tensile modulus and strength) of injection molded fiber-reinforced thermoplastics (IMFT) plays an important role in the design of structures made with such composites. Based on the Laminate analogy approach (LAA), a unified distribution function (UDF) of tensile properties is derived by introducing the assumption that the fiber length distribution (FLD) and fiber orientation distribution (FOD) are independent of each other. The UDF of tensile properties is simplified by introducing the modified monotonic functions of fiber length and orientation factors (λL and λO). Compared with the tensile modulus and strength… More >

Zhimin Zhao, Liyun Feng, Dongsheng Song, Ming Zhang^*

Journal of Polymer Materials, Vol.42, No.4, pp. 929-957, 2025, DOI:10.32604/jpm.2025.074529 - 26 December 2025

Abstract Global water pollution is becoming increasingly serious, and compound pollutants such as heavy metals and organic dyes pose multidimensional threats to ecology and human health. Metal-organic skeleton compounds (MOFs) have been proven to be highly efficient in capturing a variety of pollutants by virtue of their large specific surface area, adjustable pore channels, and abundant active sites. However, the easy agglomeration of powders, the difficulty of recycling, and the poor long-term stability have limited their practical applications. Cellulose, as the most abundant renewable polymer in nature, has the characteristics of a three-dimensional network, mechanical flexibility,… More >

Kezheng Gao¹, Shuaifei Li¹, Qingyuan Niu², Xiaojing Zhang^2,*

Journal of Renewable Materials, Vol.13, No.12, pp. 2309-2353, 2025, DOI:10.32604/jrm.2025.02025-0108 - 23 December 2025

Abstract The current global shortage of oil resources and the pollution problems caused by traditional barrier materials urgently require the search for new substitutes. Biodegradable bio-based barrier materials possess the characteristics of being renewable, environmentally friendly, and having excellent barrier properties. They have become an important choice in fields such as food packaging, agricultural film covering, and medical protection. This review systematically analyzes the design and research of this type of material, classifying biobased and biodegradable barrier materials based on the sources of raw materials and synthesis pathways. It also provides a detailed introduction to the More >