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Search Results (98)
  • Open Access

    ARTICLE

    Long Noncoding RNA FOXC2-AS1 Predicts Poor Survival in Breast Cancer Patients and Promotes Cell Proliferation

    Haisong Yang*, Tengxiang Chen, Shu Xu, Shiyong Zhang*, Mengmeng Zhang*

    Oncology Research, Vol.27, No.2, pp. 219-226, 2019, DOI:10.3727/096504018X15213126075068

    Abstract Breast cancer (BC) is the most common malignant tumor in women. Recently, long noncoding RNAs (lncRNAs) have been proposed as critical regulators in biological processes, including tumorigenesis. FOXC2-AS1, a single antisense oligonucleotide RNA transcribed from the negative strand of forkhead box protein C2 (FOXC2), has been identified as an oncogene in osteosarcoma. In the present study, we investigated the prognosis value and biological role of FOXC2-AS1 in BC. Our findings revealed that FOXC2-AS1 was significantly increased in BC tissues and cell lines, and Kaplan–Meier survival analysis indicated that a high level of FOXC2-AS1 was associated with poor prognosis of BC… More >

  • Open Access

    ARTICLE

    Adjuvant Chemotherapy Following Surgical Resection Improves Survival in Patients With Early Stage Small Cell Lung Cancer

    Yuanshan Yao, Yinjie Zhou, Zhenhua Yang, Hongbo Huang, Haibo Shen

    Oncology Research, Vol.27, No.2, pp. 203-210, 2019, DOI:10.3727/096504018X15202953107093

    Abstract The purpose of this study was to determine the effects of resection coupled with standard chemotherapy on the survival prognosis of patients with early stage small cell lung carcinoma (SCLC). Patients (n=110) with mediastinal lymph node-negative SCLC were enrolled in this study. The baseline clinical data of patients with surgery were retrospectively reviewed. Overall survival (OS) and progression-free survival (PFS) were measured by Kaplan–Meier and log-rank test analyses. Ninety-eight patients received mediastinoscopy biopsy, and pulmonary lobectomy or sublobar resection, and 67 patients underwent adjuvant chemotherapy after pulmonary lobectomy. Adjuvant chemotherapy after surgical intervention was associated with longer OS (median OS:… More >

  • Open Access

    ARTICLE

    High Blood miR-802 Is Associated With Poor Prognosis in HCC Patients by Regulating DNA Damage Response 1 (REDD1)-Mediated Function of T Cells

    Chao Jiang*, Xueyan Liu, Meng Wang*, Guoyue Lv*, Guangyi Wang*

    Oncology Research, Vol.27, No.9, pp. 1025-1034, 2019, DOI:10.3727/096504018X15456687424096

    Abstract miR-802 has been reported to be dysregulated in multiple tumors and contribute to tumor progression. However, its role in HCC was still largely unknown. The aim of this study is to investigate the function and mechanism of miR-802 in HCC progression. The results showed that miR-802 was upregulated in the peripheral blood and tumor tissue of HCC patients, and high levels of blood miR-802 predicted poor prognosis. miR-802 had no effect on the proliferation and migration of HCC cell lines. Interestingly, the levels of CD8/CD28 and regulated in development and DNA damage response 1 (REDD1) were declined along with the… More >

  • Open Access

    ARTICLE

    Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells

    Hai-Tao Li, Dao-Yong Dong, Qiang Liu, Yi-Qin Xu, Langbo Chen

    Oncology Research, Vol.27, No.4, pp. 423-429, 2019, DOI:10.3727/096504017X15030178624579

    Abstract LACTB, a mitochondrial protein, was ubiquitously expressed in different mammalian tissues, such as liver, heart, and skeletal muscle. It has been shown that LACTB is downexpressed in breast cancers, and it suppresses the proliferation and promotes the apoptosis of breast cancers. However, its role in the progression and prognosis of glioma remains unknown. In this study, we analyzed the clinicopathological features and outcomes of LACTB expression in 98 glioma patients and investigated the effects of LACTB overexpression on the proliferation, invasion, and angiogenesis of glioma cells in vitro. We observed a significant decrease in LACTB expression in glioma, and downexpression… More >

  • Open Access

    ARTICLE

    Correlating Transcriptional Networks to Papillary Renal Cell Carcinoma Survival: A Large-Scale Coexpression Analysis and Clinical Validation

    Xingliang Feng*1, Meng Zhang*†1, Jialin Meng*, Yongqiang Wang, Yi Liu*, Chaozhao Liang*, Song Fan*

    Oncology Research, Vol.28, No.3, pp. 285-297, 2020, DOI:10.3727/096504020X15791676105394

    Abstract We aimed to investigate the potential mechanisms of progression and identify novel prognosis-related biomarkers for papillary renal cell carcinoma (PRCC) patients. The related data were derived from The Cancer Genome Atlas (TCGA) and then analyzed by weighted gene coexpression network analysis (WGCNA). The correlation between each module and the clinical traits were analyzed by Pearson’s correlation analysis. Pathway analysis was conducted to reveal potential mechanisms. Hub genes within each module were screened by intramodule analysis, and visualized by Cytoscape software. Furthermore, important hub genes were validated in an external dataset and clinical samples. A total of 5,839 differentially expressed genes… More >

  • Open Access

    ARTICLE

    The Comprehensive Analysis of Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study

    Zhiyi Peng*1, Guohong Cao†1, Qinming Hou, Ling Li§, Shihong Ying*, Junhui Sun, Guanhui Zhou, Jian Zhou#, Xin Zhang*, Wenbin Ji**, Zhihai Yu††, Tiefeng Li‡‡, Dedong Zhu§, Wenhao Hu§§, Jiansong Ji¶¶, Haijun Du##, Changsheng Shi***, Xiaohua Guo†††, Jian Fang‡‡‡, Jun Han§§§, Wenjiang Gu¶¶¶, Xiaoxi Xie###, Zhichao Sun****, Huanhai Xu††††, Xia Wu‡‡‡‡, Tingyang Hu§§§§, Jing Huang¶¶¶¶, Hongjie Hu‡‡‡‡, Jiaping Zheng####, Jun Luo####, Yutang Chen####, Wenqiang Yu§§§§, Guoliang Shao####

    Oncology Research, Vol.28, No.3, pp. 249-271, 2020, DOI:10.3727/096504019X15766663541105

    Abstract This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of… More >

  • Open Access

    ARTICLE

    Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma

    Bo Ling, Zuliang Huang, Suoyi Huang, Li Qian, Genliang Li, Qianli Tang

    Oncology Research, Vol.28, No.6, pp. 561-578, 2020, DOI:10.3727/096504020X15907428281601

    Abstract There is growing evidence on the clinical significance of tumor microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactions in tumor microenvironments have not been thoroughly studied or systematically analyzed so far. In this study, 22 immune cell components in the lung adenocarcinoma (LUAD) TME were analyzed using gene expression profile from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The TME-based molecular subtypes of LUAD were defined to evaluate further the relationship between molecular subtypes, prognosis, and clinical characteristics. A TME risk score model was constructed by using the differentially expressed genes (DEGs) of… More >

  • Open Access

    RETRACTION

    Retraction notice to “High Blood miR-802 Is Associated With Poor Prognosis in HCC Patients by Regulating DNA Damage Response 1 (REDD 1)-Mediated Function of T Cells” [Oncology Research 27(9) (2019) 1025-1034]

    Chao Jiang*, Xueyan Liu, Meng Wang*, Guoyue Lv*, Guangyi Wang*

    Oncology Research, Vol.28, No.7-8, pp. 833-833, 2020, DOI:10.3727/096504018X16233193839045

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Prognosis Analysis of Lung Cancer Patients

    Yicheng Xie1,*, Jinyue Xia2

    Journal of Intelligent Medicine and Healthcare, Vol.1, No.1, pp. 43-54, 2022, DOI:10.32604/jimh.2022.032405

    Abstract Lung cancer is now the most common type of cancer worldwide, with high levels of morbidity and mortality. The cost of treatment and emotional stress put a high burden on families and society. This paper aims to collect relevant information and provide predictive analysis for the prognosis of patients with lung cancer. Using the public data of SEER database and the method of machine learning, a model is constructed to predict the five-year survival of patients with lung cancer. The re-coding method is used for data processing, the eigenvalues are re-coded to adapt to the construction of the model, and… More >

  • Open Access

    ARTICLE

    Immune-related DNA methylation signature associated with APLN expression predicts prognostic of hepatocellular carcinoma

    FEIFEI TIAN1, HUAN HU1, DI WANG1, HUAN DING1, QINGJIA CHI2, HUAPING LIANG3, WENLI ZENG4,*

    BIOCELL, Vol.46, No.10, pp. 2291-2301, 2022, DOI:10.32604/biocell.2022.020198

    Abstract This study used transcriptome and epigenetic data to predict the prognosis of immune-related genes (IRGs) Apelin (APLN) in patients with hepatocellular carcinoma (HCC). The TCGA database has gene expression and clinical data for HCC. And DNA methylation 450 k data for HCC was download from the University of California Santa Cruz (UCSC) Xena browser. Performing clinical and prognostic analysis of APLN expression, results show that APLN is highly expressed in tumor samples. And it has an increasing trend with the development of clinical stage and T stage. To explore the prognostic role of APLN, the Immune-related DNA methylation (DNAm) sites… More >

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