Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Min Ma^1,2,3,#, Zhuxiu Wang^4,#, Yan Cao⁴, Juanying Yang⁴, Zeliang Zhuang⁵, Linqian Shi^4,*, Qian Gao^4,*

BIOCELL, Vol.49, No.12, pp. 2399-2413, 2025, DOI:10.32604/biocell.2025.071255 - 24 December 2025

Abstract Objectives: Keratin 6A (KRT6A) has been implicated in the progression of multiple malignancies; however, its expression pattern and biological role in cervical cancer (CC) have not been elucidated. This study aims to investigate KRT6A expression in CC tissues and evaluate its effects on cellular proliferation, migration, and invasion, thereby assessing its potential as a biomarker and therapeutic target. Methods: Differentially expressed genes were screened from the Gene Expression Omnibus (GEO) dataset (GSE9750) using the thresholds |log2FC| > 2 and false discovery rate (FDR) < 0.05. Immunohistochemistry was performed to evaluate KRT6A protein expression in tumor… More >

Wenjie Zhou^#, Jiawei Ding^#, Danfeng Xu^*

Oncology Research, Vol.33, No.11, pp. 3493-3522, 2025, DOI:10.32604/or.2025.066783 - 22 October 2025

Abstract Objectives: Despite the fact that prostate cancer is one of the most common tumors in men, this study intends to evaluate the predictive significance of immune and metabolic genes in prostate cancer using multi-omics data and experimental validation. Methods: The research developed and validated a prognostic model utilizing The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, integrating immune and metabolic gene sets. Additionally, the prognostic gene Adenylate Kinase 5 (AK5) was analyzed in prostate cancer tissue microarrays from Ruijin Hospital. The functional role of the AK5 gene was validated through knockdown and… More >

Jun Li¹, Kangmin Yu¹, Zhiyong Chen¹, Dan Xing², Binshan Zha¹, Wentao Xie¹, Huan Ouyang¹, Changjun Yu^3,*

Oncology Research, Vol.33, No.11, pp. 3469-3492, 2025, DOI:10.32604/or.2025.066193 - 22 October 2025

Abstract Objectives: Colorectal cancer (CRC) remains a major contributor to global cancer mortality, ranking second worldwide for cancer-related deaths in 2022, and is characterized by marked heterogeneity in prognosis and therapeutic response. We sought to construct a machine-learning prognostic model based on a complement-related risk signature (CRRS) and to situate this signature within the CRC immune microenvironment. Methods: Transcriptomic profiles with matched clinical annotations from TCGA and GEO CRC cohorts were analyzed. Prognostic CRRS genes were screened using Cox proportional hazards modeling alongside machine-learning procedures. A random survival forest (RSF) predictor was trained and externally validated.… More >

Yi Jin¹, Zexing Shan², Fan Yang¹, Xinwen Fan¹, Jie Lin³, Zeqing Huang^1,*, Xudong Zhu^3,4,*

Oncology Research, Vol.33, No.10, pp. 2937-2960, 2025, DOI:10.32604/or.2025.062250 - 26 September 2025

Abstract Background: As a major histopathological subtype of gastric cancer (GC), stomach adenocarcinoma (STAD) is an important malignant tumor in the digestive system. Increasing evidence also indicates that endoplasmic reticulum (ER) stress plays a pivotal role in the pathogenesis and progression of GC. Therefore, this study aims to screen and identify vital ER stress-related genes that could contribute to the malignant development and poor prognosis for STAD. Methods: A novel ER stress-related risk score signature was developed employing machine learning techniques. Then, a prognostic prediction nomogram was also built based on the clinicopathological characteristics and the… More > Graphic Abstract

Hande İştar^1,#,*, Buğra Harmandar¹, Melike Korkmaz Toker², Fulden Cantaş Türkiş³

Congenital Heart Disease, Vol.20, No.4, pp. 503-517, 2025, DOI:10.32604/chd.2025.068540 - 18 September 2025

Abstract Background: The neutrophil–lymphocyte ratio (NLR) is a simple, cost-effective marker of systemic inflammation. This study aims to evaluate the association between perioperative NLR and postoperative outcomes in pediatric patients undergoing congenital heart surgery with cardiopulmonary bypass (CPB). Methods: We retrospectively reviewed 70 patients under 18 years of age who underwent surgery between 2018 and 2023. NLR was measured preoperatively and on postoperative days (POD) 0, 1, 2, 3, and 6. Receiver operating characteristic analysis identified optimal cutoffs, and associations with postoperative outcomes were assessed. Results: The preoperative NLR cutoff of 1.14 (AUC = 0.75) was associated with More >

Hailong Li^1,#, Wen Ouyang^2,#, Yiyin Long¹, Yun Peng¹, Ziyi Liu¹, Qi Zhou¹, Rong Xu^1,*, Wei Du^1,*

Oncology Research, Vol.33, No.9, pp. 2549-2571, 2025, DOI:10.32604/or.2025.065050 - 28 August 2025

Abstract Background: The study aimed to explore the clinical value of mitochondrial ribosomal protein L18 (MRPL18) in breast cancer. Methods: Multiple databases were used to validate the expression of MRPL18. The prognostic impact and predictive value of MRPL18 were evaluated by using predictive models. Protein-protein interaction (PPI) networks were constructed by using GeneMANIA. Enrichment analysis is used to explore the signaling pathway regulated by MRPL18. Cell counting kit-8 (CCK-8) assays, colony formation, migration assays, flow cytometry, and xenograft models were employed to evaluate the role of MRPL18 in tumor progression. The immune response of MRPL18 was More >

Bi Feng^#, Siqi Yang^#, Zhiqiang He, Yushi Dai, Ruiqi Zou, Yafei Hu, Haijie Hu^*, Fuyu Li^*

Oncology Research, Vol.33, No.9, pp. 2353-2377, 2025, DOI:10.32604/or.2025.061422 - 28 August 2025

Abstract Objectives: Hepatocellular carcinoma (HCC) is among the most frequently occurring malignant tumors of the digestive tract and is associated with an increased mortality rate worldwide. This study aimed to develop and validate a prognostic model based on immunogenic cell death (ICD)-related genes to predict patient survival and guide individualized treatment strategies for HCC. Methods: ICD-related genes were identified from the GeneCards database using a relevance score threshold of >10. A combination of least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox analysis was used to screen prognostic genes and construct a risk score… More >

Shuyan Kong^1,#, Danting Li^1,#, Haonan Meng^1,#, Haoxiang Zhang¹, Xiaochun Jiang¹, Peilin Zheng², Shoujun Huang^1,*

BIOCELL, Vol.49, No.8, pp. 1481-1504, 2025, DOI:10.32604/biocell.2025.066205 - 29 August 2025

Abstract Background: Small ubiquitin-like modifier (SUMO)-specific proteases (SENPs) cleave the isopeptidic bond between SUMO1/2/3 and protein substrates, thus regulating the structure, activity, and lifetime of a variety of proteins. Recently, accumulating evidence has suggested that SENPs play a role in the initiation and progression of human cancers. Nevertheless, the potential role of the SENP family of proteins in liver cancer has yet to be fully elucidated. Methods: This study conducted a comprehensive bioinformatics analysis of the SENP family in liver cancer, including differential expression profiling, survival analysis, mutation and copy number variations (CNVs) assessment, immune infiltration… More >